Seetharam K.A.,Katuri Medical College
Indian Journal of Dermatology, Venereology and Leprology | Year: 2013
Alopecia areata (AA) is a common form of non-scarring hair loss of scalp and/or body. Genetic predisposition, autoimmunity, and environmental factors play a major role in the etiopathogenesis of AA. Patchy AA is the most common form. Atopy and autoimmune thyroiditis are most common associated conditions. Peribulbar and intrabulbar lymphocytic inflammatory infiltrate resembling "swarm of bees" is characteristic on histopathology. Treatment is mainly focused to contain the disease activity. Corticosteroids are the preferred treatments in form of topical, intralesional, or systemic therapy. Camouflage in the form of wigs may be an alternative option in refractory cases.
Rao V.,Katuri Medical College |
Kiran R.,ASRAM Medical College
Journal of Cardiovascular Disease Research | Year: 2011
Background: Coronary artery disease (CAD) is the most common cause of sudden death, none and death of men and women over 20 years of age. The aim of the study was to know if there is any linear correlation between oxidants and abnormal lipid profile parameters in CAD. Materials and Methods: The present study includes 42 known CAD cases (age = 41-75 years) and 33 age- and sex-matched healthy controls. Malondialdehyde ( MDA), total cholesterol, high-density lipoprotein (HDL) cholesterol, and triacylglyceride were measured and low-density lipoprotein (LDL) cholesterol was calculated in both cases and controls, respectively. Results: MDA was significantly increased in cases than controls (P = 0.0000001). Total cholesterol was high in cases than controls (P = 0.0000001). HDL cholesterol was significantly decreased in cases than controls (P = 0.0000001). LDL cholesterol was high in cases than controls (P = 0.0000001). Triacylglyceride was high in cases than controls (P = 0.0000001). Insignificant positive correlation were observed between MDA and total cholesterol (r = 0.258), between MDA and LDL cholesterol (r = 0.199), and between MDA and HDL cholesterol (r = 0.134). Negative correlation was observed between MDA and triacylglyceride (r = -0.314). Conclusion: Increased oxidative stress and abnormal lipid profile were observed in CAD cases. Our study showed that statistically significant linear relationship could not be established between increased oxidative stress and abnormal lipid profile parameters, suggesting that increased oxidative stress and abnormal lipid profile are two independent risk factors in the pathomechanism of atherogenesis.
Tirumalasetti N.,Katuri Medical College
Indian Journal of Pathology and Microbiology | Year: 2013
Angiolymphoid hyperplasia with eosinophilia typically involves head and neck with rare involvement of other sites like breast. A 27year old female presented with a painless swelling in the upper and outer quadrant of left breast. Fine needle aspiration cytology showed sheets of lymphoid cells along with numerous eosinophils. Subsequent histopathological examination showed eosinophilic plump and vacuolated endothelial cells in small groups and sheets within a fibrous background, typically accompanied by lymphoid aggregates and eosinophils, suggestive of angiolymphoid hyperplasia with eosinophilia. Vascular tumors of the breast are extremely rare. The goal of this case report is to advert to this unusual clinical picture, to review and discuss diagnostics, differential diagnoses and treatment options.
Narra R.,Katuri Medical College and Hospital |
Mandapalli A.,Advanced Diagnostic Center |
Kamaraju S.K.,Katuri Medical College
Journal of Clinical Imaging Science | Year: 2015
Acute necrotizing encephalopathy (ANE) is a rapidly progressing neurologic disorder that occurs in children after common viral infections of the respiratory or gastrointestinal systems. This disease is commonly seen in East Asia. Normal healthy infants and children can get affected. The condition carries a poor prognosis with high morbidity and mortality rates. We report here a case of a 23-year-old female with ANE and describe its neuroimaging findings. Magnetic resonance imaging examination performed showed symmetric lesions involving the thalami, brainstem, and cerebellum. Copyright: © 2015 Narra R.
Chittimoju V.K.,Katuri Medical College |
Pasula Dr. S.,D D Institute of Medical Science and Research
International Journal of Pharma and Bio Sciences | Year: 2013
Asthma is a very common disease with immense social impact. Its acute exacerbations are commonly treated with salbutamol. The study intends to determine the magnitude of changes in serum magnesium, potassium, phosphate and calcium during treatment of acute severe asthma with parenteral salbutamol. This is a prospective study comprising of 80 patients who presented to casualty with symptoms of acute severe asthma and met the inclusion criteria. Baseline serum magnesium, potassium, phosphate and calcium levels were measured. Nebulised salbutamol was administered every thirty minutes till symptoms subsided. After 80 minutes, repeat serum levels of electrolytes were determined. Treatment followed with Parenteral salbutamol administration during the emergency treatment of acute severe asthma is associated with statistically significant decreases in serum magnesium, potassium, and phosphate levels. It is also associated with decrease in serum calcium levels, although the decrease was not statistically significant. The mechanism and clinical significance of these findings are currently unknown and warrant further study.