Patil S.A.,Karnataka University |
Unki S.N.,Karnataka University |
Kulkarni A.D.,Karnataka University |
Naik V.H.,Karnataka University
Journal of Molecular Structure | Year: 2011
A series of Co(II), Ni(II) and Cu(II) complexes have been synthesized with Schiff bases derived from 2-hydroxy-1-naphthaldehyde and 2-oxo-2H-chromene-3- carbohydrazide/6-bromo-2-oxo-2H-chromene-3-carbohydrazide. The chelation of the complexes has been proposed in the light of analytical, spectral (IR, UV-Vis, 1H NMR, ESR, FAB-mass and fluorescence), magnetic and thermal studies. The measured molar conductance values indicate that, the complexes are non-electrolytic in nature. The redox behavior of the complexes was investigated with electrochemical method by using cyclic voltammetry. The Schiff bases and their metal complexes have been screened for their in vitro antibacterial (Escherichia coli, Staphylococcus aureus, Bacillus subtilis and Salmonella typhi) and antifungal activities (Candida albicans, Cladosporium and Aspergillus niger) by MIC method. The DNA cleavage is studied by agarose gel electrophoresis method. © 2010 Elsevier B.V. All rights reserved.
Phadke K.V.,Karnataka University |
Manjeshwar L.S.,Karnataka University
Polymer Bulletin | Year: 2014
Carboxymethyl guar gum (CMGG) was synthesized by carboxymethylation of guar gum (GG), which was blended with gelatin (GE) to obtain a novel semi-interpenetrating polymer network (semi-IPN) in the form of microspheres prepared by water-in-oil emulsion method to investigate the controlled release of theophylline (THP), an antiasthmatic drug. Electronic spectroscopy revealed the drug encapsulation ranging from 56 to 74 %. Fourier Transform infrared spectroscopy confirmed the carboxymethylation of GG as well as the semi-IPN structure of the blend polymer. Scanning electron microscopy indicated the smooth surfaces with spherical microspheres. Differential scanning calorimetric and X-ray diffraction studies showed the molecular level dispersion of drug in the microspheres. The in vitro drug release profiles were analyzed to study the effect of polymer blend composition, % drug loading and amount of glutaraldehyde added as a crosslinker. The drug release was extended up to 26 h. The in vitro release data performed in acidic and alkaline media were analyzed using the empirical equations to understand the release profiles of THP. © 2014 Springer-Verlag Berlin Heidelberg.
Sonalika W.G.,Hitkarini Dental College and Hospital |
Bhat K.G.,Maratha Mandals Nathajirao lgekar Institute Of Dental Science And Research Center |
Patil B.R.,Karnataka Cancer Treatment and Research Institute |
Muddapur M.V.,Karnataka University
Oral Oncology | Year: 2012
Objectives: Tobacco chewing habit, presence of squamous cell carcinoma in oral cavity and radiotherapy causes alterations in healthy oral microflora. Abnormal flora developed due to radiotherapy in oral squamous cell carcinoma (OSCC) patients can exacerbate mucositis and can cause systemic infections. The role of oral microorganisms in carcinogenesis is gaining interest recently. Abnormal flora in development of second tumor in the field of first tumor is to be established. The study fundamentally tries to evaluate the shift that occurs during the radiotherapy in OSCC patients. Methods: Microbial analysis of saliva samples from OSCC patients undergoing radiotherapy, tobacco chewers and controls was undertaken. The microorganisms were grouped into categories as total aerobes, total anaerobes, candida, coliforms and gram negative anaerobic bacteria. Results: The frequency of isolation of total aerobes, total anaerobes, coliforms and gram negative anaerobic bacteria was significantly high in OSCC patients compared to healthy controls whereas candida was isolated most frequently during radiation period. The tobacco chewers showed significant increase in colony forming units of total aerobes and coliforms. All the microbial groups were high in OSCC and radiotherapy patients. While OSCC patients showed significant increase in total anaerobes and gram negative anaerobes, candida was increased in radiotherapy patients only. Conclusion: Habits promote coliforms. Tumor supports efficiently anaerobes and candida. The latter is supported more by radiation. The study stresses the importance on administration of appropriate antimicrobial therapy right at the time of diagnosis of the lesion. © 2012 Elsevier Ltd. All rights reserved.
