Kanuni Sultan Suleyman Research and Training Hospital

İstanbul, Turkey

Kanuni Sultan Suleyman Research and Training Hospital

İstanbul, Turkey

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Kuru O.,Kanuni Sultan Suleyman Research and Training Hospital | Sen S.,Suleymaniye Research and Training Hospital | Akbayir O.,Kanuni Sultan Suleyman Research and Training Hospital | Pinar Cilesiz Goksedef B.,Haseki Research and Training Hospital | And 3 more authors.
Archives of Gynecology and Obstetrics | Year: 2012

Objectives To evaluate maternal and fetal outcomes among women with hyperemesis gravidarum (HG). Methods In a university hospital and a research and training hospital, a retrospective cohort study was conducted among women with singleton deliveries between 2003 and 2011. Maternal outcomes evaluated included gestational diabetes, pregnancy-induced hypertension, cesarean delivery. Neonatal outcomes also determined were 5-min Apgar score of less than 7, low birth weight, small for gestational age (SGA), preterm delivery, fetal sex, and stillbirth. Results There were no statistical diVerences in the mean of age, parity, the number of artiWcial pregnancy, and smoking between two groups. Infants from HG pregnancies manifested similar birth weight (3,121.5 ± 595.4 vs. 3,164 ± 664.5 g) and gestational age (38.1 ± 2.3 vs. 38.1 ± 2.6 weeks), relative to infants from the control group (p = 0.67 and 0.91, respectively). In addition, no statistical signiWcant diVerences were found in the rates of SGA birth, preterm birth, gestational diabetes, pregnancy-induced hypertension, and adverse fetal outcome between two groups (p > 0.05). Cesarean delivery rates were similar in two groups (31.9% in hyperemesis group vs. 27% in control group, p = 0.49). Comparing the gender of the newborn baby and Apgar scores less than 7 at 5 min, there were no statistically signiWcant diVerences between two groups (p = 0.16 and 0.42, respectively). Conclusion Hyperemesis gravidarum is not associated with adverse pregnancy outcomes. © 2012 Springer-Verlag.


PubMed | Yuzuncu Yil University and Kanuni Sultan Suleyman Research and Training Hospital
Type: Journal Article | Journal: European annals of allergy and clinical immunology | Year: 2017

Intravenous immunoglobulin (IVIG) is commonly used in primary and secondary immunodeficiency diseases as well as autoimmune conditions as immunomodulatator treatment. Immediate adverse events which are generally mild and occur during infusion are seen in 6 hours. Reported immediate adverse events are in a wide range from 1%-40% in pediatric patients. 115 patients who received IVIG (except newborns) were included into this crosssectional study. IVIG was given to patients for primary immunodeficiencies (n=8), ITP (n=65), Kawasaki disease (n=11), secondary immunosupression (n=28), and passive immunization (n=3). 5%, 10% IVIG preparations and pentaglobin were used. Headache, fever, chills, nausea, rash, arthralgia, myalgia and back pain were accepted as mild immediate events. There were 62 (54%) boys and 53 (46%) girls aged 1 month-18 years. Mean age of the group was 7.44.6 years. Immediate adverse events due to IVIG infusions were seen in 29 (25.2%) of all patients. Gender and types of the disease were not different in significance regarding the presence of adverse events. The rate of adverse events did not change with receiving pre-medication. The most common reaction was fever/chills. Immediate reactions were seen in first 6 hours in 7 patients and during infusion in the remaining. They were treated with slowing of the infusion rate and infusion was stopped in 3 patients because of moderate events. Because of the increasingly use of IVIG therapy, it is important to know the side effects. High doses, high infusion rates, accompanying infection may worsen the adverse effects especially in primary immunodeficiency diseases.


PubMed | Sisli Etfal Research and Training Hospital, Marmara University, Kanuni Sultan Suleyman Research and Training Hospital, Kartal Lutfi Krdar Research and Tranining Hospital and 5 more.
Type: Journal Article | Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology | Year: 2016

The objective of this study was to assess the iodine status of pregnant women in a metropolitan city which was stated as iodine sufficient area after salt iodination program. This multicenter, cross-sectional study was carried out on 3543 pregnant women. Age, gestational weeks, smoking, consumption of iodized salt, dietary salt restriction, history of stillbirth, abortus and congenital malformations were questioned. Spot urine samples were analyzed for urine iodine concentration (UIC). The outcomes were: (a) median UIC in three trimesters of pregnancy and (b) frequency of ID among pregnant women. The median UIC was 73g/L. The median UIC was 77g/L (1-324), 73g/L (1-600) and 70g/L (1-1650) in three trimesters of pregnancy, respectively (p: 0.14). UIC <50g/L was observed in 36.6% (n: 1295) and UIC<150g/L was observed in 90.7% (n: 3214) of pregnant women. Only 1% (n: 34) of the pregnant women had UIC levels higher than 500g/L. This study showed that more than 90% of the pregnant women in this iodine-sufficient city are facing some degree of iodine deficiency during their pregnancy. A salt iodization program might be satisfactory for the non-pregnant population, but it seems to be insufficient for the pregnant population.


