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Nishi-Tokyo-shi, Japan

Wakisaka Y.,Kyushu University | Ago T.,Kyushu University | Kamouchi M.,Kyushu University | Kuroda J.,Kyushu University | And 15 more authors.
Journal of the Neurological Sciences | Year: 2014

Background Ischemic stroke is accompanied by an inflammatory response, which exacerbates brain injury and deteriorates functional outcome. S100A12 is expressed abundantly in granulocytes, and has been implicated to play an important role on inflammatory reactions in various disease states. We aimed to determine the association between plasma S100A12 levels and a functional outcome in patients with acute ischemic stroke. Methods We prospectively included 171 patients with acute ischemic stroke within 24 h after onset in this study. Plasma samples were collected for the measurement of S100A12 levels. Poor functional outcome was defined as a modified Rankin Scale of 2-6 at day 90 after stroke onset. Results Of 171 patients, 74 (43.3%) had a poor functional outcome at day 90 after stroke onset. Plasma S100A12 levels on admission were significantly higher in patients with a poor functional outcome (2.1 [1.2-5.1] ng/mL, median [interquartile]) than in those with a favorable outcome (1.1 [0.5-2.0] ng/mL; p < 0.001). Multivariate analysis showed that the highest quartile of plasma S100A12 levels on admission showed a significantly higher risk for a poor functional outcome (odds ratio, 4.01; 95% confidence interval, 1.09-16.10; p = 0.03) than the lowest quartile. Conclusions High plasma S100A12 levels on admission are associated with a poor functional outcome in patients with acute ischemic stroke. © 2014 Elsevier B.V. All rights reserved. Source

Yokojima S.,RIKEN | Yokojima S.,KAITEKI Institute Inc. | Kobayashi T.,Mitsubishi Group | Shinoda K.,Mitsubishi Group | And 4 more authors.
Journal of Physical Chemistry B | Year: 2011

Unusual blue shift of the absorption maxima of two nitronyl nitroxide attached diarylethene through phenyl units (DAE-phe-NN) with increasing number of phenyl units is examined by time dependent density functional theory (TDDFT). The extended n-conjugation between nitronyl nitroxide and diarylethene is rather suppressed by the bridge phenyl units. In comparison, the red shift found in two nitronyl nitroxide attached diarylethenes through thiophene units (DAE-thio-NN) with increasing number of thiophene units is due to the longer n-conjugation induced by smaller dihedral angles between diarylethene and bridge and between bridges. © 2011 American Chemical Society. Source

Fukunaga K.,Mitsubishi Group | Uehara F.,Mitsubishi Group | Aritomo K.,Mitsubishi Group | Shoda A.,Mitsubishi Group | And 25 more authors.
Bioorganic and Medicinal Chemistry Letters | Year: 2013

A series of 2-(2-phenylmorpholin-4-yl)pyrimidin-4(3H)-ones was synthesized and examined for their inhibitory activity against glycogen synthase kinase-3β (GSK-3β). We found 21, 29 and 30 to possess potent in vitro GSK-3β inhibitory activity with good in vitro PK profiles. 21 demonstrated significant decrease of tau phosphorylation after oral administration in mice and excellent PK profiles. © 2013 Elsevier Ltd. All rights reserved. Source

Gao Q.,Mitsubishi Group | Gao Q.,KAITEKI Institute Inc. | Yokojima S.,Tokyo Institute of Technology | Fedorov D.G.,Japan National Institute of Advanced Industrial Science and Technology | And 6 more authors.
Journal of Chemical Theory and Computation | Year: 2010

An ab initio computational method, based on the fragment molecular orbital (FMO) method, for calculating nuclear magnetic resonance (NMR) chemical shifts has been developed by introducing the concept of a merged fragment with a cutoff distance. Using point charges or density based on electrostatic potential obtained from FMO calculations, the NMR calculations (GIAO and CSGT) with the 6-31G(d) and 6-311G(d,p) basis sets were performed on α-helix and β-sheet polypeptides. The cutoff distance defines the optimal merged fragment size for NMR calculations. This method accurately reproduces electrostatic effects and magnetic susceptibilities. The chemical shifts determined with a cutoff distance not shorter than 8 Å for both α-helix and β-sheet polypeptides agree well with those calculated by conventional ab initio NMR calculations. © 2010 American Chemical Society. Source

Uehara F.,Mitsubishi Group | Shoda A.,Mitsubishi Group | Aritomo K.,Mitsubishi Group | Fukunaga K.,Mitsubishi Group | And 16 more authors.
Bioorganic and Medicinal Chemistry Letters | Year: 2013

The discovery of a series of 6-(4-pyridyl)pyrimidin-4(3H)-ones derived from a hit compound with low molecular weight and sufficient chemical space is reported. Transformation of substituents led to subnanomolar potent inhibitors with in vivo tau phoshorylation lowering activity. © 2013 Elsevier Ltd. All rights reserved. Source

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