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Compounds of formula (I) or a pharmaceutically acceptable sail thereof, wherein: W is O, NH, N(C_(1)-C_(10 )alkyl) or S; each X is independently CH or N; R^(1 )is a 5 to 7-membered saturated or unsaturated, optionally substituted heterocycle containing at least 1 heteroatom selected from N or O; R^(2 )is (LQ)_(m)Y; and each R^(3 )is independently H, C_(1)-C_(10 )alkyl, aryl or heteroaryl, are surprisingly found to be inhibitors of PI3K-p110, and therefore have utility in therapy.


Compounds of formulae (I) and (II): or a pharmaceutically acceptable salt thereof, wherein: R_(1 )is a nitrogen-containing 5 to 7-membered heteroaryl or heterocycle; R_(2 )and R_(3 )are each independently (LQ)_(m)Y, are described. The compounds are PI3K inhibitors and are useful for the treatment of cancer and immune-inflammatory diseases.


Patent
Karus Therapeutics | Date: 2014-05-12

The present invention is a compound of the formula or a pharmaceutically acceptable salt thereof. The compounds are useful as HDAC inhibitors.


A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein: W is O, NH, N(C_(1)-C_(10 )alkyl) or S; each X is independently CH or N; R^(1 )is a 5 to 7-membered saturated or unsaturated, optionally substituted heterocycle containing at least 1 heteroatom selected from N or O; R^(2 )is LY; each L is a direct bond, C_(1)-C_(10 )alkylene, C_(2)-C_(10 )alkenylene or C_(2)-C_(10 )alkynylene; Y is an optionally substituted fused, bridged or spirocyclic non-aromatic 5-12 membered heterocycle containing up to 4 heteroatoms selected from N or O; and each R^(3 )is independently H, C_(1)-C_(10 )alkyl, halogen, fluoro C_(1)-C_(10 )alkyl, OC_(1)-C_(10 )alkyl, NHC_(1)-C_(10 )alkyl, SC_(1)-C_(10 )alkyl, O-fluoro C_(1)-C_(10 )alkyl, NH-acyl, NHC(O)NHC_(1)-C_(10 )alkyl, C(O)NHC_(1)-C_(10 )alkyl, aryl or heteroaryl, are useful as inhibitors of the class IA phosphoinositide 3-kinase enzyme, PI3K-p110, and therefore have potential utility in the therapy of cancer, immune and inflammatory diseases.


Patent
Karus Therapeutics | Date: 2013-03-08

A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein: R_(1), R_(2), R_(3), R and R_(6 )are each independently (LQ)_(m)Y; R_(4 )is H, halogen, optionally substituted aryl or optionally substituted alkyl; and; each X is independently CR_(7 )or N. The compounds are PI3K inhibitors and therefore have potential utility in therapy.


Compounds of formula (I): wherein: W is O, NH, N-alkyl, N-alkenyl, N-alkynyl, N-aryl, N-heteroaryl or S; each X is independently CH or N; R^(1 )is formula (b) or R^(3 )is H, alkyl, NH_(2), OH, =0 or halogen; each A and B are independently CH or N; D is NHR_(4); R^(4 )is H, alkyl, C(O) alkyl. C(O)NH_(2), C(O)NH alkyl, SO_(2) alkyl, SO_(2)NH_(2 )or SO_(2)NH alkyl; R^(2 )is aryl substituted with at least one nitrogen-containing group or R^(2 )is a nitrogen-containing heteroaryl, cycloalkyl substituted with a nitrogen-containing group, nitrogen-containing cycloalkyl, C_(1)-C_(6 )mono alkylamino, C_(1)C_(6 )bis alkylamino, C_(1)C_(6 )acylamino, C_(1)-C_(6 )aminoalkyl, mono (C_(1)C_(6 )alkyl) amino C_(1)-C_(6 )alkyl, bis (C_(1)C_(6 )alkyl) amino C_(1)C_(6 )alkyl, C_(1)-C_(6)-acylamino or C_(1 )C_(6 )alkynyl-NR^(11), R^(11 )is H, alkyl, alkenyl, alkynyl, aryl, heteroaryl, halogen, O-alkyl, NH-alkyl, N-dialkyl, C(O)R^(7), C(O)NH_(2), C(O)NHR^(7), SO_(2)R^(7), SO_(2)NH_(2), SO_(2)NHR^(7), NH-acyl, NH-sulfonyl, NR^(7)-acyl, NR^(7)-sulfonyl, NC(O)NHR^(7), NSO_(2)NHR^(7), NC(O)NR^(7)R^(7 )or NSO_(2)NR^(7)R^(7); and R^(7 )is alkyl, aryl or heteroaryl, are useful as PI3K inhibitors and are useful in therapy.


