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Lewicka-Potocka Z.,Studenckie Kolo Naukowe Przy Katedrze i Klinice Dermatologii | Szczerkowska-Dobosz A.,Katedra i Klinika Dermatologii
Przeglad Dermatologiczny | Year: 2016

Introduction. Pitted keratolysis (PK) is a mild infectious skin disorder caused by Corynebacterium spp., Kytococcus sedentarius or Dermatophilus congolensis. These bacteria produce enzymes that digest keratin, causing superficial lesions in the plantar surface. The disease is predominantly observed in young men. Objective. Pitted keratolysis despite the characteristic presentation of skin lesions is often misdiagnosed. In this article we aimed to remind readers of its clinical aspects and treatment by presenting a typical PK case. Case report. A 35-year-old man was admitted to the dermatological clinic due to skin lesions on both soles. In the physical examination we found multiple crateriform pits, associated with hyperhidrosis and malodour diagnosed as PK. Remission of lesions was observed after treatment with oral erythromycin. Conclusions. The differential diagnosis of plantar skin lesions should include PK. Due to typical clinical manifestation the diagnosis is based on physical examination. Source

Syndromes involving premature aging provide outstanding models for a better understanding of both skin senescence and of the aging process in general. Based on the molecular pathomechanisms several main subsets of such disorders can be distinguished: progeroid syndromes with dysfunction of proteins forming the nuclear envelope (Hutchinson-Gilford syndrome, Werner syndrome, lipodystrophy), syndromes involving dysfunction of the nucleotide excision/repair DNA system (xeroderma pigmentosum, Cockayne syndrome), dysfunctions of helicases - enzymes of replication and transcription (Werner, Rothmund-Thomson, Bloom syndromes and ataxia telangiectasia), mutations of genes encoding proteins of extracellular matrix (variants of Ehlers-Danlos, and cutis laxa syndromes), mutations of the genes encoding telomerase complex (dyskeratosis congenita), and a syndrome with chromosomal aberrations (Down syndrome). Recent advances in basic research have raised new hopes regarding targeted therapies with progeria and aging. Source

Reich A.,Katedra i Klinika Dermatologii
Przeglad Dermatologiczny | Year: 2012

Introduction. Generalized pustular psoriasis is one of the most severe, potentially life-threatening forms of psoriasis. Drugs, infections and pregnancy are usually the trigger. Objective. The aim of the study was to present a case of intertriginous pustular psoriasis. Case report. A 28-year-old woman, suffering from common psoriasis since the age of 7 years, developed, during the puerperium, annular lesions of pustular psoriasis with characteristic, marginal scaling. The lesions were localized in the axillae, groins and in the breast folds, spreading at the periphery with evident central clearing. No general symptoms were present and the patient only complained of moderate skin burning. She was treated with cyclosporin and 0.1% methylprednisolone aceponate cream. Skin lesions cleared completely in one month. Conclusions. Intertriginous pustular psoriasis seems to be a distinct subtype of generalized pustular psoriasis. Source

Infective skin changes are frequent complications in patients after kidney transplantation receiving immunosuppressive therapy. The aim of the study was to evaluate factors influencing on frequency and type of skin infections of bacterial and fungal origin in patients after kidney transplantation. The study was performed in 486 patients, 296 male (60.9%) and 190 female (39.1%) aged 46.1 +/- 13.1 years (18-74 years) 74.3 +/- 52.1 months after kidney transplantation remain mainly on triple immunosupresive therapy. Type, size and localization of skin changes revealed during dermatological evaluation were described according age, sex, and applied immunosuppression. The obtained results were analyzed based on t-Student's, Mann-Whitney's, chi-square and Fisher tests. It was shown that fungal infective skin changes in patients after kidney transplantation are more frequent in older population (48.4 +/- 11.8 vs. 45.2 +/- 13.4 years; p < 0.017). The significant differences concern interdigitale mycoses 49.7 +/- 11.1 vs. 45.4 +/- 13.3 years; p < 0.009, nail mycoses 51.5 +/- 10.4 vs. 45.5 +/- 13.2 years; p < 0,004 and foot mycoses 51.8 +/- 10.7 vs. 45.5 +/- 13.2 years; p < 0.0005. In male more frequent as compare with female were also fungal infections (30.7% vs. 18.4%; p < 0.002) including pityriasis versicolor 37.0% vs. 9.5%; p < 0.016 and interdigitale mycoses 18.6% vs. 9.0%; p < 0.004. Conclusions: Infective skin changes frequency in patients after kidney transplantation on immunosuppressive therapy depends on advanced age, male sex, and applied immunosuppressive therapy. Source

Due to graft preserving immunosuppressive therapy, renal transplant recipients are predisposed to the development of a variety of skin infections and skin cancers. The aim of the study was to compare prevalence frequency of infective skin changes among patients after kidney transplantation and the dialyzed population. Clinical dermatological examination was performed in 486 patients after renal transplantation. The group consisted of 296 men (60.9%) and 190 women (30.1%), of mean age 46.1+/-13.1 (18-74 years) with median time after transplantation of 74.3+/-52.1 months. Most of the patients (80.7%) before transplantation were treated by maintenance hemodialysis. The most frequent immunosuppression regiments were combination of cyclosporine A (CsA) with mycofenolate mofetil (MMF) and steroids (GKS)-207 patients (42.5%); tacrolimus (TAC) with MMF and GKS-102 (20.9%) and CsA with azathiopine and GKS-53 patients (10.9%). The group of 112 dialyzed patients consisted of: 57 males (50.9%) and 55 females (49.1%), aged 57.4+/-15.4 years without history of immunosuppressive therapy and were on maintenance dialysis for 63.2+/-74.0 months. Most of this group (77.7%) was on maintenance hemodialysis, while the remaining 22.3% on peritoneal dialysis. The obtained results were analyzed based on t-Student's, Mann-Whitney's, chi-square and Fisher tests. It was shown that infective skin changes were significantly more frequent in the group of patients after kidney transplantation as compared with the dialyzed population. They were observed in 53.9% and 9.8% of the studied populations, respectively (p<0.0001). In the studied group after kidney transplantation the most frequent were viral changes (38.9%). Fungal infection was observed in 25.9% of these patients, while bacterial in 1.2% of this study group. In the dialyzed population fungal infections were diagnosed in 8.9%, while viral in 3.6% of patients. No bacterial changes were observed in this group. Acne was observed in 16.5% of patients after kidney transplantation. 1. In the group of patients after kidney transplantation receiving immunosuppressive therapy viral, fungal and bacterial infective skin changes were significantly more frequent as compared with the dialyzed patients. 2. The most frequent skin changes observed in patients after kidney transplantation were viral warts. Source

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