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Daejeon, South Korea

Lee J.-Y.,Kangwon National University | Lee K.-S.,KBSI | Park Y.,Kangwon National University | Choi H.-M.,Kangwon National University | And 2 more authors.
Journal of the Geological Society of India | Year: 2013

The chemical and isotopic compositions of groundwater and stream water in the Haean basin, Korea, which have been intensively used for agricultural irrigation, were examined. The field parameters and chemical compositions were typical of relatively uncontaminated waters, except for the agricultural impact. The low EC levels indicated that the waters had not experienced any significant geochemical processes such as water-rock interaction and evaporation. The very similar chemical compositions and ionic ratios were also indicative of fast circulation and good hydraulic connection. The oxygen and hydrogen isotopic compositions of most of the samples in wet and dry seasons showed very similar range which indicated a single source for both waters without any significant geochemical alteration. However, in the wet season, evaporation trends were observed in some groundwaters because of inflow of irrigation return flow from a rice paddy field. The isotopes of both waters were affected by the altitude and amount of precipitation. © 2013 Geological Society of India.

Ahn J.-H.,KAIST | Kim J.-Y.,KAIST | Jung C.,KAIST | Moon D.-I.,KAIST | And 5 more authors.
Technical Digest - International Electron Devices Meeting, IEDM | Year: 2011

A novel biosensor based on an independent double-gate FinFET is demonstrated for the first time. It features a silicon nanowire implemented on a bulk substrate, a floating gate for charge sensing, and a control gate for current driving. The detection of charged polymers and DNA is demonstrated for the diagnosis of breast cancer. © 2011 IEEE.

Lee A.-R.,Gyeongsang National University | Park C.-J.,Gwangju Institute of Science and Technology | Cheong H.-K.,KBSI | Ryu K.-S.,KBSI | And 6 more authors.
Nucleic Acids Research | Year: 2016

Z-DNA binding proteins (ZBPs) play important roles in RNA editing, innate immune response and viral infection. Structural and biophysical studies show that ZBPs initially form an intermediate complex with B-DNA for B-Z conversion. However, a comprehensive understanding of the mechanism of Z-DNA binding and B-Z transition is still lacking, due to the absence of structural information on the intermediate complex. Here, we report the solution structure of the Zα domain of the ZBP-containing protein kinase from Carassius auratus (caZαPKZ). We quantitatively determined the binding affinity of caZαPKZ for both B-DNA and Z-DNA and characterized its B-Z transition activity, which is modulated by varying the salt concentration. Our results suggest that the intermediate complex formed by caZαPKZ and B-DNA can be used as molecular ruler, to measure the degree to which DNA transitions to the Z isoform. © 2016 The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

Yoon H.,KAIST | Lee A.T.,KAIST | Choi E.-A.,KAIST | Seo K.,KAIST | And 5 more authors.
Journal of the American Chemical Society | Year: 2010

Single-crystalline free-standing hexagonal Fe1.3Ge nanowires (NWs) are synthesized for the first time using a chemical vapor transport process without using any catalyst. Interestingly, Fe1.3Ge NWs are found to be ferromagnetic at room temperature, while bulk Fe1.3Ge has the lower critical temperature of 200 K. We perform first-principles density functional calculations and suggest that the observed strong ferromagnetism is attributed to the reduced distances between Fe atoms, increased number of Fe-Fe bonds, and the enhanced Fe magnetic moments. Both experimental and theoretical studies show that the magnetic moments are enhanced in the NWs, as compared to bulk Fe1.3Ge. We also modulate the composition ratio of as-grown iron germanide NWs by adjusting experimental conditions. It is shown that uniaxial strain on the hexagonal plane also enhances the ferromagnetic stability. © 2010 American Chemical Society.

Erraguntla M.,KBSI | Tomasulo P.,Blood Systems Inc. | Land K.,Blood Systems Inc. | Kamel H.,Blood Systems Inc. | And 4 more authors.
Proceedings of the Annual Hawaii International Conference on System Sciences | Year: 2014

Blood donation is a voluntary activity in the United States and provides critical blood units for transfusions. Blood is collected, processed and transported by blood centers to hospitals, though some hospitals also collect blood directly from donors. Blood donation is very safe, but a small percentage of donors can have reactions and some of these reactions can lead to serious injury. Donor hemovigilance is the surveillance and analysis of donor reactions with the goal of understanding the factors influencing reactions and indentifying steps to improve donor safety [9]. Historically in the U.S., donor hemovigilance is managed by individual collection centers to improve their specific organization's donation processes. The Department of Health and Human Services (HHS) has developed a software tool (called DonorHART™) to collect, organize and analyze reactions that occur at different participating blood centers and hospitals [6, 8]. Data mining is used to analyze factors influencing the donor reactions, and the insights are shared with the community to help blood center and hospital managers and quality improvement administrators undertake interventions to improve donor safety [10]. The paper presents the history of the donor hemovigilance development and two data mining efforts performed on the data collected to improve the safety of blood donation processes. © 2014 IEEE.

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