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Kalaycoglu E.,Ahi Evren Chest and Cardiovascular Surgery Education and Research Hospital | Gokdeniz T.,Kars Kafkas Medical Faculty | Aykan A.C.,Ahi Evren Chest and Cardiovascular Surgery Education and Research Hospital | Gursoy M.O.,Gaziemir State Hospital | And 3 more authors.
International Journal of Cardiovascular Imaging | Year: 2014

Several studies suggested that headache attacks and its frequency were mainly responsible for increased cardiovascular (CV) disease and mortality in patients with migraine with aura (MWA). Elevated serotonin level has been found to play a role in migraine attacks. Serotonin was best studied within the CV system for its role in the development of pulmonary hypertension, which had negative impact on right ventricular (RV) functions. Therefore, in this study we aimed to evaluate RV functions during headache attacks in MWA patients and its relation to attack frequency with the utility of 2-dimensional speckle tracking echocardiography (2D STE). Fifty-three patients with the diagnosis of MWA were enrolled in the study. All patients were evaluated by conventional and 2D-STE echocardiography and venous blood sampling for serotonin was obtained during headache-free period (HFP) and headache-attack period (HAP). Also, patients were divided into two groups according to attack frequency. Patients exhibited higher serotonin levels during HAP than HFP (p < 0.001). Regarding 2D-STE derived RV-free-strain parameters, patients had lower RV-free wall longitudinal speckle-tracking strain (RV-free-ST), RV-free systolic strain rate (RV-free-STR-S), RV-free early diastolic strain rate (RV-free-STR-E) and RV-free-STR-E/A ratio levels during HAP when compared with HFP (p 0.002, p 0.006, p < 0.001 and p 0.001, respectively). Thirty-one patients (58.4 %) had low-frequency attack. Patients with high-frequency attacks had increased serotonin levels (p 0.040) and decreased RV-free-ST, RV-free-STR-S, RV-free-STR-E and RV-free-STR-E/A ratio values during HAP when compared to low-frequency group (p 0.026, p 0.029, p 0.037 and p 0.019 respectively). This study demonstrated that migraine attacks, especially at higher frequencies, could have negative impact on RV systolic functions in MWA patients. © 2014, Springer Science+Business Media Dordrecht. Source


Cobanoglu H.B.,Kanuni Education and Research Hospital | Constantinides M.,New York University | Ural A.,Karadeniz Technical University
Facial Plastic Surgery Clinics of North America | Year: 2012

Histopathologic examination is the gold standard for the diagnosis of skin cancer. Because analysis of molecular parameters such as nucleic acids and DNA are also gaining importance in diagnosis, prognosis, and therapy, an understanding of the molecular mechanisms underlying the pathogenesis of nonmelanoma skin cancer of the head and neck is of growing importance for the diagnostician and surgeon alike. This article presents a description of the effect on cells and impact on DNA of ultraviolet radiation, with a discussion of squamous cell and basal cell carcinoma in terms of the effects of genetic pathways and apoptosis. © 2012 Elsevier Inc. Source


Saylan S.,Kanuni Education and Research Hospital | Eroglu A.,Karadeniz Technical University | Dohman D.,Karadeniz Technical University
BioMed Research International | Year: 2014

Background. This study aimed to compare the effects of rectal midazolam addition after applying bupivacaine and caudal anesthesia on postoperative analgesia time, the need for additional analgesics, postoperative recovery, and sedation and to find out its adverse effects in children having lower abdominal surgery. Methods. 40 children between 2 and 10 years of ASA I-II were randomized, and they received caudal anesthesia under general anesthesia. Patients underwent the application of caudal block in addition to saline and 1 mL/kg bupivacaine 0.25%. In the postoperative period, Group C (n = 20) was given 5 mL saline, and Group M (n = 20) was given 0.30 mg/kg rectal midazolam diluted with 5 mL saline. Sedation scale and postoperative pain scale (CHIPPS) of the patients were evaluated. The patients were observed for their analgesic need, first analgesic time, and adverse effects for 24 hours. Results. Demographic and hemodynamic data of the two groups did not differ. Postoperative sedation scores in both groups were significantly lower compared with the preoperative period. There was no significant difference between the groups in terms of sedation and sufficient analgesia. Conclusions. We conclude that caudal anesthesia provided sufficient analgesia in peroperative and postoperative periods, and rectal midazolam addition did not create any differences. This trial is registered with ClinicalTrials.gov NCT02127489. © 2014 Sedat Saylan et al. Source


