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Zhengzhou, China

Duan M.,Kang Xin Comprehensive Ward | Huang G.,Kang Xin Comprehensive Ward | Xu X.,Kang Xin Comprehensive Ward | Cao X.,Kang Xin Comprehensive Ward
Life Science Journal | Year: 2014

Objective By observing the clinical efficacy and drug side effects of lipid-lowering treatment of ezetimibe combined with atorvastatin calcium, we evaluated the value of ezetimibe in postoperative patients' blood lipids management after interventional therapy of acute coronary syndrome. Method 160 abnormal plasma lipid patients with acute coronary syndrome who accepted coronary artery interventional therapy in our hospital, were randomly divided into two groups-the control group taking atorvastatin calcium tablets, the experimental group taking ezetimibe and atorvastatin calcium tablets, we compared the changes and side effects of low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) after treatment for a month between the two groups. Result After 30 days, TC, TG (Trigly cerides) and LDL-C in plasma of the experimental group are lower than the other group (p<0.01). Conclusion The clinical effect of ezetimibe combined with atorvastatin calcium tablets in treating hyperlipemia was obviously superior to taking atorvastatin calcium tablets alone, such as making the blood fat standardized earlier and without increasing side effects, which was particularly suitable for substandard plasma lipid patients after interventional treatment of acute coronary syndrome. Source


Mingqin D.,Kang Xin Comprehensive Ward | Lixia W.,Kang Xin Comprehensive Ward | Xuanchao C.,Kang Xin Comprehensive Ward | Xianjing X.,Kang Xin Comprehensive Ward
Life Science Journal | Year: 2014

Objective To detect the NF-κB expression of mononuclear cells in peripheral blood of older patients with acute coronary syndrome before and after drugs treatment, and discuss the relations and clinical significance among NF-κB, coronary artery lesions and drug efficacy. Method Choosing 88 older patients with acute coronary syndrome (ACS) who were verified by coronary angiography as the research group and additionally 56 older patients with normal coronary angiography as a control group, taking all patients' blood sample from cubital veins respectively after admission and treatment for a month, determining the NF-κB expressing activity of mononuclear cells in peripheral blood by flow cytometry, and then observing the changes before and after treatment. Result There was no statistical difference in gender, age, TC and HDL-C between the two groups, but the proportion of diabetes and TC, LDL-C levels in patients of ACS group were significantly higher than those in the control group (P<0.01); levels of hs-CRP, NF-κ B patients with ACS were significantly higher than those of control group (P<0.01). In ACS group levels of hs-CRP and NF-κB decreased obviously after treatment for a month (P<0.01). Conclusion A detection for levels of NF-κ B expression activity not only has a certain clinical significance in pathogenetic condition and prognosis estimation, but also has a certain value on assessing the curative effect of crown expansion drugs of ACS, lipid-lowering drugs and platelet aggregation inhibitors. Source

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