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Liestal, Switzerland

Knupp M.,Kantonsspital Liestal | Hintermann B.,Clinic of Orthopaedic and Trauma Surgery
Foot and Ankle Clinics

Triple arthrodesis is largely used to restore painful hindfoot deformity. However, the procedure has been connected to several postoperative complications. Therefore, an isolated fusion of the talonavicular and the subtalar joint through a single medial approach has gained popularity. This " diple" arthrodesis provides effective correction of deformities and reduces the risk of wound healing problems on the lateral side of the foot. © 2011 Elsevier Inc. Source

Knupp M.,Kantonsspital Liestal
The Journal of bone and joint surgery. American volume

A known complication of the surgical treatment of clubfoot deformity is hindfoot valgus deformity of the ankle and/or the subtalar joint leading to calcaneofibular and/or anterior ankle impingement and flatfoot deformity. The purpose of this prospective study was to assess the radiographic outcome, pain relief, and functional improvement in patients with symptomatic overcorrected clubfoot deformity who were managed with a supramalleolar osteotomy. Fourteen patients with an overcorrected clubfoot deformity and a mean age of 36.9 ± 14.0 years were managed with a supramalleolar osteotomy. The mean duration of follow-up was 50.6 months. Radiographic assessment included comparison of the preoperative and postoperative distal tibial joint surface angle, tibiotalar angle, and amount of calcaneal offset on the hindfoot alignment view. Clinical outcomes were quantified with use of a visual analog score for pain and the American Orthopaedic Foot & Ankle Society (AOFAS) hindfoot score. No perioperative complications occurred. Radiographically, all osteotomy sites healed within eight weeks and the orientation of the distal tibial articular surfaces was normalized in all cases. Clinically, calcaneofibular and anterior ankle impingement resolved in all patients and the mean visual analog score for pain decreased significantly from 4.1 ± 1.7 to 2.2 ± 1.5 (p < 0.05). The mean AOFAS hindfoot score increased significantly from 51.6 ± 12.3 preoperatively to 77.8 ± 11.8 postoperatively (p < 0.05). The ankle motion increased significantly from 25° ± 12° preoperatively to 29° ± 9° postoperatively (p < 0.05). All patients walked in normal shoes. Supramalleolar osteotomy is an effective surgical procedure for the treatment of ankle impingement in patients with an overcorrected congenital clubfoot deformity. The correction is associated with a low risk of perioperative complications and leads to significant reduction of pain, increased ankle motion, and improved clinical outcome (p < 0.05). Source

Muller F.,University of Basel | Christ-Crain M.,University of Basel | Bregenzer T.,Kantonsspital | Krause M.,Kantonsspital Munsterlingen | And 3 more authors.

Background: Guidelines recommend blood culture sampling from hospitalized patients with suspected community-acquired pneumonia (CAP). However, the yield of true-positive results is low. We investigated the benefit of procalcitonin (PCT) on hospital admission to predict blood culture positivity in CAP. Methods: This was a prospective cohort study with a derivation and validation set including 925 patients with CAP who underwent blood culture sampling on hospital admission. Results: A total of 73 (7.9%) patients had true bacteremia (43 of 463 in the derivation cohort, 30 of 462 in the validation cohort). The area under the receiver operating characteristics curve of PCT in the derivation and validation cohorts was similar (derivation cohort, 0.83; 95% CI, 0.78-0.89; validation cohort, 0.79; 95% CI, 0.72-0.88). Overall, PCT was a significantly better predictor for blood culture positivity than WBC count, C-reactive protein, and other clinical parameters. In multivariate regression analysis, only antibiotic pretreatment (adjusted odds ratio, 0.25; P<.05) and PCT serum levels (adjusted odds ratio, 3.72; P<.001) were independent predictors. Overall, a PCT cutoff of 0.1 μg/L would enable reduction of the total number of blood cultures by 12.6% and still identify 99% of the positive blood cultures. Similarly, 0.25 μg/L and 0.5 μg/L cutoffs would enable reduction of blood cultures by 37% and 52%, respectively, and still identify 96% and 88%, respectively, of positive blood cultures. Conclusions: Initial PCT level accurately predicted blood culture positivity in patients with CAP. PCT measurement has the potential to reduce the number of drawn blood cultures in the emergency department and to implement a more targeted allocation of limited health-care resources. © 2010 American College of Chest Physicians. Source

