Kanuni Research and Training Hospital
Kanuni Research and Training Hospital
Afsar S.,Acibadem University |
Hemsinli D.,Kanuni Research and Training Hospital |
Ozyazgan S.,Istanbul University |
Akkan A.G.,Istanbul University
Pharmacology | Year: 2016
Background: Structural and functional changes in potassium channels of vascular smooth muscle cells may contribute to the development of diseases such as hypertension. We aim to investigate the vascular effects of potassium channel openers and blockers in human internal mammary artery (HIMA). Methods: Remaining segments of HIMA from 18 consecutive patients undergoing coronary artery bypass surgery were obtained to examine the vascular effects of various potassium channel openers (staurosporine, hydrochlorothiazide and cromakalim) and potassium channel blockers (4-aminopyridin [4-AP], charybdotoxin [CTX] and glibenclamide [GLBC]). Results: Noradrenaline (NA)-induced maximal contractions were inhibited by all 3 K+-channel blockers but only fully inhibited by 4-AP (95.6%). Only NA-induced contractions were reversed by CTX. Only K+-induced maximal contractions were significantly inhibited by 4-AP (95.6%, p < 0.05). Only acetylcholine-induced relaxation was fully inhibited by CTX. Only sodium nitroprusside-induced relaxations in potassium chloride-precontracted strips could be reversed by GLBC. Conclusions: Drugs affecting potassium channels may be useful in the treatment of hypertension and management of perioperative vasospasm during the coronary artery bypass surgery. © 2015 S. Karger AG.
Kazaz S.N.,Kanuni Research and Training Hospital |
Oztop I.,Dokuz Eylül University
UHOD - Uluslararasi Hematoloji-Onkoloji Dergisi | Year: 2017
Systemic chemotherapy, genotype-based targeted therapies and immunotherapy are widely used in the treatment of advanced non-small-cell lung cancer (NSCLC). Among the targeted therapies, the agents targeting the epidermal growth factor receptor (EGFR), the echinoderm microtubule-associated protein-like 4 anaplastic lymphoma kinase (EML4-ALK) rearrangement and C-ros oncogene 1 (ROS-1) have currently become standard treatment for cases presenting such molecular anomalies. Of them, cases with ALK-rearrangement displayed dramatic results with a first generation ALK-inhibitor crizotinib; however, most of the patients develop a resistance in a few years. Especially the central nervous system relapses pose the most common clinical problem. Next generation ALK-inhibitors are promising with a high level of effectiveness in this resistance, in which various molecular mechanisms take part. Also, it gains increasing importance to re-perform a biopsy in the progression stage and reveal the mechanisms causing the secondary resistance in those patients. © 2017, UHOD - Uluslararasi Hematoloji Onkoloji Dergisi. All rights reserved.
Fidan S.,Kanuni Research and Training Hospital |
Kocak G.,Kanuni Research and Training Hospital |
Fidan E.,Kanuni Research and Training Hospital
Journal of the College of Physicians and Surgeons Pakistan | Year: 2016
Prostate cancer is the second most common cancer in men in the world. The presentation of this cancer may range from microscopic to metastatic forms. Patients with prostate cancer may experience metastasis to the gastrointestinal system. Here, we present a case of prostate cancer metastasizing to the third portion of duodenum, a very uncommon site of metastasis. To the best of authors' knowledge, this is the first case report in the literature.
Eda K.,Kanuni Research and Training Hospital |
Uzer K.,Kanuni Research and Training Hospital |
Murat T.,Karadeniz Technical University |
Cenk U.,Izmir University
Clinical Nutrition | Year: 2016
Purpose: Radiotherapy is a critical component of breast cancer treatment. Many skin reactions ranging from erythema to moist desquamation and ulceration can be induced by high dose external beam radiotherapy. There is no golden standard for treating radiation dermatitis. Glutamine is an amino acid which improved wound healing through its anabolic effects and improvements in wound matrix formation in burn patients. We designed a study to show effects of glutamine in radiation induced dermatitis. Material and method: Forty patients who received radiotherapy for breast cancer were randomized into 2 groups. In group 1 the patients were treated with 15 gr of enteral glutamine whereas the patients in group 2 were treated with placebo. The radiation induced skin reactions were evaluated in both groups. Results: In glutamine treated group 88, 9% of patients developed grade I toxicity comparing to 80% of patients in placebo group developed grade II toxicity. This difference between the groups was statistically significant. (p < 0.001). Conclusion: Enteral glutamine minimizes radiation induced dermatitis. © 2015 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism.
