Kanagawa Prefectural Cardiovascular and Respiratory Disease Center

Yokohama-shi, Japan

Kanagawa Prefectural Cardiovascular and Respiratory Disease Center

Yokohama-shi, Japan
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Sakai F.,Saitama University | Ogura T.,Kanagawa Prefectural Cardiovascular and Respiratory Disease Center | Iwasawa T.,Kanagawa Prefectural Cardiovascular and Respiratory Disease Center | Yanagawa N.,Komagome Hospital | Takemura T.,Red Cross
Japanese Journal of Chest Diseases | Year: 2013

Combined pulmonary fibrosis and emphysema (CPFE) is defined as pulmonary emphysema in the upper lungs and interstitial pneumonia of varying types in the lower lung at CT. This syndrome is defined by imaging findings and clinical characteristics, including heterogeneous diseases, the coincidence of pulmonary fibrosis and idiopathic interstitial pneumonia to pulmonary fibrosis is deeply related to smoking. CT findings of CPFE vary because many kinds of diseases are included in the concept.


Sakai F.,Saitama University | Tominaga J.,Saitama University | Kaga A.,Saitama University | Usui Y.,Saitama University | And 4 more authors.
Pulmonary Medicine | Year: 2012

Based on clinical and radiological findings, Cottin defined combined pulmonary fibrosis and emphysema (CPFE) as pulmonary emphysema in the upper lungs and interstitial pneumonia in the lower lungs with various radiological patterns. Pathologic findings of CPFE probably corresponded with diffuse interstitial pneumonia with pulmonary emphysema, emphysema with fibrosis, and the combination of both. We described reported radiological findings of CPFE. © 2012 Fumikazu Sakai et al.


Sakai F.,Saitama University | Tominaga J.,Saitama University | Iwasawa T.,Kanagawa Prefectural Cardiovascular and Respiratory Disease Center | Ogura T.,Kanagawa Prefectural Cardiovascular and Respiratory Disease Center
Japanese Journal of Chest Diseases | Year: 2012

Combined pulmonary fibrosis and emphysema (CPFE) was advocated by Cottin V et al. in 2005. They defined CPFE by clinical and radiological features ; pulmonary emphysema in the upper lung and various patterns of interstitial fibrosis, and most frequently the UIP pattern. CPFE shows characteristic pulmonary function tests (normal FEV1% and decreased DLCO despite severe emphysema) and imaging features. We will describe the imaging and pathologic features of CPFE. Imaging characteristics of CPFE include emphysema in the upper lung and pulmonary fibrosis in the lower lungs. The most striking imaging feature is multiple large thick walled cysts ; sometimes in subpleural regions in the upper lungs and within foci of fibrosis in the lower lungs. Lung cancer is frequently seen in CPFE patients. Pathologically, the UIP pattern is the most frequent pattern ; however, bronchocentric fibrosis is also frequently seen suggesting a deep relationship with smoking. We will discuss feature issues in the progressive clinical investigation concerning CPFE.

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