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Mathura, India

Pyogenic granuloma represents an exuberant connective tissue proliferation due to a chronic stimulus or injury. Aetiological factor for this lesion may sometimes be hard to identify, but the fact that it is usually located close to the gingival margin suggests that calculus, food materials and overhanging restorations are important irritants. It rarely grows more than 2 cm in diameter and usually does not cause any changes in the alveolar bone. We report an unusual case of pyogenic granuloma with unknown aetiology that presented as an extraordinarily large sessile bilobular lesion and showed a large radiographic defect in the alveolar bone with a sun-ray pattern. This kind of clinicoradiological appearance of pyogenic granuloma as presented in our case is rare and the first of its kind. Copyright 2014 BMJ Publishing Group. All rights reserved. Source


Shiromany A.,Kd Dental College | Sood R.,Maharaja Ganga Singh Dental College and Research Center | Akifuddin S.,Daswani Dental College and Hospital | Sidhu G.K.,Maharaja Ganga Singh Dental College and Research Center | And 2 more authors.
Journal of Clinical and Diagnostic Research | Year: 2014

Objective: The role of mast cells as the key effector of allergic inflammation, anaphylactic inflammatory reactions and in the pathogenesis of chronic inflammation, is well-known. The present study is adopted to compare mast cells and inflammatory cells within periapical granuloma and cysts and localize the mast cells and quantify their number in the periapical cysts so as to propose a role of mast cells in the pathogenesis of this lesion.Materials and Methods: Biopsy specimens of 30 periapical lesions were stained with hematoxylin–eosin, and immunohistochemical Mast Cell Tryptase from Bio SB (IHC detection system kit) antibody. The tryptase positive mast cells and mononuclear inflammatory cells were counted in 10 consecutive high power fields (100X) using the binocular microscope from Motic attached to a computer with Motic Advanced Images 3.2 software.Results: Comparative microscopic analysis indicated that periapical cyst shows more percentage of mast cells and less percentage of inflammatory cell than periapical granuloma (comparison of mean and standard deviation of total number of mast cells and inflammatory cells, mast cells 3.15±1.39 in the granuloma group and 4.43±1.91in the cyst group, inflammatory cells, 67.11±1.2 in the granuloma group and 52.66±0.8 in the cyst group). Numerous degranulated mast cells were observed in the fibrous wall than the inflammatory infiltrate of the periapical cysts. The mean and standard deviation of degranulated mast cells between the inflammatory and fibrous zone within the cyst group, being 0.95±1.10 and1.68±1.34 respectively. The values varied significantly between the two zones.Conclusion: The number of inflammatory cells in the cyst group is less than periapical granuloma and total number of mast cells in the cyst group is more as compared to periapical granuloma. The degranulated cells were quantified and they were higher in the fibrous area of the cysts than the inflammatory zone. This study could support the fact that the various mediators released on degranulation play a role in the connective tissue remodeling, chronicity and expansion of the periapical lesion. © 2014, Journal of Clinical and Diagnostic Research. All rights reserved. Source


Agrawal M.,Purvanchal Institute of Dental science | Kumar M.,Kd Dental College | Agrawal V.,BRD Medical College
Journal of Oral Biology and Craniofacial Research | Year: 2012

Vascular lesions have been classified as hemangiomas or vascular malformations depending on the presence of cellular proliferation. These lesions have been known to cause significant morbidity and even mortality in both children and adults. Confusing nomenclature, relative rarity of these lesions, inappropriate diagnosis, lack of precise imaging studies and deficiency of multidisciplinary approach are some of the factors which result in ineffective treatment of such patients. Here, we report a rare case of venous vascular malformation presenting as a mass in the sub mandibular region with no clinical stigmata which was diagnosed with the help of various imaging techniques and subsequently treated by surgery. © 2012 Craniofacial Research Foundation. Source


Parashar S.,Kd Dental College | Maurya R.,Orthodontist Corps Dental Unit | Gupta A.,Institute of Dental science | Anand N.,Kd Dental College
Journal of Clinical and Diagnostic Research | Year: 2015

Introduction: With increasing use of Indian made orthodontic materials, need was felt to know nickel and chromium release from these material. Materials and Methods: This study was conducted on simulated appliances consisting of brackets (022”Roth, Modern orthodontics, Ludhiana, India), from second premolar to central incisor, buccal tube and 0.019×0.025- inch SS arch wires secured with SS ligatures. Immersion was done in artificial saliva. Samples were analysed to using Atomic Absorption Photospectrometer (GVC ScientificEquipment Pvt. Ltd Australia) at AES Laboratories (P) Ltd., Noida India on 1st, 7th, 14th and 28th day. Results: SPSS (ver 17, Inc., Chicago, Illinois, USA) was used toperform the statistical analysis. Descriptive statistics i.e. median and 25 and75 percentiles were used. Peak nickel release was on 7th day and subsequently declined over 14th and 28th day. The peak level of chromium concentration was on 14th day, which declined thereafter. Conclusion: Average daily release of nickel and chromium over a period of one month was 97.368 μg/day and 47.664 μg/day respectively. The estimated release rates were approximately 32% and 16% of the reported average daily dietary. © 2015, Journal of Clinical and Diagnostic Research. All rights reserved. Source


Upadhyay J.,Kd Dental College | Upadhyay R.B.,Kd Dental College | Agarwal P.,Kd Dental College
Asian Pacific Journal of Cancer Prevention | Year: 2011

Being simple and inexpensive toluidine blue has been in use for more than two decades for the detection of potentially malignant oral lesions (PMOL's) and malignant lesions. Although there has been concensus that staining often assists in the identification of these lesions, results have been diverse. In most studies false negative were not recorded as biopsies of lesions that did not retain toluidine blue were not performed. Thus the present study attempted to evaluate the efficacy of toluidine blue vital dye for detection of PMOL's. The study included 47 biopsies(TBP:35 and TBN:12), of which 23 cases were confirmed as dysplastic(TBP=17 and TBN=6), 7 as hyperkeratosis (TBP=4 and TBN=3), 8 as epithelial hyperplasia(TBP=6 and TBN=3) and 5 as other benign lesions(TBP=4 and TBN=1). The validity test revealed a senstivity of 73.9% and specificity of 30%. The positive predictive value was 54.8% and negative predictive value of 50%. The study intends to highlight the false negative result (26.1%) which was mainly attributed to mild dysplasia and the false positive (32.6%) which included hyperkeratosis, hyperplasia, lichen planus and traumatic ulcer. The study concludes that toludine blue staining should not blindly direct the clinician's opinion, and strongly discourages the use of toluidine blue as a screening test and the results should be interpreted with caution. Source

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