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Dermience M.,University of Liege | Mathieu F.,Kashin Beck Disease Fund Asbl Vzw | Barthelemy J.-P.,University of Liege | Maesen P.,University of Liege | And 5 more authors.
Biotechnology, Agronomy and Society and Environment | Year: 2013

Kashin-Beck disease (KBD) is an endemic and chronic osteochondropathy. This disease principally occurs in the Tibet Autonomous Region and in several provinces of the People's Republic of China. The etiology of the disease remains obscure although environmental factors are assumed to be involved. Diet, in particular, differentiates the rural community, affected by KBD, from the other communities (nomads and city-dwellers), who remain unaffected. In anticipation of a nutrition survey, this study aimed to measure the mineral content (Ca, P, Mg, Fe, Zn, Mn, Cu, Ni, Se, Al, Sr, Mo, Cd, As, Pb, Hg, Cr, and Co) of eight Tibetan staple foods and to compare the results against two food composition tables (FCTs). Foods were sampled in twenty households selected from both an endemic and a non-endemic area of rural Tibet. Ten minerals involved in bone metabolism were measured using atomic and molecular spectrometric methods. Results revealed that a very limited number of food/constituent pairs showed a variation in mineral composition during a single year of testing for a given region. In addition, results showed significant differences in mineral content between the endemic and the non-endemic area, especially for wheat flour. Following our analysis of the mineral content of the Tibetan food samples, results were statistically compared with similar foods listed in two food composition tables: the USDA National Nutrient Database (USDA Food Search for Windows, Version 1.0, database version SR23), and the China Food Composition Table (book 1, 2nd edition). More than 50 to 60% of p-values < 0.05 were highlighted, suggesting the inappropriateness of using FCTs as a reference for nutrition surveys in rural Tibet, and emphasizing the need for analysis of traditional foods. Differences were found to be more or less marked depending on the element considered, and calcium content seemed to show the greatest difference. Although it is obviously too early for definite conclusions to be reached (insufficient number of samples by food and insufficient number of foods analyzed), it seems that the present pilot-study indicates significant discrepancies between measured and tabulated values of the mineral content of certain foods. A more complete survey would therefore seem mandatory. Source

Dermience M.,University of Liege | Li X.W.,China National Center for Food Safety Risk Assessment | Mathieu F.,Kashin Beck Disease Fund Asbl Vzw | Claus W.,Kashin Beck Disease Fund Asbl Vzw | And 3 more authors.
Journal of Food Composition and Analysis | Year: 2014

Traditional foods play a major role in the diet of rural people living in the Tibet Autonomous Region of the People's Republic of China. Because these foods are mainly derived from local agriculture as well as artisanal production, their mineral composition may show significant discrepancies when compared with food composition data. This study aims at providing relevant data on the mineral composition of the main Tibetan foods. Sixteen different foodstuffs were sampled, including water, concentrated brewed black tea, chang, tsampa, wheat flour, dried cheese, dried yak meat, dried mutton, blood sausage, dried wild peaches, dried Chinese radish, and dried nettles. They were analyzed by inductively coupled plasma mass spectrometry (ICP-MS) for 19 minerals: Na, K, P, Ca, Mg, Fe, Zn, Mn, Cu, Ni, Se, Mo, Al, As, Cr, Co, Cd, Pb, and V. The validity of the results was ensured by the use of standard reference materials. A statistical comparison of the mean mineral contents of the analyzed foods against food composition data from the China Food Composition (CFC) table was carried out. It revealed significant discrepancies, emphasizing the importance of food analysis for nutritional assessment in Tibet autonomous region. To the best of our knowledge, the mineral compositions of some traditional Tibetan foods are here reported for the first time. © 2014 Elsevier Inc. Source

Dermience M.,University of Liege | Lognay G.,University of Liege | Mathieu F.,Kashin Beck Disease Fund Asbl Vzw | Goyens P.,Kashin Beck Disease Fund Asbl Vzw | Goyens P.,Free Universities of Brussels
Journal of Trace Elements in Medicine and Biology | Year: 2015

The human skeleton, made of 206 bones, plays vital roles including supporting the body, protecting organs, enabling movement, and storing minerals. Bones are made of organic structures, intimately connected with an inorganic matrix produced by bone cells. Many elements are ubiquitous in our environment, and many impact bone metabolism. Most elements have antagonistic actions depending on concentration. Indeed, some elements are essential, others are deleterious, and many can be both. Several pathways mediate effects of element deficiencies or excesses on bone metabolism. This paper aims to identify all elements that impact bone health and explore the mechanisms by which they act. To date, this is the first time that the effects of thirty minerals on bone metabolism have been summarized. © 2015 Elsevier GmbH. Source

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