PubMed | Katuri Medical College
Type: Journal Article | Journal: Journal of clinical and diagnostic research : JCDR | Year: 2016
Tuberculosis is one of the most important public health problem worldwide. Detecting patients with active pulmonary Kochs disease is an important component of tuberculosis control programs. However, at times in patients even with a compatible clinical picture, sputum smears do not reveal acid-fast bacilli and smear-negative pulmonary tuberculosis remains a common problem.The present study is aimed to compare the results of induced sputum and bronchial washings smear in patients suspected to have sputum smear negative pulmonary tuberculosis.A prospective study conducted from August 2014 to July 2015, comprising 120 patients fulfilling study criteria. Patients with respiratory symptoms and chest roentgenogram suspicious of pulmonary tuberculosis with no previous history of anti-tuberculosis treatment and two spontaneous sputum smear samples negative for acid fast bacilli were included. Patients with active haemoptysis and sputum positive were excluded from the study. Sputum induction was done by using 5-10 ml of 3% hypertonic saline through ultrasonic nebulizer taking safety precautions. All the patient underwent fibreoptic bronchoscopy after six hours fasting on the same day. About 20 ml of normal saline instilled into the suspected pathology area and washings were taken with gentle suction. The sample processing and fluorescent staining for acid fast bacilli was done in a designated microscopy lab.Out of 120 sputum smear negative pulmonary tuberculosis patients, induced sputum smear examination detected acid fast bacilli in 76 patients (63.3%) and acid fast bacilli detected from bronchial washings in 94 patients (78.3%). Smear positivity was higher in cavitary and infiltrative lesions as compared to consolidation and infrahilar pattern disease.Even though both induced sputum and bronchial washings procedures were valuable for the diagnosis of sputum smear negative, sputum induction with hypertonic saline should be the initial procedure of choice, which can be repeated twice / thrice in a day or two consecutive days. If the patient still remains induced sputum smear negative and if the clinical probability of tuberculosis is high, starting anti-tuberculosis treatment and closely monitoring patient and reserving bronchoscopy to those patients who do not improve and to exclude alternative diagnosis seems to be a practically useful approach.
Rao V.,Katuri Medical College |
Kiran R.,ASRAM Medical College
Journal of Cardiovascular Disease Research | Year: 2011
Background: Coronary artery disease (CAD) is the most common cause of sudden death, none and death of men and women over 20 years of age. The aim of the study was to know if there is any linear correlation between oxidants and abnormal lipid profile parameters in CAD. Materials and Methods: The present study includes 42 known CAD cases (age = 41-75 years) and 33 age- and sex-matched healthy controls. Malondialdehyde ( MDA), total cholesterol, high-density lipoprotein (HDL) cholesterol, and triacylglyceride were measured and low-density lipoprotein (LDL) cholesterol was calculated in both cases and controls, respectively. Results: MDA was significantly increased in cases than controls (P = 0.0000001). Total cholesterol was high in cases than controls (P = 0.0000001). HDL cholesterol was significantly decreased in cases than controls (P = 0.0000001). LDL cholesterol was high in cases than controls (P = 0.0000001). Triacylglyceride was high in cases than controls (P = 0.0000001). Insignificant positive correlation were observed between MDA and total cholesterol (r = 0.258), between MDA and LDL cholesterol (r = 0.199), and between MDA and HDL cholesterol (r = 0.134). Negative correlation was observed between MDA and triacylglyceride (r = -0.314). Conclusion: Increased oxidative stress and abnormal lipid profile were observed in CAD cases. Our study showed that statistically significant linear relationship could not be established between increased oxidative stress and abnormal lipid profile parameters, suggesting that increased oxidative stress and abnormal lipid profile are two independent risk factors in the pathomechanism of atherogenesis.
Narra R.,Katuri Medical College and Hospital |
Mandapalli A.,Advanced Diagnostic Center |
Kamaraju S.K.,Katuri Medical College
Journal of Clinical Imaging Science | Year: 2015
Acute necrotizing encephalopathy (ANE) is a rapidly progressing neurologic disorder that occurs in children after common viral infections of the respiratory or gastrointestinal systems. This disease is commonly seen in East Asia. Normal healthy infants and children can get affected. The condition carries a poor prognosis with high morbidity and mortality rates. We report here a case of a 23-year-old female with ANE and describe its neuroimaging findings. Magnetic resonance imaging examination performed showed symmetric lesions involving the thalami, brainstem, and cerebellum. Copyright: © 2015 Narra R.
Seetharam K.A.,Katuri Medical College
Indian Journal of Dermatology, Venereology and Leprology | Year: 2013
Alopecia areata (AA) is a common form of non-scarring hair loss of scalp and/or body. Genetic predisposition, autoimmunity, and environmental factors play a major role in the etiopathogenesis of AA. Patchy AA is the most common form. Atopy and autoimmune thyroiditis are most common associated conditions. Peribulbar and intrabulbar lymphocytic inflammatory infiltrate resembling "swarm of bees" is characteristic on histopathology. Treatment is mainly focused to contain the disease activity. Corticosteroids are the preferred treatments in form of topical, intralesional, or systemic therapy. Camouflage in the form of wigs may be an alternative option in refractory cases.
