Mori K.,Kansai University of Welfare Sciences
Nihon eiseigaku zasshi. Japanese journal of hygiene | Year: 2016
Japan is one of the leading countries worldwide in terms of longevity. However, with the increase in the elderly population, the number of individuals requiring some type of daily living assistance has currently exceeded 6 million. Cerebrovascular disease is the main reason for the requirement of care among the elderly. However, individuals in the late old age (≥75 years)-the number of which is rapidly increasing-also experience problems related to the functional decline of their musculoskeletal system, owing to age-related frailty and falls/fractures. Increasing the amount of physical activity not only helps prevent the onset of lifestyle-related diseases, but can also prevent the age-related decline in motor function. Hence, elderly individuals should perform exercises for health promotion and preventative care. However, as the physical functions and chronic diseases differ among individuals, it appears that the exercise programs offered as part of primary and secondary prevention programs may not be effective. Hence, physical therapists should play a large role in establishing appropriate and individualized exercise programs, as they have considerable experience in providing exercise therapy in the context of medical care for elderly people with varying conditions and risks.
Nomura T.,Kansai University of Welfare Sciences
Nihon eiseigaku zasshi. Japanese journal of hygiene | Year: 2016
The limitations of what physical therapists can differ from country to country. In Japan, physical therapists are national licensed health care professionals who can help patients improve or restore their mobility. Most Japanese physical therapists provide care for people in health care facilities, medical-welfare transitional facilities, and welfare facilities for the elderly. Currently, physical therapists are unable to sufficiently contribute to primary preventive health care in Japan. However, there are many health problems that physical therapists could help alleviate. For example, low back pain (LBP) more likely than any other condition prevents people from working; thus, making the establishment of effective measures to prevent and reduce LBP vital. An estimated 20,500,000 Japanese individuals have diabetes mellitus (DM) or are at a high risk of developing the disease. DM commonly accompanies stroke and/or heart disease, and is characterized by complications that result from chronic hyperglycemia. Evidence-based physical therapy is effective for the prevention and treatment of LBP and DM. The Japanese Physical Therapy Association established the Japanese Society of Physical Therapy (JSPT) in June 2013. The JSPT has 12 departmental societies and 10 sections. We believe that the JSPT will advance the study of the potential role of physical therapists in primary preventive health care. In the future, it is expected that Japanese physical therapists will contribute to primary preventive health care.
Fujii S.,Japan National Cardiovascular Center Research Institute |
Tanimukai H.,Osaka University |
Kashiwagi Y.,Kansai University of Welfare Sciences
Case Reports in Oncology | Year: 2012
Objective: H 2 blockers have been reported to be responsible for drug-induced delirium. We compared the incidence of delirium between two groups of patients who were treated with H 2 blockers (H 2 group) or proton pump inhibitors (PPI group) for anastomotic ulcer prevention following surgical treatment of esophageal cancer. Method: The incidence and severity of delirium were retrospectively compared in patients of the H 2 group (30 cases; age, 65.2 ± 8.1 years) and the PPI group (30 cases; 65.2 ± 6.5 years). The diagnosis of delirium was based on the Diagnostic and Statistical Manual of Mental Disorders-IV-Text Revision. Delirium severity was rated on the Delirium Rating Scale (DRS). Results: The incidence of delirium was significantly lower in the PPI group than in the H 2 group (p = 0.047). In the 11 patients from the H 2 group who developed delirium, discontinuation of H 2 blockers resulted in a significant reduction in the DRS score (p = 0.009). In three patients for whom H 2 blockers were discontinued, DRS scores decreased by 50% or more three days after discontinuation compared to the prediscontinuation score. Conclusions: These results suggested that switching antiulcer drugs from H 2 blockers to PPIs reduced delirium and thus provided an appropriate coping method for drug-induced delirium from antiulcer drugs. Copyright © 2012 S. Karger AG, Basel.
Shimizu H.,Kansai University of Welfare Sciences
Nihon rinsho. Japanese journal of clinical medicine | Year: 2012
Angiotensin II is a potent stimulator of vascular smooth mustle cells that increases blood pressure, and angiotensin type 1 receptors have been identified on osteoblasts; thus, the renin-angiotensin system has been suggested to be involved in bone metabolism. The authors reported that angiotensin II significantly increased TRAP-positive multinuclear osteoclasts with the up-regulation of RANKL expression through extracellular kinase of osteoblast. These effects were abolished with co-treatment of angiotensin converting enzyme (ACE) inhibitors or angiotensin type 1 receptor blockers (ARB). Recently, RANK-RANKL-OPG system is proved to be involved in vascular calcification and RAAS also might be involved in the development of the disease. Thus, target therapy for RAAS might bring additional beneficial effects on bone metabolic diseases such as osteoporosis, rheumatoid arthritis and vascular calcification other than blood pressure lowering effect.
Yasuhiro N.,Kansai University of Welfare Sciences
Proceedings of the 2012 IIAI International Conference on Advanced Applied Informatics, IIAIAAI 2012 | Year: 2012
This study was reported the learning Web-site type database structure for the child and family welfare and reflection of practice. And, the reflective family social work practice education was tried. © 2012 IEEE.
