Murad H.,King Abdulaziz University |
Murad H.,Ain Shams University |
Ayuob N.,KAU |
Ayuob N.,Mansoura University
Pain Physician | Year: 2015
Background: Chronic pain may be associated with diabetes mellitus and/or depression. Use of therapies that target both comorbidities is encouraged. Objective: This study was designed to investigate the potential antinociceptive, neuroprotective, and antidepressant effects of combinations of pioglitazone or metformin with fluoxetine in chronic constriction injury (CCI) in rats. Study Design: Experimental trial in rats. Setting: University lab in Saudia Arabia. Methods: Two sets of experiments were performed. In each one, 9 groups of rats (n = 8) were used: sham, CCI, and 7 CCI-treated groups. Treatments were given orally starting on day 7 post-surgery as follows (mg/kg/day): fluoxetine (10, 20, and 40), pioglitazone (20), metformin (50), fluoxetine (20) + pioglitazone, and fluoxetine (20) + metformin. In the first set, on day 14 post-surgery mechanical allodynia, thermal hyperalgesia, and serum cytokines were measured. Moreover, immunoreactivity of glial fibrillary acidic protein (GFAP, a marker for astrocytic activation) in the spinal cord was assessed and histopathological changes in the ipsilateral sciatic nerve were examined. In the second set, on days 14 and 21 post-surgery the forced swimming test was done. Results: IIn the first set, all treatments significantly decreased (not increased) mechanical allodynia while all treatments except F10 and F20 significantly decreased (not increased) thermal hyperalgesia compared to the CCI group. The F20+M group showed the highest decreases (not increases), however still significantly lower than those of the sham group. The treatments didn’t impair motor function in the rotarod test. All treatments significantly decreased serum levels of tumor necrosis factor interleukin-6, and monocyte chemoattractant protein-1 while increasing the level of interleukin-10. The CCI-induced marked increase of GFAP immunoexpression has been reduced to moderate with fluoxetine (40) and pioglitazone, and to mild with metformin and the combination groups. The CCI-induced changes in sciatic nerve were less in fluoxetine (40), pioglitazone, and metformin groups, and least in the combination groups. In the second set, the immobility duration was significantly reduced by F20, F40, P, F20+P, and F20+M compared to the CCI group. The F20+P group showed the highest decrease, however still significantly lower than that of the sham group. The treatments didn’t affect locomotor activity in the open field test. Limitations: Measuring the cytokines levels only in blood and not in the spinal cord and sciatic nerve and measuring the outcome measures in the first set of experiments at only one time-point. Conclusions: Co-administration of pioglitazone or metformin with low-dose fluoxetine improved mechanical allodynia, thermal hyperalgesia, and neurohistopathological changes while coadministration of pioglitazone, but not metformin, improved the depressive-like behavior in the peripheral nerve injury model of neuropathic pain in rats. Extrapolation of the current results to clinical reality could be beneficial for pain patients with diabetes and/or depression, however this needs further confirmatory studies. © 2015, American Society of Interventional Pain Physicians. All rights reserved.
Abou-Zeid A.,Cairo University |
IEEE Global Engineering Education Conference, EDUCON | Year: 2014
Quality of engineering education is a core principle that can never be sacrificed. To ensure quality, engineering programs/schools seek national and/or international accreditation from relevant accreditation agencies. As higher education in Saudi Arabia is evolving rapidly and to ensure high education quality standards, the Ministry of Higher Education is requesting all the institutions of higher education to be accredited by the National Commission for Academic Accreditation & Assessment (NCAAA). The accreditation process is not very much liked by most of the faculty members as they have the misconception that it is an exhausting time consuming, not to say complex and unnecessary, process. Most faculty members are not enthusiastic about going through the preparation process and its requirements from data collection, documents and forms preparation, data aggregation, data analysis, collecting evidences, and developing corrective action and future plans as needed. This paper describes requirements for programs accreditation, the preparation process, and the challenges faced during the accreditation process. Few papers were published discussing different issues related to the accreditation process in Saudi Universities. Despite the importance of the accreditation related issues discussed in those papers, the authors believe that the challenges associated with the accreditation process and their causes are not fully reported and are very important to be presented. Programs, colleges, and faculty members need to realize those challenges to try to avoid them and make the accreditation process easier and smoother. Knowledge and information gained via observation, unstructured interviews with faculty members, discussions with colleagues from different Saudi universities, and extensive involvement of the authors in the accreditation process in a private university and a public university is utilized to state challenges and barriers experienced throughout different stages of the accreditation journey. The private university was preparing for NCAAA and the public university was preparing for ABET. Although the study is based more on the national accreditation experience, it was found that similar challenges were faced and same recommendations apply for both national and international accreditation. This means that type of accreditation and differences between programs/universities was not the problem and proves that the readiness of the program and the institution is the most important catalyst of the accreditation process. The main challenges faced by different programs were added workload, understaffing, inadequate training, inability to properly prepare required forms and documents, lack of faculty commitment to the accreditation process, high faculty turn over, and lack of proper support from higher administration. The paper discusses the main causes of the problems faced during the process and presents some recommendations that might help making the accreditation process easier and smoother. The study concludes with the fact that faculty and staff commitment and belief in the importance of quality and the benefits of accreditation to the programs and institution is the key success factor in attaining accreditation. Administration cannot force faculty and staff to go quality but can convince them that quality is the perfect life style for the institution. © 2014 IEEE.
