Kamineni Institute of Medical science

Narketpally, India

Kamineni Institute of Medical science

Narketpally, India
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Laxma Reddy P.V.,University of Texas at El Paso | Kavitha B.,Kamineni Institute of Medical science | Kumar Reddy P.A.,Yeungnam University | Kim K.-H.,Hanyang University
Environmental Research | Year: 2017

The TiO2 based photocatalyst has great potential for the disinfection/inactivation of harmful pathogens (such as E.coli in aqueous media) along with its well-known usefulness on various chemical pollutants. The disinfection property of TiO2 is primarily attributed to surface generation of reactive oxygen species (ROS) as well as free metal ions formation. Furthermore, its disinfection capacity and overall performance can be significantly improved through modifications of the TiO2 material. In this review, we provide a brief survey on the effect of various TiO2 materials in the disinfection of a wide range of environmentally harmful microbial pathogens (e.g., bacteria, fungi, algae, and viruses) in aqueous media. The influencing factors (such as reactor design, water chemistry, and TiO2 modifications) of such processes are discussed along with the mechanisms of such disinfection. It is believed that the combined application of disinfection and decontamination will greatly enhance the utilization of TiO2 photocatalyst as a potential alternative to conventional methods of water purification. © 2017 Elsevier Inc.

Borra S.K.,Kamineni Institute of Medical science | Lagisetty R.K.,Kamineni Institute of Medical science | Mallela G.R.,Kamineni Institute of Medical science
African Journal of Pharmacy and Pharmacology | Year: 2011

This study was performed to determine the effects of Aloe vera on indomethacin induced ulcers in rats. Albino rats (Wister strain) of either sex weighing between 150 and 200 gms were randomly allotted into four groups with six animals each. Indomethacin was administered orally in the dose of 20 mg/kg body weight and kept fasting for 6 h. A. vera powder was mixed with gum acacia, the solution was administered orally through the oral gavage to rats in the dose of 200 mg/kg. Omeprazole (20 mg/kg) was administered intraperitoneally as a standard drug for present study. At the end of the study, rats were sacrificed and stomachs were opened and stored in 5% formalin solution, ulcer index and histological changes were studied. Student-'t' test analysis was used for the present study. It was found that A. vera showed statistically significant anti-ulcer activity comparable to standard drug omeprazole. The mean ulcer indexes of two drugs were statistically significant (P value is < 0.001). Therefore, the results were suggestive of anti ulcerogenic activity of A. vera. ©2011 Academic Journals.

Banji D.,P.A. College | Pinnapureddy J.,P.A. College | Banji O.J.F.,P.A. College | Saidulu A.,P.A. College | Hayath M.S.,Kamineni Institute of Medical science
European Journal of Pharmacology | Year: 2011

Methotrexate is employed in low doses for the treatment of rheumatoid arthritis. One of the major drawbacks with methotrexate is hepatotoxicity resulting in poor compliance of therapy. Curcumin is an extensively used spice possessing both anti-arthritic and hepatoprotective potential. The present study was aimed at investigating the effect of curcumin (30 and 100 mg/kg) in combination with subtherapeutic dose of methotrexate (1 mg/kg) is salvaging hepatotoxicity, oxidative stress and producing synergistic anti-arthritic action with methotrexate. Wistar albino rats were induced with arthritis by subplantar injection of Freund's Complete Adjuvant and pronounced arthritis was seen after 9 days of injection. Groups of animals were treated with subtherapeutic dose of methotrexate followed half an hour later with 30 and 100 mg/kg of curcumin from day 9 up to days 45 by intraperitoneal route. Methotrexate treatment in Freund's Complete Adjuvant induced arthritic animals produced elevation in the levels of aminotransferases, alkaline phosphatase, total and direct bilirubin. Enhanced oxidative stress in terms of measured lipid peroxides was observed in the methotrexate treated group. Curcumin significantly circumvented hepatotoxicity induced by methotrexate as evidenced by a change in biochemical markers possibly due to its strong anti-oxidant action. Hepatoprotective potential of curcumin was also confirmed from histological evaluation. Sub-therapeutic dose of methotrexate elicited substantial anti-arthritic action when used in combination with curcumin implying that the latter potentiated its action. Concomitant administration of curcumin with methotrexate was also found to minimize liver damage. © 2011 Elsevier B.V.

Metta S.,Gandhi Medical College | Basalingappa D.R.,Kamineni Institute of medical science | Uppala S.,Dr Pinnamaneni Sidhartha Institute of Medical science and Research Foundation | Mitta G.,Gandhi Medical College
Journal of Clinical and Diagnostic Research | Year: 2015

Background: Cigarette smoke promotes atherogenesis by producing oxygen-derived free radicals. Aim: The present study was conducted to determine the effect of cigarette smoking on lipid peroxidation and erythrocyte antioxidant status in ischemic heart disease (IHD). Materials and Methods: A total of 327 male subjects were enrolled for this study, divided into two groups consisting of 200 patients, who were consecutively admitted for IHD in the intensive cardiac care unit (ICCU) of a Government Hospital and 127 age matched male healthy subjects. Both the groups were subsequently categorised into smokers and non smokers sub groups depending upon the smoking history {>/= 20 pack years of smoking; (20 cigarettes per day for one year constitutes one pack year)}. All 327 subjects were investigated for lipid profile, malondialdehyde (MDA) levels and the antioxidant enzymes catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPX). Statistical Analysis: The differences in the parameters between the groups were tested for significance by one way ANOVA using the SPSS software version 19. A p-value of < 0.001 was considered to be significant statistically. Multiple comparisons were made between all the four groups by Post Hoc Tukey test. Results: There was highly significant difference (p<0.001) observed in GPX activity, in comparison to CAT and SOD (p=0.032, p=0.009) between smokers vs non smokers in control group as well as patient group. The plasma MDA levels were found to be increased significantly (p<0.001) in IHD patients, who smoked as compared to those who did not. Conclusion: Chronic smoking enhances erythrocyte lipid peroxidation in IHD patients with concomitant failure of both plasma and erythrocyte antioxidant defense mechanisms. Along with conventional lipid markers and plasma MDA levels, the erythrocyte GPX activity was observed to be a better marker of oxidative stress, in chronic smokers, who are at risk of developing IHD. © 2015, Journal of Clinical and Diagnostic Research. All rights reserved.

