Kazakh National Medical University

www.kaznmu.kz/
Almaty, Kazakhstan

Kazakh National Medical University is a university in Almaty, Kazakhstan. It is the no.1 medical institute in all of Kazakhstan. Many of Kazakhstan's leading physicians are affiliated with the university. It is dedicated to S.D. Asfendiyarov who was the first rector when the university was established in 1931. In 2001, the government classified it as a "national" university. There are more than 11000 students, PhD students study at KazNMU, and there are more than 1500 faculty members working at KazNMU, including more than 200 doctors of science, 130 professors, more than 500 candidates of science and 15-laureates of State prizes. Wikipedia.


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Gasparyan A.Y.,University of Birmingham | Akazhanov N.A.,Kazakh National Medical University | Voronov A.A.,Kuban State University | Kitas G.D.,University of Birmingham | Kitas G.D.,University of Manchester
Journal of Korean Medical Science | Year: 2014

Unique identifiers of researchers and authors can help all stakeholders of scientific communications improve their workflows. There have been several attempts to establish professional networks of scholars and list their scholarly achievements on digital platforms. Some of these platforms such as Google Scholar, Web of Knowledge and PubMed are searched to pick relevant peer reviewers, assess authors' publication history or choose suitable candidates for research and academic projects. However, each of these hubs has its specific applications, limiting the universal use for permanent tagging of researcher profiles. The Open Researcher and Contributor ID (ORCID) initiative, launched in 2012, is aimed at registering scholarly contributors and averting the persistent ambiguity of recorded author names. The ORCID registry is growing fast and integrating with other IDgenerating platforms, thereby increasing the functionality of the integrated systems. ORCID identifiers are increasingly used for selecting peer reviewers and acknowledging various scholarly contributions (e.g., published articles, reviewer comments, conference presentations). The initiative offers unique opportunities for transparent disclosures of author contributions and competing interests and improving ethical standards of research, editing, and publishing. © 2014 The Korean Academy of Medical Sciences.


Gasparyan A.Y.,University of Birmingham | Ayvazyan L.,Yerevan State Medical University | Akazhanov N.A.,Kazakh National Medical University | Kitas G.D.,University of Birmingham | Kitas G.D.,University of Manchester
Croatian Medical Journal | Year: 2013

This article overviews evidence on common instances of conflict of interest (COI) in research publications from eneral and specialized fields of biomedicine. Financial COIs are viewed as the most powerful source of bias, which may even distort citation outcomes of sponsored publications. The urge to boost journal citation indicators by stakeholders of science communication is viewed as a new secondary interest, which may compromize the interaction between authors, peer reviewers and editors. Comprehensive policies on disclosure of financial and non-financial COIs in scholarly journals are presented as proxies of their indexing in evidence-based databases, and examples of successful medical journals are discussed in detail. Reports on clinical trials, systematic reviews, meta-analyses and clinical practice guidelines may be unduly influenced by author-pharmaceutical industry relations, but these publications do not always contain explicit disclosures to allow the readers to judge the reliability of the published conclusions and practice-changing recommendations. The article emphasizes the importance of adhering to the guidance on COI from learned associations such as the International Committee of Medical Journal Editors (ICMJE). It also considers joint efforts of authors, peer reviewers and editors as a foundation for appropriately defining and disclosing potential COIs.


Gasparyan A.Y.,University of Birmingham | Ayvazyan L.,Yerevan State Medical University | Akazhanov N.A.,Kazakh National Medical University | Kitas G.D.,University of Birmingham | Kitas G.D.,University of Manchester
Croatian Medical Journal | Year: 2014

Aim: To analyze mistakes and misconduct in multidisciplinary and specialized biomedical journals. Methods: We conducted searches through PubMed to retrieve errata, duplicate, and retracted publications (as of January 30, 2014). To analyze publication activity and citation profiles of countries, multidisciplinary, and specialized biomedical journals, we referred to the latest data from the SCImago Journal & Country Rank database. Total number of indexed articles and values of the h-index of the fifty most productive countries and multidisciplinary journals were recorded and linked to the number of duplicate and retracted publications in PubMed. Results: Our analysis found 2597 correction items. A striking increase in the number of corrections appeared in 2013, which is mainly due to 871 (85.3%) corrections from PLOS One. The number of duplicate publications was 1086. Articles frequently published in duplicate were reviews (15.6%), original studies (12.6%), and case reports (7.6%), whereas top three retracted articles were original studies (10.1%), randomized trials (8.8%), and reviews (7%). A strong association existed between the total number of publications across countries and duplicate (rs = 0.86, P < 0.001) and retracted items (rs = 0.812, P < 0.001). A similar trend was found between country-based h-index values and duplicate and retracted publications. Conclusion: The study suggests that the intensified self-correction in biomedicine is due to the attention of readers and authors, who spot errors in their hub of evidence-based information. Digitization and open access confound the staggering increase in correction notices and retractions.


