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Sklenar Z.,Farmakologicky Ustav | Horackova K.,Katedra Analyticke Chemie | Kraus J.,Otorinolaryngologicke Oddeleni A.S. | Scigel V.,UStav Klinicke a Experimentalni Stomatologie | Slanar O.,Farmakologicky Ustav
Otorinolaryngologie a Foniatrie | Year: 2013

Compounded (magistral, pharmacist - prepared) preparations are requested in minority of prescriptions, but still represent important therapeutic option in otorhinolaryngology (ORL). Since 2010, there has been a significant increase in substances suitable for the use in ORL that are newly available for extemporaneous preparation in pharmacies and allow to create new formulations. Formulas that no longer meet the requirements of effective pharmacotherapy can be found in practice. Rationalization of pharmacotherapy is the current trend in all fields and relates not only to the commercially available products, but also to the compounded drugs, although this area changes very slowly. This paper reviews several aspects of magistral preparation including the reasoning for the use of extemporaneously prepared products important for ORL, updates on the changes in national health insurance policy for the reimbursement of these preparations and focuses on compounding possibilities in ORL in connection with substances (nystatin, lidocaine, xylometazoline hydrochloride, alpha tocopherol acetate). The paper also presents adjustment packages newly available for magistral preparations and suitable dosage forms.


Plzak Z.,Ustav Anorganicke Chemie AV CR | Milde D.,Katedra Analyticke Chemie
Chemicke Listy | Year: 2012

The development of terminology in metrology in the last decade is discussed. The role of International Vocabulary in Metrology (3rd ed., VIM 3) and its Czech translation as paramount normative documents is highlighted. Some terms from VIM 3 are tabulated, focusing on those most likely to be encountered in analytical and clinical laboratories. Some quality assurance terms are also added. The impact of new concepts and new Czech equivalents of the terms is discussed.


Fiala O.,Onkologicka a radioterapeuticka klinika | Pesek M.,Klinika Pneumologie a Ftizeologie | Terl M.,Klinika Pneumologie a Ftizeologie | Finek J.,Onkologicka a radioterapeuticka klinika | And 2 more authors.
Studia Pneumologica et Phthiseologica | Year: 2015

The development of diagnostic and therapeutic procedures in recent years have led to considerably longer survival and improved quality of life of patients with advanced-stage non-small cell lung cancer (NSCLC). Undoubtedly, one of the keys to the success is the gradual introduction of the concept of personalized cancer treatment. The concept is based on individualization of the treatment approach based on various predictive factors that help us estimate the response to a particular treatment modality in advance. The review aims at presenting personalized cancer treatment of patients with advanced-stage NSCLC.


Svecova H.,Katedra Analyticke Chemie | Souckova J.,Katedra Analyticke Chemie | Skopalova J.,Katedra Analyticke Chemie | Novotny R.,Laborator mikroskopickych metod | Bartak P.,Katedra Analyticke Chemie
Chemicke Listy | Year: 2012

The behavior of 1,2-distearoyl-sn-glycero-3-phosphatidylcholine (DSPC) was studied in spontaneous revesiculation used in preparation of liposomes uncontaminated with residues of organic solvents or surfactants. Cyclic voltammetry at hanging Hg drop electrode, nephelometry and transmission electron microscopy were used to study the aggregation of DSPC. Changes in current and potential of voltammetric charging peaks, similar to those due to formation of micelles in surfactant solutions, were investigated at certain concentrations of phospholipids in neutral phosphate buffer. Simultaneously, changes in turbidity of DSPC solutions were recorded. These concentrations have been characterized as critical aggregation concentrations (0.07-0.10 and 0.19-0.24 mmol l -1).


Markova E.,Katedra Analyticke Chemie | Smyslova P.,Katedra Analyticke Chemie | Macikova P.,Katedra Analyticke Chemie | Skopalova J.,Katedra Analyticke Chemie | Bartak P.,Katedra Analyticke Chemie
Chemicke Listy | Year: 2012

Electrochemical oxidation of 2,4,6-tribromophenol (TBP) has been studied by cyclic and differential pulse voltammetries at a glassy carbon electrode in 50 % aqueous methanol the pH range 2.5-12. The formation of electroactive products was observed in acid solution. A film of polymeric oxidation product that passivates the electrode surface was formed depending on the concentration and scan rate in neutral and alkaline solutions. Neutral and alkaline solutions of TBP were subjected to controlled potential electrolysis with Pt gauze electrode and the coating formed on the electrode was analyzed by GC-MS. The main products of TBP oxidation were 2,6-dibromo-4- -(2,4,6-tribromophenoxy)phenol and 3,3',5,5'-tetrabromo- -1,1'-bi(cyclohexa-2,5-dien-1-ylidene)-4,4'-dione.

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