Sheikh N.A.,Kamineni Institute of Medical science
Indian Journal of Forensic Medicine and Toxicology | Year: 2012

Hospitals' committed to patient care and community healths have been cited to paradoxically defy their own objectives. On one hand they cure patients and on the other, have emerged as a source of several diseases. The Hospital waste is of special kind of waste. By the nature of its origin, hospital waste can become a health hazard and in extreme cases a source of epidemic. In order to provide for better management of hospital waste the Bio-medical (Handling and Management) Rules, 1998 was notified under the Environment Protection Act, 1986. The problem of hospital waste is more of quality as compared to quantity. It has been computed by the WHO that the average waste generated by hospitals in developed countries is in the range of 1-5 kg/bed/day, in comparison, the average for developing countries is between 1 to 2 kg/bed/day. This calls for coordination between all hospital departments that generate waste and agencies employed for the segregation, collection, transportation, treatment and disposal of waste.

Nirgude A.S.,Kamineni Institute of Medical science
Indian journal of public health | Year: 2010

Fluorosis is an important public health problem in certain parts of India. Nalgonda is one of the fluorosis endemic districts of Andhra Pradesh. A cross-sectional study was undertaken to assess the prevalence of dental and skeletal fluorosis in Panagal, one of the urban slum areas of Nalgonda town of Andhra Pradesh. 265 individuals residing in 92 households of five colonies of Panagal were selected by multi-stage random sampling. Fluorosis was assessed by standard clinical methods and water samples were tested for fluoride level. It was observed that mean fluoride level in ground water samples in the area was 4.01 mg/l and that of Nagarjunsagar water was 0.74 mg/l. The mean age of the study subjects in the area was 34.73 years. The overall prevalence of skeletal fluorosis was 24.9% and that of dental fluorosis was 30.6%. The prevalence increased with age. Skeletal and dental fluorosis is endemic in the study area.

Kotha G.K.,Kamineni Institute of Medical science | Venkatramana B.J.,Kamineni Institute of Medical science | Maryada V.R.,Kamineni Institute of Medical science | Jawalkar H.,Kamineni Institute of Medical science
Journal of Hand Surgery | Year: 2014

We report a case of nodular fasciitis occurring on the dorsum of the right middle finger, the dorsum of the right hand, and the right upper back associated with cortical erosions of the scapula. Ray amputation of the middle finger and marginal excision of the hand and periscapular masses were performed. There was no recurrence of the tumor at either site a year later. Copyright © 2014 by the American Society for Surgery of the Hand. All rights reserved.).

Sujatha V.V.,Kamineni Institute of Medical science
Tropical Doctor | Year: 2012

We present two cases of retained intrauterine contraceptive devices (IUCDs).The first presented with perimenopausal bleeding and dysmenorrhoea and the symptomswere resolved following the removal of an IUCD. The second presented with postmenopausal bleeding and had a Lippes loop in the uterine cavity.The symptoms resolved after the removal of the device.

Shetty S.,Kamineni Institute of Medical science
Indian Journal of Otolaryngology and Head and Neck Surgery | Year: 2012

Tympanoplasty is one of the ever evolving surgical procedures mainly aimed at restoring the hearing loss and eradication of middle ear disease. We have made an attempt to assess the hearing improvement of various types and techniques of tympanoplasty. A prospective observational study was done on 50 cases of CSOM, of which 45 cases were tubotympanic type, and 5 cases were attico-antral. Patients of only pure conductive component with good cochlear reserve and good Eustachian tube function were considered for the study. This study aims at assessing the hearing improvement with various types of tympanoplasty. © 2011 Association of Otolaryngologists of India.

Sandhya Manohar W.,Kamineni Institute of Medical science
Indian Journal of Forensic Medicine and Toxicology | Year: 2016

Background: The semantic meaning of crime against women is direct or indirect physical or mental cruelty to women. Latest figures from the National Crime Records Bureau show that a crime was recorded against women every three minutes. Every hour, at least two women are sexually assaulted and every six hours, a young married woman is beaten to death, burnt or driven to suicide. Material and Method: The present study was carried out by retrospective evaluation of Sexual crimes against women; all the cases of Sexual crimes against women reported during the year 2012 to 2014 were selected for the study. Results: Total of 3,37,922 cases of crime against women were reported in the country during the year 2014. The IPC component of crimes against women has accounted for 93.91% of total crimes and the rest 6.08% were SLL crimes against women. Rape under section 376 of IPC accounts for maximum 83.4% whereas custodial rape accounts for 0.48% and Gang Rape accounts for 5.7% in the year 2014. Attempt to commit Rape account for 10.3% in this year. 19.89% of the total victims of rape were girls under 15 years of age, 44.1% were women in the age-group 18-29 years. It is to be noted that 29.5% of incest rape victims were in age group of 12-15 years. Conclusion: The result of the study clearly points to the enactment of laws alone against sexual crimes against women cannot offer a sure remedy for these social evils. Early intervention and prevention may be the most effective way to address this constellation of disadvantage. The complex issue can be tackled by providing comprehensive care pro-actively. © 2016, Indian Journal of Forensic Medicine and Toxicology. All rights reserved.

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