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Eda K.,Kanuni Research and Training Hospital | Uzer K.,Kanuni Research and Training Hospital | Murat T.,Karadeniz Technical University | Cenk U.,Izmir University
Clinical Nutrition

Purpose: Radiotherapy is a critical component of breast cancer treatment. Many skin reactions ranging from erythema to moist desquamation and ulceration can be induced by high dose external beam radiotherapy. There is no golden standard for treating radiation dermatitis. Glutamine is an amino acid which improved wound healing through its anabolic effects and improvements in wound matrix formation in burn patients. We designed a study to show effects of glutamine in radiation induced dermatitis. Material and method: Forty patients who received radiotherapy for breast cancer were randomized into 2 groups. In group 1 the patients were treated with 15 gr of enteral glutamine whereas the patients in group 2 were treated with placebo. The radiation induced skin reactions were evaluated in both groups. Results: In glutamine treated group 88, 9% of patients developed grade I toxicity comparing to 80% of patients in placebo group developed grade II toxicity. This difference between the groups was statistically significant. (p < 0.001). Conclusion: Enteral glutamine minimizes radiation induced dermatitis. © 2015 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. Source

Rakici S.Y.,Recep Tayyip Erdogan University | Erdemli S.D.,Kanuni Research and Training Hospital | Yazici Z.A.,Recep Tayyip Erdogan University | Cengiz E.,Kanuni Research and Training Hospital | And 2 more authors.
International Journal of Clinical and Experimental Medicine

Wernicke’s encephalopathy (WE) is a disease classically associated with nutrition deficiency. It is characterized by typical symptoms like confusion, ataxia and ophthalmoparesis, and developes due to thiamine deficieny in alcoholic patients. Recently, it has been shown that WE could ocur in patients with gastric carcinoma without a history of alcohol use. In this paper, we have made some suggestions about early diagnosis, treatment and prevention of WE by discussing the development of WE in a patient with unresectable gastric carcinoma, who had been inpatient for a long time and given radiotherapy and chemotherapy. © 2015, E-Century Publishing Corporation. All rights reserved. Source

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