Kampala International University

Kampala, Uganda

Kampala International University ] is a private multi-campus university in Uganda, the third-largest economy in the East African Community. Wikipedia.

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Ajayi A.M.,Kampala International University | Ajayi A.M.,University of Ibadan | Tanayen J.K.,Kampala International University | Magomere A.,Kampala International University | Ezeonwumelu J.O.C.,Kampala International University
Journal of Intercultural Ethnopharmacology | Year: 2017

Aim: Chenopodium opulifolium is a specie of the Chenopodiaceae commonly used as vegetables in local diet and for treating different ailment in Uganda. This study was conducted to evaluate the antioxidant, antinociceptive and anti-inflammatory effects of the aqueous extract of C. opulifolium leaves (AECO). Materials and Methods: The dried leaf of the plant was extracted by maceration in water. Qualitative and quantitative phytochemical analysis, antioxidants, and membrane stabilizing effects were determined in the extract. The extract was then investigated for acute toxicity, antinociceptive (writhing, hot plate and open field test), and anti-inflammatory (egg albumin-induced paw edema) effects in rodents. Results: Phytochemical analysis revealed the presence of alkaloids, tannins, phlobatannins, flavonoids, and saponins in AECO. Total caffeic acid derivatives and total flavonoids content were 91.7 mgCAE/g sample and 94.7 mgRE/g sample, respectively. AECO demonstrated antioxidant effects in both 1,1-diphenyl-2-picryl-hydrazyl and NO assays. Significant membrane stabilizing activity was observed in both the heat and hypotonic solution-induced lysis of erythrocytes. The acute toxicity test showed that AECO (5000 mg/kg) did not cause any significant change in behavior or death in rats. AECO (100-400 mg/kg) produced a significant antinociceptive effect in both the writhing and hot plate tests, but no significant reduction in the locomotory activity in mice. Furthermore, the extract significantly (P < 0.05) reduced egg albumin-induced rat paw edema by 44.2%, 44.5%, and 51.2%, respectively, after 120 min. Conclusion: The results showed that C. opulifolium extract possesses significant antioxidant, antinociceptive and anti-inflammatory effects, and these affirm the reasons for its folkloric use. © EJManager.

Komolafe A.T.,University of Ibadan | Yara P.O.,Kampala International University
European Journal of Scientific Research | Year: 2010

English Language plays a prominent role in the Nigerian educational system. It is a second language that is learned and used extensively in addition to the mother tongues. The study investigated the impact of Sentence Combining Instructional Strategy on primary school pupils' achievement in written English in and attitude to composition writing. The study adopted a pretest, posttest control quasi-experimental design. Two hundred and ninety primary five pupils from 12 schools randomly drawn from public primary schools in Akinyele Local Government Area of Oyo state were used for the study. Two validated instruments Achievement Test in Composition Writing (ATCW) and Operational Guide for Instruction (OGI) were used to collect data for analysis. Three hypotheses were answered. The data were analysed using descriptive, inferential statistics, ANCOVA and MCA. The results showed there was significant main effect of treatment on pupils achievement in written English expression (F (2,287) = 17.475; p<.05) and there was significant main effect of gender on pupils' attitude to written English expression (F(1,288) = 11.602; p<.05). There was significant interaction effect of treatment and gender on pupils' attitude to written English expression (F(2,287) = 3.993; p<.05). It is recommended that teachers and textbook writers should adopt these techniques for classroom practice and development of curriculum materials. © EuroJournals Publishing, Inc. 2010.

Nansunga M.,Kampala International University | Barasa A.,Kampala International University | Abimana J.,Kampala International University | Alele P.E.,Sudan University of Science and Technology | Kasolo J.,Makerere University
Journal of Ethnopharmacology | Year: 2014

Ethnopharmacological relevance Priva adhaerens (Forssk.) Chiov., a wildly growing plant, is reported in central Uganda to be an effective traditional remedy for diarrhea. The objective of this study was to provide a scientific basis for the ethnopharmacological utility of this plant whose aqueous leaf and shoot extract was evaluated for acute toxicity and antidiarrheal activity using a murine model. Materials and methods Acute toxicity of the aqueous leaf and shoot extract was assessed after determining the major phytochemicals present in the extract. The aqueous leaf and shoot extract was assayed against castor oil-induced diarrhea, transit time, and enteropooling, in comparison to loperamide, a standard drug. Results The oral LD50 value obtained for Priva adhaerens aqueous extract was greater than 5000 mg/kg in rats; the aqueous leaf and shoot extract possessed several important phytochemicals. Furthermore, the aqueous extract significantly, and dose-dependently, reduced frequency of stooling in castor oil-induced diarrhea, intestinal motility, and castor oil-induced enteropooling in rats. Conclusion This murine model shows that it is relatively safe to orally use the aqueous leaf and shoot extract of Priva adhaerens. The aqueous extract contains phytochemicals that are active for the treatment of diarrhea in a rat model. © 2014 Elsevier Ireland Ltd.