Shettar A.K.,Karnataka University |
Vedamurthy A.B.,Karnataka University
Pharmacognosy Journal | Year: 2017
Objective: Evaluating Anthelmintic activity of Ximenia americana, Hopea ponga and Vitex leucoxylon extracts by using in vitro assay. Methods: The serial exhaustive extraction was carried out with a series of solvents: chloroform, ethyl acetate, methanol, ethanol and water with increasing polarity using Soxhlet apparatus. The concentrated and dried extracts were evaluated for anthelmintic activity by employing standard in vitro method (Pheretima Posthuma model). Results: In vitro anthelmintic study shows that in case of Ximenia americana chloroform extract showed higher anthelmintic activity where as incase of Hopea ponga and Vitex leucoxylon methanol extract exhibited significant activity when compared to other solvent extracts. Conclusion: Results confirm that methanol extract of Hopea ponga exhibited highest anthelmintic activity among all tested extracts. This study provides scientific evidence that the leaves of Ximenia americana, Hopea ponga and Vitex leucoxylon have anthelmintic efficacy. However further comprehensive chemical and pharmacological investigation should be carried out to isolate the active compounds and appropriate elucidation of its mechanism of action and it helps in the development of new pharmaceuticals to treat Helminthiasis. © 2017 Phcog.Net.
Bujurke N.M.,Karnataka University |
Naduvinamani N.B.,Gulbarga University |
Basti D.P.,Alagappa Chettiar College of Engineering And Technology
Tribology International | Year: 2011
The effect of surface roughness on the magnetohydrodynamic squeeze film behavior between two rectangular plates is analyzed. A generalized form of surface roughness pattern is considered. A stochastic random variable with non-zero mean, variance and skewness is used to model mathematically the surface roughness of the squeeze film bearings. The modified averaged stochastic Reynolds equation governing the squeeze film pressure is derived. The expressions for the squeeze film pressure, load carrying capacity and squeeze film time are obtained. Numerical computations of the results show that the negatively skewed surface roughness pattern increases the load carrying capacity and squeeze film time. On the contrary the performance of squeeze film suffers due to positively skewed surface roughness pattern. Further the magnetic effect characterized by the Hartmann number improves the performance of the squeeze film lubrication as compared to the classical non-conducting lubricant case. © 2011 Elsevier Ltd. All rights reserved.
Manjunatha M.,Cmr Institute Of Technology |
Naik V.H.,Karnataka University |
Kulkarni A.D.,Karnataka University |
Patil S.A.,Karnataka University
Journal of Coordination Chemistry | Year: 2011
A series of Co(II), Ni(II) and Cu(II) complexes, [ML·2H 2O] of Schiff bases derived from 4, 4-diaminodiphenyl sulfone (dapsone) and 8-formyl-7-hydroxy-4-methylcoumarin/5-formyl-6- hydroxycoumarin have been synthesized. From analytical, spectral (IR, NMR, UV-Vis, ESR and FAB mass), and magnetic studies it has been concluded that the metal complexes possess octahedral geometry and are non-electrolytes. The redox behavior of the metal complexes is investigated by cyclic voltammetry. The Schiff bases and their metal complexes have been screened for antibacterial (Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Klebsiella, Salmonella, Streptococcus, Staphylococcus proteus) and antifungal activities (Fusarium, Candida, Rhizopus, Penicillium chrysogenum and Aspergillus niger) by the minimum inhibitory concentration method. The anthelmintic activity of the ligands and their metal complexes against earthworms was investigated. The DNA cleavage study was done by agarose gel electrophoresis. Anti-inflammatory activity studies showed the test compounds are comparable to the standard drug diclofenac sodium. © 2011 Taylor & Francis.
