Kato Ladies Clinic

Shinjuku, Japan

Kato Ladies Clinic

Shinjuku, Japan
SEARCH FILTERS
Time filter
Source Type

Osada H.,Nihon University | Silber S.,St Lukes Hospital | Kakinuma T.,Nihon University | Nagaishi M.,Nihon University | And 2 more authors.
Reproductive BioMedicine Online | Year: 2011

The treatment for severe adenomyosis has usually been hysterectomy, because there is no line of demarcation between diseased and normal tissue. Yet many such women wish to retain their uterus and some even wish to bear children. This report evaluates the efficacy of a new method of adenomyomectomy, where adenomyotic tissues are radically excised and the uterine wall is reconstructed by a triple-flap method, without overlapping suture lines, to prevent uterine rupture in subsequent pregnancies. This is a prospective case series followed for 10 years from June 1998 to August 2008 of 104 women with severe adenomyosis verified histologically and with magnetic resonance imaging. There was a dramatic reduction in both dysmenorrhoea and hypermenorrhoea and all patients returned to having normal menstrual cycles. Of 26 women who wished to conceive, 16 became pregnant, 14 (53.8%) went to term and delivered a healthy baby and there were no cases of uterine rupture. Adenomyosis symptoms recurred in only four out of 104 cases. The procedure thus resulted in a dramatic reduction in symptoms and allowed over half of women who wished to conceive to go to term without uterine rupture. The usual treatment for severe adenomyosis has usually been hysterectomy, because there is no line of demarcation between diseased and normal tissue. Yet many such women wish to retain their uterus and some even wish to bear children. This report evaluates the efficacy of a new method of adenomyomectomy, where adenomyotic tissues are radically excised and the uterine wall is reconstructed by a triple-flap method without overlapping suture lines to prevent uterine rupture in subsequent pregnancies. This is a prospective case series followed for 10 years from June 1998 to August 2008 of 104 women with severe adenomyosis verified histologically and with magnetic resonance imaging. Radical excision of affected tissues, reconstruction of the endometrial cavity and reconstruction of the uterine wall in multiple overlapping layers was performed. The changes in symptoms for dysmenorrhoea and hypermenorrhoea were evaluated using a modified visual analogue scale. Post-operative pregnancy and delivery rate was calculated among those women who desired to conceive. There was a dramatic reduction in both dysmenorrhoea and hypermenorrhoea symptoms and all patients returned to having normal menstrual cycles. Of 26 women who wished to conceive, 16 became pregnant, 14 (53.8%) went to term and delivered a healthy baby and there were no cases of uterine rupture. Adenomyosis symptoms recurred in only four out of 104 cases. The procedure resulted in a dramatic reduction in both dysmenorrhoea and hypermenorrhoea post-surgically and allowed over half of women who wished to conceive to go to term without uterine rupture. © 2010, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.


Silber S.,St Lukes Hospital | Kagawa N.,Kato Ladies Clinic | Kuwayama M.,Kato Ladies Clinic | Gosden R.,Cornell University
Fertility and Sterility | Year: 2010

Objective: To evaluate the function of human ovarian transplants. Design: Follow a series of fresh ovarian transplants for up to 5 years, and compare fresh and frozen ovarian tissue transplantation. Setting: Tertiary referral community hospital. Patient(s): Nine women with premature ovarian failure who received an ovary donated from a monozygotic twin sibling, and 16 young cancer patients undergoing ovarian cryopreservation. Two of the transplant recipients were cancer survivors rendered sterile by their therapy. Intervention(s): Fresh ovary transplantation between monozygotic twin sisters, as well as transplantation of previously frozen ovarian tissue, and study of cryopreserved tissue in cancer patients. Main Outcome Measure(s): Return of normal menstrual cycling, hormone levels, pregnancy, healthy babies, duration of transplant function, and ovarian tissue evaluation. Result(s): Normal serum FSH and regular menstrual cycles returned by 5 months after surgery in all cases, both fresh and frozen. Fourteen spontaneous pregnancies were established leading to eight healthy live births and two healthy ongoing conceptions. All three frozen tissue transplants conceived spontaneously, one delivered, and two were ongoing. Oocyte survival with slow freezing was 42% and after vitrification 89%. Conclusion(s): Ovarian transplantation in humans is a robust procedure, even after cryopreservation, and vitrification might prove to be more effective than slow freezing. Copyright © 2010 American Society for Reproductive Medicine, Published by Elsevier Inc.