Sekabira; K.,Kampala International University | Oryem Origa; H.,Makerere University | Basamba; T.A.,Makerere University | Mutumba; G.,Makerere University | Kakudidi E.,Makerere University
International Journal of Environmental Science and Technology | Year: 2010

Water quality monitoring in developing countries is inadequate, especially in stream water affected by urban effluents and runoff. The purpose of this study was to investigate heavy metal contaminants in the Nakivubo Stream water in Kampala, Uganda. Water samples Nakivubo Channelized Stream, tributaries and industrial effluents that drain into the stream were collected and analysed for the total elemental concentration using flame atomic absorption spectrophotometer. The results showed that: 1) the wastewater was highly enriched with lead and manganese above the maximum permissible limit; 2) the levels of dissolved oxygen were below the maximum permissible limit, while the biological oxygen demand was above the maximum permissible limit. All industrial effluents/wastewater were classified as strong (> 220 mg/L). Factor analysis results reveal two sources of pollutants; 1) mixed origin or chemical phenomena of industrial and vehicular emissions and 2) multiple origin of lead (vehicular, commercial establishment and industrial). In conclusion, Nakivubo Channelized Stream water is not enriched with heavy metals. These heavy metals (lead, cadmium and zinc) were rapidly removed by co-precipitation with manganese and iron hydroxides and total dissolved solids into stream sediments. This phenomena is controlled by pH in water. © IRSEN, CEERS, IAU.

Sekabira K.,Kampala International University | Origa H.O.,Makerere University | Basamba T.A.,Makerere University | Mutumba G.,Makerere University | Kakudidi E.,Makerere University
International Journal of Environmental Science and Technology | Year: 2010

Globally, aquatic ecosystems are highly polluted with heavy metals arising from anthropogenic and terrigenous sources. The objective of this study was to investigate the pollution of stream sediments and possible sources of pollutants in Nakivubo Channel Kampala, Uganda. Stream sediments were collected and analysed for heavy metal concentration using flame atomic absorption spectrophotometer. The degree of pollution in Nakivubo channelized stream sediments for lead, cadmium, copper, zinc, manganese and iron was assessed using enrichment factor, geo-accumulation index and pollution load index. The results indicated that (1) the sediments have been polluted with lead, cadmium and zinc and have high anthropogenic influences; (2) the calculation of geo-accumulation index suggest that Nakivubo stream sediments have background concentration for copper, manganese and Fe (Igeo < 0); (3) factor analysis results reveal three sources of pollutants as explained by three factors (75.0%); (i) mixed origin or retention phenomena of industrial and vehicular emissions; (ii) terrigenous and (iii) dual origin of zinc (vehicular and industrial). In conclusion, the co-precipitation (inclusion, occlusion and adsorption) of lead, cadmium and zinc with manganese and iron hydroxides, scavenging ability of other metals, very low dissolved oxygen and slightly acidic to slightly alkaline pH in stream water could account for the active accumulation of heavy metals in Nakivubo stream sediments. These phenomena may pose a risk of secondary water pollution under sediment disturbance and/or changes in the geo-chemistry of sediments. © IRSEN, CEERS, IAU.

Sekabira K.,Kampala International University | Origa H.O.,Makerere University | Basamba T.A.,Makerere University | Mutumba G.,Makerere University | Kakudidi E.,Makerere University
International Journal of Environmental Science and Technology | Year: 2011

Biological technologies for wastewater remediation techniques employed to remove contaminants in urban stream water are increasingly receiving attention worldwide. The purpose of this study was therefore to determine the concentrations of lead, cadmium, copper, zinc, manganese and iron in algal biomass and establish the feasibility of using algae in phytoextraction and bio-monitoring of environmental quality. Analysis of algal biomass samples in the Nakivubo urban stream ecosystem, Kampala, Uganda, showed that there was contamination by lead, cadmium, copper and zinc as indicated by enrichment factor and pollution load index values. It is suspected that industrial and vehicular emissions are the major sources of these pollutants. Calculated bio-concentration factor was ≥ 1000 but with low concentration thresholds in each element, suggesting that algal biomass was a very good heavy metal accumulator. The bio-concentration values in algal biomass were found to be in the order of copper > zinc > lead > cadmium in the Nakivubo Channelized stream. In conclusion, algae can be a promising aquatic bio-fil ter plant for phytoextraction andbio-monitoring of polluted urban stream ecosystems and wastewater. © IRSEN, CEERS, IAU.