Patent
Karus Therapeutics | Date: 2014-04-30

Compounds of the invention are of the formula wherein:


Patent
Karus Therapeutics | Date: 2013-11-06

A compound of the formula: (I) or a pharmaceutically acceptable salt thereof, wherein: L is a 5-membered nitrogen-containing heteroaryl which is optionally fused to a benzene; Y is a 5, 6 or 7-membered nitrogen-containing heteroaryl, which is optionally fused to a benzene; and W is a zinc-binding group. The compounds are HDAC inhibitors and therefore have potential utility in therapy.


News Article | November 8, 2016
Site: www.newsmaker.com.au

The Global Pancreatic Cancer - Pipeline Market Research Report 2016 is a valuable source of insightful data for business strategists. It provides the Pancreatic Cancer - Pipeline industry overview with growth analysis and historical & futuristic cost, revenue, demand and supply data (as applicable). The research analysts provide an elaborate description of the value chain and its distributor analysis. This Pancreatic Cancer - Pipeline market study provides comprehensive data which enhances the understanding, scope and application of this report. This report provides comprehensive analysis of lKey market segments and sub-segments lEvolving market trends and dynamics lChanging supply and demand scenarios lQuantifying market opportunities through market sizing and market forecasting lTracking current trends/opportunities/challenges lCompetitive insights lOpportunity mapping in terms of technological breakthroughs The Major players reported in the market include: Birken AG Fibrocell Science,Inc. GlaxoSmithKline Plc InMed Pharmaceuticals Inc. Karus Therapeutics Limited RegeneRex Biopharmaceuticals,Inc. Scioderm,Inc. Shire Plc Stratatech Corporation Reasons for Buying this Report This report provides pin-point analysis for changing competitive dynamics It provides a forward looking perspective on different factors driving or restraining market growth It provides a six-year forecast assessed on the basis of how the market is predicted to grow It helps in understanding the key product segments and their future It provides pin point analysis of changing competition dynamics and keeps you ahead of competitors It helps in making informed business decisions by having complete insights of market and by making in-depth analysis of market segments It provides distinctive graphics and exemplified SWOT analysis of major market segments Global Pancreatic Cancer - Pipeline Market Research Report 2016 Chapter 1 Pancreatic Cancer - Pipeline Market Overview     1.1 Product Overview and Scope of Pancreatic Cancer - Pipeline     1.2 Pancreatic Cancer - Pipeline Market Segmentation by Type       1.2.1 Global Production Market Share of Pancreatic Cancer - Pipeline by Type in 2015       1.2.1 Type I       1.2.2 Type II       1.2.3 Type III     1.3 Pancreatic Cancer - Pipeline Market Segmentation by Application       1.3.1 Pancreatic Cancer - Pipeline Consumption Market Share by Application in 2015       1.3.2 Application I       1.3.3 Application II       1.3.4 Application III     1.4 Pancreatic Cancer - Pipeline Market Segmentation by Regions       1.4.1 North America       1.4.2 China       