Kaohsiung Armed Forced General Hospital

Kaohsiung, Taiwan

Kaohsiung Armed Forced General Hospital

Kaohsiung, Taiwan

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Fan W.-S.,Dalin Tzu Chi General Hospital | Chang C.-H.,National Chung Cheng University | Horng C.-T.,Kaohsiung Armed Forced General Hospital | Yao H.-Y.,Kaohsiung Armed Forced General Hospital | And 3 more authors.
Optics Communications | Year: 2017

We designed a crystalline microstructure during cataract lesions and calculated the aberration value of the eye by using ray trace modeling to identify the corresponding spherical aberration, coma aberration, and trefoil aberration value under different pathological-change degrees. The mutual relationship between microstructure and aberration was then discussed using these values. Calculation results showed that with increased layer number of microstructure, the influence of aberration value on spherical aberration was the greatest. In addition, the influence of a relatively compact microstructure on spherical aberration and coma aberration was small, but that on trefoil aberration was great. © 2016 Elsevier B.V.


PubMed | Central Taiwan University of Science and Technology, Chung Shan Medical University and Kaohsiung Armed Forced General Hospital
Type: Evaluation Studies | Journal: International journal of environmental research and public health | Year: 2015

With the progress of science, technology and medicine, the proportion of elderly people in society has gradually increased over the years. Thus, the medical care and health issues of this population have drawn increasing attention. In particular, among the common medical problems of the elderly, the occurrence of cataracts has been widely observed. In this study, we developed retinal imaging technology by establishing a human eye module with ray tracing. Periodic hole arrays with different degrees were constructed on the anterior surface of the lens to emulate the eyesight decline caused by cataracts. Then, we successfully predicted the incidence of cataracts among people with myopia ranging from -3.0 D to -9.0 D. Results show that periodic hole arrays cause severe eyesight decline when they are centralized in the visual center. However, the wide distribution of these arrays on the anterior surface of the lens would not significantly affect ones eyesight.


Lin J.-D.,National Cheng Kung University | Huang S.-Y.,Chung Shan Medical University | Wang H.-S.,National Cheng Kung University | Lin S.-H.,National Cheng Kung University | And 6 more authors.
Optics Express | Year: 2014

This study demonstrates for the first time a continuously tunable photonic bandgap (PBG) of wide spectral range based on a blue phase (BP) wedge cell. A continuously shifting PBG of the BP wedge cell occurs due to the thickness gradient of the wedge cell at a fixed temperature. The wedge cell provides a gradient of boundary force on the LCs and thus forms a distribution of BP crystal structure with a gradient lattice. Additionally, a spatially tunable lasing emission based on a dye-doped BP (DDBP) wedge cell is also demonstrated. The tunable band of the PBG and lasing emission is about 130 nm and 70 nm, respectively, which tuning spectral ranges are significantly wider than those of CLC and DDCLC wedge cells, respectively. Such a BP device has a significant potential in applications of tunable photonic devices and displays. © 2014 Optical Society of America.


Lee C.-R.,National Cheng Kung University | Lin J.-D.,National Cheng Kung University | Mo T.-S.,Tainan University of Technology | Horng C.-T.,Kaohsiung Armed Forced General Hospital | And 2 more authors.
Optics Express | Year: 2015

This work investigates the performance evolution of color cone lasing emissions (CCLEs) based on dye-doped cholesteric liquid crystal (DDCLC) cells at different fabrication conditions. Experimental results show that the energy threshold (Eth) and relative slope efficiency (ηs) of the lasing signal emitted at each cone angle (0°-35°) in the CCLE decreases and increases, respectively, when the waiting time in a homogenously rubbed aligned DDCLC cell is increased from 0 hr to 216 hr (9 days). This result occurs because defect lines gradually shrink with the anchoring of the surface alignment when the waiting time is increased. Hence, the scattering loss decreases, and the dwelling time of the fluorescence photons in the resonator increases, which in turn enhances the CCLE performance. With the aligned cell given the pretreatment of a rapid annealing processing (RAP), the waiting time for obtaining an optimum CCLE can markedly be reduced sixfold. The surface alignment of the DDCLC cell also plays a necessary role in generating the CCLE. This work provides an insight into the temporal evolution of the performance for the CCLE laser and offers a method (RAP) of significantly speeding up the formation of a CCLE laser with optimum performance. © 2015 Optical Society of America.