Seetharam K.A.,Katuri Medical College |
Sridevi K.,Katuri Medical College |
Vidyasagar P.,Katuri Medical College
Indian Pediatrics | Year: 2012
Chikungunya fever, a re-emerging RNA viral infection produces different cutaneous manifestations in children compared to adults. 52 children with chikungunya fever, confirmed by positive IgM antibody test were seen during 2009- 2010. Pigmentary lesions were common (27/52) followed by vesiculobullous lesions (16/52) and maculopapular lesions (14/52). Vesiculobullous lesions were most common in infants, although rarely reported in adults. Psoriasis was exacerbated in 4 children resulting in more severe forms. In 2 children, guttate psoriasis was observed for the first time.
Tirumalasetti N.,Katuri Medical College
Indian Journal of Pathology and Microbiology | Year: 2013
Angiolymphoid hyperplasia with eosinophilia typically involves head and neck with rare involvement of other sites like breast. A 27year old female presented with a painless swelling in the upper and outer quadrant of left breast. Fine needle aspiration cytology showed sheets of lymphoid cells along with numerous eosinophils. Subsequent histopathological examination showed eosinophilic plump and vacuolated endothelial cells in small groups and sheets within a fibrous background, typically accompanied by lymphoid aggregates and eosinophils, suggestive of angiolymphoid hyperplasia with eosinophilia. Vascular tumors of the breast are extremely rare. The goal of this case report is to advert to this unusual clinical picture, to review and discuss diagnostics, differential diagnoses and treatment options.
Narra R.K.,Katuri Medical College |
Jehendran M.V.,Katuri Medical College
BMJ Case Reports | Year: 2015
We present a case report of splenic abscess causing pneumoperitoneum in a case of uncontrolled diabetes. The patient presented with chronic pain abdomen and fever which later evolved to acute abdomen during the course of hospital stay. An X-ray showed pneumoperitoneum and exploratory laparotomy was performed under a strong clinical suspicion of hollow viscus perforation. The patient was treated with antibiotics and had an uneventful recovery. © 2015 BMJ Publishing Group. All rights reserved.
Tharaknath V.R.,Katuri Medical College |
Prabhakar Y.V.S.,Katuri Medical College |
Kumar K.S.,Katuri Medical College |
Babu N.K.,Katuri Medical College
Annals of Indian Academy of Neurology | Year: 2013
This is a case report of suicidal ingestion of chlorfenapyr, presenting with neurological complications after a latent period of more than a week, and rapidly progressing to death within days of symptoms. Chlorfenapyr is a moderately hazardous pesticide according to World Health Organization toxicity classification, and kills target organism by depriving it of energy through interference with oxidative phosphorylation at mitochondrial level. A pro-pesticide, chlorfenapyr takes time to convert to its active form and either this active form or a toxic metabolite causes delayed neurological symptoms. It causes significant neurotoxicity in rat models. This case report provides for the first time from India (second worldwide), clinical and "radiological evidence" (magnetic resonance imaging showing demyelinating/oedematous changes) of "chlorfenapyr neurotoxicity in humans." It also highlights the "latent period" between ingestion and onset of fatal manifestations. Earlier, similar case reports of human deaths with delayed onset neurological symptoms, due to chlorfenapyr poisoning have been reported, from Japan, Columbia, and Korea.
Chittimoju V.K.,Katuri Medical college |
Pasula Dr. S.,D D Institute of Medical Science and Research
International Journal of Pharma and Bio Sciences | Year: 2013
Diabetic retinopathy is a sight threatening complication of diabetes mellitus and is one of the leading causes of acquired blindness. There is a series of risk factors related to the development and progression of diabetic retinopathy such as hypomagnesemia, dyslipidemia, duration of diabetes, poor diabetes control. There was a significant increase in the HbA1c and microalbumin were as magnesium is decreased in urine in diabetic patients with retinopathy and also in diabetic patients without retinopathy, when compared to the control group. The severity of diabetic retinopathy in the studied groups was influenced by factors such as duration of diabetes mellitus, good glycemic control, hypomagnesemia and microalbuminuria.
PubMed | Katuri Medical College
Type: Journal Article | Journal: Indian dermatology online journal | Year: 2016
Keratosis lichenoides chronica also known as Nekams disease is a rare mucocutaneous disorder, characterized clinically by asymptomatic violaceous keratotic papules arranged in linear, reticular, or plaque form usually on the trunk and extremities and histologically by interface dermatitis. The disease is considered rare with only 128 cases being reported in the literature till date and very few from India. We report a case of a 40-year-old man who presented with constellation of features of lichen planus, seborrheic dermatitis, and apthous ulcers, which upon workup was found to be Nekams disease.