Nagaki K.,Okayama University |
Yamamoto M.,Kansai University of Welfare Sciences |
Yamaji N.,Okayama University |
Mukai Y.,Osaka Kyoiku University |
Murata M.,Okayama University
PLoS ONE | Year: 2012
Due to the ease with which chromosomes can be observed, the Allium species, and onion in particular, have been familiar materials employed in cytogenetic experiments in biology. In this study, centromeric histone H3 (CENH3)-coding cDNAs were identified in four Allium species (onion, welsh onion, garlic and garlic chives) and cloned. Anti-CENH3 antibody was then raised against a deduced amino acid sequence of CENH3 of welsh onion. The antibody recognized all CENH3 orthologs of the Allium species tested. Immunostaining with the antibody enabled clear visualization of chromosome behavior during mitosis in the species. Furthermore, three-dimensional (3D) observation of mitotic cell division was achieved by subjecting root sections to immunohistochemical techniques. The 3D dynamics of the cells and position of cell-cycle marker proteins (CENH3 and α-tubulin) were clearly revealed by immunohistochemical staining with the antibodies. The immunohistochemical analysis made it possible to establish an overview of the location of dividing cells in the root tissues. This breakthrough in technique, in addition to the two centromeric DNA sequences isolated from welsh onion by chromatin immuno-precipitation using the antibody, should lead to a better understanding of plant cell division. A phylogenetic analysis of Allium CENH3s together with the previously reported plant CENH3s showed two separate clades for monocot species tested. One clade was made from CENH3s of the Allium species with those of Poaceae species, and the other from CENH3s of a holocentric species (Luzula nivea). These data may imply functional differences of CENH3s between holocentric and monocentric species. Centromeric localization of DNA sequences isolated from welsh onion by chromatin immuno-precipitation (ChIP) using the antibody was confirmed by fluorescence in situ hybridization and ChIP-quantitative PCR. © 2012 Nagaki et al.
Niikawa Y.,Kansai University of Welfare Sciences
Proceedings - 2nd IIAI International Conference on Advanced Applied Informatics, IIAI-AAI 2013 | Year: 2013
In order that a specialist may perform 'learning of child and family welfare and reflection of practice', the development of reflective family social work is effective. And, the structure of reflective family social work educational program is reported by this research. Moreover, the reflective family social work practice education which utilized 'Family Support Power Education Program for Continuation and Revival of Independent Learning' was tried. © 2013 IEEE.
Yamamoto M.,Kansai University of Welfare Sciences
Nucleus (India) | Year: 2015
Polyploidization and hybridization are the key components in plant evolution leading to the formation of new species/cultivars with improved traits. Allium L. (Amaryllidaceae) is an economically important genus encompassing great diversity in various morphological characters, particularly in its life forms along with bulbs and rhizomes. The conventional and modern crop improvement approaches have met with limited success in obtaining desired polyploidy / hybrid features in Allium since most of the species either pose crossing barriers or the resultant hybrids show infertility. In order to understand the possible role of chromosome dynamics, the present author studied the cytogenetic factors responsible for failure of polyploidization and hybridization events in an Allium hybrid “Negi-Nira” (A. fisutulosum × A.tuberosum, 2n = 24). The morphological characterization as well as genome organization of “Negi-Nira” has been discussed. It is emphasized that whereas genomic incompatibility may limit inter-specific crossability, the erratic meiosis further drives gametic sterility. The erratic meiosis-directed sterility was confirmed by the crossing experiment by pollinating “Negi-Nira” with the pollen of Welsh onion (donor). However, peculiar reproduction pattern through formation of bulbils (pseudobulbs) might occur consequent to artificial pollination stimulus in Allium. The immunolocalization of chromosome functional components including centromere-specific histone H3 (CENH3), ChIP-isolated centromeric DNA from Welsh onion, rDNA, 5S and tubulin evidently revealed the dynamic distribution pattern on the chromosomes of the onion hybrid “Negi-Nira”. The study suggests that the chromosome dynamics including erratic meiosis accompanied with irregularities in chromosomal functional components, centromeric proteins might have played a vital role in the development of crossing barriers among Allium species leading to the induction of peculiar reproduction ability in their hybrids. © 2016, Archana Sharma Foundation of Calcutta.
Mizutori S.,Kansai University of Welfare Sciences |
Aiba H.,Kyoto Koka Women's University
EPJ Web of Conferences | Year: 2016
The level and width statistics of the two kinds of the random matrix models coupled to the continuum are analyzed. In the first model, the gaussian orthogonal ensemble with random couplings to the continuum, not only the width statistics deviate from the Porter-Thomas distribution due to the super-radiant mechanism, but also the distribution of the nearest neighbor level spacings shows deviation from the Wigner one simultaneously. In the second model, the two body random ensemble with correlated couplings to the continuum, the correlation between the target and the compound states leads to the global energy dependence of the widths. Within the narrow energy interval where states with widths deviating from the global energy dependence lie, the distributions behave similar way with the case of the random couplings. Namely, the deviation of statistics of the nearest neighbor level spacings from the Wigner distribution and the deviation of the width statistics from the Porter-Thomas distribution take place simultaneously within the models we investigated. © The Authors, published by EDP Sciences, 2016.
Shimizu H.,Kansai University of Welfare Sciences
Clinical calcium | Year: 2014
Hypertension, osteoporosis and vascular calcification are major diseases in the recent aging society and may share the same backgrounds genetically and environmentally. As treatments to prevent aging-related diseases simultaneously are desirable, we investigate common backgrounds underling these diseases. Renin- angiotensin system, which causes high blood pressure, is found to be involved in bone metabolism. Angiotensin II has been shown to accelerate osteoporosis through RANKL up-regulation in osteoblast. RANKL, in turn, contributes to vascular calcification by regulating bone morphogenetic protein-2 and MGP expression, as well as bone-related proteins. Angiotensin type 1 receptor blockers (ARBs) ameliorate osteoporosis and vascular calcification beyond their blood pressure lowering effects. These pleiotropic effects of antihypertensive drugs such as ARBs might benefit especially hypertensive postmenopausal women.