Katedra i Klinika Endokrynologii

Wrocław, Poland

Katedra i Klinika Endokrynologii

Wrocław, Poland
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Nomejko A.,Towarzystwo Rozwoju Rodziny We Wroclawiu | Dolinska-Zygmunt G.,Zaklad Psychologii Klinicznej i Zdrowia Instytutu Psychologii | Zdrojewicz Z.,Katedra i Klinika Endokrynologii
Seksuologia Polska | Year: 2012

Introduction. Theme of the presented research is the young adult.s subjective quality of life considered in the context of their sexual life satisfaction. Material and methods. 51 men and 49 women in the age of 23.35, working and staying in informal relationships for over a year have been examined. The Quality of Life Questionary by Stra.-Romanowska and Sexual Life Satisfaction Questionary by Nomejko have been used in the measurement. Results. Sexual life satisfaction is essentially connected with the global quality of life and is it.s predictor. The higher is satisfaction of the questioners in this area, the higher is the global sense of life quality, especially in the psychophysical sphere. The quality of life is also connected with the subjective sphere. Conclusions. Sexual life satisfaction is important for the global appraisal of quality of life made by young adult.s. Basing on the level of satisfaction in the one area we can conclude about the other one.s satisfaction. There.s no differences between sexes in this area. sexual life satisfaction is equally important for both men and women. The sexual life satisfaction is also important for the appraisal of other life quality areas. © 2012 Via Medica.

Zdrojewicz Z.,Katedra i Klinika Endokrynologii | Lachowski M.,Studenckie Kolo Naukowe Endokrynologii Przy Katedrze i Klinice Endokrynologii
Postepy Higieny i Medycyny Doswiadczalnej | Year: 2014

Putrescine plays a very important role in the regulation of division, differentiation and maturation of cells as well as apoptosis. As the polycationic molecule it stabilizes the structure of DNA and participates in the functioning of cell membranes. It is able to interact with series of ion channels and has affinity for many receptors. The article presents the participation of putrescine in the metabolism of iron and mechanism of its transport across biological membranes. Especially important for the homeostasis of putrescine has ornithine decarboxylase and availability of its substrate - ornithine. Affecting to this enzyme is the simplest and widely used method of controlling the concentration of putrescine. For this purpose its inhibitor - eflornithine is applied. There was also a number of other enzymes involved in the metabolism of putrescine that was presented. Current information about the clinical relevance of putrescine in infertility, embryonic development, hirsutism, epilepsy, Alzheimer's disease, Parkinson's disease, prevention of metastases and hemostasis was also described. These processes were presented, in which putrescine plays a major role and focused on the latest reports. Attention was drawn to the situations where it has beneficial effects and those in which it is the cause of the pathology. Some of the cited reports are in phase of speculation on the possible use of it, but a significant part is already confirmed and used in clinical practice. The facts presented in this article show how great is the meaning of putrescine and how important role this simple specimen plays in the metabolic processes of living organisms. Copyright © Postepy Higieny i Medycyny Dos̈wiadczalnej 2015.

Zdrojewicz Z.,Katedra i Klinika endokrynologii | Glod J.,Studenci Vi roku wydzialu Lekarskiego uniwersytetu Medycznego we wroclawiu | Dolowiec A.,Studenci Vi roku wydzialu Lekarskiego uniwersytetu Medycznego we wroclawiu
Family Medicine and Primary Care Review | Year: 2014

Telemedicine is medicine that allows distant communication. it combines information technology, telecommunication and medicine. along to the development of iT, its availability and use will be able to reach a wider group of recipients. in the near future, it will allow patients to access a family doctor easier, the better monitoring of patients’ health with chronic diseases, patients’ education and consultation with other doctors. in general practitioner’s practice it is used in the treatment of diabetes. currently in Poland through telemedicine systems it is possible to do vision and hearing examination via the internet. However, its applications are found generally in cardiology (TeleekG) and emergency medicine (Lifenet). © Wydawnictwo Continuo.

