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Calis H.T.,Kayseri Education and Research Hospital | Berberoglu N.,Erciyes University | Calis M.,Erciyes University
European Journal of Physical and Rehabilitation Medicine | Year: 2011

Background: Subacromial impingement syndrome (SIS) is the most common reason for shoulder pain. Ultrasound and laser are the physical therapy modalities, in conservative treatment of SIS. Aim: The aim of this study was to define and compare the efficacy of ultrasound, laser and exercise in the treatment of SIS. Design: This was a randomized controlled trial withpre and post-treatment evaluations Setting: Out-patients referred to physical medicine and rehabilitation unit. Population: This study was performed on 52 patients with SIS. The patients were randomly allocated into three groups Methods: The patients were treated five days a week for three weeks with hotpack+ultrasound+exercise (the first group); hotpack+laser+exercise (the second group), or hotpack+exercise (the third group). The pre and post treatment ranges of motion were measured in the patients. The visual analogue scale (VAS) was used to evaluate the severity of pain. Constant scoring was used to evaluate the shoulder functions and the results were compared after the treatment. Results: When the post-treatment results of the groups were compared with the pretreatment results, there was a statistically significant improvement in each of the three groups, in the pain, the range of motion and the functional improvement at the shoulder (P<0.05). However, the inter-group comparison did not reveal any statistically significant difference in the parameters indicating improvement (P>0.05). Conclusion: The results of this study demonstrated that ultrasound and laser treatments were not superior to each other in the treatment of SIS. Clinical Rehabilitation Impact. Exercise treatment forms the base for the conservative treatment. Source

Cihan Y.B.,Kayseri Education and Research Hospital
Asian Pacific Journal of Cancer Prevention | Year: 2014

Background: The aim of this study was to investigate the relationship of body mass index with overall and progression-free survival as well as other prognostic factors of breast cancer in patients with non-metastatic breast cancer. Materials and Methods: We retrospectively reviewed 456 patients diagnosed with breast cancer in the Radiation Oncology department of Kayseri Teaching Hospital between 2005 and 2013. We investigated relationship of body mass index with prognosis and other prognostic factors. Results: The study included 456 patients (447 women and 9 men). Mean age at presentation was 55.6 years. Of the cases, 96.9% underwent modified radical mastectomy and 95.0% received chemotherapy, while 82.4% received radiotherapy and 60.0% were given hormone therapy. Body mass index was >25 mg/kg2 in 343 cases. Five- and 10-years overall survival rates were 77% and 58% whereas progression-free survival rates were 65% and 49%, respectively. In univariate analyses, factors including stage (p=0.046), tumor diameter (p=0.001), lymph node metastasis (p=0.006) and body mass index (p=0.030) were found to be significantly associated with overall survival, while perinodal involvement was found to be significantly associated with progression-free survival (p=0.018). In multivariate analysis, stage (p=0.032; OR: 3.8; 95% CI: 1.1-13), tumor diameter (p < 0.000; OR: 0.0; 95% CI: 0.0-0.3), lymph node metastasis (p=0.005; OR: 0.0; 95% CI: 0.0-0.5) and BMI (p=0.027; OR: 0.02; 95% CI: 0.0-0.8) remained as significantly associated with OS. Conclusions: In our study, it was seen that overall survival time was shorter in underweight and obese patients when compared to normal weight patients. Source

Benderli Cihan Y.,Kayseri Education and Research Hospital | Ozturk Yildirim S.,Erciyes University
Biological Trace Element Research | Year: 2011