PubMed | Selcuk University, Gulhane Military Medical Faculty, Uludag University, Kanuni Sultan Suleyman Research and Training Hospital and 14 more.
Type: Journal Article | Journal: Clinical and experimental rheumatology | Year: 2015

To develop and assess the validity and reliability of an adherence scale concerning medical treatment in paediatric FMF patients.The Medication Adherence Scale in FMF Patients (MASIF) is a 18-item questionnaire that evaluates adherence to medication in four domains. Validation of the instrument was accomplished in paediatric FMF patients (aged 2-18 years) under medication at least for 6 months. The first step was to build up the scale through qualitative approach (with interviews using semi-structured questions). Validation analyses included assessment of feasibility, face and content validity; construct validity, internal consistency and test-retest reliability.One hundred and fifty patients with FMF were enrolled in the study. The mean age of the patients was 11.114.02 years and 48.7% of them were male. The MASIF was found to be feasible and valid for both face and content. It correlated with the Morisky Medication Adherence Scale as a gold standard thereby demonstrating good construct validity (r=0.515, p<0.001). Assessment of content validity identified four subscales. The internal consistency, Cronbachs alpha was 0.728. There was a positive and significant correlation between test and retest scores (r=0.843; p<0.001). Also, a significant correlation between parents and childrens reports (r=0.781, p<0.001).Based on these results, the use of this scale to assess and follow up the adherence to treatment in paediatric FMF patients under medical treatment is recommended.


Sahbaz A.,Bülent Ecevit University | Ersan F.,Kanuni Sultan Suleyman Research and Training Hospital | Aydin S.,Kanuni Sultan Suleyman Research and Training Hospital
Journal of Obstetrics and Gynaecology Research | Year: 2014

Aim: We aim to evaluate the effect of Nigella sativa oil (NSO) on postoperative peritoneal adhesion formation in female rats. This experimental study is the first on the prevention of postoperative adhesion formation by NSO. Methods: Twenty-four Wistar albino female rats were randomly assigned to three groups of eight rats each. Rats in group 1 were each injected i.p. with 1 mL of NSO. In group 2, an adhesion model was created with no injection of NSO. In group 3, an adhesion model was created and the area was covered with 1 mL of NSO. The rats were killed on postoperative day 8, and the severity of adhesions was evaluated macroscopically and histopathologically. Results: There was a statistically significant difference in adhesion scores between group 2 (control) and group 3 (NSO-treated) (P = 0.003). Statistically significant differences in angiogenesis, fibrosis and inflammation were observed between the control and Nigella sativa groups (P = 0.002, P = 0.001 and P = 0.004, respectively). Conclusion: Covering peritoneal surfaces with NSO after peritoneal trauma is effective in decreasing peritoneal adhesion formation. © 2014 Japan Society of Obstetrics and Gynecology.


Sayin N.,Kanuni Sultan Suleyman Research and Training Hospital | Kara N.,Gaziantep Sehit Kamil State Hospital | Pekel G.,Pamukkale University | Altinkaynak H.,Erzurum Regional Training and Research Hospital
Cutaneous and Ocular Toxicology | Year: 2014

Objective: To evaluate the effect of chronic cigarette smoking on dry eye parameters, endothelial cells, and corneal thickness. Design: Prospective cross-sectional case series. Methods: In this cross-sectional study, 49 eyes of 49 chronic smokers (smoker group) and 53 eyes of 53 age-matched, healthy non-smokers (non-smoker group) were enrolled. All participants underwent measurements of tear breakup time (TBUT), central corneal thickness (CCT) measurements with contact pachymeter and the Schirmer test with anesthesia. Corneal endothelial cells were evaluated by non-contact specular microscopy and photographed for analysis of cell density and hexagonality and the coefficient of variation in cell size. Results: The mean Schirmer score and TBUT value were significantly lower in the smoker group compared to the non-smoker group (p=0.015) and p<0.001, respectively). No statistically significant difference was found in the mean CCT, mean endothelial cell density, endothelial cell size, SD of size, and CV of size between smokers and non-smokers (p>0.05). However, a lower percentage of endothelial hexagonal cells were observed in smokers than non-smokers (p<0.001). Discussion and conclusion: Our results suggest that cigarette smoking seems to affect the Schirmer score, TBUT value, and hexagonal cells of the corneal endothelium. © 2014 Informa Healthcare USA, Inc. All rights reserved: reproduction in whole or part not permitted.


