Entity

Time filter

Source Type


Yang B.-L.,Beijing University of Chinese Medicine | Ding G.,Jangsu Kanion Pharmaceutical Co.
Zhongguo Zhongyao Zazhi | Year: 2013

Objective: To investigate the efficacy of Qigui Tongfengshu granule in treating gouty arthritis. Method: Qigui Tongfengshu granule was used to treat 16 patients with gouty arthritis for 14 d. Result: The recovery rate, marked effective rate, effective rate and improvement rate were 37.5%, 50%, 6.25%, 6.25%, respectively. The total effective rate was 100%. Before and after treatment, the comparison showed statistical significance. Conclusion: Qigui Tongfengshu granule is significantly effective for gouty arthritis, and has the effect of anti-inflammation, analgesia and reduction in blood uric acid. Source


Hou W.,Nanjing University | Hou W.,State Key Laboratory of Pharmaceutical New Technology for Chinese Medicine | Chen B.,Jangsu Kanion Pharmaceutical Co. | Chen B.,State Key Laboratory of Pharmaceutical New Technology for Chinese Medicine | And 2 more authors.
Zhongguo Zhongyao Zazhi | Year: 2011

Objective: To establish the chromatographic fingerprint for the quality control of gamboge. Method: Analysis on a Luna C8(4.6 mm x250 mm, 5 μ) column eluted with mobile phases containing acetonitrile and 0.1% glacial acetic acid in water in gradient mode. The flow rate was 1.0 mL • min -1 and the detection wavelength was at 362 nm. The temperature of column was 25°C. And data of 11 batches of gamboge samples from different sources were analysed by "similarity evaluation for chromatographic Fingerprint of Traditional Chinese Medicine" software. Result: Thirteen common peaks were selected in chromatograms, and all the common peeks were separated effectively. Conclusion: The precision, repeatability, and stability of this method were satisfying. The method developed can be used to identify and evaluate the quality of gamboge. Source


Zhu Q.-Q.,Nanjing University | Xiao W.,Jangsu Kanion Pharmaceutical Co. | Wang Z.-Z.,Jangsu Kanion Pharmaceutical Co. | Sun Y.-C.,Jangsu Kanion Pharmaceutical Co. | And 2 more authors.
Chinese Traditional and Herbal Drugs | Year: 2013

Objective: To study the application of four kinds of hollow fiber ultrafiltration membranes by taking Qihong Maitong Injection (QMI) microfiltrated liquid as the research object. Methods: Polysulfone, polyether sulfone, polypropylene, and blended composite membranes with the entrapment relative molecular mass of 100000 for ultrafiltration were selected to determine the best appropriate ultrafiltration membrane material. The membrane flux of ultrafiltration was determined by taking the content of active ingredients (Astragalus total saponin, astragaloside IV, and hydroxy safflower yellow A), solid reduction rate, protein reduction rate, related substances, and pyrogen inspection of different membrane materials as the evaluation indexes. Results: The suitability of four different kinds of ultrafiltration membrane materials with the same entrapment relative molecular mass was different. The pure water flux recovery rates of polypropylene, polyether sulfone, and blended composite materials are higher than that of polysulfone material. The component permeation rates of polypropylene and polyether sulfone materials were higher, while the solid and protein reduction rates of polysulfone and blend compound materials were higher. For QMI, the ultrafiltration membrane with entrapment relative molecular mass of 100000 could effectively remove the pyrogen. Conclusion: The polypropylene-100000 ultrafiltration membrane could not only effectively remove the solid and high polymer material, but also keep the active ingredients. It is suitable for the purification of QMI. Source


Li Y.,Nanjing University | Li Y.,State Key Laboratory of Pharmaceutical New Technology for Chinese Medicine | Xiao W.,Jangsu Kanion Pharmaceutical Co. | Xiao W.,State Key Laboratory of Pharmaceutical New Technology for Chinese Medicine | And 6 more authors.
Zhongguo Zhongyao Zazhi | Year: 2012

Objective: To establish an HPLC method for simultaneous determination of contents of loureirin A, loureirin B, 7,4′-dihydroxy flavone, pterostilbene and resveratrol in resina draconis and its extracts. Method: Kromasil 100-5C 18 column (4.6 mm x 250 mm, 5 μm) was used with the mobile phase of acetonitrile-1% glacial acetic acid at a flow rate of 1.0 mL·min -1 and the column temperature at 40°C. The detective wave length of loureirin A and B was detected at 278 nm, and 7,4′-dihydroxy flavone, pterostilbene and resveratrol was at 319 nm. Result: All the five active components reached the resolved peaks within 40 min, indicating a good linearity (r≥0.9997). The average recoveries of loureirin A, loureirin B, 7,4′-dihydroxy flavone, pterostilbene and resveratrol in resina draconis were 102.9%, 96.81%, 97.29%, 100.7% and 103.7%, with RSDs of 0.23%, 1.5%, 0.42%, 0.58% and 0.34%, respectively. The average recoveries of loureirin A, loureirin B, 7,4′-dihydroxy flavone, pterostilbene and resveratrol in extract of resina draconis were 102.2%, 96.93%, 97.90%, 102.0% and 103.3%, with RSDs of 1.7%, 0.91%, 1.4%, 1.5% and 1.2%, respectively. Conclusion: The method is so easy, accurate, highly repeatable and stable that it provides good reference for the quality control of resina draconis and its extracts. Source


Jin M.,Nanjing University of Traditional Chinese Medicine | Jin M.,State Key Laboratory of Pharmaceutical New Technology for Chinese Medicine | Guo Q.,Jangsu Kanion Pharmaceutical Co. | Guo Q.,State Key Laboratory of Pharmaceutical New Technology for Chinese Medicine | And 8 more authors.
Zhongguo Zhongyao Zazhi | Year: 2011

Objective: To study the pharmacokinetics and bioavailability of ginkgolides sustained-release tablet and conventional tablet in Beagle dogs. Method: The concentrations of ginkgolides in plasma were determined by LC-MS. The main pharmacokinetic parameters of ginkgolides sustained-release tablet and conventional tablet in vivo were obtained using Pharmacokinetic software DAS 2.0. Result: The Cmax of grinkgolide A in ginkgolide sustained-release tablet and conventional tablet were 443.51, 1 039.30 μg·L-1, respecitvely. tmax were 2.92, 1.08 h, respectively. AUC0-12 h were 1 808.21, 2 041.37 h·g -1·L-11, respectively. MRT were 5.18, 3.18 h, respectively. The relative bioavailability of ginkgolides A was 88.58%. The Cmax of ginkgolide B in ginkgolide sustained-release tablet and conventional tablet were 407.13, 547.38 μg·L-1, respectively. tmax were 2.92, 1.08 h, respectively. AUC 0-12 h were 1 987.31, 1 748.04 h·μg -1·L-1, respectively. MRT were 6.05, 4.98 h, respectively. The relative bioavailability of ginkgolides B was 113.69%. Conclusion: The ginkgolides sustained-release tablets have good sustained release characteristics and are bioequivalent to the reference formulation. Source

Discover hidden collaborations