PubMed | Kanuni Research and Training Hospital, Karadeniz Technical University and Izmir University
Type: Journal Article | Journal: Clinical nutrition (Edinburgh, Scotland) | Year: 2016
Radiotherapy is a critical component of breast cancer treatment. Many skin reactions ranging from erythema to moist desquamation and ulceration can be induced by high dose external beam radiotherapy. There is no golden standard for treating radiation dermatitis. Glutamine is an amino acid which improved wound healing through its anabolic effects and improvements in wound matrix formation in burn patients. We designed a study to show effects of glutamine in radiation induced dermatitis.Forty patients who received radiotherapy for breast cancer were randomized into 2 groups. In group 1 the patients were treated with 15 gr of enteral glutamine whereas the patients in group 2 were treated with placebo. The radiation induced skin reactions were evaluated in both groups.In glutamine treated group 88, 9% of patients developed grade I toxicity comparing to 80% of patients in placebo group developed grade II toxicity. This difference between the groups was statistically significant. (p<0.001) CONCLUSION: Enteral glutamine minimizes radiation induced dermatitis.
Rakici S.Y.,Recep Tayyip Erdoğan University |
Erdemli S.D.,Kanuni Research and Training Hospital |
Yazici Z.A.,Recep Tayyip Erdoğan University |
Cengiz E.,Kanuni Research and Training Hospital |
And 2 more authors.
International Journal of Clinical and Experimental Medicine | Year: 2015
Wernicke’s encephalopathy (WE) is a disease classically associated with nutrition deficiency. It is characterized by typical symptoms like confusion, ataxia and ophthalmoparesis, and developes due to thiamine deficieny in alcoholic patients. Recently, it has been shown that WE could ocur in patients with gastric carcinoma without a history of alcohol use. In this paper, we have made some suggestions about early diagnosis, treatment and prevention of WE by discussing the development of WE in a patient with unresectable gastric carcinoma, who had been inpatient for a long time and given radiotherapy and chemotherapy. © 2015, E-Century Publishing Corporation. All rights reserved.
PubMed | Antalya Research and Training Hospital, Kanuni Research and Training Hospital and Karadeniz Technical University
Type: | Journal: The international journal of lower extremity wounds | Year: 2016
Ischemic wounds unresponsive to standard treatment in thromboangiitis obliterans are associated with amputation, morbidity, and mortality. In this study, hyperbaric oxygen therapy was added to standard treatment of 36 patients with thromboangiitis obliterans with ischemic ulcerated wounds in the extremities. Full recovery was observed in 52.7% of cases (25% at discharge, 27.7% during follow-up). Resting pain after treatment decreased significantly compared to pretreatment levels based on visual analog scale scores (7.1 1.7 vs 2.2 3.0, P = .0001). Mean wound area also decreased significantly after treatment (22.6 17.5 vs 13.02 16.5, P = .0001). The number of patients requiring no assistance during routine daily activities increased significantly (25% vs 55.5%, P = .001). All patients were at Fontaine stage IV before hyperbaric oxygen therapy. The number of patients at stage IIB increased significantly after treatment, while that of patients at stage IV decreased significantly (0% vs 47.2%, P = .0001, and 100% vs 47.2%, P = .0001, respectively). None of our patients was able to walk without pain before treatment; however, walking distance was significantly extended in 16 patients who were capable of walking (0 vs 190.6 129.4 meters, P = .0001). In addition, 11.1% of patients underwent major amputation during follow-up.