Zenica, Bosnia and Herzegovina
Zenica, Bosnia and Herzegovina

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Bajramovic-Omeragic L.,Kantonalna Bolnica Zenica | Calkic L.,Kantonalna Bolnica Zenica | Hadzic E.,Kantonalna Bolnica Zenica | Alickovic I.,Dom Zdravlja Kakanj
Lijecnicki Vjesnik | Year: 2015

Colchicine poisonings are serious and highly fatal conditions that occur as a result of food poisoning from plants that contain this alkaloid or overdose with drug containing colchicine. The leaves of edible wild garlic because of their similarity are often replaced with highly poisonous leaves of autumn crocus, causing poisoning. Described are two cases of food poisoning with Colchicum autumnale, who had similar symptoms in the initial stage, but different clinical course and outcome. Signs of poisoning require early identification and intensive supportive therapy, which increases the chances of survival.


Calkic L.,Kantonalna bolnica Zenica | Golubovic S.,Sveuciliste u Banja Luci | Bajramovic-Omeragic L.,Kantonalna bolnica Zenica | Tandir S.,Sveuciliste u Zenici | Hadzic E.,Kantonalna bolnica Zenica
Infektoloski Glasnik | Year: 2012

The possibility and route of intrafamilial transmission of hepatitis C (HC) has been prospectively explored among patients with hepatitis C with unknown route of transmission (n = 119) and their family contacts (n = 297). The geographical area of research was Zenica-Doboj Canton, during the period from 2008 to 2009. In 31,07 % (119/383; P < 0,05) of patients the transmission of disease was unknown. In this group of patients women predominated (52,94 %; 63/119; P > 0,05). The major risk factors for the occurrence of disease (P < 0,00) were: a combination of two or more risk factors (OR 13,67; 95 % CI 6,10-30,64); a family member with HC (OR 7,28 and 95 % CI 0,89-59,22); members of the household who use drugs (OR 5,88; 95 % CI 1,68-20,60); the presence of a chronic illness in the household (OR 5,80; 95 % CI 2,74-12,77); sharing a razor (OR 4,45; 95 % CI 2,36-8,37); exposure to blood in the household (OR 3,57; 95 % CI 1,91-6,26). The frequency of HCV genotypes was significant (P < 0,00) for 1a (χ2 = 12,33) in the group with unknown routes, and for 1b (χ2 = 11,50) in the group of patients with known routes of disease transmission. Cumulative incidence of newly discovered HC within examined familial contacts is 1,35 % (4/297). The total probability of the exposure in newly discovered familial contacts (OR 1,38; 95 % CI 0,15-12,48) is greater than in unexposed individuals. Anti-HCV point prevalence in examined familial contacts is 4,13 %, and among the general population 2,42 %. The results of this research suggest that the presence of a family member with HC is a significant risk factor. Therefore, for the purpose of disease prevention there is a need for a routine serological testing and continuous monitoring of all intrafamilial contacts of anti- HCV positive individuals.


Alajbegovic A.,Neuroloska Klinika | Alajbegovic S.,Kantonalna Bolnica Zenica | Delilovic-Vranic J.,Neuroloska Klinika
Medicinski Glasnik | Year: 2011

In order to examine precipitating factors for occurrence of multiple sclerosis or inception of a relapse in patients suffering from multiple sclerosis a specially designed questionnaire was used, including history records of patients with multiple sclerosis treated at the Clinic of Neurology of the Clinical Center of Sarajevo in the period between January 1st and December 31st 2006. The number of patients with MS was 71 (48 women and 23 men). An infection as a precipitating factor was noted in 21 (29.57%) cases, stress was noted in 12 patients (16.9%) whereas 43 patients (60,12%) had the RR type of the disease. Nine patients were treated with interferon therapy (12.67%) and 47 patients (66.1%) with high doses of metilpredinisolone . Depression disorder was noted in 23 (32.9%) patients whereas 7 patients had cognitive dysfunction (9.86%). Results of this study, which have shown epidemiological characteristics of multiple sclerosis for the first time in Bosnia and Herzegovina, indicate that there is a need to create a unified register of patients and to request compliance with therapeutic guidelines.


This study was aimed at comparing the efficiency and tolerability of two reference protocols Cisplatin and Etoposide and Cisplatin and Vinorelbine in advanced Non-Small Cell Lung Cancer. A total of 60 patients (two groups consisting of 30 patients) were treated for advanced Non-Small Cell Lung Cancer during the period from January to December 2005 according to the reference protocols (Cisplatin 100 mg/m2 D1; Vinorelbine 30 mg/m2 D1, D8 on 4 weeks) and (Cisplatin 100 mg/m D1; Etoposide 100 mg/m2 D1, D3, D5 on 4 weeks) at the Department of Oncology of KBC "Bezanijska kosa". All patients were analysed for tumour response, progression free survival as well as for toxicity. X2 test, Kaplan Meiers curves and Log rank test were used for statistical analysis. Although the recorded response rates were a bit lower than in previously published trials, they were not significantly different p = 0.485. No statistically significant difference was recorded in either progression free survival or overall survival. The chemotherapeutical Cisplatin/Etoposide protocol proved to be more toxic both in hematologic (3% vs. 10%) and total toxicities (p = 0.047). Our study proved both protocols to have equivalent efficacy. However, the Cisplatin, Vinorelbine protocol could be recommended because of its less expressed toxic effects.


PubMed | Kantonalna bolnica Zenica
Type: Comparative Study | Journal: Medicinski pregled | Year: 2011

This study was aimed at comparing the efficiency and tolerability of two reference protocols Cisplatin and Etoposide and Cisplatin and Vinorelbine in advanced Non-Small Cell Lung Cancer.A total of 60 patients (two groups consisting of 30 patients) were treated for advanced Non-Small Cell Lung Cancer during the period from January to December 2005 according to the reference protocols (Cisplatin 100 mg/m2 D1; Vinorelbine 30 mg/m2 D1, D8 on 4 weeks) and (Cisplatin 100 mg/m D1; Etoposide 100 mg/m2 D1, D3, D5 on 4 weeks) at the Department of Oncology of KBC Bezanijska kosa. All patients were analysed for tumour response, progression free survival as well as for toxicity. X2 test, Kaplan Meiers curves and Log rank test were used for statistical analysis.Although the recorded response rates were a bit lower than in previously published trials, they were not significantly different p = 0.485. No statistically significant difference was recorded in either progression free survival or overall survival. The chemotherapeutical Cisplatin/Etoposide protocol proved to be more toxic both in hematologic (3% vs. 10%) and total toxicities (p = 0.047).Our study proved both protocols to have equivalent efficacy. However, the Cisplatin, Vinorelbine protocol could be recommended because of its less expressed toxic effects.

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