1.4.3 Europe       1.4.4 Southeast Asia       1.4.5 Japan       1.4.6 India     1.5 Global Market Size (Value) of Pancreatic Cancer - Pipeline (2011-2021) Chapter 2 Global Economic Impact on Pancreatic Cancer - Pipeline Industry     2.1 Global Macroeconomic Environment Analysis       2.1.1 Global Macroeconomic Analysis       2.1.2 Global Macroeconomic Environment Development Trend     2.2 Global Macroeconomic Environment Analysis by Regions     2.3 Effects to Pancreatic Cancer - Pipeline Industry Chapter 3 Global Pancreatic Cancer - Pipeline Market Competition by Manufacturers     3.1 Global Pancreatic Cancer - Pipeline Production and Share by Manufacturers (2015 and 2016)     3.2 Global Pancreatic Cancer - Pipeline Revenue and Share by Manufacturers (2015 and 2016)     3.3 Global Pancreatic Cancer - Pipeline Average Price by Manufacturers (2015 and 2016)     3.4 Manufacturers Pancreatic Cancer - Pipeline Manufacturing Base Distribution, Sales Area and Product Type     3.5 Pancreatic Cancer - Pipeline Market Competitive Situation and Trends       3.5.1 Pancreatic Cancer - Pipeline Market Concentration Rate       3.5.2 Pancreatic Cancer - Pipeline Market Share of Top 3 and Top 5 Manufacturers       3.5.3 Mergers & Acquisitions, Expansion Chapter 4 Global Pancreatic Cancer - Pipeline Production, Revenue (Value) by Region (2011-2016)     4.1 Global Pancreatic Cancer - Pipeline Production by Region (2011-2016)     4.2 Global Pancreatic Cancer - Pipeline Production Market Share by Region (2011-2016)     4.3 Global Pancreatic Cancer - Pipeline Revenue (Value) and Market Share by Region (2011-2016)     4.4 Global Pancreatic Cancer - Pipeline Production, Revenue, Price and Gross Margin (2011-2016)     4.5 North America Pancreatic Cancer - Pipeline Production, Revenue, Price and Gross Margin (2011-2016)     4.6 Europe Pancreatic Cancer - Pipeline Production, Revenue, Price and Gross Margin (2011-2016)     4.7 China Pancreatic Cancer - Pipeline Production, Revenue, Price and Gross Margin (2011-2016)     4.8 Japan Pancreatic Cancer - Pipeline Production, Revenue, Price and Gross Margin (2011-2016)     4.9 Southeast Asia Pancreatic Cancer - Pipeline Production, Revenue, Price and Gross Margin (2011-2016)     4.10 India Pancreatic Cancer - Pipeline Production, Revenue, Price and Gross Margin (2011-2016) Chapter 5 Global Pancreatic Cancer - Pipeline Supply (Production), Consumption, Export, Import by Regions (2011-2016)     5.1 Global Pancreatic Cancer - Pipeline Consumption by Regions (2011-2016)     5.2 North America Pancreatic Cancer - Pipeline Production, Consumption, Export, Import by Regions (2011-2016)     5.3 Europe Pancreatic Cancer - Pipeline Production, Consumption, Export, Import by Regions (2011-2016)     5.4 China Pancreatic Cancer - Pipeline Production, Consumption, Export, Import by Regions (2011-2016)     5.5 Japan Pancreatic Cancer - Pipeline Production, Consumption, Export, Import by Regions (2011-2016)     5.6 Southeast Asia Pancreatic Cancer - Pipeline Production, Consumption, Export, Import by Regions (2011-2016)     5.7 India Pancreatic Cancer - Pipeline Production, Consumption, Export, Import by Regions (2011-2016) Chapter 6 Global Pancreatic Cancer - Pipeline Production, Revenue (Value), Price Trend by Type     6.1 Global Pancreatic Cancer - Pipeline Production and Market Share by Type (2011-2016)     6.2 Global Pancreatic Cancer - Pipeline Revenue and Market Share by Type (2011-2016)     6.3 Global Pancreatic Cancer - Pipeline Price by Type (2011-2016)     6.4 Global Pancreatic Cancer - Pipeline Production Growth by Type (2011-2016) Chapter 7 Global Pancreatic Cancer - Pipeline Market Analysis by Application     7.1 Global Pancreatic Cancer - Pipeline Consumption and Market Share by Application (2011-2016)     7.2 Global Pancreatic Cancer - Pipeline Consumption Growth Rate by Application (2011-2016)     7.3 Market Drivers and Opportunities       7.3.1 Potential Applications       7.3.2 Emerging Markets/Countries Chapter 8 Global Pancreatic Cancer - Pipeline Manufacturers Analysis     8.1 Birken AG       8.1.1 Company Basic Information, Manufacturing Base and Competitors       8.1.2 Product Type, Application and Specification       8.1.3 Sales, Revenue, Price and Gross Margin (2011-2016)       8.1.4 Business Overview     8.2 Fibrocell Science,Inc.       8.2.1 Company Basic Information, Manufacturing Base and Competitors       8.2.2 Product Type, Application and Specification       8.2.3 Sales, Revenue, Price and Gross Margin (2011-2016)       8.2.4 Business Overview     8.3 GlaxoSmithKline Plc       8.3.1 Company Basic Information, Manufacturing Base and Competitors       8.3.2 Product Type, Application and Specification       8.3.3 Sales, Revenue, Price and Gross Margin (2011-2016)       8.3.4 Business Overview     8.4 InMed Pharmaceuticals Inc.       8.4.1 Company Basic Information, Manufacturing Base and Competitors       8.4.2 Product Type, Application and Specification       8.4.3 Sales, Revenue, Price and Gross Margin (2011-2016)       8.4.4 Business Overview     8.5 Karus Therapeutics Limited       8.5.1 Company Basic Information, Manufacturing Base and Competitors       8.5.2 Product Type, Application and Specification       8.5.3 Sales, Revenue, Price and Gross Margin (2011-2016)       8.5.4 Business Overview     8.6 RegeneRex Biopharmaceuticals,Inc.       8.6.1 Company Basic Information, Manufacturing Base and Competitors       8.6.2 Product Type, Application and Specification       8.6.3 Sales, Revenue, Price and Gross Margin (2011-2016)       8.6.4 Business Overview     8.7 Scioderm,Inc.       8.7.1 Company Basic Information, Manufacturing Base and Competitors       8.7.2 Product Type, Application and Specification       8.7.3 Sales, Revenue, Price and Gross Margin (2011-2016)       8.7.4 Business Overview     8.8 Shire Plc       8.8.1 Company Basic Information, Manufacturing Base and Competitors       8.8.2 Product Type, Application and Specification       8.8.3 Sales, Revenue, Price and Gross Margin (2011-2016)       8.8.4 Business Overview     8.9 Stratatech Corporation       8.9.1 Company Basic Information, Manufacturing Base and Competitors       8.9.2 Product Type, Application and Specification       8.9.3 Sales, Revenue, Price and Gross Margin (2011-2016)       8.9.4 Business Overview Get It Now @ https://www.wiseguyreports.com/checkout?currency=one_user-USD&report_id=723319