PubMed | Bakirkoy Research and Training Hospital for Psychiatry Neurology and Neurosurgery, Kanuni Sultan Suleyman Research and Training Hospital and Bahcelievler State Hospital
Type: Journal Article | Journal: International journal of psychiatry in clinical practice | Year: 2016

Impulsivity is an important aspect of obsessive-compulsive disorder (OCD) which is classified under a new heading in DSM-5 with other impulsivity related disorders like trichotillomania. Due to its heterogeneous nature, different obsessions may be linked to varying impulsivity profiles. Aim of this study was to investigate the impulsivity traits and their relationship with obsession types by comparing OCD subjects who display sexual, religious and aggressive obsessions or other obsessions to healthy controls.Outpatients with OCD (n=146) and healthy controls (n=80) were evaluated with Sociodemographic Data Form, SCID-I, SCID non-patient version, Yale-Brown Obsessive Compulsive Scale (Y-BOCS) and Barratt Impulsiveness Scale (BIS-11).BIS-11 attention scores of the OCD group were significantly higher than healthy subjects. In patients with sexual, aggressive, religious obsessions, BIS-11 attention scores were significantly higher than those who have other obsession types and that of controls.Higher levels of attentional impulsivity, particularly in patients suffering from sexual, aggressive or religious obsessions suggest a common diathesis for a dysfunction in neural correlates corresponding to these symptoms. The results of our study may promote further studies conducted with more advanced and objective neuropsychometric tests evaluating features of the clinical course, neurobiology and the response to OCD treatment.


Ersoy Tunali N.,Halic University | Marobbio C.M.T.,University of Bari | Tiryakioglu N.O.,Halic University | Punzi G.,University of Bari | And 3 more authors.
Molecular Genetics and Metabolism | Year: 2014

The hyperornithinemia-hyperammonemia-homocitrullinuria syndrome is a rare autosomal recessive disorder caused by the functional deficiency of the mitochondrial ornithine transporter 1 (ORC1). ORC1 is encoded by the SLC25A15 gene and catalyzes the transport of cytosolic ornithine into mitochondria in exchange for citrulline. Although the age of onset and the severity of the symptoms vary widely, the disease usually manifests in early infancy. The typical clinical features include protein intolerance, lethargy, episodic confusion, cerebellar ataxia, seizures and mental retardation. In this study, we identified a novel p.Ala15Val (c.44C > T) mutation by genomic DNA sequencing in a Turkish child presenting severe tantrum, confusion, gait disturbances and loss of speech abilities in addition to hyperornithinemia, hyperammonemia and homocitrullinuria. One hundred Turkish control chromosomes did not possess this variant. The functional effect of the novel mutation was assessed by both complementation of the yeast ORT1 null mutant and transport assays. Our study demonstrates that the A15V mutation dramatically interferes with the transport properties of ORC1 since it was shown to inhibit ornithine transport nearly completely. © 2014.


Abdallah A.,Bakirkoy Research and Training Hospital for Neurology | Gokcedag A.,Kanuni Sultan Suleyman Research and Training Hospital | Ofluoglu A.E.,Bakirkoy Research and Training Hospital for Neurology | Emel E.,Bakirkoy Research and Training Hospital for Neurology
American Journal of Case Reports | Year: 2014

Objective: Rare disease.Background: Myositis ossificans is a non-neoplastic benign reactive bone and cartilage matrix-producing pseudotumor that develops in skeletal muscles adjacent to the joint. The clinical and pathologic appearance of myositis ossificans varies depending on the time elapsed after heterotopic bone formation. Although its etiology is unclear, it usually occurs at the site of the injured muscle, most commonly in large muscles of the extremities, especially the quadriceps and brachialis. It rarely occurs in the paravertebral muscle of the lumbar spine.Case Report: We present the rare case of a 31-year-old Turkish man with calcifying myositis ossificans not associated with trauma, referred to our hospital with severe low back pain with restriction of low back motions. Radiological investigation suggested a sclerotic osteoblastic on the left facet joint of L4–5. To confirm the diagnosis, the patient was managed surgically by total excision of the mass, which resulted in a good functional recovery. At his 12-month follow-up examination, he was neurologically intact and no recurrence was seen.Conclusions: Cases like this should be investigated well, so careful correlation of the clinical and radiologic findings with taking a biopsy is necessary to confirm diagnosis. ©Am J Case Rep, 2014.


PubMed | Istanbul University and Kanuni Sultan Suleyman Research and Training Hospital
Type: Clinical Trial | Journal: Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis | Year: 2015

The plasminogen activator system controls intravascular fibrin deposition; besides, it also participates in a wide variety of physiologic and pathologic processes, including cancer.In this study, we examined the levels of plasminogen activator inhibitor 1 (PAI-1) and vitronectin in 32 newly diagnosed pediatric patients with malignancies, determined by enzyme-linked immunosorbent assay between January 2009 and January 2010 and compared them to 35 age-matched healthy children, using SPSS 16.0 software.The mean level of PAI-1 was 23.02 15 (8.2-71.19) ng/mL and vitronectin was 83.10% 23.77% (12%-126%) in the tumor group. Thirty-five healthy children in the same age range were enrolled in the control group. The levels of PAI-1 and vitronectin were 23.63 10.44 (11.67-58.85) ng/mL and 85% 20.85% (39%-126%), respectively. No significant difference was found between the 2 groups by independent sample t-test (P = .86 and P = .69).This is a preliminary study done in children with malignancies, investigating PAI-1 and vitronectin. Further study is needed, including larger trials and tumor tissue with histopathological examination as in adults.

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