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Ozgurhan E.B.,Beyoglu Eye Education and Research Hospital | Agca A.,Beyoglu Eye Education and Research Hospital | Kara N.,Kanuni Sultan Suleyman Education and Research Hospital | Yuksel K.,Beyoglu Eye Education and Research Hospital | And 2 more authors.
Cornea | Year: 2013

Purpose: To evaluate the clinical outcomes of topical bevacizumab as adjunctive to the surgical excision for treatment of recurrent pterygium. Methods: The 44 patients who underwent recurrent pterygium excision with conjunctival autograft transplantation were enrolled in this prospective and interventional study. The patients were randomized in 2 groups: study group, 1 month after surgery, 22 patients received only topical bevacizumab (5 mg/mL) 4 times daily for 2 months; control group, 1 month after surgery, 22 patients were administered only an artificial tear 4 times daily for 2 months. Patients were prospectively followed for 6 months after pterygium surgery. The main outcome measures were pterygium recurrence, corneal neovascularization, and other postoperative complications. Results: No statistically significant differences were observed between the 2 groups in terms of age, gender distributions, laterality, length of pterygium, and number of recurrence. A pterygium recurrence was not noted in any patients in the study group but was noted in 2 of 22 eyes (9%) in the control group during the follow-up after surgery (P = 0.244). Although none of the patients developed corneal neovascularization in the study group, 5 of 22 eyes (22.7%) developed this condition in the control group during the follow-up after surgery (P = 0.024). No serious complications were observed during the follow-up period in both the groups. Conclusions: Topical bevacizumab therapy 1 month after surgical excision of recurrent pterygium is well tolerated and effective to prevent neovascularization. Although the recurrence rate is lower in the study group without significant difference, further studies are required to support this result. Copyright © 2013 by Lippincott Williams & Wilkins. Source


Sayin N.,Kanuni Sultan Suleyman Education and Research Hospital | Kara N.,University of Gaziantep | Pekel G.,Pamukkale University | Altinkaynak H.,Ataturk Training and Research Hospital
Indian Journal of Ophthalmology | Year: 2015

Purpose: To measure the choroidal thickness (CT) after dynamic exercise by using enhanced depth imaging optical coherence tomography (EDI-OCT). Materials and Methods: A total of 19 healthy participants performed 10 min of low-impact, moderate-intensity exercise (i.e., riding a bicycle ergometer) and were examined with EDI-OCT. Each participant was scanned before exercise and afterward at 5 min and 15 min. CT measurement was taken at the fovea and 1000 μ away from the fovea in the nasal, temporal, superior, and inferior regions. Retinal thickness, intraocular pressure, ocular perfusion pressure (OPP), heart rate, and mean blood pressure (mBP) were also measured. Results: A significant increase occurred in OPP and mBP at 5 min and 15 min following exercise (P 0.05). The mean subfoveal CT at baseline was 344.00 ± 64.71 μm compared to 370.63 ± 66.87 μm at 5 min and 345.31 ± 63.58 μm at 15 min after exercise. CT measurements at all locations significantly increased at 5 min following exercise compared to the baseline (P 0.001), while measurements at 15 min following exercise did not significant differ compared to the baseline (P 0.05). There was no significant difference in retinal thickness at any location before and at 5 min and 15 min following exercise (P 0.05). Conclusion: Findings revealed that dynamic exercise causes a significant increase in CT for at least 5 min following exercise. Source


Celebi S.,Kanuni Sultan Suleyman Education and Research Hospital | Uysal A.I.,Tokat State Hospital | Inal F.Y.,Tokat State Hospital | Yildiz A.,Sisli Etfal Education and Research Hospital
Journal of Laparoendoscopic and Advanced Surgical Techniques | Year: 2014

Aim: The aim of this study is to determine whether laparoscopic repair (LR) of inguinal hernia is superior to open repair (OR) in bilateral cases. Subjects and Methods: Sixty-two boys older than 6 years with bilateral hernias were included in our prospective, randomized, single-blinded clinical trial. All patients were administered morphine via patient-controlled analgesia for 24 hours. Pain scores were evaluated by the patients using a visual analog scale (VAS) at 1, 2, 4, 12, and 24 hours postoperatively. Operative time, pain scores, analgesic doses, and first mobilization attempt were evaluated. Parents also provided assessments of their children's recovery and wound appearance. Results: Operative time was found to be slightly higher in OR compared with LR. VAS scores were higher in OR than in LR at 1 hour postoperatively (6.78 versus 3.88, respectively; P<.05). At the other times, VAS scores showed no significant differences. Although OR patients requested and delivered analgesics more frequently than LR patients, the difference was not significant. The scores given by parents for wound appearance were significantly higher in the bilateral LR group than in the bilateral OR group (89±4.23 and 78±6.7, respectively; P<.05). Conclusions: This trial demonstrates that LR in bilateral cases offers benefits compared with OR in terms of lower pain scores and analgesic requirements and of reduced operative and patient recovery times. However, the only significant difference was better wound cosmesis in bilateral LR cases. © 2014, Mary Ann Liebert, Inc. Source