Kato K.,Kato Ladies Clinic | Takehara Y.,Kato Ladies Clinic | Segawa T.,YuMe | Kawachiya S.,Kato Ladies Clinic | And 4 more authors.
Reproductive Biology and Endocrinology | Year: 2012

Background: The two main complications associated with the use of assisted reproduction techniques, ovarian hyperstimulation syndrome and multiple pregnancies, could be eliminated by milder ovarian stimulation protocols and the increased use of a single embryo transfer (SET) policy. A retrospective, cohort study was performed in private infertility centre to evaluate the embryological and clinical results of a large exclusively SET program according to patient age (lower or equal 29, 30-34, 35-39, 40-44 and equal or higher 45 years).Materials: A total of 7,244 infertile patients have undergone 20,244 cycles with a clomiphene-based minimal stimulation or natural cycle IVF protocol during 2008. Following oocyte retrieval, fertilization and embryo culture a total of 10,401 fresh or frozen single embryo transfer procedures were performed involving cleavage-stage embryos or blastocysts.Results: Successful oocyte retrieval rate (78.0 %) showed no age-dependent decrease until 45 years. Fertilization (80.3 %) and cleavage (91.1 %) rates were not significantly different between age groups. Blastocyst formation (70.1 % to 22.8 %) and overall live birth rates (35.9 % to 2 %) showed an age-dependent decrease. Frozen-thawed blastocyst transfer cycles gave the highest chance of live birth per embryo transfer (41.3 % to 6.1 %).Conclusions: High fertilization and cleavage rates were obtained regardless of age whereas blastocyst formation and live birth rates showed an age-dependent decrease. An elective single embryo transfer program based on a minimal ovarian stimulation protocol yields acceptable live birth rates per embryo transfer in infertile patients up until their mid-forties. However in very advanced age patients (equal or higher 45 years old) success rates fall below 1 © 2012 Kato et al; licensee BioMed Central Ltd.


Kawachiya S.,Kato Ladies Clinic | Matsumoto T.,YuMe | Bodri D.,Kato Ladies Clinic | Kato K.,Kato Ladies Clinic | And 2 more authors.
Reproductive BioMedicine Online | Year: 2012

A retrospective cohort study was conducted in a private infertility centre to evaluate the use of non-steroidal anti-inflammatory drugs (NSAID) in natural-cycle IVF (nIVF) treatment. A total of 1865 first-rank nIVF cycles performed during 2009-2010 were evaluated. Low-dose, post-trigger NSAID was administered in a non-randomized way in cycles at higher ovulation risk where an imminent LH surge was detected on triggering day. Main outcome measures were premature ovulation rate, embryo transfer rate per scheduled cycle and clinical pregnancy and live birth rates per embryo transfer. NSAID use was associated with a significantly lower risk of premature ovulation (3.6% versus 6.8%, adjusted OR 0.24, 95% CI 0.15-0.39, P < 0.0001) and higher embryo transfer rate (46.8% versus 39.5%, adjusted OR 1.38, 95% CI 1.06-1.61, P = 0.012) per scheduled cycle. Clinical pregnancy (39.1% versus 35.9%) and live birth rates per embryo transfer (31.3% versus 31.4%) were comparable. In this retrospective series, short-term low-dose NSAID application positively influenced nIVF cycles by diminishing the rate of unwanted premature ovulations and increasing the proportion of cycles reaching embryo transfer. © 2011 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.


Kawachiya S.,Kato Ladies Clinic | Bodri D.,Clinica Eugin | Shimada N.,YuMe | Kato K.,Kato Ladies Clinic | And 2 more authors.
Fertility and Sterility | Year: 2011

In a 7-year (2002-2008) retrospective study of a large IVF program based on minimal ovarian stimulation and single ET (47,841 single ETs), monozygotic twinning occurred in 1.01% of 14,956 clinical pregnancies. Blastocyst culture was associated with a significantly increased monozygotic twinning risk (adjusted odds ratio, 2.04; 95% confidence interval, 1.29-4.48), whereas embryo freezing, type of stimulation protocol used, intracytoplasmic sperm injection fertilization, or zona removal did not influence its incidence. © 2011 by American Society for Reproductive Medicine.


News Article | November 18, 2016
Site: www.businesswire.com

GÖTEBORG, Sweden--(BUSINESS WIRE)--Regulatory News: Kato Ladies Clinic in Japan, one of the world´s largest IVF clinics, has decided to invest in the newly launched time-lapse system EmbryoScope+. The order comprises eight EmbryoScope+ time-lapse incubators providing the Kato Ladies Clinic with a time-lapse capacity of approximately 6000 treatments per year, making it the largest time-lapse capacity in a single clinic in the world. The first units will be installed during the fourth quarter 201


Sakata T.,University of Tokyo | Saito A.,University of Tokyo | Mizuno J.,Kato Ladies Clinic | Sugimoto H.,University of Tokyo | And 3 more authors.
Analytical Chemistry | Year: 2013

In this study, we have proposed and demonstrated experimentally a novel monitoring device of single mouse embryo activity after in vitro fertilization (IVF) using a semiconductor-based field effect transistor (FET). The FET biosensor realized to detect it noninvasively, quantitatively, and continuously by change of hydrogen ions with positive charges, which were induced by dissolved carbon dioxide due to cellular respiration activity during cleavage. The electrical signal of FET biosensor should become an effective indication to evaluate objectively single embryo activity as its morphology is observed subjectively after IVF. The platform based on the FET biosensor will contribute to promote elective single embryo transfer (eSET) in human assisted reproductive technology (ART). © 2013 American Chemical Society.