Lin S.-M.,Tri Service General Hospital | Lin S.-M.,Kaohsiung Armed Forced General Hospital | Liang J.-B.,Tri Service General Hospital | Chien K.-H.,Tri Service General Hospital | And 5 more authors.
Life Science Journal | Year: 2014

Purpose: To report a case of asymptomatic Wilson's disease (WD) in which the identification of a Kayser-Fleischer (K-F) ring and its characterization by confocal biomicroscopy led to the diagnosis. Methods: Case report. Results: Confocal biomicroscopy showed clustered, highly reflective, and round foci in Descemet's membrane, which we believed to be depositions of copper in this patient with asymptomatic WD. Conclusion: WD is characterized by toxic copper accumulation that can result in irreversible organ damage, neurologic deficit, and even death. Patients concurrent WD and hepatitis B show aggregate manifestations and worse prognosis than those of patients with WD alone. Hence, early diagnosis and treatment of WD are important in populations with high hepatitis B prevalence. The presence of a K-F ring is a pathognomonic sign of WD but is often confused as a sign of another disease such as corneal dystrophy or toxic or metabolic disorder. Early use of confocal biomicroscopy prior to a traditional serum test, urine assay, and liver biopsy may provide a fast, accurate, and non-invasive method to detect WD and potentially save a patient's life.


Lee C.-R.,National Cheng Kung University | Lin S.-H.,National Cheng Kung University | Guo J.-W.,National Cheng Kung University | Lin J.-D.,National Cheng Kung University | And 6 more authors.
Optical Materials Express | Year: 2015

This paper reports for the first time an electrically and thermally controllable nanoparticle (NP) random laser in a well-aligned dye-doped liquid crystal (DDLC) cell. Experimental results show that the random lasing emission is attributed to the amplification of the fluorescence via the multiple scattering of the randomly distributed NPs in the diffusion rout of the well-aligned DDLC cell. The random laser can be electrically and thermally controlled by varying the applied voltage and cell temperature, respectively. As the applied voltage is increased, the orientational change of the LCs from homogeneous to homeotropic texture decreases the dye absorption and thus the spontaneous fluorescence emission, resulting in the decrease of the random lasing emission. The random lasing intensity decreases with increasing temperature at the nematic phase and dramatically increases after the nematic→isotropic (N→I) phase transition. The result in the former stage is attributed to the decreases in the absorption and thus in the spontaneous fluorescence emission for the laser dyes because of the decrease in the order of the laser dyes with increasing temperature at the nematic phase. The result in the latter stage results from the significant decrease of the loss because of the disappearance for the strong leakage of the scattering fluorescence light through the boundaries of the LCs and the glass substrates after the N→I phase transition. Moreover, the anisotropy of the random lasing is crucially determined by two factors: the anisotropies in the spontaneous emission and the leakage of the scattering fluorescence light. © 2015 Optical Society of America.


Huang Y.-C.,National Taichung University of Science and Technology | Horng C.-T.,Kaohsiung Armed Forced General Hospital | Chen S.-T.,Chung Shan Medical University | Lee S.-S.,Chung Shan Medical University | And 7 more authors.
Environmental Toxicology | Year: 2016

Endotoxins exist anywhere including in water pools, dust, humidifier systems, and machining fluids. The major causal factor is endotoxins in many serious diseases, such as fever, sepsis, multi-organ failure, meningococcemia, and severe morbidities like neurologic disability, or hearing loss. Endotoxins are also called lipopolysaccharide (LPS) and are important pathogens of acute lung injury (ALI). Rutin has potential beneficial effects including anti-inflammation, antioxidation, anti-hyperlipidemia, and anti-platelet aggregation. Pre-treatment with rutin inhibited LPS-induced neutrophil infiltration in the lungs. LPS-induced expression of vascular cell adhesion molecule (VCAM)-1 and inducible nitric oxide synthase (iNOS) was suppressed by rutin, but there was no influence on expression of intercellular adhesion molecule-1 and cyclooxygenase-2. In addition, activation of the nuclear factor (NF)κB was reduced by rutin. Furthermore, we found that the inhibitory concentration of rutin on expression of VCAM-1 and iNOS was similar to NFκB activation. In conclusion, rutin is a potential protective agent for ALI via inhibition of neutrophil infiltration, expression of VCAM-1 and iNOS, and NFκB activation. © 2014 Wiley Periodicals, Inc.