Zdrojewicz Z.,Katedra i Klinika Endokrynologii | Pachura E.,Studentka VI roku Wydzialu Lekarskiego | Pachura P.,Studentka VI roku Wydzialu Lekarskiego
Family Medicine and Primary Care Review | Year: 2014

Recently, drug interactions with grapefruit juice (GFJ) have received considerable attention from basic scientists, physicians, industry and drug regulatory agencies. GFJ has been shown to inhibit cytochrome P450 3A4 isoenzyme and P-glycoprotein transporters in the intestine and liver. The GFJ-induced inhibitory effects are considered to be responsible for alterations in drug bioavailability, and pharmacokinetic and pharmacodynamic changes when drugs are ingested concurrently with GFJ. However, little or no interaction is observed when GFJ is taken concomitantly with parentally administered drugs. Therefore, health care professionals and the public need to be advised of the potential risks associated with the concomitant use of GFJ and interacting medications, especially cardiovascular drugs and agents with a narrow therapeutic index. Physicians should give due consideration to the adjustment of dosages of interacting drugs or advise patients about proper administrations of certain drugs. © by Wydawnictwo Continuo.

In the last twenty years the introduction of new imaging techniques has caused increasing incidence of accidental detection of adrenal tumors, which are usually mild and in most cases are hormonally inactive adenomas. Among hormonal disorders in patients with adrenal incidentalomas the hypercortisolism is often described, which, if not treated properly, leads to multiple organ complications, and further to the patient's death. The aim of the study was the retrospective analysis of the group of patients with adrenal incidentaloma, verified by histopathology for assessment of subclinical Cushing's syndrome. Among the group of 225 patients: 62 men and 163 women with incidentally detected adrenal tumors in age from 19 to 81 years diagnosed and treated in the Department of Clinical Endocrinology, University Hospital in Krakow, 59 patients was sent to surgery: 15 men and 42 women. Two groups of patients were analysed, divided on the basis of histopathological examination result. Group A consisted of patients with adrenal cortical adenoma: 38 people (11 men and 27 women). In group B there were people with so-called other hormonal inactive adrenal tumors - 17 people (4 men and 13 women). The average age of the patients in group A was 52.05 +/- 11.52 years, in group B 51.44 +/- 14.14 years. In group A the mean morning level of cortisol was 18.23 +/- 6.42 ug/dl and did not differ statistically significantly from the results of group B (mean morning cortisol level of 15.86 +/- 4.6 ug/dl). However a significantly higher nocturnal cortisol levels in the blood serum of patients with group A versus group B was observed (6.78 +/- 5.65 ug/dl vs. 3.57 +/- 1.77 ug/dl). There was no cortisol diurnal rhythm disorders in group B, while in group A slightly disrupted cortisol diurnal rhythm was found in 17 people. Mean values of 24-hour urine 17-OHCS and free cortisol were statistically higher in group A than in group B, although mean values remained within normal limits. In 24 patients from group A where abnormalities in the screening test with 1 mg DXA were found, a test with 2 and 8 mg was performed, which showed incomplete suppression of the excretion of steroid metabolites in the urine after administration of 8 mg in 17 subjects, and 3 of the total absence of suppression. In group B in 4 people there was no suppression in 1 mg of DXA test, while the suppression test with 8 mg of DXA was normal. A detailed analysis of the clinical signs, meticulously carried out and repeated hormonal diagnosis with the use of functional tests should be focused on the detection of subclinical hormonal disorders, which is crucial in preventing organ damage and making a decision of the right treatment of the patient, which is surgical.

Zdrojewicz Z.,Katedra I Klinika Endokrynologii
Family Medicine and Primary Care Review | Year: 2010

According to Polish Society of Menopause and Andropause, andropause is a period of man's life following appearance of - progressing with age - deficiency of androgenic hormones, testosterone and dehydroepiandrosterone as well as growth hormone and melatonin, phenomena that usually develop after 50th year of age. Symptomatology of these changes is characterized by gradual deterioration of the quality of life, general physical and mental condition, work skills, libido and sexual functions' disorders, deterioration of intellectual competence and sleep disorders. The objective of this article is presentation pathophysiology of the period, considering clinical and laboratory diagnostics, treatment as well as myths related to andropause. © Copyright by Wydawnictwo Continuo.