News Article | February 23, 2017
Performance marketing agency beats 2,500 agencies and tops leaderboard for new business acquisition and revenue growth. KAU Media Group (KMG), the UK's fastest growing performance marketing agency has won Google's Game On award for the final quarter of 2016. The competition, which is open to the 2,500 Google Partners, recognises digital marketing agencies demonstrating the largest amount of revenue and new business growth in each quarter. KMG finished top among over 1,000 entries in the Q4 round of the competition. Officially launched in January 2016, KMG has grown substantially in the last year by dramatically increasing new business acquisition and reported a 2016 revenue figure of £1.6 million. Due to rapid client growth and a subsequent increase in Google advertising spend, KMG has been accredited with Google Premier Partner status. With a client base ranging from local businesses to some of the largest enterprises in the country, KMG provides them with a level playing field in the digital performance marketing and advertising space. KMG Analytics platform enables clients to see in real-time their return on advertising spend (ROAS). Google's Game On awards were introduced to all partner agencies at the start of 2016, during this experience, agencies get the chance to access latest research and consumer behavior information. The awards are held on a quarterly basis and measure agencies on their level of Google advertising spend in addition to new business and revenue for the quarter. Kashif Khokhar, CEO of KAU Media Group added: "This is an amazing achievement for our business considering the competition we were up against and that we only launched in January 2016. The level of service and transparency that we're providing to our clients is unrivalled in this high-growth marketplace. The most important thing for our clients is their ROAS, we feel that there are very few agencies out there who can give clients this insight. We're a young business with energetic, talented people who are passionate about our clients and helping them meet their ambitions and full potential. With over 5 million SMEs in the UK we're operating in a market with unlimited potential for growth." Chris Healy, Sales Director at Freeborn Citroen commented "KAU Media Group deliver performance marketing at its best. They are very professional and understand our goals. We have grown our brand and generated huge sales numbers in a challenging market. Long may this growth continue." The opportunity for businesses to position themselves in the shop window has never been higher. Today there are over 2.5 billion users of Google Search and in excess of 100 billion search queries per month. As a result, firms are challenged to position themselves across the digital landscape by optimising their performance on search engines and social media channels through a variety of methods. KMG's unique approach to performance marketing provides clients with enterprise level bid management technology and strategy, resulting in one of the highest retention rates of any agency in the UK. Launched in 2016, KMG is a full service agency that deliver compelling digital performance marketing solutions. KMG's winning solutions and experience helps to deliver great results across several key areas; search engine marketing, search engine optimisation, social media marketing, display marketing, SmartChat and website design. This combination has helped many of its clients to interact and engage with customers in a new and better way. For more info go to http://www.kaumediagroup.com/
Hedia H.S.,KAU |
Aldousari S.M.,KAU |
Abdellatif A.K.,KAU |
Materialpruefung/Materials Testing | Year: 2012
Many experimental researches succeeded to improve fatigue properties of materials by treating their surfaces. In this study, the benefits of na-nocomposite material are used to investigate the fatigue life of stainless steel specimens with different surface roughness. Nanocomposite coating was prepared with different concentrations (0.3 %, 0.5 %, and 0.7 %) of multi wall carbon nano tubes MWCNT. This coating was applied on stainless steel test specimens with four different values of the surface roughness (0.3, 0.8, 1.6, and 2.5). It turned out that fatigue life increased more than four times compared to the original material when using 0.5 % and 0.7 % MWCNT concentration in coating composition with the 0.3 surface roughness, while no significant difference was detected at another roughness. © Carl Hanser Verlag.
Materialpruefung/Materials Testing | Year: 2012
The crushing energy for applications in the mineral processing industry is usually determined by an empirical bond index, regardless of the mechanical properties of a rock. Although several attempts have been made to obtain the comminution energy based on theoretical approaches, it would be beneficial to examine this relation based on a physical concept. In this paper, some Saudi samples of bauxite, kaolinite, granodiorite, magnetite, granite, feldspar and quartz were tested for hardness, abrasion, compressive strength as well as modulus of elasticity and the bond work index of these samples was estimated. The value of the bond work index of the above samples has shown a variation from 10.8 kWh ton 1 for bauxite (high abrasion value and low compressive strength) to 20.4 kWh ton -1 for granite (low abrasion value and high modulus of elasticity). The correlation between the abrasion value (X 2) and work index (W I) is found to be W 1 = -1.8 Ln(X 2) + 11.5 with a correlation coefficient of 0.80. © Carl Hanser Verlag.
