Entity

Time filter

Source Type


Bilkova A.,Katedra Bunkovej A Molekularnej Biologie Lieciv | Sepova H.K.,Katedra Bunkovej A Molekularnej Biologie Lieciv | Bilka F.,Katedra Bunkovej A Molekularnej Biologie Lieciv | Balazova A.,Katedra Bunkovej A Molekularnej Biologie Lieciv
Ceska a Slovenska Farmacie | Year: 2011

Lactic acid bacteria comprise several genera of gram-positive bacteria that are known for the production of structurally different antimicrobial substances. Among them, bacteriocins are nowadays in the centre of scientific interest. Bacteriocins, proteinaceous antimicrobial substances, are produced ribosomally and have usually a narrow spectrum of bacterial growth inhibition. According to their structure and the target of their activity, they are divided into four classes, although there are some suggestions for a renewed classification. The most interesting and usable class are lantibiotics. They comprise the most widely commercially used and well examined bacteriocin, nisin. The non-pathogenic character of lactic acid bacteria is advantageous for using their bacteriocins in food preservation as well as in feed supplements or in veterinary medicine. Source


Kinova Sepova H.,Katedra Bunkovej A Molekularnej Biologie Lieciv | Bilkova A.,Katedra Bunkovej A Molekularnej Biologie Lieciv | Bilka F.,Katedra Bunkovej A Molekularnej Biologie Lieciv | Bezakova L.,Katedra Bunkovej A Molekularnej Biologie Lieciv
Ceska a Slovenska Farmacie | Year: 2010

Lactic acid bacteria comprise several genera of Gram-positive bacteria that are known for the production of different antimicrobial substances. Lactic acid and related organic acids, usual metabolites of saccharide metabolism, inhibit the growth of other microbes mainly by lowering pH. Bacteriocins, proteinaceous antimicrobial substances, are produced ribosomally and those of lactic acid bacteria are well examined. Some species, for example Lactobacillus reuteri, are able to produce specific substances with miscellaneous structures. One of them, reutericyclin, a derivate of tetramic acid, is the first discovered antibiotic produced by a lactic acid bacterium. Reuterin, a complex of 3- hydroxypropionaldehyde and its related forms, is a strong antimicrobial substance produced by several species of the genus Lactobacillus. Because of a non-pathogenic character of lactic acid bacteria, they can be used as food preservatives or as promising antimicrobials in human and/or animal therapy. Source


Hoffman P.,Katedra Bunkovej A Molekularnej Biologie Lieciv | Bezakova L.,Katedra Bunkovej A Molekularnej Biologie Lieciv | Holkova I.,Katedra Bunkovej A Molekularnej Biologie Lieciv | Pekarova M.,Katedra Bunkovej A Molekularnej Biologie Lieciv | Oblozinsky M.,Katedra Bunkovej A Molekularnej Biologie Lieciv
Chemicke Listy | Year: 2012

Lipoxygenases form a family of nonheme ironcontaining enzymes involved in the lipid peroxidation processes. They participate, together with cyclooxygenases and cytochrome P-450, in the arachidonic acid metabolism, forming a group of cell signal molecules and secondary messengers called eicosanoids. The lipoxygenasecatalyzed reactions are highly controlled processes mediated by steric shielding of substrate by bulky amino acid side chains in the reaction center. Equally important is the channeling of molecular oxygen and the anchoring of substrate in a substrate-binding cavity. From the viewpoint of development of new effective drugs, study of lipoxygenases and biologically active eicosanoids opens new horizons for affecting pathological processes. Source

Discover hidden collaborations