Pismensky S.V.,Moscow State University | Kalzhanov Z.R.,Kazakh National Medical University | Eliseeva M.,Federal Medical Biological Agency of Russia | Kosmas I.P.,University of Ioannina | Mynbaev O.A.,Moscow State University
BMC Surgery | Year: 2011

Background: Many factors have been put forward as a driving mechanism of surgery-triggered adhesion formation (AF). In this study, we underline the key role of specific surgical trauma related with open surgery (OS) and laparoscopic (LS) conditions in postoperative AF and we aimed to study peritoneal tissue inflammatory reaction (TIR), remodelling specific complications of open surgery (OS) versus LS and subsequently evaluating AF induced by these conditions. Methods. A prospective randomized study was done in 80 anaesthetised female Wistar rats divided equally into 2 groups. Specific traumatic OS conditions were induced by midline incision line (MIL) extension and tissue drying and specific LS conditions were remodelled by intraperitoneal CO 2insufflation at the 10 cm of water. TIR was evaluated at the 24 th, 72 nd, 120 th and 168 th hour by scoring scale. Statistical analysis was performed by the non-parametric t test and two-way ANOVA using Bonferroni post-tests. Results: More pronounced residual TIR was registered after OS than after LS. There were no significant TIR interactions though highly significant differences were observed between the OS and LS groups (p < 0.0001) with regard to surgical and time factors. The TIR change differences between the OS and LS groups were pronounced with postoperative time p < 0.05 at the 24 th and 72 nd; p < 0.01 - 120 th and p < 0.001 - 168 th hrs. Adhesion free wounds were observed in 20.0 and 31.0% of cases after creation of OS and LS conditions respectively; with no significant differences between these values (p > 0.05). However larger adhesion size (41.67 33.63) was observed after OS in comparison with LS (20.31 16.38). The upper-lower 95% confidential limits ranged from 60.29 to 23.04 and from 29.04 to 11.59 respectively after OS and LS groups with significant differences (p = 0.03). Analogous changes were observed in adhesion severity values. Subsequently, severe TIR parameters were followed by larger sizes of severe postoperative adhesions in the OS group than those observed in the LS group. Conclusions: MIL extension and tissue drying seem to be the key factors in the pathogenesis of adhesion formation, triggering severe inflammatory reactions of the peritoneal tissue surrounding the MIL resulting in local and systemic consequences. CO 2insufflation however, led to moderate inflammation and less adhesion formation. © 2011 Pismensky et al; licensee BioMed Central Ltd.


Nogaeva M.G.,Kazakh National Medical University
Terapevticheskii Arkhiv | Year: 2015

Aim. To analyze overall and new-onset osteoarthritis (OA) morbidity among the adult population in the Republic of Kazakhstan in 2011-2012. Subjects and methods. The data of annual statistical reports «On Population Health and Public Health System» (Form No. 12) in 2011-2012 were analyzed. The indicators in the Republic of Kazakhstan were taken from the statistical collected articles «Population Health in the Republic of Kazakhstan and Activities of Healthcare Facilities». Results. A comparative analysis of the indicators revealed a rising trend in overall morbidity by 1%, including in the incidence of musculoskeletal diseases (MSD) by 3% (the increase rate per 100,000 population was 2%). An analysis of the incidence of MSD per 100,000 population in some regions of the Republic of Kazakhstan showed an upward trend in the Almaty Region: the incidence increased among the women and the 18 or more year olds by 23 and 16%, respectively. Among the adults (aged 18 years or older) and women, the number of patients with a newly diagnosed coxarthrosis (CA) increased by 43 and 18%, respectively; the number of those with gonarthrosis (GA) rose by 36 and 33%, respectively. The people older than 60 years of age and women showed 122 and 82% rises in the number of patients with a newly diagnosed CA; there were 78% increment rates in the patients with GA and 68% in the women. Conclusion. In the Republic of Kazakhstan, there was a high incidence of OA in both the people aged 18 years or older with newly diagnosed CA, GA and the people over 60 years of age, in women in particular.


Semenova R.I.,Kazakh National Medical University | Musina N.S.,Kazakh National Medical University
Terapevticheskii Arkhiv | Year: 2012

Aim. To evaluate the clinical efficacy of ebrantil used in patients with resistant arterial hypertension (RAH) in Stage lll-V chronic kidney disease (CKD). Subjects and methods. Sixty-five patients with Stage III-V CKD and RAH (systolic blood pressure (SBP) 215.7±4.0 mm Hg and diastolic blood pressure (DBP) 114.6+2.3 mm Hg) were followed up. The patients received intravenous ebrantil (urapidil) in a dose of 25 mg for 5 days and then were switched to its oral use as 30-60-mg capsules twice daily for 12 weeks. Results. The intravenous infusion caused a significant fall in SBP and DBP by 23.6 and 16.7%, respectively, within 60-90 min. A steady-state antihypertensive effect was achieved on days 5-7 (SBP and DBP was lowered to 146.8±6.1 and 95.6±5.3 mm Hg, respectively; p<0.05). After 12 weeks of the therapy, SBP was 144.4±6.3 mm Hg and DBP was 93.3±4.1 mm Hg (p<0.05). Conclusion. The use of ebrantil in patients with CKD and RAH produces an effective BP without marked adverse reactions.


