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Enez Darcin A.,Kanuni Sultan Suleyman Research and Training Hospital | Kose S.,University of Houston | Noyan C.O.,Istanbul University | Nurmedov S.,Acbadem Health Care Group | And 2 more authors.
Behaviour and Information Technology | Year: 2016

Individuals with psychosocial problems such as social phobia or feelings of loneliness might be vulnerable to excessive use of cyber-technological devices, such as smartphones. We aimed to determine the relationship of smartphone addiction with social phobia and loneliness in a sample of university students in Istanbul, Turkey. Three hundred and sixty-seven students who owned smartphones were given the Smartphone Addiction Scale (SAS), UCLA Loneliness Scale (UCLA-LS), and Brief Social Phobia Scale (BSPS). A significant difference was found in the mean SAS scores (p < .001) between users who declared that their main purpose for smartphone use was to access social networking sites. The BSPS scores showed positive correlations with all six subscales and with the total SAS scores. The total UCLA-LS scores were positively correlated with daily life disturbance, positive anticipation, cyber-oriented relationship, and total scores on the SAS. In regression analyses, total BSPS scores were significant predictors for SAS total scores (β = 0.313, t = 5.992, p < .001). In addition, BSPS scores were significant predictors for all six SAS subscales, whereas UCLA-LS scores were significant predictors for only cyber-oriented relationship subscale scores on the SAS (β = 0.130, t = 2.416, p < .05). The results of this study indicate that social phobia was associated with the risk for smartphone addiction in young people. Younger individuals who primarily use their smartphones to access social networking sites also have an excessive pattern of smartphone use. © 2016 Informa UK Limited, trading as Taylor & Francis Group Source

Abdallah A.,Bakirkoy Research and Training Hospital for Neurology | Gokcedag A.,Kanuni Sultan Suleyman Research and Training Hospital | Ofluoglu A.E.,Bakirkoy Research and Training Hospital for Neurology | Emel E.,Bakirkoy Research and Training Hospital for Neurology
American Journal of Case Reports | Year: 2014

Objective: Rare disease.Background: Myositis ossificans is a non-neoplastic benign reactive bone and cartilage matrix-producing pseudotumor that develops in skeletal muscles adjacent to the joint. The clinical and pathologic appearance of myositis ossificans varies depending on the time elapsed after heterotopic bone formation. Although its etiology is unclear, it usually occurs at the site of the injured muscle, most commonly in large muscles of the extremities, especially the quadriceps and brachialis. It rarely occurs in the paravertebral muscle of the lumbar spine.Case Report: We present the rare case of a 31-year-old Turkish man with calcifying myositis ossificans not associated with trauma, referred to our hospital with severe low back pain with restriction of low back motions. Radiological investigation suggested a sclerotic osteoblastic on the left facet joint of L4–5. To confirm the diagnosis, the patient was managed surgically by total excision of the mass, which resulted in a good functional recovery. At his 12-month follow-up examination, he was neurologically intact and no recurrence was seen.Conclusions: Cases like this should be investigated well, so careful correlation of the clinical and radiologic findings with taking a biopsy is necessary to confirm diagnosis. ©Am J Case Rep, 2014. Source

Tatlidede A.D.,Istanbul University | Yalcin A.D.,Umraniye Research and Training Hospital | Canpolat T.G.,Kanuni Sultan Suleyman Research and Training Hospital
Klinik Psikofarmakoloji Bulteni | Year: 2013

Cerebral hemiatrophy (or Dyke-Davidoff-Masson Syndrome) is a neurodevelopmental disorder characterized by atrophy or hypoplasia of one cerebral hemisphere accompanied by ipsilateral calvarial changes. Clinically, the condition presents with contralateral motor dysfunction, facial asymmetry, epilepsy and intellectual impairment. Psychiatric manifestations are uncommon and the neuropsychiatric aspect of the disease is not well described. Here, we report a 26-year-old female who presented with left cerebral hemiatrophy and schizoaffective disorder. We discuss the relevance of left-sided neurodevelopmental cerebral atrophy in the context of disrupted neural development of brain lateralization, plasticity, and evidence regarding left hemisphere dysfunction in schizophrenia and schizoaffective disorder. Source

Sayin N.,Kanuni Sultan Suleyman Research and Training Hospital | Kara N.,Gaziantep Sehit Kamil State Hospital | Pekel G.,Pamukkale University | Altinkaynak H.,Erzurum Regional Training and Research Hospital
Cutaneous and Ocular Toxicology | Year: 2014

Objective: To evaluate the effect of chronic cigarette smoking on dry eye parameters, endothelial cells, and corneal thickness. Design: Prospective cross-sectional case series. Methods: In this cross-sectional study, 49 eyes of 49 chronic smokers (smoker group) and 53 eyes of 53 age-matched, healthy non-smokers (non-smoker group) were enrolled. All participants underwent measurements of tear breakup time (TBUT), central corneal thickness (CCT) measurements with contact pachymeter and the Schirmer test with anesthesia. Corneal endothelial cells were evaluated by non-contact specular microscopy and photographed for analysis of cell density and hexagonality and the coefficient of variation in cell size. Results: The mean Schirmer score and TBUT value were significantly lower in the smoker group compared to the non-smoker group (p=0.015) and p<0.001, respectively). No statistically significant difference was found in the mean CCT, mean endothelial cell density, endothelial cell size, SD of size, and CV of size between smokers and non-smokers (p>0.05). However, a lower percentage of endothelial hexagonal cells were observed in smokers than non-smokers (p<0.001). Discussion and conclusion: Our results suggest that cigarette smoking seems to affect the Schirmer score, TBUT value, and hexagonal cells of the corneal endothelium. © 2014 Informa Healthcare USA, Inc. All rights reserved: reproduction in whole or part not permitted. Source

Ersoy Tunali N.,Halic University | Marobbio C.M.T.,University of Bari | Tiryakioglu N.O.,Halic University | Punzi G.,University of Bari | And 3 more authors.
Molecular Genetics and Metabolism | Year: 2014

The hyperornithinemia-hyperammonemia-homocitrullinuria syndrome is a rare autosomal recessive disorder caused by the functional deficiency of the mitochondrial ornithine transporter 1 (ORC1). ORC1 is encoded by the SLC25A15 gene and catalyzes the transport of cytosolic ornithine into mitochondria in exchange for citrulline. Although the age of onset and the severity of the symptoms vary widely, the disease usually manifests in early infancy. The typical clinical features include protein intolerance, lethargy, episodic confusion, cerebellar ataxia, seizures and mental retardation. In this study, we identified a novel p.Ala15Val (c.44C > T) mutation by genomic DNA sequencing in a Turkish child presenting severe tantrum, confusion, gait disturbances and loss of speech abilities in addition to hyperornithinemia, hyperammonemia and homocitrullinuria. One hundred Turkish control chromosomes did not possess this variant. The functional effect of the novel mutation was assessed by both complementation of the yeast ORT1 null mutant and transport assays. Our study demonstrates that the A15V mutation dramatically interferes with the transport properties of ORC1 since it was shown to inhibit ornithine transport nearly completely. © 2014. Source

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