Otsubo M.,Okayama Prefectural University |
Kurashige K.,Kagoshima Prefectural College |
Kameyama Y.,Okayama Prefectural University |
Kubo T.,Okayama Prefectural University
Journal of Japan Industrial Management Association | Year: 2010
A timetable must be made at least once, and probably several times, every year in all kinds of educational institutions including elementary, junior high and senior high schools, and universities. At the junior and senior high school levels, many teachers only teach one or more subjects for some classes, and thus adjustments of some classes and lessons need to be taken into consideration. This problem is a kind of assignment problem which we refer to as the school timetabling problem. In a junior high school that has 24 classes, it takes about one week for seven planners to complete the school timetable, and this work is performed twice a year. In a past study, we applied the tabu search to the timetabling problem for junior high school, and proposed three algorithms. In addition, we showed that the weight for the violation of constraints greatly influenced the search. However, one problem was that it was very difficult for planners to find the best weight setting. In this paper, we propose some methods for automatically adjusting the weight setting during tabu search. When the solution is not improved over a period, the weight setting is changed according to each rule. By applying these methods to a numerical experiment for an existing junior high school, we show that they impove search efficiency. In particular, the method that depended on the number of violation of constraints when changing the weight setting is more effective. This indicates that planners do not need to be conscious of the weight setting. In addition, the timing of weight change and application of the algorithm in a past study are described.
Takeshita H.,Kagoshima University |
Takeshita H.,Kagoshima Immaculate Heart University |
Takeshita H.,University of Shizuoka |
Horiuchi M.,Kagoshima University |
And 6 more authors.
Environmental Health and Preventive Medicine | Year: 2012
Objectives To determine the impact of long-term voluntary exercise, representing habitual exercise for the prevention of lifestyle-related diseases, on glucose, lipid, and amino acid metabolism in mice. Methods Twenty-four mice aged 6 weeks were divided into three groups. Two groups (16 mice) were housed individually in either cages equipped with a running wheel (8 mice, exercising, Ex-mice) or without (8 mice, sedentary, Se-mice) for 24 weeks. The remaining group (8 mice) was sacrificed at 6 weeks of age. Biomarkers related to glucose, lipid, and amino acid metabolism were examined. Results Ex-mice ran voluntarily, predominantly in the dark. The distance per day peaked at 4 weeks and then decreased until 12 weeks to around the level seen at the beginning of the experimental period, and was maintained at 4.9 ± 0.2 km/day from 12 to 24 weeks. Ex-mice showed a similar adrenal weight and vitamin C content to Se-mice but had a significantly lower body weight and higher food intake. Ex-mice also showed a higher skeletal muscle weight, a lower white adipose tissue and liver weight, associated with lower plasma leptin and insulin-like growth factor-1 levels, and a lower hepatic triglyceride content. Analysis of plasma amino acids showed that Ex-mice had significantly higher phenylalanine, tyrosine, and glutamine levels, resulting in a significantly lower Fischer's ratio. Conclusions We present an animal model of long-term voluntary exercise under low stress. Findings related to the effects of long-term voluntary exercise on lipid, and amino acid metabolism in our mouse model indicate that such an exercise regimen may affect pathophysiological states related to appetite and behavior. © The Japanese Society for Hygiene 2011.
Voluntary exercise under a food restriction condition decreases blood branched-chain amino acid levels, in addition to improvement of glucose and lipid metabolism, in db mice, animal model of type 2 diabetes
Marchianti A.C.N.,Kagoshima University |
Marchianti A.C.N.,University of Jember |
Arimura E.,Kagoshima University |
Arimura E.,Kagoshima Prefectural College |
And 2 more authors.
Environmental Health and Preventive Medicine | Year: 2014
Objectives: Exercise is effective for preventing the onset and development of type 2 diabetes mellitus (T2DM) in human cases; however, the effect of exercise on the pathophysiology using animal models of T2DM has not been fully evaluated.Methods: We applied voluntary exercise under pair-fed (P) conditions in db mice, an animal model of T2DM. Exercising (Ex) and sedentary (Se) mice were placed in a cage, equipped with a free or locked running wheel, for 4 weeks, respectively. The amount of food consumed by ad libitum-fed wild-type mice under the Se condition (ad-WT) was supplied to all mice, except ad libitum db mice (ad-db). Blood parameters and expression of the genes involved in nutrient metabolism were analyzed.Results: PEx-db (pair-fed and exercising) mice showed significantly lower HbA1c, body weight and liver weight than PSe-db and ad-db mice. Decreased hepatic triglycerides in PEx-db mice corresponded to a lower expression of lipogenic enzyme genes in the liver. Moreover, PEx-db mice showed significantly lower plasma branched-chain amino acids (BCAA), arginine, proline, and tyrosine, in addition to increased skeletal muscle (SM) weight, than PSe-db and ad-db mice, in spite of little influence on the expression of the BCAA transaminase gene, in SM and WAT.Conclusion: We found that exercise under a food restriction condition decreases several amino acids, including BCAA, and may improve insulin sensitivity more than mere food restriction. We propose that the decreased concentration of blood amino acids may be a valuable marker evaluating the effects of exercise on diabetic conditions. © 2014, The Japanese Society for Hygiene.
Takeishi K.-I.,Kagoshima University |
Horiuchi M.,Kagoshima University |
Kawaguchi H.,Kagoshima University |
Deguchi Y.,Shin Nippon Biomedical Laboratories Ltd. |
And 6 more authors.
Evidence-based Complementary and Alternative Medicine | Year: 2012
Acupuncture, an alternative medicine, has been widely applied for people with sleep disturbances; therefore, the effects should be evaluated objectively. Micro-minipigs (MMPigs), the smallest miniature pigs for animal experiments, were used. Acupuncture was performed at two different points: Dafengmen is located on the head and is an anatomically similar point to human-Baihui (GV20), an effective acupoint for sleep disturbances in humans; pig-Baihui is on the back. The procedure was performed as follows: shallow, within 5mm depth for several seconds; deep, 10-20mm depth for 20min. The sleep conditions were evaluated by actigraph, and the amount of catecholamine in pooled urine after acupuncture treatment. MMPigs with deep acupuncture at Dafengmen showed significantly efficient values on actigraph and catecholamine analysis as compared with untreated MMPigs. The effective acupoint for sleep conditions in the porcine model is at an anatomically similar point to humans, rather than the point determined by traditional Chinese medicine. Copyright 2012 Ka-ichiro Takeishi et al.
Iyota H.,Kagoshima Prefectural College
Colloid and Polymer Science | Year: 2012
The adsorption, micelle formation, and salting-out of dodecylammonium chloride in the presence of NaCl were studied from the viewpoint of mixed adsorption and aggregate formation. The surface tension of aqueous solutions of a NaCl-dodecylammonium chloride mixture was measured as a function of the total molality and composition of the mixture. Judging from phase diagrams of mixed adsorption and aggregate formation, NaCl and dodecylam-monium chloride are miscible in the adsorbed film and coagel particle at high NaCl concentrations due to specific (nonelectrostatic) interaction between dodecylamonium ion and the counterion, while they are immiscible in the micelle. The difference in miscibility among the oriented states was ascribed to the difference in geometry among the states and to the interaction between bilayers in a coagel particle. Miscibility and specific interaction are compared between the mixtures of NaCl with dodecylammonium chloride and sodium dodecylsulfate. © Springer-Verlag 2012.