Academia Sinica, China and Kaohsiung Medical University | Date: 2015-03-02
Disclosed herein is a bi-specific antibody that specifically directs a therapeutic agent to a cancer cell by targeting a tumor antigen of the cancer cell, and thereby suppresses the growth of the cancer or blocking the invasion or metastasis of the cancer. The bi-specific antibody of the present disclosure includes a first antigen binding site that binds to polyethylene glycol (PEG); and a second antigen binding site that binds to a target ligand, such as a tumor antigen.
Kaohsiung Medical University | Date: 2017-04-19
A bone nail apparatus includes a bone nail, a light source unit and a focalizing unit. The bone nail has a tube wall and at least one through hole. The tube wall is enclosed to form a receiving space. The at least one through hole extends through the tube wall and communicates with the receiving space. The light source unit includes a light emitter and at least one light transmission tube. The at least one light transmission tube is connected to the light emitter and receives a light therefrom. The at least one light transmission tube is received in the receiving space of the bone nail. Each light transmission tube has a light-outputting end aligned with a respective one of the at least one through hole. The focalizing unit has a light-receiving face facing one of the at least one through hole.
University of Macau, Hong Kong Baptist University and Kaohsiung Medical University | Date: 2016-05-31
A compound of the formula: Also, a method for antagonizing STAT3 dimerization in a patient in need thereof which by administering to such patient a therapeutically acceptable dose of the compound of Formula I. Further, a method for treating a cancer patient in need thereof by administering a therapeutically effective dose of the compound of Formula I.
Kaohsiung Medical University | Date: 2016-02-05
This invention is announcing a composition of flavonoid skeleton in the formula I or formula II compound, wherein each of the substituents is given the definition as set forth in the specification and claims. This composition have the capacity to treating or preventing a virus infection in a subject.
Kaohsiung Medical University | Date: 2016-01-21
A compound for treating a metabolic syndrome, comprising a structure of a 6Cs unit-3Cs unit-6Cs unit (C6-C3-C6) as shown in formula I, wherein: when R_(1 )and R_(2 )are both hydrogens, C3 has only single bonds; when R_(1 )is an oxygen and R_(2 )is one selected from a group consisting of an alkoxy, a benzyloxy and a halogen, C3 has only single bonds; when R_(1 )is a deuterium and R_(2 )is one selected from a group consisting of a hydrogen, an alkoxy, a benzyloxy and a halogen, C3 has one of a single bond and a double bond.
Kaohsiung Medical University | Date: 2016-07-22
The present invention provides a method for determining a survival rate and prognosis state for a patient having esophageal carcinoma, comprising: (a) providing a tissue sample from the patient; (b) measuring a expression level of a target gene in the tissue sample from the patient using reagents specific for the target gene product that are selected from the group consisting of probes, primers, antibodies, and antibody fragments, wherein the expression level is RNA expression, a protein expression at a cellular level or a tissue level; (c) comparing the expression level to a predetermined threshold indicative of a survival rate and prognosis state for the patient; and (d) providing a survival rate and prognosis state for the patient so that care for the patient is able to be determined in accordance with the survival rate and prognosis state, wherein the target gene is peptidase inhibitor 3 (PI3).
Kaohsiung Medical University | Date: 2016-08-23
The present invention is related to a method for detecting a protein comprising: (1) providing a fusion protein, wherein the fusion protein comprises the protein which is fused with a secondary antibody detected protein tag, wherein the secondary antibody detected protein tag comprises at least one epitope selected from the Fc region of at least one primary antibody which is capable of being detected by a corresponding secondary antibody; (2) contacting the fusion protein with a secondary antibody which binds to the secondary antibody detected protein tag to form a protein/antibody complex; and (3) detecting the protein/antibody complex.
Kaohsiung Medical University | Date: 2015-05-11
The present invention relates to a gold fluorescence resonance energy transfer nanoprobe comprising a gold fluorescence donor, a gold fluorescence acceptor, and a linker fragment that connects the gold fluorescence donor and the gold fluorescence acceptor, wherein the fluorescence resonance energy transfer is carried out between the gold fluorescence donor and the gold fluorescence acceptor. This all gold probe employing fluorescence resonance energy transfer technique can be used for detecting diseases such as arthritis, osteoporosis, and cancer metastasis.
Kaohsiung Medical University | Date: 2015-02-05
A method for bone regeneration which comprises administering a short term release composition into a bone area of a subject in need thereof, wherein the composition comprises a poly(lactic-co-glycolic acid) cross-linked alendronate (PLGA-ALN), wherein the composition releases the alendronate into the bone area, wherein the bone tissue of the bone area is exposed in situ to a therapeutically effective amount of the alendronate over 9 days.
Kaohsiung Medical University | Date: 2015-03-17
The present invention discloses a method of harnessing versatile phosphoramidation reactions to regioselectively incorporate alkynyl/azido groups into post-synthetic nucleic acids primed with phosphate at the 5 termini. With and without the presence of copper, the modified nucleic acids were subjected to azide-alkyne cycloaddition to obtain various nucleic acid conjugates including a peptide-oligonucleotide conjugate (POC) with a high yield.