Moussa W.E.,KAU |
Almalki R.M.,KAU |
Alamoudi M.A.,KAU |
2016 13th Learning and Technology Conference, L and T 2016 | Year: 2016
Object Oriented Programming (OOP) recently became the most influential programming paradigm. Several studies [2, 3, 4] indicated deficiencies in learning introductory OOP courses. In King Abdulaziz University-Saudi Arabia, based on a survey that had been designed and distributed to female students of introductory OOP course, results showed that students faced difficulties in understanding OOP, specifically 47% of students faced difficulties in Polymorphism. Visualization tools visualize the execution of programs, using visual hints, and interactivity to improve the students' understanding in programming concepts. This paper proposes the development of "OOPVisual", a 3D interactive visualization tool that will simulate OOP concepts to help students with their understanding. © 2016 IEEE.
Hedia H.S.,KAU |
Materialpruefung/Materials Testing | Year: 2011
Since the introduction of aseptic surgery by Lister towards the end of the eighteenth century, engineering materials have been implanted into the human body in many forms. Implant surgery has developed to the extent that implants are now used in most branches of surgery and are becoming increasingly more sophisticated. Orthopaedic surgery probably uses more implants than any other branch of medicine. Fracture fixation being one of the oldest and most common applications. This literature review tries to inclusively summarize the recent development in bio-medical materials and its applications in human joint implants up to year 2010. © Carl Hanser Verlag, München.
Materialpruefung/Materials Testing | Year: 2011
The merge of materials science with the biological sciences has produced some advanced materials which are called functionally graded materials (FGMs) in order to provide the desired material characteristics. The FGMs concept originates in Japan in 1984 during the space plan project. FGMs are materials or structures in which the material properties vary with location in such a way as to optimize some functions of the overall FGMs. It is well known that the main inorganic component of natural bone is hydroxyapatite (HAP) and that the main organic component is collagen (Col). Hydroxyapatite HAP implants are not bioabsorbable, and because induction of bone into and around the artificially made HAP is not always satisfactory, loosening or breakage of HAP implants may occur after implantation in the clinical application. The development of a new material which is bioabsorbable and which has osteo-conductive activity is needed. Therefore, the aim of the current investigation is to design an implant, in the presence of cancellous bone as a thin layer around it, from functionally graded material. In this study, a novel biomaterial, collagen/hydroxyapatite (Col/HAP) as a functionally graded material (FGM), was developed using the finite element and optimization techniques which are available in the AN-SYS package. These materials have a self-organized character similar to that of natural bone. The investigations have shown that the maximum stress in the cortical bone and cancellous bone for the Col/HAP functionally graded implant has been reduced by about 40 % and 19 % respectively compared to currently used titanium dental implants. © Carl Hanser Verlag.
Hedia H.S.,KAU |
Materialpruefung/Materials Testing | Year: 2010
By definition, Functionally graded materials (FGM) are new advanced composite materials which are used to produce components featuring engineered gradual transitions in microstructure and/or composition. FGMs permit tailoring of material composition so as to derive maximum benefits from their inhomogeneity. The aim of the study behind this contribution is to optimize the composition variation between the ceramic and the metal in order to minimize the maximum stress concentration around the hole in a plate made of FGMs in case of the plate is subjected to pressure, heating or both pressure and heating. The finite element method (FEM) has been used to optimize the material composition of functionally graded materials made from Al 1100 as the metal portion and SiC as the ceramic portion using the ANSYS package. The objective has been to minimize the stress concentration factor around a hole in a plate expressed by the ratio between the principal stress calculated by the ANSYS and the applied stress at different volume fractions of the metal and the ceramic. The investigations have shown that when applying pressure or heating to the plate the optimum for minimizing the stress concentration is to have a ceramic-rich plate and when the plate is subjected to both pressure and heating the optimality is to have a metal-rich plate.
A. Saad M. Aldousari S.M.,KAU
Materialpruefung/Materials Testing | Year: 2013
Recently, nano-materials have received more attention due to their potential application as practical structural and functional materials. The unique mechanical properties of CNTs, especially their high strength and stiffness, make them highly attractive for potential improvement of mechanical properties of structural materials. The aim of this research is to investigate experimentally the effect of coated nano-composite with different concentrations on fatigue life behaviour of carbon steel specimens with 0.3 im surface finish. Nano-adhesives of epoxy resin are synthesized and evaluated. They are modified by multi walled carbon nanotubes (MWCNT) (0.3 wt.-%, 0.5 wt.-%, 0.7 wt.-%) as reinforcement. Fatigue tests are conducted on specimens using a rotating bending machine of the cantilever type to evaluate the fatigue strength and these are compared with them obtained for the neat material. By comparing the results of specimens coated with different concentrations of MWCNTepoxy composition with the base materials, it is found that 0.5 wt.-% of MWCNT composition is the best selection for specimens having 0.3 urn roughness. As compared to the base materials, the fatigue life increased by 383%, 785%, 1239%, and 800% by coating with neat epoxy as well as with 0.3 wt.-%, 0.5 wt.-%, and 0.7 wt.-% MWCNT-epoxy, respectively.