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Bijapur, India

Karnataka State Women’s University Bijapur also known as KSWUB was established in August 2003 and is the first university exclusively for women in Karnataka. It is situated in Bijapur Wikipedia.

Patil R.H.,Bangalore University | Babu R.L.,Bangalore University | Babu R.L.,Karnataka State Womens University | Naveen Kumar M.,Bangalore University | And 5 more authors.
Inflammation | Year: 2016

Apigenin is one of the plant flavonoids present in fruits and vegetables, acting as an important nutraceutical component. It is recognized as a potential antioxidant, antimicrobial, and anti-inflammatory molecule. In the present study, the mechanism of anti-inflammatory action of apigenin on lipopolysaccharide (LPS)-induced pro-inflammatory cytokines and activator protein-1 (AP-1) factors in human lung A549 cells was investigated. The anti‐inflammatory activity of apigenin on LPS-induced inflammation was determined by analyzing the expression of pro-inflammatory cytokines, nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and different AP-1 factors. Apigenin significantly inhibited the LPS-induced expression of iNOS, COX-2, expression of pro-inflammatory cytokines (IL-1β, IL-2, IL-6, IL-8, and TNF-α), and AP-1 proteins (c-Jun, c-Fos, and JunB) including nitric oxide production. Study confirms the anti-inflammatory effect of apigenin by inhibiting the expression of inflammatory mediators and AP-1 factors involved in the inflammation and its importance in the treatment of lung inflammatory diseases. © 2015, Springer Science+Business Media New York. Source

Madagi S.B.,Karnataka State Womens University
Journal of Natural Science, Biology and Medicine | Year: 2013

Orphan Receptor of Nuclear Receptor superfamily is the one with no known endogenous ligands. Many of these orphan receptors are associated with different types of diseases and therefore deserve special attention to find the potential ligands they would be associated with. The major task of molecular pharmacology is the deorphanization of the large number of nuclear receptors with unidentified endogenous agonists. The deorphanization provides a promising research for new therapeutics. The Testicular Receptor 4 being negative modulator to other members of the nuclear receptor superfamily, is one of the Orphan members of this family and is associated with prostate cancer, breast cancer, sickle cell anemia and joint diseases. The knowledge that related receptors of the same family often have ligands with similar structural features has helped us to utilize the chemogenomic approach to deorphanize the orphan receptor. Chemogenomics approach involves screening of known ligands of a protein family having analogous domain architecture for identification of new leads for existing protein family members. The deorphanization involved the database homology searching, followed by domain identification, active site prediction, sequence and structure comparative studies. A ligand library set was prepared based on these studies and was used to deorphanize the receptor. The molecular docking study conducted using PyRx revealed that estradiol and tretinion as a potential ligand for Testicular Receptor 4. Source

Murthy S.,Bangalore University | Bali G.,Karnataka State Womens University | Sarangi S.K.,Bangalore University
Journal of Environmental Biology | Year: 2014

A bacterial strain (Bacillus cereus) with the ability to grow under conditions of high concentrations of lead was isolated from the industrial effluent collected from Peenya Industrial Area, Bangalore. The effect of lead on growth, protein content and lead biosorption capacity of Bacillus cereus was investigated. The results revealed that with increase in lead concentration (100, 200, 300, 400 and 500 mg l-1) there was a decrease in growth, protein content (10.6, 8.2, 6.7, 3.8 and 1.9 mg g-1 d. wt.) and lead biosorption ( 90.3, 57.8, 48.94,31.3 and 22.24 %) Bacillus cereus, signifying toxic effect of lead on the bacterial strain. Plasmid DNA was isolated from Bacillus cereus to study its resistance mechanism. The size of the plasmid was approximately 33kb. Transformation results suggest that lead resistance gene may be present on the chromosomal DNA rather than the plasmid DNA as the transformants did not show lead resistance. © Triveni Enterprises, Lucknow (India). Source

Malipatil V.,Karnataka State Womens University | Madagi S.,Karnataka State Womens University | Bhattacharjee B.,PES Institute of Technology
Indian Journal of Pharmacology | Year: 2013

Objective: Sexually transmitted diseases (STD) are the serious public health problems and also impose a financial burden on the economy. Sexually transmitted infections are cured with single or multiple antibiotics. However, in many cases the organism showed persistence even after treatment. In the current study, the set of druggable targets in STD pathogens have been identified by comparative genomics. Materials and Methods: The subtractive genomics scheme exploits the properties of non-homology, essentiality, membrane localization and metabolic pathway uniqueness in identifying the drug targets. To achieve the effective use of data and to understand properties of drug target under single canopy, an integrated knowledge database of drug targets in STD bacteria was created. Data for each drug targets include biochemical pathway, function, cellular localization, essentiality score and structural details. Results: The proteome of STD pathogens yielded 44 membrane associated proteins possessing unique metabolic pathways when subjected to the algorithm. The database can be accessed at http://biomedresearchasia.org/index.html. Conclusion: Diverse data merged in the common framework of this database is expected to be valuable not only for basic studies in clinical bioinformatics, but also for basic studies in immunological, biotechnological and clinical fields. Source

Malipatil V.,Karnataka State Womens University | Madagi S.,Karnataka State Womens University
International Journal of Pharma and Bio Sciences | Year: 2013

Increase in biological data at an alarming rate, has made possible the use of such data in identification of drug targets. Ureaplasma urealyticum serovar 10 str. ATCC 33699 is a causative agent for sexually transmitted infections. In present study novel comparative genomic approach is used to identify the drug targets. This approach has been successfully used in Pseudomonas aeroginosa. In current study similar work has been done to mine the drug targets. Analysis in the present study showed a total of 265 essential proteins, out of which 14 showed pathways related to both human and pathogen. The 2 proteins are exclusively pathogen specific and are part of unique metabolic pathways. The 3-D structure of the drug targets was predicted by fold based method and virtual screening was performed to find the natural lead compounds that bind to target. ADME-tox properties of the natural compounds showing better binding affinity were also studied. Source

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