Kahramanmaraş, Turkey
Kahramanmaraş, Turkey

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Ulger F.E.B.,Kahramanmaras Necip Fazl City Hospital | Ulger A.,Kahramanmaras Pazarck State Hospital | Colak M.,Kahramanmaras Pazarck State Hospital
Vascular | Year: 2014

We present a case of common carotid artery agenesis which is an extremely rare congenital anomaly. Less than 35 cases have been reported. These anomalies are typically asymptomatic and usually discovered as an incidental finding. Color Doppler ultrasonography is an effective and sensitive method for detecting absence of common carotid artery. But it is insufficient to identify the anomaly as a whole. Magnetic resonance angiography is a complementary technique to describe the origin of the external carotid artery and internal carotid artery. © The Author(s) 2014.


PubMed | Kahramanmaras Pazarck State Hospital and Kahramanmaras Sutcu Imam University
Type: Journal Article | Journal: Respiratory care | Year: 2016

To our knowledge, there is no study on the level of telomerase in subjects with COPD during an exacerbation period. The objective of this work was to compare lipid peroxidation, telomerase, zinc (Zn), copper (Cu), and malondialdehyde levels in asymptomatic smokers and subjects with COPD exacerbation.The study included 45 subjects with COPD exacerbation and 42 healthy subjects with tobacco use as a control group. Samples were taken from blood and after the serum levels of telomerase malondialdehyde, Cu, and Zn were measured, the values were compared between the 2 groups. Tests for respiratory function were performed, and sedimentation and C-reactive protein levels were measured.The COPD exacerbation group had a significantly (P < .001) lower Cu/Zn ratio compared with the control group; however, the COPD exacerbation group had significantly (P < .001) higher levels of telomerase malondialdehyde, Cu, and Zn compared with the control group. Malondialdehyde, Cu, Zn, and FEV1 were found negatively correlated in the COPD exacerbation and control groups (P < .001). The COPD exacerbation group had lower FEV1 and FVC compared with the control group. The COPD exacerbation group had significantly (P < .001) higher levels of C-reactive protein and a higher blood cell sedimentation rate compared with the control group.The reason why the subjects had a reduced Cu/Zn ratio and increased levels of telomerase, Cu, and Zn is likely to be oxidative stress, which can be defined as an increased exposure to oxidants and/or decreased antioxidant capacities It is obvious from this study that lung oxidant-antioxidant balance is abnormal in subjects with COPD exacerbation and also that the increased level of telomerase is associated with this imbalance.

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