News Article | November 8, 2016
Site: www.newsmaker.com.au

The Global Open-Angle Glaucoma - Pipeline Market Research Report 2016 is a valuable source of insightful data for business strategists. It provides the Open-Angle Glaucoma - Pipeline industry overview with growth analysis and historical & futuristic cost, revenue, demand and supply data (as applicable). The research analysts provide an elaborate description of the value chain and its distributor analysis. This Open-Angle Glaucoma - Pipeline market study provides comprehensive data which enhances the understanding, scope and application of this report. This report provides comprehensive analysis of lKey market segments and sub-segments lEvolving market trends and dynamics lChanging supply and demand scenarios lQuantifying market opportunities through market sizing and market forecasting lTracking current trends/opportunities/challenges lCompetitive insights lOpportunity mapping in terms of technological breakthroughs The Major players reported in the market include: Birken AG Fibrocell Science,Inc. GlaxoSmithKline Plc InMed Pharmaceuticals Inc. Karus Therapeutics Limited RegeneRex Biopharmaceuticals,Inc. Scioderm,Inc. Shire Plc Stratatech Corporation Reasons for Buying this Report This report provides pin-point analysis for changing competitive dynamics It provides a forward looking perspective on different factors driving or restraining market growth It provides a six-year forecast assessed on the basis of how the market is predicted to grow It helps in understanding the key product segments and their future It provides pin point analysis of changing competition dynamics and keeps you ahead of competitors It helps in making informed business decisions by having complete insights of market and by making in-depth analysis of market segments It provides distinctive graphics and exemplified SWOT analysis of major market segments Global Open-Angle Glaucoma - Pipeline Market Research Report 2016 Chapter 1 Open-Angle Glaucoma - Pipeline Market Overview     1.1 Product Overview and Scope of Open-Angle Glaucoma - Pipeline     1.2 Open-Angle Glaucoma - Pipeline Market Segmentation by Type       1.2.1 Global Production Market Share of Open-Angle Glaucoma - Pipeline by Type in 2015       1.2.1 Type I       1.2.2 Type II       1.2.3 Type III     1.3 Open-Angle Glaucoma - Pipeline Market Segmentation by Application       1.3.1 Open-Angle Glaucoma - Pipeline Consumption Market Share by Application in 2015       1.3.2 Application I       1.3.3 Application II       1.3.4 Application III     1.4 Open-Angle Glaucoma - Pipeline Market Segmentation by Regions       1.4.1 North America       1.4.2 China       1.4.3 Europe       1.4.4 Southeast Asia       1.4.5 Japan       1.4.6 India     1.5 Global Market Size (Value) of Open-Angle Glaucoma - Pipeline (2011-2021) Chapter 2 Global Economic Impact on Open-Angle Glaucoma - Pipeline Industry     2.1 Global Macroeconomic Environment Analysis       2.1.1 Global Macroeconomic Analysis       2.1.2 Global Macroeconomic Environment Development Trend     2.2 Global Macroeconomic Environment Analysis by Regions     2.3 Effects to Open-Angle Glaucoma - Pipeline Industry Chapter 3 Global Open-Angle Glaucoma - Pipeline Market Competition by Manufacturers     3.1 Global Open-Angle Glaucoma - Pipeline Production and Share by Manufacturers (2015 and 2016)     3.2 Global Open-Angle Glaucoma - Pipeline Revenue and Share by Manufacturers (2015 and 2016)     3.3 Global Open-Angle Glaucoma - Pipeline Average Price by Manufacturers (2015 and 2016)     3.4 Manufacturers Open-Angle Glaucoma - Pipeline Manufacturing Base Distribution, Sales Area and Product Type     3.5 Open-Angle Glaucoma - Pipeline Market Competitive Situation and Trends       3.5.1 Open-Angle Glaucoma - Pipeline Market Concentration Rate       3.5.2 Open-Angle Glaucoma - Pipeline Market Share of Top 3 and Top 5 Manufacturers       3.5.3 Mergers & Acquisitions, Expansion Chapter 4 Global Open-Angle Glaucoma - Pipeline Production, Revenue (Value) by Region (2011-2016)     4.1 Global Open-Angle Glaucoma - Pipeline Production by Region (2011-2016)     4.2 Global Open-Angle Glaucoma - Pipeline Production Market Share by Region (2011-2016)     4.3 Global Open-Angle Glaucoma - Pipeline Revenue (Value) and Market Share by Region (2011-2016)     4.4 Global Open-Angle Glaucoma - Pipeline Production, Revenue, Price and Gross Margin (2011-2016)     4.5 North America Open-Angle Glaucoma - Pipeline Production, Revenue, Price and Gross Margin (2011-2016)     4.6 Europe Open-Angle Glaucoma - Pipeline Production, Revenue, Price