Chen W.-Y.,National Chung Hsing University | Huang Y.-C.,National Taichung University of Science and Technology | Yang M.-L.,Chung Shan Medical University | Lee C.-Y.,Chung Shan Medical University | And 8 more authors.
International Immunopharmacology | Year: 2014

Lipopolysaccharide (LPS), also called endotoxin, is the important pathogen of acute lung injury (ALI), which is a clinical syndrome that still lacks effective therapeutic medicine. Rutin belongs to vitamin P and possesses various beneficial effects. In this study, we investigate the potential protective effects and the mechanisms of rutin on LPS-induced ALI. Pre-administration with rutin inhibited LPS-induced arterial blood gas exchange and neutrophils infiltration in the lungs. LPS-induced expression of macrophage inflammatory protein (MIP)-2 and activation of matrix metalloproteinase (MMP)-9 were suppressed by rutin. In addition, the inhibitory concentration of rutin on phosphorylation of Akt was similar as MIP-2 expression and MMP-9 activation. In conclusion, rutin is a potential protective agent for ALI via suppressing the blood gas exchange and neutrophil infiltration. The mechanism of rutin is down-regulation of MIP-2 expression and MMP-9 activation through inhibition of Akt phosphorylation. © 2014 Elsevier B.V.


Sun H.-Y.,Chung Shan Medical University | Chiang Y.-T.,National Chung Cheng University | Yeh S.-M.,Central Taiwan University of Science and Technology | Huang S.-Y.,Chung Shan Medical University | And 2 more authors.
Optics Communications | Year: 2016

This study aims to determine whether IntraLase surgery can cause rainbow glare. Monte-Carlo ray tracing method is used to study visual conditions of an ordered microstructure array on the cornea. A corneal flap in the simulated eye model can generate numerous microbubbles caused by IntraLase surgery. Moreover, this study evaluates the visual performance under different conditions such as the size and interval of the microbubble structure on the cornea with vary incident angles and diameters of light. The results of this study can help elucidate the real cause of rainbow glare as a side effect of IntraLase. © 2016 Elsevier B.V. All rights reserved.


Chien C.-C.,Kaohsiung Armed Forced General Hospital | Huanga H.-T.,Kaohsiung Armed Forced General Hospital | Lung F.-W.,Kaohsiung Armed Forced General Hospital | Lin C.-H.,Kaohsiung Armed Forced General Hospital
Journal of Substance Use | Year: 2011

Zolpidem, a non-benzodiazepine hypnotic drug, shows a high affinity for the BZ1 (ω1) subtypes of the modulatory sites within the GABAA receptor complex, but classical benzodiazepines (diazepam, lorazepam) have a non-specific affinity profile at ω1 and ω2 subtypes of the GABAA receptor. Therefore, zolpidem is thought to be safer than benzodiazepines. We present five cases with withdrawal delirium, seizure, acute psychosis and orofacial dyskinesia that developed following cessation of zolpidem. Adverse effects such as withdrawal seizure and withdrawal delirium have been rarely reported in relation to zolpidem. Chemically unrelated to benzodiazepines, zolpidem is thought to have fewer adverse effects, but shares a pharmacokinetic profile with the benzodiazepines. It is advised that the normal criteria for the prescription of benzodiazepines also be used when prescribing non-benzodiazepine sedatives and hypnotics, as they act upon the same receptor, namely, the benzodiazepine-GABA-chloride complex. However, at higher than recommended doses for extended periods of time, the addictive potential of zolpidem may be similar to that of the benzodiazepines. It is possible that zolpidem abandons its selectivity for the BZ1 receptors and demonstrates all the actions of classic benzodiazepines. © 2011 Informa UK, Ltd.

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