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Banasiewicz T.,Katedra i Klinika Chirurgii Ogolnej | Borycka-Kiciak K.,Klinika Chirurgii Ogolnej I Przewodu Pokarmowego | Dobrowolska-Zachwieja A.,Katedra I Klinika Gastroenterologii | Friediger J.,Oddzial Chirurgii Ogolnej | And 7 more authors.
Przeglad Gastroenterologiczny | Year: 2010

This article presents the point of view of a group of experts in physiology, gastroenterology and surgery regarding effectiveness of butyric acid preparation in dietary treatment in patients with small and large bowel diseases. The literature review revealed that butyric acid given per os as sodium salt (sodium butyrate) has a number of beneficial effects on function and regeneration of intestines. The dietary product of special medicinal use Debutir™ (Polfa-Łódź) contains sodium butyrate as an active substance, protected in a triglyceride matrix, which allows slow release of sodium butyrate along the entire gastrointestinal tract, thereby permitting its positive effects to be exerted on the entire small and large bowel. Experts have pointed out the clinical need to introduce butyric acid and its salt in dietary treatment in patients with intestine diseases. Experts have specified several groups of patients who would gain special benefits from enriching the diet with butyric acid. Use of butyric acid preparations is recommended for elderly people, and for patients with irritable bowel disease (IBD), after intestine resection and pouchitis. The strong trophic effect of sodium butyrate justifies its use in patients with cancer cachexia, with chronic diseases and immunity disturbances. Source

Chlebowska-Smigiel A.,Katedra Biotechnologii | Gniewosz M.,Katedra Biotechnologii | Wilczak J.,Katedra Nauk Fizjologicznych | Kamola D.,Katedra Nauk Fizjologicznych
Zywnosc. Nauka. Technologia. Jakosc/Food. Science Technology. Quality | Year: 2014

The effect was studied of pullulan additive on the growth and fermentation capacity of nine strains of lactic acid bacteria of the genus Lactobacillus. Deep batch cultures were grown during a period of 24 h in an MRS control and experimental medium with 2.0 % of pullulan added. During that 24 h period, it was reported that the bacteria grew from the initial number of 104 cfu/cm ³ to the count of 107 ÷ 109 cfu/cm³ depending on the strain studied. No significant differences were reported between the count of bacteria cultured in the control medium and in the experimental medium with pullulan added. In order to compare the fermentation capacity of strains at time "0" and at the end of growing those bacteria in the two media, a content of short chain fatty acids (SCFA) was determined using an HPLC method. The following acids were found: formic acid, lactic acid, acetic acid, propionic acid, and hydroxybutyric acid. A higher total content of SCFA was reported in the MRS control medium compared to the MRS experimental medium. The pullulan additive added to the MRS medium contributed to an increased production of lactic acid by the two strains of LAB and of acetic acid by 5 of the 9 LAB strains analyzed. © by Polskie Towarzystwo Technologów Żywności, Kraków 2014. Source

Banasiewicz T.,Katedra i Klinika Chirurgii Ogolnej | Borycka-Kiciak K.,Klinika Chirurgii Ogolnej I Przewodu Pokarmowego | Kiciak A.,Klinika Chirurgii Ogolnej I Przewodu Pokarmowego | Kotunia A.,Katedra Nauk Fizjologicznych | And 3 more authors.
Przeglad Gastroenterologiczny | Year: 2010

Butyric acid is naturally produced by symbiotic bacteria in the colon. Owing to this many studies have been conducted on its practical use for treatment and prevention of intestinal disorders. Considering the physicochemical properties of butyric acid (volatility, strong odour) in clinical practice butyrate salts are commonly used, in particular sodium butyrate. Clinical studies have shown a number of positive effects of sodium butyrate in ulcerative colitis, diversion colitis as well as bowel inflammation after radiotherapy and chemotherapy. Sodium butyrate supplementation led to regeneration of intestinal mucosa and restored physiological functions of the gut. Source

Kotunia A.,Katedra Nauk Fizjologicznych | Pietrzak P.,Katedra Nauk Fizjologicznych | Guilloteau P.,French National Institute for Agricultural Research | Zabielski R.,Katedra Nauk Fizjologicznych
Przeglad Gastroenterologiczny | Year: 2010

Sodium butyrate (NaB) dissociating to butyric acid is regarded as a molecule which may be potentially applied in gastrointestinal mucosa treatment. In humans, NaB is produced by colonic bacteria. In certain cases, NaB production may be diminished; hence supplementation with exogenous NaB is essential the more so as NaB is a major energy source for colonocytes. In this review, we would like to discuss present knowledge about the role of NaB in the gastrointestinal tract, in particular its trophic, proapoptotic, cytoprotective and anti-inflammatory role. Source

Mickiewicz M.,Katedra Nauk Fizjologicznych | Pietrzak P.,Katedra Nauk Fizjologicznych | Kotunia A.,Katedra Nauk Fizjologicznych | Metges C.C.,Research Institute for the Biology of Farm Animals FBN | And 2 more authors.
Przeglad Gastroenterologiczny | Year: 2010

Intrauterine growth retardation (IUGR) is a worldwide problem. In Poland 6% children every year are given birth with IUGR symptoms. In order to classify offspring as IUGR, three conditions must be fulfilled: low birth weight, fast compensation for weight loss, and in consequence excessive fat content in the body. There are many papers about connection between IUGR and development of so called civilization diseases in adults. Different protein level content and incorrect energetic balance of the diet of pregnant mothers is considered a main reason of IUGR. Surprisingly, there is nearly no data on gastrointestinal tract development in IUGR newborns. Our preliminary data suggest that in IUGR fetuses the gastrointestinal tract development is different from that in normal fetuses leading to disturbances in e.g. closing intestinal barrier and absorption which might explain further health disturbances. Better understanding of these processes will help to elaborate nutrition programs that will reduce the consequences of IUGR. Source

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