Ahalya N.,Indian Institute of Science |
Kanamadi R.D.,Karnataka University |
Ramachandra T.V.,Indian Institute of Science
International Journal of Environment and Pollution | Year: 2010
The potential to remove chromium(VI) from aqueous solutions through biosorption using coffee husk was investigated. The effects of pH, contact time, initial concentration and adsorbent dosage on the adsorption of Cr(VI) were studied. The data obeyed Langmuir and Freundlich adsorption isotherms. The Langmuir adsorption capacity was found to be 44.95 mg/g. The Freundlich constants K f and n were 1.027 [mg/g (litre/mg) n] and 1.493, respectively. Desorption studies indicated the removal of 60% of the hexavalent chromium. Infrared spectral studies revealed the presence of functional groups, such as hydroxyl and carboxyl groups, on the surface of the biomass, which facilitates biosorption of Cr(VI). Copyright © 2010 Inderscience Enterprises Ltd.
Chabbi A.,Karnataka University |
Ganesh C.B.,Karnataka University
Fish Physiology and Biochemistry | Year: 2012
The tilapia, Oreochromis mossambicus, shows a short ovarian cycle of 24-26 days in nonmouthbrooding condition. In this study, the stripped female O. mossambicus were exposed to repeated mild acute stressors such as handling, chasing, frequent netting and low water levels daily for a period of 26 days. The follicular dynamics did not show significant difference during previtellogenic phase (day 12), whereas the mean number of stage IV (vitellogenic) follicles remained significantly lower compared with controls at the end of vitellogenic phase (day 18). The stage V (vitellogenic, preovulatory) follicles were completely absent in contrast to their presence in controls prior to spawning (day 23). The control fish spawned spontaneously after 24 days and entered mouthbrooding phase, whereas those exposed to stressors did not spawn. Furthermore, the serum levels of estradiol (E2) remained significantly lower concomitant with a significant increase in the serum cortisol concentration during vitellogenic and prespawning phase compared with those of the controls. The LH cells in the PPD of the pituitary gland showed weak immunoreactivity through vitellogenic and prespawning phase in fish exposed to stressors indicating the diminished secretory activity in contrast to the intensely stained ir-material in controls. The study reveals the disruptive effects of aquacultural stressors on the spawning cycle through suppression of LH and E2 secretion along the pituitary-ovary axis. The results suggest that the ovarian stress response depends on the phase of the cycle and that the interruption of the spawning cycle is due to inhibition of recruitment of preovulatory follicles in O. mossambicus. © 2012 Springer Science+Business Media B.V.
Suresh S.R.,Karnataka University |
Basavanna M.,Karnataka University
International Journal of Earth Sciences and Engineering | Year: 2014
Banded Iron Formations (BIF) is the economically prominent litho-units of the Sandur Schist Belt, hosting high-grade iron ore deposits. Different cycles of formation of these BIF are well-known. In the Joga area, oxide-, carbonate-and sulphide-facies of BIF are recognised. These BIF are more siliceous in nature and belong predominantly to oxide-facies, with clusters of sulphide-facies occurring in tectonically deformed zones. Gold content of the vein quartz associated with BIF of Joga area varies from 0.02 to 0.49 gram per ton. © 2014 CAFET-INNOVA TECHNICAL SOCIETY. All rights reserved.
Bheemareddy V.S.,Karnataka University |
Lakshman H.C.,Karnataka University
Vegetos | Year: 2011
Water stress is considered to be the main environmental factor limiting growth development and affecting the development of many crop plants. AM fungi are a type of endomycorrhiza known to enhance adoption ability of host plants under water stress conditions and help the host plants to cope up with situations of drought. The objective of this study was to evaluate the relative physiological indices in mycorrhizal and nonmycorrhizal Triticum aestivum L. Var in response to water stress applied at 60 DAS and 90 DAS for ten days. Experiments were conducted on four Triticum aestivum L. varieties namely DWR 162, DWR195, DWR 225 and NI 5439 with and without mycorrhizal inoculation. Glomus fasciculatum was the AM fungus used for inoculation. Accumulation of plant metabolites such as proline, carbohydrates, proteins and peroxidase were determined in four Triticum aestivum L. varieties under inoculated and control conditions with and without water stress. Results revealed that there is more accumulation of metabolites in mycorrhizal plants than nonmycorrhizal plants. Under water stress conditions, mycorrhizal plants accumulated more metabolites than nonmycorrhizal plants. Among the four Triticum aestivum L.varieties DWR 225 and DWR 162 have shown more accumulation of metabolites to tolerate water stress by improving osmotic adjustment.