Our work aimed at extending the search for the trace elements (TE) abnormalities in patients with lung cancer and in healthy controls who smoke, and also for evidence of a possible association between lung cancer and TE. The analysis of the hair from patients with Stage-IIIB non-small cell lung cancer (group 1) and healthy controls (group 2) were analyzed using the inductively coupled plasma mass spectrometry technique in order to obtain information on the correlation between the lung cancer patients and healthy controls. Sixty-seven one-hair samples in group 1 were individually collected before chemoradiotherapy. For comparison, 74 hair samples were collected from group 2. In group 1, the trace elements present at the highest levels were measured to be Ca, Zn, Sn, Na and Mg, respectively, and they were quantified as 68.2, 53.2, 33.9, 23.3, and 28.9 μg. kg -1, respectively. In group 2, the trace elements present at the highest levels were Zn, Mg, Ca, Fe, and Se, respectively, and they were quantified as 109.7, 31.9, 30.8, 25.0, and 20.1 μg.kg -1. In group 1, the highest levels of Ca, Sn, and Na were 2.03, 1.06, and 1.01 times higher, respectively, compared with group 2. In group 2, Zn, Mg, Fe, and Se were 2, 1.01, 2.7, and 1.6 times higher, respectively, compared with group 1. When the levels of trace elements were compared between groups 1 and 2 using Student's t test, the levels of Ag, Au, Be, Bi, Ca, Cd, Ce, Co, Cr, Cu, Fe, Ga, Hg, K, Ni, Rb, Rh, Sb, Sc, Ti, V, and Zn were found to be statistically different (p<0.05). According to Pearson's correlation, the most powerful correlation was found for Cr-As (r=0.858) couple in group 1 (r=0.745) and for Mn-Cr couple in group 2. The factors obtained according to converted matrix were observed to be as follows: for group 1, first factor, ten variables (Cd, Li, Cs, Ag, Rb, Pd, Ga, Zn, Al, and K); second factor, seven variables (Cr, As, Sn, Co, Ca, Rh, and Fe) and third factor, four variables (Mn, Au, Cu, and Hg). Within the first factor that best describes the overall change, the most important variables are Cd and Li, respectively the first and the second factors. Group 2 contained the following: first factors, six variables, Cr, Mn, Al, Ba, Rb, and Pb; second factor, eight variables, Co, As, Sn, Cd, Hg, Cs, Ca, and Ce; third factor, five variables Na, Ga, Be, B, and Sr; and fourth factor, two variables K and Ag. First, second, third, and fourth factors explain the 36% of the overall change. Within the first factor that best described the overall change, the most important variables were Cr and Mn. In this analysis, we observed that the group 2 trace elements accumulated were heavy metals and that the control group showed both heavy metals and macroelements required for the body. The average trace elements levels in the two groups were evaluated. In addition, the general role of trace elements in the lung carcinogenic processes was discussed. The study revealed that the carcinogenic processes are significantly affecting the trace elements and the trace elements distribution in the hair of lung cancer patients compared with the healthy controls. It was revealed that there was a relation between lung cancer and trace elements, especially heavy metals. Our findings suggest that the heavy metals accumulated in the body may pose a high risk for lung cancer development. © Springer Science+Business Media, LLC 2011. Source

Caglayan A.O.,Kayseri Education and Research Hospital
Interactive Cardiovascular and Thoracic Surgery | Year: 2010

Atrial fibrillation (AF) is a consequence of a complex interplay of genetic, epigenetic and environmental factors. In addition, AF is a major contributor to stroke, heart failure, and mortality Several family studies have shown a strong polygenetic predisposition for AF but, so far, most of the linkage analysis and candidate gene studies have discovered only monogenic, rare, deleterious mutations. While research in human genetics has moved from monogenic to oligogenic to complex diseases, its pharmacogenetics branch has followed, usually a few years behind. The present paper reviews the potential contributions of genetic approaches to AF. © 2010 Published by European Association for Cardio-Thoracic Surgery. All rights reserved. Source

Cihan Y.B.,Kayseri Education and Research Hospital
Journal of B.U.ON. | Year: 2014

Purpose: To determine the prognostic value of trace element levels in cases with locally advanced non-small cell lung cancer (NSCLC).Methods: This prospective study included patients receiving chemoradiotherapy for locally advanced NSCLC and healthy individuals as control group. In both groups, 37 trace element levels in hair were studied by inductively coupled plasma-mass spectrometer technique. Treatment response and survival were evaluated and possible relationship between them and trace element levels was investigated.Results: The mean age was 58.01±7.7 years in the patient group (N=70) and 56.3±9.03 years in the control group (N=85). When trace element levels were compared, it was found that there was significant differences between groups regarding Al, As, Be, Ca, Cr, Hg, Li, Ni, Rh, Sb, Se, Sn, Ti and Zn levels (p<0.05; Student's t-test). In the patient group, mean overall survival (OS) and progression-free survival (PFS) were 16.3 and 11.4 months, respectively. After concurrent chemoradiotherapy, complete response (CR) was detected in 7 patients (10%), partial response (PR) in 16 (22.9%), stable disease (SD) in 18 (25.7%) and progression (PD) in 29 patients (41.4%). In univariate and multivariate analyses. Au and Cu levels were significantly associated with PFS (p=0.017 and p=0.020, respectively).Conclusion: An increase was noticed in heavy metal levels in patients with NSCLC. Copper and gold affected significancy PFS while other trace elements had no significant impact on survival. Source

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