Swathi,Kvg Medical College |
Vangara S.V.,Kasturba Medical College Manipal
Journal of Bone and Joint Surgery - Series A | Year: 2011
Background: Standard texts of anatomy provide cursory and varied descriptions of the superior peroneal retinaculum and the contents of the tunnel formed by it. The available clinical literature suggests that the boundaries and contents of the superior peroneal tunnel have a direct bearing on the causation of peroneal tendinopathies. Knowledge of the anatomy of this region is essential for successful diagnosis and treatment. Methods: Fifty-eight embalmed lower limbs were dissected and the boundaries and contents of the superior peroneal tunnel were ascertained. Sixty dry fibulas were also studied to observe the contour of the retromalleolar groove. Results: The tunnel was spacious, with the superior peroneal retinaculum forming its roof. The floor of the tunnel has an osseous and a nonosseous component. The osseous component is formed by the retromalleolar groove of the fibula, and the nonosseous component is formed by the lower part of the posterior intermuscular septum of the leg. Muscle fibers of the peroneus brevis muscle were the most frequent additional contents followed by an aberrant muscle, termed the peroneus quartus. A split peroneus brevis tendon, a double peroneus longus tendon, and an accessory peroneal nerve were some of the variants observed. In the study of the dry fibulas, it was observed that the contour of the retromalleolar groove was constantly concave. Conclusions: The study suggests that frequent additional structures can normally exist within the spacious superior peroneal tunnel. The retromalleolar groove has a concave contour and forms only a part of the floor of the tunnel and so is an unlikely cause of tendinopathies. The findings may facilitate radiographic evaluation of the tunnel and lead to improvements in the treatment of peroneal tendinopathies. COPYRIGHT © 2011 BY THE JOURNAL OF BONE AND JOINT SURGERY, INCORPORATED.
Hebbar M.,Kasturba Medical College Manipal |
Girisha K.M.,Kasturba Medical College |
Shukla A.,Kasturba Medical College Manipal
BMJ Case Reports | Year: 2016
Cleidocranial dysplasia (CCD) is a rare genetic disorder of bone, characterised by hypoplastic/aplastic clavicles, delayed closure of fontanelles and sutures of the cranium and dental abnormalities. We describe a novel frameshift pathogenic variation-c.470dupT ( p.M157Ifs∗4, NM-001024630) in the runt-related transcription factor 2 (RUNX2) gene-that adds to the spectrum of mutations in this gene. The current case also illustrates the clinical and radiological findings in an adult with CCD. © 2016 BMJ Publishing Group. All rights reserved.
PubMed | Kasturba Medical College Manipal and Kasturba Medical College
Type: | Journal: BMJ case reports | Year: 2016
Cleidocranial dysplasia (CCD) is a rare genetic disorder of bone, characterised by hypoplastic/aplastic clavicles, delayed closure of fontanelles and sutures of the cranium and dental abnormalities. We describe a novel frameshift pathogenic variation-c.470dupT (p.M157Ifs*4, NM_001024630) in the runt-related transcription factor 2 (RUNX2) gene-that adds to the spectrum of mutations in this gene. The current case also illustrates the clinical and radiological findings in an adult with CCD.
Shenoy V.P.,Kasturba Medical College Manipal |
Mukhopadhyay C.,Kasturba Medical College Manipal
Journal of Clinical and Diagnostic Research | Year: 2014
Background: A new rapid Immunochromatographic test (ICT) kit (SDBioline TB Ag MPT64RAPID®) developed by Standard Diagnostics, South Korea was evaluated for rapid differentiation of M. tuberculosis from non tuberculous mycobacteria (NTM). It detects MPT 64 antigen in M. tuberculosis isolates using mouse monoclonal MPT 64 antibody. The kit was assessed for routine identification of the Acid Fast Bacilli(AFB) isolated in our laboratory. Materials and Methods: Two hundred eight culture isolates of Mycobacteria were tested using ICT test kit for detection of MPT 64 antigen from liquid and solid culture. H37Rv strain was employed as the positive reference control. Any negative result was referred for confirmation by Gen Probe Accu Probe assay for MTB Complex (Gen-Probe, San Diego, Calif.). Speciation of NTM was performed using genotypic Mycobacterium CM assay (Hain's life sciences, Germany). Results: Of the 208 culture positive isolates tested, 182 (87.5%) were found positive for Mycobacterium tuberculosis Complex and remaining 26 (12.5%) were considered as NTM. These results were further confirmed by Gen Probe Accu probe assay that served as the reference method for detection of MTBC. H37Rv reference strain was taken as a control for ICT test and molecular tests. The reference strain showed the presence of MPT64 antigen band in the ICT test. Similar bands were formed in all MTBC (182) isolates tested, proving 100 per cent sensitivity and no bands were detected in 48 (100%) NTM isolates tested, proving 100 per cent specificity of the ICT kit. Conclusion: Tuberculosis is a global pandemic. Rapid identification of Mycobacteria as MTB complex or non-tuberculous Mycobacteria from culture is important for treatment of infected cases and drug susceptibility testing of the culture isolate. MPT 64 TB antgen detection using SD Bioline Immunochromatographic test is a simple and cost effective method for differentiation of Mycobacterial cultures as MTB complex from non- tuberculous Mycobacteria.
