Tangshan Kailuan General Hospital

Tangshan, China

Tangshan Kailuan General Hospital

Tangshan, China
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Wang J.Y.,Tianjin Medical University | Wang J.Y.,Tangshan Maternal and Children Health Hospital | Zhang N.,Tangshan Kailuan General Hospital | Yang X.,Tangshan Maternal and Children Health Hospital | And 3 more authors.
Bangladesh Journal of Pharmacology | Year: 2015

The purpose of this study is to assess whether MHC class I-presented tumor antigen is appraisable for T-cell responses against ovarian cancer. In ovarian cancer cell, human leukocyte antigen A2 (HLA-A2) associated with peptides was used to promote the activation of naive T cells so as to activate antigen-specific T cells. 7 or 4 patients were observed grade 1 or 2 injection site reactions, respectively. 5, 2 or 1 patients were observed grade 1, 2 or 3 pain reactions, respectively. 4 or 1 patients were observed grade 1 or 2 induration reactions. Total number mean value of patients experiencing response to the particular peptide was 7.73, and total number mean value of peptides to which the patients responded was 7.45. MHC class I-presented tumor antigen is appraisable for T-cell responses against ovarian cancer in China. © 2015, Bangladesh Pharmacological Society. All rights reserved.


Wang Y.-L.,Tangshan Kailuan General Hospital | Li J.-F.,Tangshan Kailuan General Hospital | Wang Y.-P.,Peoples Hospital Of Zunhua | Ming G.,Tangshan Kailuan General Hospital
Chinese Journal of Tissue Engineering Research | Year: 2016

BACKGROUND: Umbilical cord blood mesenchymal stem cell transplantation can reduce myocardial apoptosis and myocardial fibrosis, thereby improving the cardiac function. OBJECTIVE: To observe the effect of umbilical cord blood mesenchymal stem cell transplantation on myocardial apoptosis in rats. METHODS: (1) In vitro test: Normal myocardial cells cultured for 72 hours were enrolled as control group. Myocardial cells injured by adriamycin alone were enrolled as injury group. Adriamycin-injured myocardial cells were co-cultured with umbilical cord blood mesenchymal stem cells as co-culture group. After 48 hours of culture, TUNEL assay was used to assess myocardial apoptosis in rats. (2) In vivo test: Forty-five Sprague-Dawley rats were randomized into normal control, adriamycin, and umbilical cord blood mesenchymal stem cell transplantation (cell transplantation) groups. Two weeks after cell transplantation, PowerLab was used to test cardiac function, and western blot employed to detect Bax and Caspase-3 expression levels. Meanwhile, pathological changes of the myocardial tissues were observed in the three groups. RESULTS AND CONCLUSION: (1) In vitro test: The apoptotic rate of myocardial cells was significantly increased in the injury group compared with the control group, but decreased significantly in the co-culture group compared with the injury group (P < 0.05). (2) In vivo test: In the cell transplantation group, the cardiac function indexes, expression levels of Bax and Caspase-3 and myocardial infarction size were significantly improved compared with the adriamycin group (P < 0.05), but still not recovered to the normal levels (P < 0.05). These results show that umbilical cord blood mesenchymal stem cells acting on the rat myocardial cells can inhibit adriamycin-induced myocardial apoptosis, and the relevant mechanism is probably related to down-regulation of Bax and caspase-3 expression. © 2016, Journal of Clinical Rehabilitative Tissue Engineering Research. All rights reserved.


Lin L.,Tianjin Medical University | Lin L.,Tangshan Kailuan General Hospital | Jin C.,Tangshan Kailuan General Hospital | Wei X.,Tangshan Kailuan General Hospital | And 5 more authors.
International Journal of Clinical and Experimental Medicine | Year: 2015

Objective: The aim of this study is to examine and compare the efficacy of everolimus-eluting stents (EES) and zotarolimus-eluting stents (ZES) in coronary heart disease in diabetic or non-diabetic patients. Methods: A total of 666 patients needed for percutaneous coronary intervention were randomly selected from June 2008 to June 2013 in our hospital and were divided into two groups: (i) coronary heart disease with diabetes group and (ii) nondiabetes group. Patients in each group were further assigned to receive treatment of either EES or ZES. Then we observed the major adverse cardiac events, including mortality, nonfatal myocardial infarction and non-fatal cerebrovascular events over the period of 15 months after initial stent implantation. Results: Compared to the non-diabetic group, more patients in diabetic group had received anti-hypotensive treatment (72% vs. 49%, P < 0.0001) and hypolipemic treatment (80% vs. 67%, P < 0.0001) before the percutaneous coronary intervention. In both diabetic group and non-diabetic group, patients received ZES treatment had a much greater incidence rate of major adverse cardiac events compared to the patients received EES treatment (P < 0.05). Meanwhile, target lesion revascularization rate in the ZES group was also significantly higher than that in the EES group. The data showed big differences between ZES and EES groups with important statistical significance (P < 0.05). Conclusion: Patients with coronary heart disease and diabetes have a higher risk of major adverse cardiac events after stent implantation. EES treatment is safer with higher efficacy in our study, being a more effective stent for the patients merged with diabetes. © 2015 E-Century Publishing Corporation. All rights reserved.


Yang X.,Tianjin Medical University | Yang X.,Tangshan Maternal and Children Health Hospital | Wang J.,Tianjin Medical University | Wang J.,Tangshan Maternal and Children Health Hospital | And 3 more authors.
European Journal of Gynaecological Oncology | Year: 2016

Purpose: To assess the complications and clinical outcomes of concurrent chemoradiotherapy (CCRT) or pure radiotherapy (RT) in local advanced cervical carcinoma (LACC) patients. Materials and Methods: A retrospective study was carried out in 113 consecutive LACC (FIGO Stage IB2-IIIB) patients, of whom 68 received CCRT; the others received pure RT. Five-year overall survival (OS) and the incidence, type, and severity of postoperative complications were analyzed. Results: The five-year survival rate for CCRT and pure RT were 67.7% and 46.8%, respectively (p = 0.018). The incidences of bone marrow suppression and gastrointestinal reaction for CCRT and pure RT were 100% vs. 88.89% (p < 0.001) and 70.6% vs. 33.33% (p < 0.001). Only 16.18% patients received CCRT developed chronic radiation enteritis, and 4.35% developed chronic radiation cystitis. While 11.11% patients received pure RT experienced chronic radiation enteritis (p = 0.449), 4.44% experienced chronic radiation cystitis (p = 0.312). Conclusions: This retrospective study demonstrated that CCRT followed by radical surgery achieved a better outcome compared with pure RT in LACC patients, but could apparently rise the incidence and severity of hematologic and gastrointestinal toxicity.

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