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Dolinska-Zygmunt G.,Zaklad Psychologii Klinicznej i Zdrowia Instytutu Psychologii | Zdrojewicz Z.,Katedra i Klinika Endokrynologii
Seksuologia Polska | Year: 2012

Introduction. Theme of the presented research is the young adult.s subjective quality of life considered in the context of their sexual life satisfaction. Material and methods. 51 men and 49 women in the age of 23.35, working and staying in informal relationships for over a year have been examined. The Quality of Life Questionary by Stra.-Romanowska and Sexual Life Satisfaction Questionary by Nomejko have been used in the measurement. Results. Sexual life satisfaction is essentially connected with the global quality of life and is it.s predictor. The higher is satisfaction of the questioners in this area, the higher is the global sense of life quality, especially in the psychophysical sphere. The quality of life is also connected with the subjective sphere. Conclusions. Sexual life satisfaction is important for the global appraisal of quality of life made by young adult.s. Basing on the level of satisfaction in the one area we can conclude about the other one.s satisfaction. There.s no differences between sexes in this area. sexual life satisfaction is equally important for both men and women. The sexual life satisfaction is also important for the appraisal of other life quality areas. © 2012 Via Medica. Source


In the last twenty years the introduction of new imaging techniques has caused increasing incidence of accidental detection of adrenal tumors, which are usually mild and in most cases are hormonally inactive adenomas. Among hormonal disorders in patients with adrenal incidentalomas the hypercortisolism is often described, which, if not treated properly, leads to multiple organ complications, and further to the patient's death. The aim of the study was the retrospective analysis of the group of patients with adrenal incidentaloma, verified by histopathology for assessment of subclinical Cushing's syndrome. Among the group of 225 patients: 62 men and 163 women with incidentally detected adrenal tumors in age from 19 to 81 years diagnosed and treated in the Department of Clinical Endocrinology, University Hospital in Krakow, 59 patients was sent to surgery: 15 men and 42 women. Two groups of patients were analysed, divided on the basis of histopathological examination result. Group A consisted of patients with adrenal cortical adenoma: 38 people (11 men and 27 women). In group B there were people with so-called other hormonal inactive adrenal tumors - 17 people (4 men and 13 women). The average age of the patients in group A was 52.05 +/- 11.52 years, in group B 51.44 +/- 14.14 years. In group A the mean morning level of cortisol was 18.23 +/- 6.42 ug/dl and did not differ statistically significantly from the results of group B (mean morning cortisol level of 15.86 +/- 4.6 ug/dl). However a significantly higher nocturnal cortisol levels in the blood serum of patients with group A versus group B was observed (6.78 +/- 5.65 ug/dl vs. 3.57 +/- 1.77 ug/dl). There was no cortisol diurnal rhythm disorders in group B, while in group A slightly disrupted cortisol diurnal rhythm was found in 17 people. Mean values of 24-hour urine 17-OHCS and free cortisol were statistically higher in group A than in group B, although mean values remained within normal limits. In 24 patients from group A where abnormalities in the screening test with 1 mg DXA were found, a test with 2 and 8 mg was performed, which showed incomplete suppression of the excretion of steroid metabolites in the urine after administration of 8 mg in 17 subjects, and 3 of the total absence of suppression. In group B in 4 people there was no suppression in 1 mg of DXA test, while the suppression test with 8 mg of DXA was normal. A detailed analysis of the clinical signs, meticulously carried out and repeated hormonal diagnosis with the use of functional tests should be focused on the detection of subclinical hormonal disorders, which is crucial in preventing organ damage and making a decision of the right treatment of the patient, which is surgical. Source


Zdrojewlcz Z.,Katedra i Klinika Endokrynologii
Family Medicine and Primary Care Review | Year: 2011

Scientists are trying to relieve women of the burden of responsibility for contraception and are working on an effective and non-invasive method of preventing pregnancies for men. For 400 years a condom has triumphed in this area. However - besides vasectomy - a good alternative has not been found so far. Since the beginning of the 20 th century it has been known that an increased temperature of testicles has a bad influence on the process of spermatogenesis. This fact has been an inspiration to produce suspensors and to research into ultrasound waves. Another method of men's contraception is blocking the flow of semen from deferent ducts by injecting them with polyuretan, silicone or meleinine anhydride which tears cell membranes of a sperm. It has been noticed that some medicines such as phenoxybensamine, nifedipine - which lower blood pressure - and thiorizadine - used in schizophrenia treatment - can be used as a pharmacological contraceptive. Some research has also been done on a hormonal pill for men. There are three ways of influencing the men's endocrine system: administering synthetic testosterone, which impacts on the secretion of GnRH and LH, a progesterone which interacts with gonadotrophines and GnRH antagonists. A medicine which seems to have no effect on the endocrine system blocks enzymes in the sperm head that are responsible for joining a sperm to an egg cell. Two, even more interesting methods of men's contraception seem to be a vaccine which elicits an immune response to the human's reproductive system and preventing the sperm from reaching maturity using Adjuvin - a medicine which has an influence on Sertoly's cells located in testicles. © Wydawnictwo Continuo. Source


Zdrojewicz Z.,Katedra i Klinika Endokrynologii
Family Medicine and Primary Care Review | Year: 2010

According to Polish Society of Menopause and Andropause, andropause is a period of man's life following appearance of - progressing with age - deficiency of androgenic hormones, testosterone and dehydroepiandrosterone as well as growth hormone and melatonin, phenomena that usually develop after 50th year of age. Symptomatology of these changes is characterized by gradual deterioration of the quality of life, general physical and mental condition, work skills, libido and sexual functions' disorders, deterioration of intellectual competence and sleep disorders. The objective of this article is presentation pathophysiology of the period, considering clinical and laboratory diagnostics, treatment as well as myths related to andropause. © Copyright by Wydawnictwo Continuo. Source


Zdrojewicz Z.,Katedra i Klinika Endokrynologii | Lachowski M.,Studenckie Kolo Naukowe Endokrynologii Przy Katedrze i Klinice Endokrynologii
Postepy Higieny i Medycyny Doswiadczalnej | Year: 2014

Putrescine plays a very important role in the regulation of division, differentiation and maturation of cells as well as apoptosis. As the polycationic molecule it stabilizes the structure of DNA and participates in the functioning of cell membranes. It is able to interact with series of ion channels and has affinity for many receptors. The article presents the participation of putrescine in the metabolism of iron and mechanism of its transport across biological membranes. Especially important for the homeostasis of putrescine has ornithine decarboxylase and availability of its substrate - ornithine. Affecting to this enzyme is the simplest and widely used method of controlling the concentration of putrescine. For this purpose its inhibitor - eflornithine is applied. There was also a number of other enzymes involved in the metabolism of putrescine that was presented. Current information about the clinical relevance of putrescine in infertility, embryonic development, hirsutism, epilepsy, Alzheimer's disease, Parkinson's disease, prevention of metastases and hemostasis was also described. These processes were presented, in which putrescine plays a major role and focused on the latest reports. Attention was drawn to the situations where it has beneficial effects and those in which it is the cause of the pathology. Some of the cited reports are in phase of speculation on the possible use of it, but a significant part is already confirmed and used in clinical practice. The facts presented in this article show how great is the meaning of putrescine and how important role this simple specimen plays in the metabolic processes of living organisms. Copyright © Postepy Higieny i Medycyny Dos̈wiadczalnej 2015. Source

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