and Gross Margin (2011-2016)     4.7 China Open-Angle Glaucoma - Pipeline Production, Revenue, Price and Gross Margin (2011-2016)     4.8 Japan Open-Angle Glaucoma - Pipeline Production, Revenue, Price and Gross Margin (2011-2016)     4.9 Southeast Asia Open-Angle Glaucoma - Pipeline Production, Revenue, Price and Gross Margin (2011-2016)     4.10 India Open-Angle Glaucoma - Pipeline Production, Revenue, Price and Gross Margin (2011-2016) Chapter 5 Global Open-Angle Glaucoma - Pipeline Supply (Production), Consumption, Export, Import by Regions (2011-2016)     5.1 Global Open-Angle Glaucoma - Pipeline Consumption by Regions (2011-2016)     5.2 North America Open-Angle Glaucoma - Pipeline Production, Consumption, Export, Import by Regions (2011-2016)     5.3 Europe Open-Angle Glaucoma - Pipeline Production, Consumption, Export, Import by Regions (2011-2016)     5.4 China Open-Angle Glaucoma - Pipeline Production, Consumption, Export, Import by Regions (2011-2016)     5.5 Japan Open-Angle Glaucoma - Pipeline Production, Consumption, Export, Import by Regions (2011-2016)     5.6 Southeast Asia Open-Angle Glaucoma - Pipeline Production, Consumption, Export, Import by Regions (2011-2016)     5.7 India Open-Angle Glaucoma - Pipeline Production, Consumption, Export, Import by Regions (2011-2016) Chapter 6 Global Open-Angle Glaucoma - Pipeline Production, Revenue (Value), Price Trend by Type     6.1 Global Open-Angle Glaucoma - Pipeline Production and Market Share by Type (2011-2016)     6.2 Global Open-Angle Glaucoma - Pipeline Revenue and Market Share by Type (2011-2016)     6.3 Global Open-Angle Glaucoma - Pipeline Price by Type (2011-2016)     6.4 Global Open-Angle Glaucoma - Pipeline Production Growth by Type (2011-2016) Chapter 7 Global Open-Angle Glaucoma - Pipeline Market Analysis by Application     7.1 Global Open-Angle Glaucoma - Pipeline Consumption and Market Share by Application (2011-2016)     7.2 Global Open-Angle Glaucoma - Pipeline Consumption Growth Rate by Application (2011-2016)     7.3 Market Drivers and Opportunities       7.3.1 Potential Applications       7.3.2 Emerging Markets/Countries Chapter 8 Global Open-Angle Glaucoma - Pipeline Manufacturers Analysis     8.1 Birken AG       8.1.1 Company Basic Information, Manufacturing Base and Competitors       8.1.2 Product Type, Application and Specification       8.1.3 Sales, Revenue, Price and Gross Margin (2011-2016)       8.1.4 Business Overview     8.2 Fibrocell Science,Inc.       8.2.1 Company Basic Information, Manufacturing Base and Competitors       8.2.2 Product Type, Application and Specification       8.2.3 Sales, Revenue, Price and Gross Margin (2011-2016)       8.2.4 Business Overview     8.3 GlaxoSmithKline Plc       8.3.1 Company Basic Information, Manufacturing Base and Competitors       8.3.2 Product Type, Application and Specification       8.3.3 Sales, Revenue, Price and Gross Margin (2011-2016)       8.3.4 Business Overview     8.4 InMed Pharmaceuticals Inc.       8.4.1 Company Basic Information, Manufacturing Base and Competitors       8.4.2 Product Type, Application and Specification       8.4.3 Sales, Revenue, Price and Gross Margin (2011-2016)       8.4.4 Business Overview     8.5 Karus Therapeutics Limited       8.5.1 Company Basic Information, Manufacturing Base and Competitors       8.5.2 Product Type, Application and Specification       8.5.3 Sales, Revenue, Price and Gross Margin (2011-2016)       8.5.4 Business Overview     8.6 RegeneRex Biopharmaceuticals,Inc.       8.6.1 Company Basic Information, Manufacturing Base and Competitors       8.6.2 Product Type, Application and Specification       8.6.3 Sales, Revenue, Price and Gross Margin (2011-2016)       8.6.4 Business Overview     8.7 Scioderm,Inc.       8.7.1 Company Basic Information, Manufacturing Base and Competitors       8.7.2 Product Type, Application and Specification       8.7.3 Sales, Revenue, Price and Gross Margin (2011-2016)       8.7.4 Business Overview     8.8 Shire Plc       8.8.1 Company Basic Information, Manufacturing Base and Competitors       8.8.2 Product Type, Application and Specification       8.8.3 Sales, Revenue, Price and Gross Margin (2011-2016)       8.8.4 Business Overview     8.9 Stratatech Corporation       8.9.1 Company Basic Information, Manufacturing Base and Competitors       8.9.2 Product Type, Application and Specification       8.9.3 Sales, Revenue, Price and Gross Margin (2011-2016)       8.9.4 Business Overview Get It Now @ https://www.wiseguyreports.com/checkout?currency=one_user-USD&report_id=723317

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