Time filter

Source Type

Bydgoszcz, Poland

AIM: To analyse etiologic factors and the clinical course of erythema nodosum in hospitalized children.MATERIAL AND METHODS: A retrospective study of 12 children and young people (7 girls and 5 boys) admitted to the Paediatric Clinic in Zabrze with erythema nodosum was performed from January 2004 to February 2014. The patients' mean age on admission was 11.9 years (2-16).RESULTS: In ten of the 12 patients elevated CRP was identified - from 10 mg/L to 131.5 mg/L, which is proof of an ongoing inflammatory process. Only two patients had a CRP level below 5 mg/L. Three of the 12 patients were diagnosed with Crohn's Disease, one with diarrhoea (Salmonella was cultured and antigen Rotavirus was found), one with arthritis, one with bilateral cervical lymphadenopathy, three with Streptococcal infection, two had elevated anti-streptolysin O level (ASO).CONCLUSION: The present research may confirm the hypothesis that EN could be the first sign of systemic diseases. However, it requires further studies because of the limited number of patients. Source

The introduction of the coagulation factor VIII and IX concentrates has changed the treatment of haemophilia patients dramatically. The concentrates were produced from pooled human plasma in the beginning. During the 1990s of the 20th century, recombinant factor VIII was accessed, then factor IX was introduced. The modern methods of elimination and inactivation of viruses led to the development of safe plasma-derived products. However, minimal risk of viral transmission is still greater by plasma-derived than recombinant concentrates. The efficacy of both products is very good in treatment of bleeds as well as in surgery and prophylaxis. The pharmacokinetics of plasma-derived and recombinant factor VIII is similar. Nevertheless, the recovery of recombinant factor IX is lower than plasma-derived, therefore the doses of recombinant factor IX should be 30% higher. The half-life of both factor IX products is almost the same. In developed countries recombinant coagulation factor concentrates are recommended treatment of choice for patients with haemophilia and almost all children are being treated with them. Source

In this review an epidemiology of overweight and obesitas in children and youngsters in Poland, Europe and the world was discussed. The methods of estimation of overweight and obesitas were discussed, as well as their influence on the incidence of various diseases with the emphasis on the diseases of the alimentary tract. From among the diseases of the alimentary tract the influence of obesitas on symptoms of gastroesophageal reflux disease, colon cancer and polyps were considered. © 2010 Almamedia Press. Source

Patients with haemophilia are treated with a variety of coagulation factor concentrates. They usually change concentrate types many times during their lifetime for different, often independent, reasons. Since recombinant coagulation factor concentrates VIII and IX became available, some patients in well-developed countries have started using these products instead of previously applied plasma-derived concentrates. At the moment, there are different types of concentrates available, including first, second and third generation recombinant concentrates, and factor VIII concentrates with full length or B deleted domain molecule. The drug's efficacy and safety are both taken into consideration when evaluating coagulation concentrates. When we talk of concentrates' safety, we consider virus safety, non-increased risk of inhibitor development and no adverse events as a potential threat to the patient's health. With the modern methods of blood donor tests and effective methods of viral inactivation having been introduced, the plasma-derived coagulation factor concentrates are currently as safe as recombinant concentrates with regard to elimination of enveloped viruses, including HIV or HCV. However, they still fail to eliminate completely the transmission of non-enveloped viruses such as e.g. hepatitis A virus (HAV) or parvovirus B19. Meanwhile, the risk of inhibitor development continues to be the subject of investigation. The results of many studies indicate there are no statistically significant differences in inhibitor incidence between patients treated with plasma-derived coagulation factor concentrates and recombinant concentrates but the results of randomized study (SIPPET) presented in December 2015 during ASH show 1,87-fold higher inhibitor incidence in recombinant factor VIII group than the plasma derived group in previous untreated children. The question concerning the potentially increased risk of inhibitor development following a switch from plasma-derived to recombinant coagulation factor concentrates, or a switch from one recombinant concentrate to another in previously treated patients, should thus be answered negatively. At the same time, further investigation is required in this field, particularly in small children. © 2016 Polskie Towarzystwo Hematologów i Transfuzjologów, Instytut Hematologii i Transfuzjologii. Source

Introduction: In the last years the extraesophageal symptoms, especially those related to the respiratory system, have played an increasing role in the clinical picture of gastroesophageal reflux disease. Aim of the study: The objective of the study was to determine the kind and frequency of recurrent respiratory tract infections and bronchial asthma in school-age children with gastroesophageal reflux disease as well as their dependence on the severity of pathologic acid reflux and its extention to the lower and upper parts of the esophagus. Material and methods: The study included 194 children aged 6 to 18 years hospitalized in our clinic due to the suspicion of gastroesophageal reflux disease. In all children a detailed history of respiratory tract infections was carried out and 24-hour pH-metry study was completed. On this basis all children were divided into three groups with various severity of gastroesophageal acid reflux. The children with a proper pH-metry recording were included into the control group. Additionally, groups with or without acid reflux in the upper part of the esophagus were discriminated. Statistical methods were applied to compare the occurrence of respiratory tract infections and bronchial asthma in all studied groups. Results: Children with gastroesophageal reflux disease suffered most often from bronchitis (25.5%) and pharyngitis (24.4%). Along with the increase in the severity of gastroesophageal reflux disease occured an increased frequency of recurrent pharyngitis and perinasal sinusitis. Patients with observed pathological acid reflux in the upper part of the esophagus suffered significantly more often from recurrent perinasal sinusitis, bronchitis and bronchial asthma. Patients with a proper recording of pH-metry significantly more often suffered from recurrent pharyngitis and otitis media, which suggests other than gastroesophageal reflux disease cause of these infections. Conclusions: 1. The studied children suffered more often from recurrent bronchitis and pharyngitis. 2. The severity of gastroesophageal reflux disease influenced the frequency of pharyngitis in children. 3. The presence of pathological reflux in the upper part of the esophagus significantly influenced the occurrence of recurrent sinusitis, bronchitis and bronchial asthma in the studied children. 4. Gastroesophageal reflux disease was only one of the causes of recurrent pharyngitis and otitis media. © 2010 Almamedia Press. Source

Discover hidden collaborations