Addoor K.R.,Kasturba Medical College Manipal
Medical Journal of Malaysia | Year: 2011
In view of the alarming increase in the incidence of diabetes mellitus in Malaysia, we conducted a study to assess the awareness of complications of diabetes among the diabetics attending the peripheral clinics in Melaka. The study period was from January 2007 to December 2007. 351 patients were included in the study. 79.8% were aware of the complications of diabetes mellitus and 87.2% were aware that diabetes can affect the eyes. However, only 50% of the patients underwent an ophthalmological evaluation. Although awareness was good, the motivation to undergo the assessment was poor.
Manu K.M.,Kasturba Medical College Manipal
The Indian journal of chest diseases & allied sciences | Year: 2012
A 71-year-old male presented with progressive exertional breathlessness and cough for the last four years. His breathlessness aggravated after a heavy meal and on lying down. He was a smoker, but had no co-morbidities. He did not remember any major trauma or surgery. Examination of the respiratory system revealed mediastinal shift to the left, diminished breath sounds over the whole of the right hemithorax and gurgling sounds all over, mainly the infrascapular area. Examination of other organ systems revealed no abnormality.
Shetty C.M.,Kasturba Medical College Manipal |
Barthur A.,Kasturba Medical College Manipal |
Kambadakone A.,Kasturba Medical College Manipal |
Narayanan N.,Kasturba Medical College Manipal |
Kv R.,Kasturba Medical College Manipal
American Journal of Roentgenology | Year: 2011
OBJECTIVE. Computed radiography (CR) has provided a ready cost-effective transition from screen film to digital radiography and a convenient entrance to PACS. This article revisits artifacts encountered in CR systems. These artifacts may obscure abnormalities, mimic a clinical entity, or hamper image quality. CONCLUSION. With the new-generation CR systems, software- and hardware-related artifacts have decreased, making operator errors more evident. The purpose of this study is to establish the current trend of CR artifacts and the new facets in identifying and resolving problems quickly that will help prevent future occurrences. This article also brings to light the importance of constant review required of this extensively studied topic to avoid diagnostic misadventures. © American Roentgen Ray Society.
Chawla A.,Kasturba Medical College Manipal
BMJ Case Reports | Year: 2014
Supernumerary kidney is a rare anomaly and most of the times it is incidentally detected. On occasions it may present with symptoms due to stones, tumours and infections. Supernumerary unit if small and dysplastic may easily escape detection. In this case report, supernumerary kidney presented as vesicoureteric reflux in a 4-year-old male child. Copyright 2013 BMJ Publishing Group. All rights reserved.
PubMed | Manipal University India and Kasturba Medical College Manipal
Type: | Journal: BMJ case reports | Year: 2016
A 24-year-old male patient with acute lymphoblastic leukaemia (ALL), in complete remission, presented with the symptoms of gradual onset painless diminution of vision in the right eye (OD) of 2-month duration. On examination, best-corrected visual acuity in OD was finger-counting at 1m and near vision was less than N
PubMed | Kasturba Medical College Manipal and Manipal University India
Type: | Journal: BMJ case reports | Year: 2016
A 15-year-old boy presented with progressive weakness of both lower limbs. He had classical clinical features suggestive of multiple hereditary exostoses (MHE). Imaging studies of the spine revealed osteochondromas at D7, D11 and L5 vertebrae. The tumour at D11 was encroaching into the spinal canal and causing cord compression. The patient underwent osteochondroma excision and posterior spinal stabilisation, following which there was complete neurological recovery by 3months.