Kato O.,Kato Ladies Clinic | Kawasaki N.,Kato Ladies Clinic | Bodri D.,Kato Ladies Clinic | Kuroda T.,Kato Ladies Clinic | And 3 more authors.
European Journal of Obstetrics Gynecology and Reproductive Biology | Year: 2012

Objective: To compare neonatal outcome between children born after vitrified versus fresh single-embryo transfer (SET). Study design: Retrospective, single-centre cohort study of 6623 delivered singletons following 29,944 single-embryo transfers. Patients underwent minimal ovarian stimulation/natural cycle IVF followed by SET of fresh or vitrified-warmed (using Cryotop, Kitazato) cleavage-stage embryos or blastocysts. Outcome measures were gestational age at delivery, birth weight, birth length, low birth weight (LBW), small for gestational age (SGA) and large for gestational age (LGA) infants, perinatal mortality and minor/major birth defects (evaluated by parent questionnaire). Results: Gestational age (38.6 ± 2 versus 38.7 ± 1.9 weeks) and preterm delivery rate (6.9% versus 6.9%, aOR: 0.96 95%CI: 0.76-1.22) in singletons born after the transfer of vitrified embryos were comparable to those born after the transfer of fresh embryos. Children born after the transfer of vitrified embryos had a higher birth weight (3028 ± 465 versus 2943 ± 470 g, p < 0.0001) and lower LBW (8.5% versus 11.9%, aOR: 0.65 95%CI: 0.53-0.79) and SGA (3.6% versus 7.6% aOR: 0.43 95%CI: 0.33-0.56) rates. Total birth defect rates (including minor anomalies) (2.4% versus 1.9%, aOR: 1.41 95%CI: 0.96-2.10) and perinatal mortality rates (0.6% versus 0.5%, aOR: 1.02 95%CI: 0.21-4.85) were comparable between the vitrified and fresh groups. Conclusions: Vitrification of embryos/blastocysts did not increase the incidence of adverse neonatal outcomes or birth defects following single embryo transfer. © 2011 Elsevier Ireland Ltd.


Kato K.,Kato Ladies' Clinic
Reproductive Medicine and Biology | Year: 2016

As survival rates and the life expectancy of those with malignancy have increased, more women in their reproductive years are referred for fertility preservation. Chemotherapy and radiotherapy can severely affect ovarian function, and the effect is irreversible. Therefore, it is optimal to attempt fertility preservation before chemotherapy and radiotherapy are initiated. Oocyte and embryo cryopreservation is the most common option for fertility preservation in women. Several reports have proven that embryo and oocyte cryopreservation can achieve a successful pregnancy. This review discusses the impact of chemotherapy and radiotherapy on ovarian function, and the importance of oocyte and embryo cryopreservation for fertility preservation. In addition, the current status of pregnancy outcomes and potential for cryopreserved oocytes to result in live births in cancer patients was reviewed. This may provide useful information for decision-making in cancer patients regarding oocyte and embryo cryopreservation and fertility preservation. © 2016 Japan Society for Reproductive Medicine


Takehara Y.,Kato Ladies Clinic | Yabuuchi A.,Kato Ladies Clinic | Ezoe K.,Kato Ladies Clinic | Kuroda T.,Kato Ladies Clinic | And 9 more authors.
Laboratory Investigation | Year: 2013

The clinical application of human adipose-derived mesenchymal stem cells (MSCs) as treatment for intractable diseases or traumatic tissue damage has attracted attention. To address the ability of reactivating injured ovaries, we prepared a rat model with damaged ovaries by using an anticancer agent, cyclophosphamide (CTX). We then investigated the restorative effects on ovarian function and the safety of adipose-derived MSCs (A-MSCs). MSCs were shown to be capable of inducing angiogenesis and restoring the number of ovarian follicles and corpus lutea in ovaries. No deformities, tumor formation or deaths were observed in F1 and F2 rats, indicating that the local injection of MSCs into the ovary did not have any obvious side effects. In addition, the localization of the Y chromosome was investigated using the fluorescent in situ hybridization method by injecting male A-MSCs into the ovaries; as a result, the Y chromosomes were localized not in the follicles, but in the thecal layers. ELISA revealed that A-MSCs secreted higher levels of vascular endothelial cell growth factor (VEGF), insulin-like growth factor-1 (IGF-1) and hepatocyte growth factor (HGF) than tail fibroblast cells. Quantitative real-time PCR and immunohistochemistry showed that higher expression levels of VEGF, IGF-1 and HGF were observed in CTX-treated ovaries after A-MSC transplantation. These findings suggest that MSCs may have a role in restoring damaged ovarian function and could be useful for regenerative medicine. © 2013 USCAP, Inc All rights reserved.

Loading Kato Ladies Clinic collaborators
Loading Kato Ladies Clinic collaborators