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Kasaoka, Japan

Ohura T.,Hokkaido University | Ohura T.,Wound Healing Research Center Kojin kai | Nakajo T.,University of Tokyo | Moriguchi T.,Kawasaki University of Medical Welfare | And 5 more authors.
Wound Repair and Regeneration

A basic fibroblast growth factor (bFGF) case and a control case whose total scores of Pressure Ulcer Healing Process-Ohura (PUHP-Ohura) and risk factors for pressure ulcers, and level of care for pressure ulcers were equivalent were paired. Twenty-three such eligible pairs were enrolled in this study. Both cases in each pair were treated under conditions in which extrinsic factors such as the use of a pressure-relief mattress and the frequency of postural change were equivalent. The efficacy of bFGF was assessed by analyzing the data obtained over time as the scores of PUHP-Ohura for nine observation items using the SAS MIXED procedure. Treatment of pressure ulcers with bFGF accelerated wound healing over time more significantly than the control in six observation items (exudate volume, ulcer depth, granulation formation, wound edge, epithelialization, total score of the PUHP-Ohura). These data suggest that it may be possible to evaluate drugs for the treatment of pressure ulcers using the PUHP-Ohura wound-assessment tool. © 2011 by the Wound Healing Society. Source

Yamaguchi M.,Tokyo Institute of Technology | Murakami Y.,Tokyo Institute of Technology | Hashizume H.,Kasaoka Daiichi Hospital | Haneishi H.,Chiba University | And 2 more authors.
Progress in Biomedical Optics and Imaging - Proceedings of SPIE

The video capture of surgery is becoming widely used but the colors reproduced by conventional RGB-based video systems differ from the original. In this work, 6-band multispectral video was applied to the open surgery for highfidelity color reproduction, and medical doctors visually evaluated the reproduced image quality. As a result, 1) the 6- band video system was rated significantly higher in "color reproducibility," "fidelity," and "material appearance." 2) The perceived color differences between 6-band/RGB and 6-band/3-band were significant. 3) Color videos from 6-band data were transmitted via network, and approximately enough quality was obtained with 15Mbps bit rate. These results show the potential of multispectral technology for the improvement of surgical video quality. © 2010 Copyright SPIE - The International Society for Optical Engineering. Source

Shimamura Y.,Okayama University of Science | Nishida K.,Okayama University of Science | Imatani J.,Okayama Saiseikai General Hospital | Noda T.,Okayama University of Science | And 3 more authors.
Acta Medica Okayama

We biomechanically evaluated the bone fixation rigidity of an ONI plate (Group I) during fixation of experimentally created transcondylar humerus fractures in cadaveric elbows, which are the most frequently observed humeral fractures in the elderly, and compared it with the rigidity achieved by 3 conventional fixation methods: an LCP reconstruction plate 3.5 using a locking mechanism (Group II), a conventional reconstruction plate 3.5 (CRP) with a cannulated cancellous screw (Group III), and a CRP with 2 cannulated cancellous screws (CS) in a crisscross orientation (Group IV). In the axial loading test, the mean failure loads were: Group I, 98.9 ± 32.6; Group II, 108.5 ± 27.2; Group III, 50.0 ± 7.5; and Group IV, 34.5 ± 12.2 (N). Group I fixations failed at a significantly higher load than those of Groups III and IV (p < 0.05). In the extension loading test, the mean failure loads were: Group I, 34.0 ± 12.4; Group II, 51.0 ± 14.8; Group III, 19.3 ± 6.0; and Group IV, 14.7 ± 3.1 (N). Group IV fixations showed a significantly lower failure load than those of Group I (p < 0.05). The fixation rigidities against mechanical loading by the ONI plate and LCP plate were comparable. These results suggested that an ONI system might be superior to the CRP and CS method, and comparable to the LCP method in terms of fixation rigidity for distal humerus fractures. © 2010 by Okayama University Medical School. Source

Yoshida K.,Showa University | Okimoto N.,Kawasaki Medical School | Kishimoto M.,Kawasaki Medical School | Fukano H.,Center for Respiratory Disease | And 7 more authors.
Journal of Infection and Chemotherapy

Moxifloxacin is a respiratory quinolone that is expected to be useful for treating community-acquired bacterial pneumonia, but few clinical studies and not a detailed evaluation of its pharmacokinetics have been conducted in Japan in patients with pneumonia. We assessed the efficacy and safety of moxifloxacin in 18 patients with community-acquired bacterial pneumonia using pharmacokinetic-pharmacodynamic analysis. There was significant improvement in body temperature, white blood cell count, C-reactive protein, and chest X-ray score on day 3 of moxifloxacin treatment, which persisted until the completion of treatment (all plt;0.05). Nine strains, including Streptococcus pneumoniae, Moraxella catarrhalis, Haemophilus influenzae, and Enterobacter cloacae, were isolated from sputum cultures of nine patients. The isolated strains were eradicated by moxifloxacin. The mean area under the concentration-time curve from 0 to 24 hours [AUC 0-24 h (AUC 0-24 h,ss)], maximum plasma concentration (C max), and trough plasma level (C trough) of moxifloxacin at steady state was 52.0 lg h/ml, 4.5, and 0.9 μg/ml, respectively. Mean AUC 0-24 h,ss/mimimum inhibitory concentration (MIC), and C max/MIC ratios for patients in whom MICs of moxifloxacin were determined for pathogenic bacteria were 723 and 62, respectively. The median AUC 0-24 h,ss/MIC and C max/MIC ratios (based on Monte Carlo simulation employing MICs for 257 strains of S. pneumoniae collected during a respiratory infection survey by the Japanese Society of Chemotherapy in 2007) were 209.56 and 17.88, respectively. Thus, when the target for the AUC/MIC ratio was set at ≥30 and that for the C max/MIC ratio at ≥5, the achievement rate for these two parameters was 97.36% and 96.71%, respectively. Two patients (11%) experienced three adverse effects [one nausea, another increased aspartate aminotransferase (AST) and alanine aminotransferase (ALT)], but the events were not serious. Based on these results, moxifloxacin(400 mg once daily) was considered useful for treating community-acquired bacterial pneumonia and is expected to show excellent efficacy and safety as well as suppressing the emergence of resistance. © Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases 2011. Source

Watanabea M.,Okayama University of Science | Arita S.,Doshisha University | Hashizumec H.,Kasaoka Daiichi Hospital | Honda M.,Okayama University | And 2 more authors.
Acta Medica Okayama

The purpose of this study was to quantitatively evaluate Akahori's preoperative classification of cubital tunnel syndrome. We analyzed the results for 57 elbows that were treated by a simple decompression procedure from1997 to 2004. The relationship between each item of Akahori's preoperative classification and clinical stage wasinvestigated based on the parameter distribution. We evaluated Akahori's classification system using multiple regression analysis, and investigated the association between the stage and treatment results. The usefulness of the regression equation was evaluated by analysis of variance of the expected and observed scores. In the parameter distribution, each item of Akahori's classification was mostly associated with the stage, but it was difficult to judge the severity of palsy. In the mathematical evaluation, the most effective item in determining the stage was sensory conduction velocity. It was demonstrated that the established regression equation was highly reliable (R = 0.922). Akahori's preoperative classification can also be used in postoperative classification, and this classification was correlated with postoperative prognosis. Our results indicate that Akahori's preoperative classification is a suitable system. It is reliable, reproducible and well-correlated with the postoperative prognosis. In addition, the established prediction formula is useful to reduce the diagnostic complexity of Akahori's classification. © 2013 by Okayama University Medical School. Source

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