Kara N.,Kanuni Sultan Suleyman Education and Research Hospital | Altinkaynak H.,Beyoglu Eye Education and Research Hospital | Baz O.,Beyoglu Eye Education and Research Hospital | Goker Y.,Beyoglu Eye Education and Research Hospital
Cornea | Year: 2013

PURPOSE: To compare the biomechanical properties of the cornea between topographically normal relatives of patients with keratoconus and age-matched controls. METHODS: Thirty healthy individuals (control group) and 30 topographically normal relatives of patients with keratoconus (study group) were enrolled in this prospective, cross-sectional comparative study. Topographical measurements including pachymetric values, keratometry values, irregularity, and inferior-superior dioptric asymmetry difference values in the right eye of each participant were obtained using Orbscan II (Bausch & Lomb Laboratories, Inc, Rochester, NY). Corneal hysteresis (CH), corneal resistance factor (CRF), corneal compensated intraocular pressure, and Goldmann-related intraocular pressure were also measured using the Reichert Ocular Response Analyzer (ORA). RESULTS: Topographic parameters were not significantly different between both groups (P > 0.05). Mean CH was 9.9 ± 1.6 mm Hg in the study group and 11.3 ± 1.0 mm Hg in the control group (P = 0.001); mean CRF was 9.8 ± 1.6 mm Hg and 11.2 ± 2.1 mm Hg in the study and control groups, respectively (P = 0.013). Mean Goldmann-related intraocular pressure was 15.0 ± 4.3 mm Hg in the study group and 15.8 ± 6.7 mm Hg in the control group (P = 0.603); mean corneal compensated intraocular pressure was 16.2 ± 4.7 mm Hg in the study group and 15.4 ± 5.8 mm Hg in the control group (P = 0.595). CONCLUSIONS: The CH and CRF values were significantly lower in the relatives of patients with keratoconus than in the controls. Future studies including monitoring of these participants with topographical and biomechanical measurements may indicate the role of this study in detection of early corneal changes in relatives of patients with keratoconus. Copyright © 2012 by Lippincott Williams & Wilkins. Source


Araz-Ersan B.,Kanuni Sultan Suleyman Education and Research Hospital | Kir N.,Istanbul University | Akarcay K.,Istanbul University | Aydinoglu-Candan O.,Istanbul University | And 4 more authors.
British Journal of Ophthalmology | Year: 2013

Purpose: To collect data towards the establishment of a guideline to predict the population under risk for the development of retinopathy of prematurity (ROP) in Turkey. Methods: Medical reports of 2950 preterm infants who underwent screening examinations for ROP between 1996 and 2010 at Istanbul Faculty of Medicine, Department of Ophthalmology were reviewed. The study population was classified as inpatient infants and referred infants. A risk factor analysis was performed limited to the 788 inpatient infants. The demographical variables regarding birth weight (BW), gestational age (GA) and postnatal age at the time of treatment were compared independently between 403 referred and 64 inpatient infants who were treated for severe ROP. Results: The mean GA of the infants with severe ROP was 31.2±2.7 weeks, mean BW was 1543.4±508.3 g. The risk factor analysis of inpatient infants revealed BW<1500 g, GA<32 weeks; intraventricular haemorrhage, respiratory distress syndrome, sepsis, apnoea and phototherapy were associated with a higher incidence of ROP. In addition, sepsis, male gender, multiple gestations, BW<1500 g were associated with a higher incidence of progression to severe ROP, whereas maternal pre-eclampsia was associated with a lower incidence. On the other hand, comparison of demographic features revealed that the referred infants with ROP were born at a significantly higher BW and needed significantly earlier treatment than inpatient infants with ROP. Conclusions: The high BW and GA of infants with severe ROP indicate wider screening criteria should be used in our country. BW might be a more important criterion than GA for ROP screening. Source

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