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Kahramanmaraş, Turkey

Garipardic M.,Kahramanmaras Sutcu Imam University | Ozkan F.,Kahramanmaras State Hospital
Pediatrics | Year: 2013

The severe ischemia or necrosis of the glans penis is a rarely seen complication after circumcision. We report the case of a 7-year-old boy with severe glans penis ischemia occurring 24 hours after circumcision with local anesthesia (0.1% xylocaine containing ephedrine). His hemogram and levels of proteins C and S and fibrinogen were normal, but the D-dimer level was higher than normal (2.57 mg/L; normal level 0-0.5 mg/L). Normal blood flow was indicated on color Doppler ultrasonography. The severe ischemia in the glans penis was successfully treated with subcutaneous injection of enoxaparin (lowmolecular- weight heparin) for 5 days, and the appearance of the glans was close to normal on the fifth day. The patient did not require any surgical intervention and was discharged without sequelae. As a result, we consider that ischemia of the glans penis may initially be managed with enoxaparin, especially in cases in which the D-dimer level is higher than normal. Copyright © 2013 by the American Academy of Pediatrics.

Durmus I.,Karadeniz Technical University | Karaman K.,Kahramanmaras State Hospital | Ozturk S.,Abant Izzet Baysal University | Kutlu M.,Karadeniz Technical University
Medical Principles and Practice | Year: 2013

Objective: To investigate the possible relationship between mitral annular calcification (MAC) and arterial stiffness. Subjects and Methods: Forty-two patients (mean age 68 ± 6 years) with MAC and an age-matched control group of 41 individuals (mean age 66 ± 6 years) were studied. Arterial stiffness and wave reflections of the study population were evaluated by using applanation tonometry (SphygmoCor). Aortic pulse wave velocity (PWV) was measured as an index of aortic stiffness. The heart rate-corrected augmentation index (AIx@75) was estimated as a composite marker of wave reflections and arterial stiffness. Results: Aortic PWV was significantly higher in patients with MAC (12.2 ± 2.3 m/s) than in controls (10.1 ± 1.3 m/s, p = 0.0001). However, AIx@75 was similar between the groups (28 ± 10 vs. 29 ± 10%, p = 0.59). Multivariate analysis involving the whole population revealed that brachial diastolic blood pressure (β = 1.87, p = 0.04) and MAC (β = 0.41, p = 0.0001) were independent determinants of aortic PWV. Conclusion: The data showed that MAC was significantly associated with increased arterial stiffness and that it was an independent determinant of aortic PWV. © 2013 S. Karger AG, Basel.

Can S.S.,Kahramanmaras State Hospital | Gencay-Can A.,Bursa Sevket Yilmaz State Hospital
Journal of Musculoskeletal Pain | Year: 2012

Objectives The aims of this study were to investigate the presence of cognitive impairment in fibromyalgia syndrome [FMS] patients using the clock drawing test [CDT] and evaluate its correlation with age, educational level, pain, fatigue, functioning, depression, anxiety, and sleep disturbance.Methods Sixty- three patients with FMS and 62 healthy normal controls [HNCs] were enrolled in thise study. Visual Analog Scale [VAS] pain, VAS fatigue, VAS sleep disturbance, Fibromyalgia Impact Questionnaire [FIQ], Beck Depression Inventory [BDI], Beck Anxiety Inventory [BAI], and the CDT of the subjects were evaluated. The CDT method used was that of Watson, Shulman, and Sunderland. Results There were no significant differences between the patients and the HNCs on demographic characteristics [P>0.05]. The FMS patients had statistically significant lower scores in three different clock scoring methods than the HNC group [P<0.005]. The Shulman scores and the Sunderland scores were significantly correlated with age or pain intensity in FMS patients [-0.27≤ r ≤-0.34, P<0.05]. There were no correlations between the CDT scores and educational level, Fibromyalgia Impact QuestionnaireIQ, Beck Depression Inventory, or Beck Anxiety Inventory scores [P>0.05].Conclusions The results of the present study showed that FMS patients had impaired cognitive performance when compared with the HNCs. Poor cognitive performance was related to only advanced age and high pain intensity. © 2012 Informa Healthcare USA, Inc.

Camkurt M.A.,Afsin State Hospital | Acar S.,Mersin University | Coskun S.,Dicle University | Gunes M.,Dicle University | And 4 more authors.
Journal of Psychiatric Research | Year: 2015

Major depression is the most common psychiatric disorder. The diagnosis of depression depends on a patient's subjective complaints, and the nature of the heterogeneous disorder. Thus, there is no known biomarker for depression to date. Previous research has indicated that microRNAs are dysregulated in bipolar disorder and schizophrenia. We aimed to investigate microRNA dysregulation in plasma samples of patients with major depression. Venous blood samples of 50 depressed patients and 41 healthy controls were collected and the quantification of microRNAs was established using qRT-PCR. We found miR-320a significantly downregulated and miR-451a significantly upregulated in depressed patients. We also found miR-17-5p and miR-223-3p upregulated, but not as significantly as miR-451a. Merging our results with previous published data shows that the blood miR-320 family may be a potential microRNA family dysregulated in major depression. Research should be performed on miR-320-related pathways and their relationship to depression. Additionally, miR-451a could serve as a candidate biomarker for depression based on the acting mechanism of ketamine. Studies targeting miR-451a levels before and after treatment could be helpful. © 2015 Elsevier Ltd.

Guney A.,Erciyes University | Bilal O.,Kahramanmaras State Hospital | Oner M.,Erciyes University | Halici M.,Erciyes University | And 2 more authors.
Knee Surgery, Sports Traumatology, Arthroscopy | Year: 2010

This study aimed to evaluate the short-and mid-term results of plica excision in patients with mediopatellar plica and associated cartilage degeneration. Seventy-six surgically treated patients with mediopatellar plica and associated cartilage degeneration at medial femoral condyle (MFC) and/or medial pole of patella were included. Patients were evaluated at baseline, at 6 weeks and 6 months after the operation for their clinical outcomes and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores. The frequency of all signs and symptoms, including all pain parameters, and WOMAC scores were significantly improved compared to baseline, at 6 weeks and 6 months after the operation (P < 0.017). Based on mean WOMAC scores, results of most patients were rated as excellent both at 6 weeks (88%) and at 6 months (94%). Surgical excision of mediopatellar plica associated with cartilage degeneration appears to result in substantial clinical improvement, thus it represents an effective treatment modality. © 2010 Springer-Verlag.

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