Nogaeva M.G.,Kazakh National Medical University
Terapevticheskii Arkhiv | Year: 2015

Aim. To analyze a trend in overall and new-onset rheumatoid arthritis morbidity among the adult population in the Republic of Kazakhstan in 2011-2012. Materials and methods. The data of 2011-2012 annual statistical reports on "Population Health and Healthcare System" (Form 12) were analyzed. The indicators in the Republic of Kazakhstan were taken from the statistics digest "Population Health in the Republic of Kazakhstan and Activities of Healthcare Facilities". Results. Comparative analysis of the indicators revealed an increment in overall morbidity by 1%, including that in the incidence of musculoskeletal diseases (MSD) by 3% (the increment rate per 100,000 was 2%). The rise in MSD prevalence was 20% among the adults (aged 18 years and older) and 21% among the women; the increase in the number of patients with a first established diagnosis of RA was 27% and that was 20% among the women. There was a higher rate of rises by 52 and 48% in the number of MSD patients aged 60 years and older and in that of women, respectively; the number of patients with a first established diagnosis of RA increased by 10% and that rose 12% in the women. The number of patients with a first established diagnosis of RA increased considerably by 27 and 20% among the adults aged 18 years and older) and by 10 and 12% among those aged 60 years or over, respectively. Conclusion. In the Republic of Kazakhstan, there is a high prevalence of MSD among people aged above 18 years and above 60 years and there is a preponderance of able-bodied persons aged 18 years or above with a first established diagnosis of RA.


Danilovich N.,Kazakh National Medical University
Journal of Public Health Policy | Year: 2010

The present study examines how growing socio-economic inequalities in transitional countries that have followed different health policy paths affect womens access to reproductive health care. I conducted surveys in Kazakhstan and Belarus and used logistic regression analyses to determine accessibility to and satisfaction with reproductive health services, reproductive status, and reproductive history based on country of residence. By all measures, access to reproductive health services was most problematic for the low-income women in Kazakhstan but to a significantly lesser extent for economically disadvantaged respondents in Belarus. Differences in education had a significant effect on women's access to reproductive health services in Kazakhstan but were not present in Belarus. Household income was the most powerful predictor of self-perceived health in Kazakhstan, but not in Belarus. The unreformed health-care system in Belarus appears to be more accessible for all women than Kazakhstan's health-care system that underwent significant market-oriented reform. © 2010 Macmillan Publishers Ltd.


Klimash A.V.,Polenovs Russian Neurosurgical Scientific Research Institute | Zhanaidarov Z.S.,Kazakh National Medical University
Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova | Year: 2016

Objective — to explore the characteristics of brain function recovery in patients after prolonged posttraumatic coma and with long-unconscious states. Material and methods. Eighty-seven patients after prolonged posttraumatic coma were followed-up for two years. An analysis of a clinical/neurological picture after a prolonged episode of coma was based on the dynamics of vital functions, neurological status and patient’s reactions to external stimuli. Results and conclusion. Based on the dynamics of the clinical/neurological picture that shows the recovery of functions of the certain brain areas, three stages of brain function recovery after a prolonged episode of coma were singled out: brain stem areas, diencephalic areas and telencephalic areas. These functional/anatomic areas of brain function recovery after prolonged coma were compared to the present classifications. © 2016, Media Sphera. All rights reserved.


Datkhayev U.,Kazakh National Medical University | Shopabayeva A.,Kazakh National Medical University | Zhakipbekov K.,Kazakh National Medical University | Yermekbayeva D.,University of International Business | And 2 more authors.
Life Science Journal | Year: 2013

The implementation of the state policy of the pharmaceutical industry requires institutional, infrastructural development and investment measures, as well as system-wide state measures of the pharmaceutical industry of the Republic of Kazakhstan. At the present stage the implementation of GMP methodology of developed countries became unavailable for the pharmaceutical company of Kazakhstan due to a high commercial value of the services of international experts. In connection with the above there occurred the problem on working out methodological approaches of rules for the organization of pharmaceutical production in accordance with international requirements. To assess the reliability of all elements of the production cycle, as well as the detailed preparation and planning of the different phases and stages it's necessary to adhere to the organization of the pharmaceutical production algorithm. Organization of pharmaceutical production is a complex and demanding task that requires knowledge and skills not only in business, informational technologies, training personnel and a variety of other areas, but in the organizational design (engineering). We determined the basic principles of organizational design and an algorithm of organizational designing for the pharmaceutical industry.

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