The increasing efficiency of genetic analyzers together with the decreasing price of DNA sequencing per single nucleotide read, makes the method of individual genomes sequencing more available for diagnostic laboratories. Nowadays genome sequencing applications are predominantly used for research purposes but in nearest future we will be using them in routine patient evaluation as we are using analytic approaches based on Sanger method now. New generation sequencing is a tool which gives the researchers excellent possibilities for the realization of personalized medicine assumptions. However, before we will be able to make full use of it, there are still some questions to be answered, as for example who should perform the analysis, interpret results and finally who should be responsible for data management.

Bolanowski M.,Katedra i Klinika Endokrynologii
Family Medicine and Primary Care Review | Year: 2013

Acromegaly is a rare disease resulting in visible body deformities and facial changes in patients, and is accompanied by numerous comorbidities and metabolic complications. They are the cause of shorter life expectancy of acromegalic patients. This is due to the asymptomatic course of the disease in its onset. In order to make shorter the time until the diagnosis, different educational methods of GP doctors and other specialists are applied. The signs and symptoms of the disease are presented to potential patients suffering from acromegaly. The website www.akromegalia.pl has been available for two years and both physicians and patients can verify their suspicions and get more knowledge on the disease. © Wydawnictwo Continuo.

Zdrojowy-Welna A.,Katedra i Klinika Endokrynologii | Bednarek-Tupikowska G.,Katedra i Klinika Endokrynologii
Family Medicine and Primary Care Review | Year: 2013

The deficiency of glucocorticoids, mineralocorticoids and adrenal androgenes is the essence of adrenal insufficiency. The general practitioner is an important person to deal with this problem. He is often the first physician who suspects the proper diagnosis which might be very difficult due to unspecific signs of adrenal insufficiency. After confirmation of the disease, general practitioner helps the patient to avoid excessive as well as insufficient hormonal substitution. There are no objective methods of therapy monitoring that is why the clinical observation remains crucial. Another important aspect is non-pharmacological treatment. It includes patient and his family education of adjusting the pharmacological therapy to stress-related situations (avoiding adrenal crisis), lifestyle consultancy, dealing with special situations such as journey etc. The general practitioner, who accompanies the patient in normal functioning, should predict periods regarding more intensive treatment and observation. It is also necessary to modify therapy of other diseases (such as hypertension, candidiasis) due to adrenal insufficiency. © Wydawnictwo Continuo.

PubMed | Katedra i Klinika Endokrynologii and Klinika Psychiatrii Doroslych UM w Poznaniu.
Type: Journal Article | Journal: Psychiatria polska | Year: 2016

Assessment of atypical symptoms in various types of depressive disorders, using the authors questionnaire for symptoms of atypical depression.The study involved 70 patients with a diagnosis of depressive episode in the course of recurrent depression, 54 patients with a diagnosis of depressive episode in bipolar disorder (BD) and 58 patients with a diagnosis of dysthymia. To assess the severity of atypical symptoms, the special questionnaire has been elaborated. In each diagnostic group, half of patients had normal body weight, and half were overweight or obese (BMI > 25).Patients with various types of depression did not differ significantly in terms of clinical and demographic factors. Symptoms of atypical depression such as increased appetite, weight gain and leaden paralysis were more common in women. Patients with bipolar depression had significantly increased symptoms such as hypersomnia (compared with dysthymia), and leaden paralysis (vs. recurrent depression and dysthymia). In overweight and obese patients, the severity of atypical symptoms correlated with body mass index and intensity of depression score on the 17-items Hamilton Depression Rating Scale. In this group, all symptoms of atypical depression were significantly more intense in patients with depression in the course of bipolar disorder.The results indicate higher prevalence of symptoms of atypical depression in bipolar disorder compared with recurrent depression and dysthymia. They also suggest the interdependency between the symptoms of atypical depression, bipolar disorder and obesity.

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