Kaohsiung Medical University | Date: 2015-02-27
A method for treating a disease is disclosed. The method includes steps of providing a subject in need thereof; and administering one selected from a group consisting of Piperazinyl Analogs and Piperazinyl Complex Analogs compound represented by formula II or formula III, a pharmaceutically acceptable salts thereof; and a pharmaceutical composition thereof to the subject in a dosage between 1 and 5.0 milligrams per kilogram of body weight, in a liquid mist, dry powder or aerosolized formulation.
Kaohsiung Medical University | Date: 2015-03-19
The present invention relates to a nanoparticle carrier and the method for manufacturing the same. The nanoparticle carrier comprises hydrophobic molecules grafted with nanogold clusters and hydrophobic molecules grafted with hydrophilic molecules. The hydrophilic molecules are located on the outer layer of the nanoparticle and the nanogold clusters are wrapped inside the nanoparticle.
Kaohsiung Medical University | Date: 2015-07-22
A series of peptides with divergent confirmations including structures of formula (1A), (1B), (2) and (3) are provided. In the formula, wherein U, G, A, B, R1, R2 and T are as defined in the specification. The divergent peptides disclosed in the present invention are characterized in a mineral binding affinity function.
Kaohsiung Medical University | Date: 2014-03-10
Disclosed are a composition for preventing and treating atherosclerosis which includes chalcone compound. In particular, the chalcone compound bound with 2-hydroxyl in ring A and 4-methyoxy in ring B has versatile therapeutic potentials on anti-atherosclerosis by acting as PPAR inducer, p44/42 MAPK inhibitor and cell cycle blocker and does not show toxicity to human aortic smooth muscle cells (HASMCs). In addition, the chalcone compound exhibits synergistic effect with the PPAR ligand (rosiglitazone) to inhibit cell proliferation and the upregulation of cyclin D1, cyclin D3, interleukin-1 (IL-1) and interleukin-6 (IL-6) induced by oxidized low density lipoprotein (Ox-LDL).
Kaohsiung Medical University | Date: 2015-05-11
The present invention relates to a gold fluorescence resonance energy transfer nanoprobe comprising a gold fluorescence donor, a gold fluorescence acceptor, and a linker fragment that connects the gold fluorescence donor and the gold fluorescence acceptor, wherein the fluorescence resonance energy transfer is carried out between the gold fluorescence donor and the gold fluorescence acceptor. This all gold probe employing fluorescence resonance energy transfer technique can be used for detecting diseases such as arthritis, osteoporosis, and cancer metastasis.