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Sukla P.,Sss Medical College And Research Institute | Zaidi S.H.N.,Sss Medical College And Research Institute | Sharma K.D.,Kamineni Academy of Medical science and Research Center
Indian Journal of Public Health Research and Development | Year: 2015

Objective: To study the different health and psycho-social problems of the elderly people in rural South Andhra Pradesh. Method: A cross- sectional study was carried out to assess the health and psycho-social problems among the elderly persons. A pilot study was conducted distributing questionnaires to the respondents with the help of their relatives. Results: Among the total 122 participants, 69 males and 53 females participated in the study. The most common health problems encountered among the elderly include problems of eye- sight, hearing, joint pains, nervous disorders, weakness, complaints related to heart, asthma, urinary problems and others. More health problems were reported by women compared to men. Conclusion: Certain common specific factors that influence the health and psycho-social problems among the elderly belong to gender-wise distribution. Hence, these findings raise a number of issues for formulating appropriate health policies for the elderly. © 2015, Indian Journal of Public Health Research and Development. All Rights Reserved.

Beedimani R.S.,Kamineni Academy of Medical science and Research Center | Kalmath B.,Al Badar Rural Dental College and Hospital
International Journal of Pharma and Bio Sciences | Year: 2014

Phosphodiesterase 5 (PDE5) is a key enzyme involved in the regulation of cGMPspecific signaling pathways in normal physiological processes such as smooth muscle contraction and relaxation. Initially, PDE5 inhibitors were developed as potential antianginal agents, but early clinical results were disappointing and the focus of these drugs moved to the treatment of Erectile Dysfunction (ED) based on the findings that nitric oxide and cyclic guanosine monophosphate were important mediators of penile erection. The overall goal of this review is to provide a comprehensive understanding of the current and potential therapeutic roles of the PDE5 enzyme inhibitors. Novel PDE5 inhibitors are highly selective for the PDE5 isoenzyme, and this may translate into potential novel indications and fewer adverse systemic effects. Larger scale, well designed clinical trials are needed to ascertain the safety, efficacy and costeffectiveness of PDE5 inhibitors in the future treatment of urological, cardiovascular, gastrointestinal, and central nervous system disorders.

Metta S.,Gandhi Medical College | Uppala S.,Dr Pinnamaneni Sidhartha Institute of Medical science and Research Foundation | Basalingappa D.R.,Kamineni Institute of Medical science | Badeti S.R.,Gandhi Medical College | And 4 more authors.
Journal of Clinical and Diagnostic Research | Year: 2015

Background: Ischemic heart disease (IHD) remains a major public health problem nationally and internationally. Smoking is a major risk factor for IHD.The deletion (D) allele of the angiotensin converting enzyme (ACE) gene polymorphism has been associated with hypertension, ischemic stroke and myocardial infarction. The present study was carried out to determine the association of the ACE gene insertion/deletion (I/D) polymorphism in IHD patients with and without smoking. Materials and Methods: One hundred seven male IHD patients admitted consecutively in the Cardiology unit of a Government Hospital and 100 age and sex matched healthy controls were enrolled in this study.The patients were further divided into smokers and nonsmokers. All the subjects were checked for I/D polymorphism of ACE gene, which is mapped to 17q23.3 with OMIM no 106180, by polymerase chain reaction (PCR). The subjects were also investigated for lipid profile and ejection fraction (EF). Results: We found significant difference in the distribution of D allele between patients and controls (p=0.009, OR 1.69, 95% CI 1.139 to 2.517).The significantly lower EF (p<0.001) was suggestive of greater cardiovascular compromise in smokers. The frequency of ID genotype was significantly associated with cases compared to controls (p=0.012, OR 2.054, 95% CI 1.1694-3.624) but was not significantly associated with smokers as compared to nonsmokers. Conclusion: We infer significant association of D allele with IHD. The smokers with ID genotype should be put on prophylactic ACE inhibitor therapy to prevent the morbidity and mortality associated with IHD. © 2015, Journal of Clinical and Diagnostic Research. All rights reserved.

