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Liu M.-E.,Long Cyuan Veterans Hospital | Tsai S.-J.,Taipei Veterans General Hospital | Jeang S.-Y.,Long Cyuan Veterans Hospital | Peng S.-L.,Long Cyuan Veterans Hospital | And 4 more authors.
Psychiatry Research | Year: 2011

To explore the effects of varenicline on the psychopathology and cognition of chronic inpatients with schizophrenia, we conducted a non-randomized control group time series investigation between March 2009 and April 2010. In a mandatory smoking cessation intervention, 41 male inpatient smokers were scheduled to undergo either a 5-week varenicline treatment (varenicline group) or the use of no drugs (non-treatment group). Depression (HAM-D), anxiety (HAM-A), and psychosis (PANSS) were evaluated at baseline, and at the 2nd, 4th, 8th and 12th week after abstinence; four neuropsychological tests, including Digit Span Forward and Backward (DSF and DSB), and Trail Making Test-A and -B, were evaluated at baseline and at the 4th, 8th and 12th week. Thirty patients completed the study. Among 15 patients in the non-treatment group, the HAM-D, HAM-A, DSF, and DSB scores were exacerbated during the 2-8. weeks of abstinence, but there were no changes in psychotic symptoms and the other two neuropsychological tests. Compared with the non-treatment group, varenicline users experienced less impairment in HAM-D and HAM-A scores at the 2nd and 4th weeks, and in DSF tasks at the 4th week after abstinence. In conclusions, varenicline can attenuate abstinence-induced adverse outcomes and appears to be well-tolerated in smokers with schizophrenia. © 2011 Elsevier Ireland Ltd. Source


Lee M.T.M.,Academia Sinica, Taiwan | Lee M.T.M.,China Medical University at Taichung | Chen C.H.,Academia Sinica, Taiwan | Chen C.H.,China Medical University at Taichung | And 36 more authors.
Molecular Psychiatry | Year: 2011

We report the first genome-wide association study in 1000 bipolar I patients and 1000 controls, with a replication of the top hits in another 409 cases and 1000 controls in the Han Chinese population. Four regions with most strongly associated single-nucleotide polymorphisms (SNPs) were detected, of which three were not found in previous GWA studies in the Caucasian populations. Among them, SNPs close to specificity protein 8 (SP8) and ST8 α-N-acetyl- neuraminide α-2,8-sialyltransferase (ST8SIA2) are associated with Bipolar I, with P-values of 4.87 × 10-7 (rs2709736) and 6.05 × 10-6 (rs8040009), respectively. We have also identified SNPs in potassium channel tetramerization domain containing 12 gene (KCTD12) (rs2073831, P9.74 × 10-6) and in CACNB2 (Calcium channel, voltage-dependent, Β-2 subunit) gene (rs11013860, P=5.15 × 10 -5), One SNP nearby the rs1938526 SNP of ANK3 gene and another SNP nearby the SNP rs11720452 in chromosome 3 reported in previous GWA studies also showed suggestive association in this study (P=6.55 × 10-5 and P=1.48 × 10-5, respectively). This may suggest that there are common and population-specific susceptibility genes for bipolar I disorder. © 2011 Macmillan Publishers Limited All rights reserved. Source


Liu M.-E.,Kaohsiung Veterans General Hospital | Tsai S.-J.,Taipei Veterans General Hospital | Tsai S.-J.,National Yang Ming University | Lu T.,Kaohsiung Veterans General Hospital | And 6 more authors.
NeuroMolecular Medicine | Year: 2011

