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Kazan, Russia

Based primarily in Kazan, Tatarstan, Russia, the Kazan State Medical University is a federal university made up of seven faculties.Kazan State Medical University is a multifunctionaland multi-eveled state institution ofhigher learning in medicine. It meets bothpersonal and social needs in acquiringeducation in medicine, in developing biomedicaland clinical science, as well asbroadening scientific knowledge of medicalscience.Kazan State Medical University functions on the basis of self-governance andbelongs to the system of Higher Education andScientific Research of the Ministry of Health ofRussia. The highest body or KSMU selfgovernanceis academic with university’sregulations.On March 6, 1994, the university was issuedwith a license number 16 G – 235 by the StateCommittee of Russian Federation of HigherEducation which grants the right to performactivities in the field of professional education.Under the auspices of Kazan State MedicalUniversity there work a pharmaceutical andtwo medical colleges in Kazan, one medicalcollege Mary EI Republic, lycee and biomedicalclasses on the secondary schoolbasis. This complex educational system in theframe work of the university provides thecontinuous higher education of medicine.Kazan State Medical University carries on anaimed preparation of experts in different fieldsof medicine for 10 republics, Povolzhie andUral regions.According to the results of a rating of medicalschools, KSMU takes the 16 place among 86other universities. Founded in 1814, KSMU was the second university institution to be founded in Kazan, the third medical university institution in the Russia. Wikipedia.

Petrov A.M.,Kazan State Medical University
Uspekhi fiziologicheskikh nauk | Year: 2013

Traditionally, membrane protein molecules that form ion channels, transporters, pumps, signaling complexes, machine of exo- and endocytosis is assigned as the main players of the cellular processes. Recently, the findings that indicate the importance of lipids in regulating of cell physiology are accumulated. Attention is attracting to cholesterol molecule because it can directly interact with different proteins and together with sphingolipids to form membrane microdomains (lipid rafts). Many receptors (for neurotransmitters, hormones, growth factors), signaling proteins and proteins involved in vesicular and ion transport are concentrated in the lipid rafts. Changes in stability and structure of rafts cause dramatic cellular dysfunction. In the review the current views on lipid variants that make up the biological membrane, the distribution of cholesterol, the organization and the formation of lipid rafts and caveolae are described. Accent is made on researches that focus on the significance of lipid rafts in the extra- and intracellular signaling, neurotransmitters release, receptor and ion channels function at the excitable cells. Source

Mukhamedyarov M.A.,Kazan State Medical University
Uspekhi fiziologicheskikh nauk | Year: 2013

Beta-amyloid peptide (betaAP) is a product of proteolytic cleavage of wide-spread transmembrane amyloid precursor protein. Betaap is physiological oligopeptide, which is present in biological fluids and tissues of healthy human organism at picomolar concentrations. However, excessive production, polymerization and accumulation of betaAP in tissues (first in neural tissue) underlie the pathogenesis of a number of neurodegenerative diseases (Alzheimer's disease and others). Although the presence of insoluble deposits of fibrillar betaAP (senile plaques) is a characteristic histopathological sign of Alzheimer's disease, soluble betaAP oligomers (dimers, trimers, etc.) possess most neurotoxicity. Soluble betaAP induces mitochondrial dysfunction, increased production of reactive oxygen species in neurons, disorganization of cell plasma membranes, disturbances of ion transport across cell membranes, impairment of synaptic transmission and long-term synaptic plasticity, etc. Recently a lot of attention is paid to possible peripheral effects of betaAP, related to its toxic influence on excitable structures of neuromuscular apparatus and cardiovascular system. At current review we represented state-of-art views on the processes of production and aggregation of betaAP in organism, cellular and molecular mechanisms of betaAP influence on physiological functions of excitable cells, the role of betaAP in pathogenesis of neurodegenerative diseases (Alzheimer's disease and others), as well as the results of our own studies in this field. Source

Ziganshin B.A.,Kazan State Medical University | Elefteriades J.A.,Yale University
Heart | Year: 2014

Thoracoabdominal aneurysm of the aorta (TAAA) is a morbid condition, the treatment of which can be associated with high mortality and complication rates, as well as prolonged length of hospital stay. Currently, three approaches to treatment of TAAAs exist: open, endovascular and hybrid repair. Over the past three decades, a significant decrease in postoperative mortality and paraplegia rates has been achieved due to effective application of such treatment adjuncts as left heart bypass, cerebrospinal fluid drainage, application of hypothermia and neuromonitoring, thereby making surgical treatment of TAAAs increasingly safer for the patient. In this report, we review indications and current approaches to surgical management of TAAAs, as well as the factors that influence the efficacy of this type of treatment. Source

Ziganshin A.U.,Kazan State Medical University
Vestnik Rossiiskoi Akademii Meditsinskikh Nauk | Year: 2011

P2-receptors are widespread in animal and human organs and tissues. Therefore, they attract much attention as potential targets of new drugs. This article presents in brief characteristics of P2 receptors and reviews the author's search for new antagonists of P2-receptors as well as his studies on the role of ectonucleotidases and unique temperature-dependence of P2 receptor activity. In addition, the presence and functional activity of P2 receptors in human uterus, fallopian tubes, heart and blood vessels are described. The possible physiological and pathophysiological role of P2 receptors in these tissues, as well as prospects for the development of drugs acting via P2 receptors is discussed. Source

Mendelevich V.D.,Kazan State Medical University
Harm Reduction Journal | Year: 2011

This article provides an overview of a sociological study of the views of 338 drug addiction treatment professionals. A comparison is drawn between the bioethical approaches of Russian and foreign experts from 18 countries. It is concluded that the bioethical priorities of Russian and foreign experts differ significantly. Differences involve attitudes toward confidentiality, informed consent, compulsory treatment, opioid agonist therapy, mandatory testing of students for psychoactive substances, the prevention of mental patients from having children, harm reduction programs (needle and syringe exchange), euthanasia, and abortion. It is proposed that the cardinal dissimilarity between models for providing drug treatment in the Russian Federation versus the majority of the countries of the world stems from differing bioethical attitudes among drug addiction treatment experts. © 2011 Mendelevich; licensee BioMed Central Ltd. Source

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