Guertler C.,University of Basel | Wirz B.,University of Basel | Christ-Crain M.,University of Basel | Zimmerli W.,Kantonsspital Liestal | And 2 more authors.
European Respiratory Journal

Long-term outcomes in patients surviving community-acquired pneumonia (CAP) are still incompletely understood. This study investigates the association of clinical parameters and blood markers with long-term mortality. We prospectively followed 877 CAP patients from a previous multicentre trial for 18 months follow-up and investigated all-cause mortality following hospital discharge. Overall mortality was 17.3% (95% CI 14.8-19.8%) with a 12.8% (95% CI 10.9-15.0%) mortality incidence rate per year. Initial risk assignment using the Pneumonia Severity Index was accurate during the 18 month follow-up. Multivariable regression models (hazard ratio, 95% CI) designated the following as independent risk factors for long-term mortality: male sex (1.7, 1.2-2.5); chronic obstructive pulmonary disease (1.5, 1.1-2.1); neoplastic disease (2.5, 1.7-3.7); and highest quartile of peak pro-adrenomedullin level (3.3, 1.7-6.2). Initial presentation with temperature >38.7°C (0.4, 0.2-0.6), chills (0.6, 0.4-0.99) and highest quartile of the inflammatory marker C-reactive-protein (0.3, 0.2-0.5) were independent protective factors. A weighted risk score based on these variables showed good discrimination (area under receiver operating characteristic curve 0.78, 95% CI 0.74-0.82). Pronounced clinical and laboratory signs of systemic inflammatory host response upon initial hospital stay were associated with favourable long-term prognosis. Further studies should address whether closer monitoring of high-risk CAP patients after hospital discharge favourably impacts long-term mortality. Copyright©ERS 2011. Source

Stufkens S.A.,Kantonsspital Liestal | Knupp M.,Kantonsspital Liestal | Horisberger M.,University of Basel | Lampert C.,Kantonsspital St. Gallen | Hintermann B.,Kantonsspital Liestal
Journal of Bone and Joint Surgery - Series A

Background: The role of the location and severity of the initial cartilage lesions associated with an ankle fracture in the development of posttraumatic osteoarthritis has not been established, to our knowledge. Methods: We performed a long-term follow-up study of a consecutive, prospectively included cohort of 288 ankle fractures that were treated operatively between June 1993 and November 1997. Arthroscopy had been performed in all cases in order to classify the extent and location of cartilage damage. One hundred and nine patients (47%) were available for follow-up after a mean of 12.9 years. The main outcome parameters were the American Orthopaedic Foot and Ankle Society (AOFAS) hindfoot score for clinical evaluation and a modified Kannus osteoarthritis score for radiographic assessment of the development of posttraumatic osteoarthritis. Results: Cartilage damage anywhere in the ankle joint was associated with a suboptimal clinical outcome (odds ratio, 5.0 [95% confidence interval = 1.3 to 20.1]; p = 0.02) and with a suboptimal radiographic outcome (odds ratio = 3.4 [95% confidence interval = 1.0 to 11.2]; p = 0.04). An association was also found between the development of clinical signs of osteoarthritis and a deep lesion (>50% of the cartilage thickness) on the anterior aspect of the talus (odds ratio = 12.3 [95% confidence interval = 1.4 to 108.0]; p = 0.02) and a deep lesion on the lateral aspect of the talus (odds ratio = 5.4 [95% confidence interval = 1.2 to 23.5]; p = 0.02). A deep lesion on the medial malleolus was associated with the development of clinical signs of osteoarthritis (odds ratio = 5.2 [95% confidence interval = 1.9 to 14.6]; p < 0.01) and radiographic signs of osteoarthritis (odds ratio = 2.9 [95% confidence interval = 1.1 to 7.9]; p = 0.03) of osteoarthritis. There was no significant correlation between cartilage lesions on the fibula and the long-term outcome. Conclusions: Our findings show that initial cartilage damage seen arthroscopically following an ankle fracture is an independent predictor of the development of posttraumatic osteoarthritis. Specifically, lesions on the anterior and lateral aspects of the talus and on the medial malleolus correlate with an unfavorable clinical outcome. Level of Evidence: Prognostic Level II. See Instructions to Authors for a complete description of levels of evidence. Copyright © 2010 by The Journal of Bone and Joint Surgery, Incorporated. Source

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