Thathapudi S.,Vasavi Medical and Research Center | Kodati V.,Geneticist and Research Coordinator | Erukkambattu J.,Kamineni Academy of Medical science and Research Center | Katragadda A.,Anus Fertility Center | And 2 more authors.
International Journal of Endocrinology and Metabolism | Year: 2014

Background: Polycystic ovarian syndrome (PCOS) is one of the most common endocrine conditions affecting women of reproductive age with a prevalence of approximately 5-10% worldwide. PCOS can be viewed as a heterogeneous androgen excess disorder with varying degrees of reproductive and metabolic abnormalities, whose diagnosis is based on anthropometric, biochemical and radiological abnormalities. To our knowledge, this is the first study investigating the anthropometric, biochemical and ultrasonographic characteristics of PCOS in Asian Indians of South India, using the Androgen Excess Society (AES-2006) diagnostic criteria. Objectives: To assess anthropometric, biochemical and ultrasonographic features of PCOS subgroups and controls among South Indian women using the AES-2006 criteria. Materials and Methods: Two hundred and four women clinically diagnosed with PCOS, and 204 healthy women controls aged 17 to 35 years were evaluated. PCOS was diagnosed by clinical hyperandrogenism (HA), irregular menstruation (IM), and polycystic ovary (PCO). PCOS was further categorized into phenotypic subgroups including the IM+HA+PCO (n = 181, 89%), HA+PCO (n = 23, 11%), IM+HA (n = 0), and also into obese PCOS (n = 142, 70%) and lean PCOS (n = 62, 30%) using body mass index (BMI). Anthropometric measurements and biochemical characteristics were compared among the PCOS subgroups. Results: The PCOS subgroups with regular menstrual cycles (HA+PCO), had more luteinizing hormone (LH), follicle stimulating hormone (FSH), fasting glucose, fasting insulin, and high insulin resistance (IR) expressed as the Homeostasis Model Assessment (HOMA) score, compared with the IM+HA+PCO subgroups and controls. Similarly, the obese PCOS had high BMI, waist to hip ratio (WHR), fasting glucose, LH, LH/FSH, fasting insulin, HOMA score (IR), and dyslipidemia, compared with lean PCOS and controls. Unilateral polycystic ovary was seen in 32 (15.7%) patients, and bilateral involvement in 172 (84.3%) patients. All the controls showed normal ovaries. Conclusions: Anthropometric, biochemical, and ultrasonographic findings showed significant differences among PCOS subgroups. The PCOS subgroups with regular menstrual cycles (HA+PCO), had high insulin resistance (IR) and gonadotropic hormonal abnormalities, compared with the IM+HA+PCO subgroups and controls. © 2014, Research Institute For Endocrine Sciences and Iran Endocrine Society; Published by Kowsar Corp. © 2014, Research Institute For Endocrine Sciences and Iran Endocrine Society.

Thathapudi S.,Vasavi Medical and Research Center | Kodati V.,Vasavi Medical and Research Center | Erukkambattu J.,Kamineni Academy of Medical science and Research Center | Addepally U.,Jawaharlal Nehru Technological University | And 2 more authors.
Genetic Testing and Molecular Biomarkers | Year: 2015

Background: Polycystic ovaries and irregular menstruation/anovulation are important diagnostic criteria along with hyperandrogenism as per the Androgen Excess Society-2006 criteria for polycystic ovarian syndrome (PCOS). In the etiopathogenesis of PCOS, one of the candidate genes causing ovarian failure is the luteinizing hormone (LH) chorionic gonadotropin hormone receptor (LHCGR). Our aim was to study the association of LHCGR polymorphism (rs2293275) with PCOS in our study population. Materials and Methods: Genetic case-control study from multiple gynecological centers from Hyderabad, a cosmopolitan city in South India. The study involved 204 women with PCOS and 204 healthy, sex-, and age-matched controls. Anthropometric and biochemical profiles were taken in a well-designed pro forma. Isolation of deoxyribonucleic acid (DNA) and genotype analysis were done for the entire study population using the polymerase chain reaction-restriction fragment length polymorphism method followed by 12% polyacrylamide gel electrophoresis. Results: In this study, we have demonstrated an association between LHCGR (rs2293275) polymorphism and PCOS. The frequency of the G allele was 0.60 in PCOS and 0.49 in controls (odds ratio [OR] 1.531, confidence interval [CI] 1.16-2.01, and p-value=0.0026), which indicates that the G allele is associated with PCOS in our population. The GG genotype conferred a significant risk of developing PCOS (OR 3.36, CI 1.96-5.75, and p-value<0.0001). We found a significant association of the GG allele with body-mass index, waist to hip ratio, insulin resistance, LH, and LH/follicle-stimulating hormone (FSH) ratio in PCOS when compared with controls. The AA allele showed high basal FSH levels. Conclusions: This study suggests that LHCGR (rs2293275) polymorphism is associated with PCOS and could be used as a relevant molecular marker to identify women with the risk of developing PCOS in our population and may provide an understanding about the etiology of PCOS. © Mary Ann Liebert, Inc. 2015.

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