Usta T.A.,Bagcilar Education and Research Hospital | Karacan T.,Kanuni Education and Research Hospital | Naki M.M.,Liv Hospital | Calk A.,Bagcilar Education and Research Hospital | And 2 more authors.
Archives of Gynecology and Obstetrics | Year: 2014

Purpose: We compare the results of total laparoscopic hysterectomy (TLH) operations conducted using standard 2-D and 3-D high definition laparoscopic vision systems and discuss the findings with regard to the recent literature.Methods: Data from 147 patients who underwent TLH operations with 2-D or 3-D high definition laparoscopic vision systems in Department of Obstetrics and Gynecology, Bagcilar Training and Research Hospital, during 2 year period between December 2010 and December 2012, were reviewed retrospectively. TLH operations were divided into two groups as those performed using 2-D, and those performed using 3-D high definition laparoscopic vision systems.Results: A statistically significant difference was found between the two groups in the operation times (p = 0.037 < 0.05). The mean operation time of the 2-D laparoscopy group (134.2 ± 61.8 min) was higher than the 3-D laparoscopy group (116.8 ± 38.5 min). No statistically significant difference was found between the 2-D and 3-D groups with respect to major, minor and total complication rates (p = 0.641 > 0.05). The operation time among obese patients was significantly shorter in those in the 3-D laparoscopy group than those in the 2-D group (p = 0.041 < 0.05).Conclusions: Recent literature indicates that 3-D laparoscopy vision system needs to be utilized more often and a higher number of ex vivo and in vivo studies have to be conducted. Furthermore, we believe that the prevalent problems encountered during laparoscopy can be overcome by the development of real-time vision devices and the appropriate training of the laparoscopists. 3-D high definition laparoscopic vision system will help to improve surgical performance and outcome of patients undergoing gynecological minimal invasive surgery. © 2014, Springer-Verlag Berlin Heidelberg. Source


Turan T.,Ahi Evren Training and Research Hospital | Mentese U.,Ahi Evren Training and Research Hospital | Agac M.T.,Ahi Evren Training and Research Hospital | Akyuz A.R.,Akcaabat State Hospital | And 7 more authors.
Anadolu Kardiyoloji Dergisi | Year: 2015

Objective: Oxidative stress plays a major role in the development of atherosclerosis. However, the relationship between oxidative stress and complexity and intensity of coronary artery disease is less clear. The aim of this study is to assess the relationship between oxidative stress markers and the complexity and intensity of coronary artery disease in patients with acute coronary syndrome (ACS). Methods: Sixty-seven consecutive patients with an early phase of ACS (<3 h) were included in this single-centre, cross-sectional, prospective study. Syntax and Gensini scores were calculated based on angiographic findings. Patients were divided into two CAD complexity groups according to their Syntax scores: low SYNTAX score (<22) and moderate to high SYNTAX score (> =22). Likewise patients were divided into two CAD severity groups according to the median Gensini score of 64: less intensive CAD with Gensini score (<64) and intensive CAD with Gensini score > =64. Blood samples were taken in 1 hour within administration in order to measure total oxidative status (TOS) and total antioxidant capacity (TAC) levels determined by Erel method. Oxidative stress index (OSI) was calculated by TOS /TAC. Results: There was no significant difference between the two SYNTAX groups for oxidative stress markers. Median TOS and OSI values were significantly high in the intensive CAD group (p=0.005, p=0.04, respectively). The Gensini score was positively correlated with TOS and OSI (p=0.003, p=0.02, respectively). Conclusion: Oxidative stress markers may be considered supportive laboratory parameters related to CAD intensity but not complexity in ACS patients. © 2015 by Turkish Society of Cardiology. Source

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