Ibaraki, Japan
Ibaraki, Japan

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There are provided 4-alkynylimidazole derivatives represented by the following general formula (I) or pharmaceutically acceptable salts thereof; the derivatives have a superior EP4 receptor antagonistic action and are useful as pharmaceuticals for the treatment of diseases associated with the EP4 receptor, for example, as anti-inflammatory and/or analgesic drugs for inflammatory diseases and diseases that involve various kinds of pains, and further as pharmaceuticals for the treatment of immune diseases that result from inflammations as evoked by tissue destruction due to the activation of Th1 cells and/or Th17 cells:


Patent
Kaken Co. | Date: 2016-01-13

An object is to provide a process for producing the compound of formula 1 in higher yield by the ring-opening addition reaction of epoxytriazole with amine under mild conditions without using a large excess of 4-methylenepiperidine. The process for producing (2R,3R)-2-(2,4-difluorophenyl)-3-(4-methylenepiperidin-1-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol or an acid addition salt thereof comprises reacting (2R,3S)-2-(2,4-difluorophenyl)-3-methyl-2-[(1H-1,2,4-triazol-1-yl)methyl]oxirane with a hydroiodide salt of 4-methylenepiperidine in a reaction solvent in the presence of sodium hydroxide.


Patent
Kaken Co. | Date: 2014-10-15

General formula (I): The present invention pertains to: a pyridone derivate or a salt thereof represented by general formula (I); or a medicine containing the pyridone derivative or salt thereof as an active ingredient. [In the formula, ring A, R^(1), R^(2), R^(3) and R^(4) are specific groups.]


Patent
Kaken Co. | Date: 2015-01-21

Provided are: a conductive paste in which sinterability of silver particles the conductive paste can be easily controlled by using silver particles having predetermined crystal transformation characteristics defined by an XRD analysis, and after a sintering treatment, excellent electrical conductivity and thermal conductivity can be stably obtained; and a die bonding method using the conductive paste. Disclosed is a conductive paste which includes silver particles having a volume average particle size of 0.1 to 30 m as a sinterable conductive material, and a dispersing medium for making a paste-like form, and in which when the integrated intensity of the peak at 2 = 38 0.2 in the X-ray diffraction chart obtainable by an XRD analysis before a sintering treatment of the silver particles is designated as S1, and the integrated intensity of the peak at 2 = 38 0.2 in the X-ray diffraction chart obtainable by an XRD analysis after a sintering treatment (250C, 60 minutes) of the silver particles is designated as S2, the value of S2/S1 is adjusted to a value within the range of 0.2 to 0.8.


Patent
Sagami Chemical Research Institute and Kaken Co. | Date: 2016-01-20

Provided are a polycyclic pyrazolinone derivative indicated by general formula (1) (in the formula, R^(1), X^(1), X^(2), X^(3), and Y indicate the definitions provided in the Specification) and a herbicide comprising same as effective component thereof.


There are provided 4-alkynylimidazole derivatives represented by the following general formula (I) or phamaceutically acceptable salts thereof; the derivatives have a superior EP4 receptor antagonistic action and are useful as pharmaceuticals for the treatment of diseases associated with the EP4 receptor, for example, as anti-inflammatory and/or analgesic drugs for inflammatory diseases and diseases that involve various kinds of pains, and further as pharmaceuticals for the treatment of immune diseases that result from inflammations as evoked by tissue destruction due to the activation of Th1 cells and/or Th17 cells:


Patent
Kaken Co. and Kyoto University | Date: 2016-04-13

Provided is a composition for maintaing a function of platelets, having as an active ingredient a pyridone derivative represented by the following general formula (I), or a salt thereof (in the formula, ring A, R^(1), R^(2), R^(3), and R^(4) represent the definitions given in the description).


Provided are a flaky-like silver powder having a low bulk density as well as a predetermined average particle size (D_(50)) and the like, which is obtainable by using a predetermined wet reduction method, a conductive paste obtainable using such a flaky-like silver powder, and a method for producing such a flaky-like silver powder. Disclosed are a flaky-like silver powder obtainable by a wet reduction method, a conductive paste obtainable using a flaky-like silver powder, and a method for producing a flaky-like silver powder, in which the average particle size (D_(50)) as an equivalent circle diameter obtainable when the flaky-like silver powder particles are viewed planarly is adjusted to a value within the range of 1.1 to 30 m, the thickness of the flaky-like silver powder particles is adjusted to 0.01 to 2 m, and the bulk density of the flaky-like silver powder is adjusted to a value within the range of 0.1 to 4 g/cm^(3).


Patent
Kaken Co. | Date: 2016-08-09

General formula (I): The present invention pertains to: a pyridone derivate or a salt thereof represented by general formula (I); or a medicine containing the pyridone derivative or salt thereof as an active ingredient. [In the formula, ring A, R^(1), R^(2), R^(3 )and R^(4 )are specific groups.]


Provided is (+)-5-(3,4-difluorophenyl)-5-[(3-methyl-2-oxopyridin-1(2H)-yl)methyl]imidazolidine-2,4-dione or a salt thereof. Also provided is a drug containing as the active ingredient (+)-5-(3,4-difluorophenyl)-5-[(3-methyl-2-oxopyridin-1(2H)-yl)methyl]imidazolidine-2,4-dione or a salt thereof.

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