Previous research studies have related the insertion/deletion (I/D) polymorphism of the angiotensin I converting enzyme (ACE) gene to cognitive function in various neuropsychiatric or neurodegenerative disorders, but not yet investigated its genetic association with specific cognitive domains. Thus, the aim of this study was to assess the possible association of the ACE I/D polymorphism with domain-specific cognitive function in normal cognitive aging. Four hundred and sixty-nine-aged ethnic Chinese men without dementia were enrolled for geno-typing and evaluated using several neuropsychological tests [Mini-Mental Status Examination (MMSE), Digit Span Forward and Backward, and Cognitive Ability Screening Instrument Chinese language version (CASI C-2.0)]. No direct association was found between ACE genotypes and the MMSE, Digit Span tests, or CASI total scores. Although subjects with I/I genotype had the lowest cognitive performance in the CASI visual construction domain (P = 0.031), this statistical difference disappeared after correction for multiple comparisons. This study suggests that the ACE I/D polymorphism does not have any genetic association with global or specific cognitive domain in aged men without dementia. © Springer Science+Business Media, LLC 2011. Source


Lai C.-Y.,Kaohsiung Medical University | Su Y.-Y.,Kaohsiung Medical University | Lin S.-T.,Kaohsiung Kai Suan Psychiatric Hospital | Yu C.-Y.,Kaohsiung Medical University | Lin Y.-C.,Kaohsiung Medical University
Journal of Nursing and Healthcare Research | Year: 2010

Background: In psychiatric acute care settings, patients with severe psychotic symptoms commonly exhibit violent behaviors due to uncontrolled emotions. Seclusion and restraint are widely used to protect and calm such patients as well as to save others from harm. However, few studies have shown the efficacy of restraint on emotional control of psychiatric patients. The use of restraint may easily disrupt the therapeutic rapport between psychiatric nurses and the patient. Previous studies suggest that music therapy can help psychotics manage their own agitated emotions and violent behaviors. Few studies have, however, researched the possible effects of music on psychotic patients restrained in a seclusion room. Purpose: This study compared the effects and differences of music and restraint on psychiatric patients' emotional control in a seclusion room in a psychiatric acute setting. Methods: An experimental research design was used. The duration of study intervention was from April to November, 2007. Psychiatric patients who were restrained in a seclusion room were recruited and randomly assigned to one experimental and one control group. Each group consisted of 28 subjects. The experimental group completed the Brief Symptom Rating Scale (BSRS) before and after a 30-minute music intervention to evaluate emotional status. In addition, subject physical condition, such as breathing, pulse rate, and blood pressure, were also examined before and after music intervention. The control group received no music intervention and experienced only an equivalent 30-minute period of restraint and seclusion. Results: Music intervention was found to reduce significantly the anxiety (F = 18.75, p < .001) and hostility (F = 13.56, p < .001) of patients isolated in a seclusion room; the anxiety (F = 16.81, p < .001) and hostility (F = 14.66, p < .001) of patients who were simply restrained also changed significantly. Results indicate that both restraint and music intervention may be effective in controlling the impulse and aggressive emotions of psychiatric patients. Furthermore, music was found to have a more prolonged effect than restraint on emotional control in psychiatric patients. Implications: Findings may be used to guide future research on this topic and to shape emotion-control interventions in psychiatric wards. Source


Wang C.-C.,Kaohsiung Medical University | Chen C.-C.,Kaohsiung Kai Suan Psychiatric Hospital | Wu S.-M.,Kaohsiung Medical University
Journal of Chromatography A | Year: 2011

Methadone (MET) metabolism has been largely demonstrated with a high inter-individual variability and, therefore, quantification of MET is very important for therapeutic drug monitoring. A cation-selective exhaustive injection and sweeping MEKC (CSEI-Sweeping) was first developed to analyze MET and its two metabolites, 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) and 2-ethyl-5-methyl-3,3-diphenyl-1-pyrroline (EMDP), in human serum. After pretreatment, the samples were electrokinetically injected into capillary (10. kV, 500. s) and swept by the separation phosphate buffer (100. mM, pH 4.0) containing 20% tetrahydrofuran and 100. mM SDS at -15. kV. The LODs were 200. pg/mL for MET and EMDP, and 400. pg/mL for EDDP. Ten volunteers were administered MET (5.0-120.0. mg/day) orally for 84 days and serum samples were taken after the daily dose of MET (days 1, 2, 7, 14, 28, 56 and 84) individually. This method was used for monitoring MET and its metabolites in heroin addicts and for pharmacokinetic investigations. © 2011 Elsevier B.V. Source

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