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Gataullin A.M.,Kazan State Power Engineering University | Ovchinnikov A.V.,Kazan State Medical Academy
Biomedical Engineering | Year: 2012

The 16-channel detection of evoked potentials (EP) is deteriorated by superposition of curves, which often occurs in spite of scaling along the time and amplitude axes. This problem is inherent in data transfer between neuro-cartographers from different manufacturers and can be solved using the LabView design platform, which allows individual EP records to be visualized by varying the time scale of data presentation. A similar approach can be applied to EEG. © 2012 Springer Science+Business Media New York. Source

Ilyina R.Y.,Kazan State Medical Academy | Pasynkova O.O.,Republican Psychiatric Clinical Hospital Named after V.M. Bekhterev | Ziganshina L.E.,Kazan Federal University
International Journal of Risk and Safety in Medicine | Year: 2013

Background: Neuroleptic induced extrapyramidal disorders are often presented in a form of orofacial hyperkinesias and dystonia. Rational use of neuroleptic drugs requires individualised approach to a patient, however simple criteria for determining individual, 'personalised' dosage regimen have not been fully developed for routine practice in resource-limited hospital settings. Objective: To study the tonus of tongue muscles as a measure of orofacial dystonia and the total hepatic oxidative capacity as a potential predictor of excessive vulnerability to neuroleptic-induced dystonia in psychiatric patients. Methods: We measured the maximal force of the tongue manoeuvre (F, g/cm 2), the total (integral) hepatic oxidative capacity by the antipyrine-test and used chlorpromazine equivalent to calculate the total daily neuroleptic load in 283 psychiatric patients and 30 healthy volunteers. Results: The tonus of tongue muscles depends on the total daily neuroleptic dose and the length of antipsychotic treatment. The higher the total daily neuroleptic dose and the longer the treatment history, the greater the tongue muscles' tonus is. The tongue muscles' tonus was greater in patients with low rate of oxidative antipyrine metabolism. Antidepressants contributed to the increased tonus of the tongue muscles in 'slow metabolisers' of antipyrine. Conclusions: The simple and cheap measurements of total hepatic oxidative capacity and of muscle tonus of the tongue could be used to predict and manage neuroleptic-induced adverse reactions. © 2013-IOS Press and the authors. All rights reserved. Source

Lutfullin I.Y.,Kazan State Medical Academy | Almetova R.R.,Kazan State Medical Academy
Human Physiology | Year: 2014

Heart rate variability of 27 young (10- to 11-year-old) athletes (ice hockey players) was studied. Special autonomic regulatory mechanisms that function both at a supine position and during active orthostatic test were found, which probably reflect the adaptation of the cardiovascular system to sports activity. © 2014, Pleiades Publishing, Inc. Source

Filina J.V.,Kazan State Medical Academy | Gabdoulkhakova A.G.,Kazan State Medical Academy | Safronova V.G.,Russian Academy of Sciences
Cellular Signalling | Year: 2014

Polymorphonuclear neutrophils (PMNs) express the high and low affinity receptors to formylated peptides (mFPR1 and mFPR2 in mice, accordingly). RhoA/ROCK (Rho activated kinase) pathway is crucial for cell motility and oxidase activity regulated via FPRs. There are contradictory data on RhoA-mediated regulation of NADPH oxidase activity in phagocytes. We have shown divergent Rho GTPases signaling via mFPR1 and mFPR2 to NADPH oxidase in PMNs from inflammatory site. The present study was aimed to find out the role of RhoA/ROCK in the respiratory burst activated via mFPR1 and mFPR2 in the bone marrow PMNs. Different kinetics of RhoA activation were detected with 0.1. μM fMLF and 1. μM WKYMVM operating via mFPR1 and mFPR2, accordingly. RhoA was translocated in fMLF-activated cells towards the cell center and juxtamembrane space versus uniform allocation in the resting cells. Specific inhibition of RhoA by CT04, Rho inhibitor I, weakly depressed the respiratory burst induced via mFPR1, but significantly increased the one induced via mFPR2. Inhibition of ROCK, the main effector of RhoA, by Y27632 led to the same effect on the respiratory burst. Regulation of mFPR2-induced respiratory response by ROCK was impossible under the cytoskeleton disruption by cytochalasin D, whereas it persisted in the case of mFPR1 activation. Thus we suggest RhoA to be one of the regulatory and signal transduction components in the respiratory burst through FPRs in the mouse bone marrow PMNs. Both mFPR1 and mFPR2 binding with a ligand trigger the activation of RhoA. FPR1 signaling through RhoA/ROCK increases NADPH-oxidase activity. But in FPR2 action RhoA/ROCK together with cytoskeleton-linked systems down-regulates NADPH-oxidase. This mechanism could restrain the reactive oxygen species dependent damage of own tissues during the chemotaxis of PMNs and in the resting cells. © 2014 Elsevier Inc. Source

Shirshikov F.V.,Kazan Federal University | Cherepnev G.V.,Kazan State Medical Academy | Ilinskaya O.N.,Kazan Federal University | Kalacheva N.V.,Kazan Federal University
Medical Hypotheses | Year: 2013

The exact mechanism by which cytotoxic ribonucleases reach the cytosol of tumor cells remains unclear. The interaction of ribonucleases with a lipid bilayer is involved in the translocation of ribonucleases across the endosomal membrane. Here, we aimed to study the hydropathy character of toxic antitumor ribonucleases (bovine seminal ribonuclease and binase) and two non-toxic ribonucleases (bovine pancreatic ribonuclease and human pancreatic ribonuclease) by sliding-window hydrophobicity analysis. Comparative hydropathy plot analysis of the non-toxic pancreatic ribonucleases and their toxic variants was also performed. The data obtained indicate that some cytotoxic ribonucleases have a hydrophobic segment, which is sterically available for the hydrophobic interaction with a tumor cell membrane and endosomal membrane. After dissociation, subunits of dimeric ribonucleases are probably capable of thermodynamically favorable interaction with the interfacial region of a lipid bilayer. Remarkably the hydrophobic segment is not identified in the amino acid sequences of non-toxic ribonucleases. The paper describes the hydrophobic properties of toxic RNases that are essential for both the model of a lipid-protein interaction and the cytotoxicity mechanism unraveling. © 2013 Elsevier Ltd. Source

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