Pule S.,Kampala International University
International Journal of Supply Chain Management | Year: 2014

This paper describes the relationship between supply chain information management and service delivery efficiency in public health sector organizations. The three specific objectives of this paper are to: examine the relationship between supply chain information processing and service delivery; assess the relationship between supply chain information storage and service delivery; and lastly, to evaluate the relationship between supply chain information flow and service delivery. The researcher employed a positivist approach using a descriptive, case study and correlational designs. Using a researcher's made five point Likert scale questionnaire, data was collected from a sample of 148 respondents. Of these, 56 respondents were from the National Medical Stores (NMS), while 92 were from supplementary sources (Mulago Hospital and Kisenyi Health Centre IV). Data was analyzed using means, and the Pearson Linear Correlation Coefficient. Findings revealed that, supply chain information management was at an average mean of 3.97, interpreted as high, while service delivery management was at an average mean of 2.94, interpreted as moderate. Correlation results on the other hand, indicated a positive and significant relationship between supply chain information management and service delivery of r-value 76% and Sig. value of 0.002. In light of this, the researcher therefore concludes that, supply chain information management positively contributes to service delivery, and that the findings of this paper can act as a cornerstone for managers to comprehend the importance of information management within the supply chain process, and in particular, appreciate the value of data collection, information storage and sharing within the supply chain network, if service delivery decisions are to be maximised. © ExcelingTech Pub, UK.

Syed M.A.,COMSATS Institute of Information Technology | Syed M.A.,Kampala International University
Biosensors and Bioelectronics | Year: 2014

Infectious diseases account for millions of sufferings and deaths in both developing as well as developed countries with a substantial economic loss. Massive increase in world population and international travel has facilitated their spread from one part of the world to other areas, making them one of the most significant global health risks. Furthermore, detection of bioterrorism agents in water, food and environmental samples as well traveler's baggage is a great challenge of the time for security purpose. Prevention strategies against infectious agents demand rapid and accurate detection and identification of the causative agents with highest sensitivity which should be equally available in different parts of the globe. Similarly, rapid and early diagnosis of infectious diseases has always been indispensable for their prompt cure and management, which has stimulated scientists to develop highly sophisticated techniques over centuries and the efforts continue unabated. Conventional diagnostic techniques are time consuming, tedious, expensive, less sensitive, and unsuitable for field situations. Nanodiagnostic assays have been promising for early, sensitive, point-of-care and cost-effective detection of microbial agents. There has been an explosive research in this area of science in last two decades yielding highly fascinating results. This review highlights some of the advancements made in the field of nanotechnology based assays for microbial detection since 2005 along with providing the basic understanding. © 2013 Elsevier B.V.

Yusuf S.,Kampala International University | Baden T.,University of Tübingen | Prieto-Godino L.L.,University of Lausanne
Metabolic Brain Disease | Year: 2014

Advances in neuroscience research over the last few decades have increased our understanding of how individual neurons acquire their specific properties and assemble into complex circuits, and how these circuits are affected in disease. One of the important motives driving neuroscience research is the development of new scientific techniques and interdisciplinary cooperation. Compared to developed countries, many countries on the African continent are confronted with poor facilities, lack of funding or career development programs for neuroscientists, all of which deter young scientists from taking up neuroscience as a career choice. This article highlights some steps that are being taken to promote neuroscience education and research in Africa. © 2013 Springer Science+Business Media.

Agwu E.,Kampala International University | Ihongbe J.C.,Ambrose Alli University | McManus B.A.,Trinity College Dublin | Moran G.P.,Trinity College Dublin | And 2 more authors.
Medical Mycology | Year: 2012

Oropharyngeal candidiasis remains a significant clinical problem in HIV-infected and AIDS patients in regions of Africa where anti-retroviral therapy isn't readily available. In this study we identified the yeast populations associated with oral lesions in HIV-infected patients in Southwest Uganda who were receiving treatment with nystatin and topical clotrimazole. Samples were taken from 605 patients and 316 (52%) of these yielded yeast growth following incubation on Sabouraud dextrose agar. Samples were subsequently re-plated on CHROMagar Candida medium to facilitate identification of the yeast species present. The majority (56%) of culture-positive samples yielded a mix of two or more species. Candida albicans was present in 87% (274/316) of patient samples and accounted for 87% (120/138) of single species samples. Candida glabrata, Candida tropicalis and Candida norvegensis were also found in cultures that yielded a single species. No Candida dubliniensis isolates were identified in this population. © 2012 ISHAM.

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