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Takeda R.,Kobe University | Naka A.,Kobe University | Ogane N.,Kanagawa Prefectural Ashigarakami Hospital | Kameda Y.,Kanagawa Prefectural Ashigarakami Hospital | And 4 more authors.
Breast Cancer: Basic and Clinical Research | Year: 2015

Adding platinum drugs to anthracycline/taxane (ANC-Tax)-based neoadjuvant chemotherapy (NAC) improves pathological com-plete response (pCR) rates in triple-negative breast cancer (TNBC). Copper transporter 1 (CTR1) and organic cation transporter 2 (OCT2) critically affect the uptake and cytotoxicity of platinum drugs. We immunohistochemically determined CTR1 and OCT2 levels in pre-chemotherapy biopsies from 105 patients with HER2-negative breast cancer treated with ANC-Tax-based NAC. In the TNBC group, Ki-67high[pathological good response (pGR), P = 0.04] was associated with response, whereas CTR1high(non-pGR, P = 0.03), OCT2high(non-pGR, P = 0.01; non-pCR, P = 0.03), and combined CTR1high and/or OCT2high(non-pGR, P = 0.005; non-pCR, P = 0.003) were associated with non-response. In multivariate analysis, Ki- 67highwas an independent factor for pGR and CTR1 for non-pGR. Combined CTR1/OCT2 was a strong independent factor for non-pGR. How-ever, no variables were associated with response in luminal BC. These results indicate that platinum uptake transporters are predominantly expressed in ANC-Tax-resistant TNBCs, which implies that advantage associated with adding platinum drugs may depend on high drug uptake. © the authors, publisher and licensee Libertas Academica Limited. Source


Numata K.,Yokohama City University | Numata K.,International University of Health and Welfare | Hasegawa S.,Keiseikai Kamishirane Hospital | Tsuchida K.,Yokohama City University | And 7 more authors.
Yokohama Medical Journal | Year: 2014

Objective: The aim of this prospective study was to evaluate the postoperative pain after hernioplasty with an ULTRA PRO Plug (UPP), which is a new light weight/large pore mesh. We compared the pain with that in patients treated with heavy weight mesh using the Prolene Hernia System (PHS) around the same time at a single institution. Materials & Methods: One hundred and three patients were treated with UPP or PHS. The postoperative pain (at rest/with movement) was assessed by means of a visual analogue scale (VAS) one day, one week, one month, six months and one year after surgery. This study was started in April 2009. Result: Between April 2009 and November 2010, fifty-two patients underwent hernioplasty with UPP (group U), while fifty-one patients underwent treated with PHS (group P). There were no significant differences in the frequencies of complaints with respect to the postoperative pain, but fewer patients complained of postoperative pain in group U. The early postoperative pain assessed by the VAS was less in group U than group P. There was one case of recurrence in each of the groups. Conclusion: UPP may be preferable to PHS for hernioplasty. However, larger randomized studies with a longer follow-up are needed to confirm our results. Source


Iwata Y.,Kanagawa Prefectural Ashigarakami Hospital | Kunishi Y.,Kanagawa Prefectural Ashigarakami Hospital | Yoshie K.,Kanagawa Prefectural Ashigarakami Hospital
Internal Medicine | Year: 2015

We herein report a case regarding a 90-year-old woman with a history of recurrent episodes of urinary tract infections presenting with fever. Urinalysis revealed bacteria and white blood cells. Computed tomography showed dilated and fecally loaded rectum and colon with signs of obstructive uropathy. The patient was treated for urinary tract infection and constipation. Her bowel habits were controlled with lubiprostone, and she was discharged in good medical condition. This case highlights the importance of considering fecal impaction as a cause of urinary tract obstruction or infection. © 2015 The Japanese Society of Internal Medicine. Source


Yamada T.,Kanagawa Prefectural Ashigarakami Hospital | Kodato T.,Kanagawa Prefectural Ashigarakami Hospital | Shirai J.,Kanagawa Prefectural Ashigarakami Hospital | Kamiya M.,Kanagawa Prefectural Ashigarakami Hospital | And 10 more authors.
Japanese Journal of Cancer and Chemotherapy | Year: 2014

We report a case of an intractable fistula repaired by transsacral direct suture. A 65-year-old man underwent low anterior resection for rectal cancer. He subsequently underwent ileostomy due to anastomosis leakage. The fistula of the anastomosis persisted 3 months after surgery. He underwent surgery to repair the fistula using a transsacral approach. After removing the coccyx, the fistula in the postrectal space was exposed directly. The presence of the fistula was confirmed by an air leak test and was closed by direct suture. After 33 days, the patient underwent ileostomy closure. Source


Numata K.,Kanagawa Prefectural Ashigarakami Hospital | Tsuchida K.,Kanagawa Prefectural Ashigarakami Hospital | Yoshida T.,Kanagawa Prefectural Ashigarakami Hospital | Osaragi T.,Kanagawa Prefectural Ashigarakami Hospital | And 6 more authors.
Japanese Journal of Gastroenterological Surgery | Year: 2013

Purpose: We assessed the usefulness of the estimation of physiologic ability and surgical stress (E-PASS) and the revised version of Hasegawa's dementia scale; revised (HDS-R) for predictive value in occurrence of postoperative delirium for elderly patients who had digestive surgical operations. Methods: Seventy-two patients assessed by HDS-R before operation were evaluated by E-PASS. We assessed the preoperative risk score (PRS) before the operation, and surgical stress score (SSS) and comprehensive risk score (CRS) were assessed after the operation. Results: Of all patients, 19.4% (14 patients) developed postoperative delirium. Patients with postoperative delirium were significantly older, with poorer PS (≥2), ASA score (≥3), lower PNI, lower HDS-R score, and higher CRS. Multivariate analysis identified HDS-R and CRS as independent predictors of the occurrence of postoperative delirium (OR 0.77 and 30.3, 95% CI 0.648-0.915 and 1.58-582, P=0.0031 and 0.0237). Of the patients whose HDSR score was 23 or less and CRS score of 0.35 or more, 83.3% developed postoperative delirium. Conclusion: HDSR and E-PASS could be helpful for the prediction of postoperative delirium. © 2013 The Japanese Society of Gastroenterological Surgery. Source

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