Kagoshima Immaculate Heart University

www.k-junshin.ac.jp/jundai/
Satsumasendai, Japan

Kagoshima Immaculate Heart University is a private women university in Satsumasendai, Kagoshima, Japan. The predecessor of the school was founded in 1933, and it was chartered as a junior university in 1961. In 1994, it became a four-year college and adopted the present name. Wikipedia.


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Yamada K.,Gifu Municipal Hospital | Tsunoda K.,Kagoshima Immaculate Heart University | Kawai K.,Gifu University | Ikeda T.,Gifu Municipal Hospital | And 4 more authors.
Diabetology International | Year: 2013

Aim: Fenofibrate (FF) is known to block ATP synthesis in mitochondria by inhibiting electron transport at NADH-ubiquinone (UQ) oxidoreductase (complex I) in the respiratory chain. Methods: Toxicity to mitochondria of bezafibrate (BF) was compared with that of FF, focusing exclusively on their effects on impairment of the electron-transport and energy-transfer systems in oxidative phosphorylation, by experiments with isolated rat liver mitochondria and submitochondrial particles (SMP). Results: FF and BF had an uncoupling effect, enhancing ATP hydrolytic activity (latent ATPase) in mitochondria. DNP-stimulated ATPase activity was not suppressed by either agent, indicating no interference with the energy-transfer system. Both reagents inhibited NAD-linked respiration but did not affect succinate-linked respiration, indicating specific inhibition of electron-transport activity in complex I. NADH oxidase in SMP was strongly inhibited by FF, and activity was recovered by treatment with tetramethyl-p-phenylenediamine, indicating that the site of inhibition is not located at the NADH dehydrogenase portion but at the UQ site in complex I. Uncoupling and electron-transport inhibition by BF were noticeably weaker than those by FF. Conclusions: From these results it was concluded that BF and FF were toxic to mitochondria through the dual actions of an uncoupling effect and electron-transport inhibition. The toxicity of BF to mitochondrial function was found to be noticeably weaker than that of FF, implying that BF might be much less toxic than FF for long term in-vivo use as an antihyperlipidemic agent. © 2013 The Japan Diabetes Society.


Takeshita H.,Kagoshima University | Takeshita H.,Kagoshima Immaculate Heart University | Takeshita H.,University of Shizuoka | Horiuchi M.,Kagoshima University | And 6 more authors.
Environmental Health and Preventive Medicine | Year: 2012

Objectives To determine the impact of long-term voluntary exercise, representing habitual exercise for the prevention of lifestyle-related diseases, on glucose, lipid, and amino acid metabolism in mice. Methods Twenty-four mice aged 6 weeks were divided into three groups. Two groups (16 mice) were housed individually in either cages equipped with a running wheel (8 mice, exercising, Ex-mice) or without (8 mice, sedentary, Se-mice) for 24 weeks. The remaining group (8 mice) was sacrificed at 6 weeks of age. Biomarkers related to glucose, lipid, and amino acid metabolism were examined. Results Ex-mice ran voluntarily, predominantly in the dark. The distance per day peaked at 4 weeks and then decreased until 12 weeks to around the level seen at the beginning of the experimental period, and was maintained at 4.9 ± 0.2 km/day from 12 to 24 weeks. Ex-mice showed a similar adrenal weight and vitamin C content to Se-mice but had a significantly lower body weight and higher food intake. Ex-mice also showed a higher skeletal muscle weight, a lower white adipose tissue and liver weight, associated with lower plasma leptin and insulin-like growth factor-1 levels, and a lower hepatic triglyceride content. Analysis of plasma amino acids showed that Ex-mice had significantly higher phenylalanine, tyrosine, and glutamine levels, resulting in a significantly lower Fischer's ratio. Conclusions We present an animal model of long-term voluntary exercise under low stress. Findings related to the effects of long-term voluntary exercise on lipid, and amino acid metabolism in our mouse model indicate that such an exercise regimen may affect pathophysiological states related to appetite and behavior. © The Japanese Society for Hygiene 2011.


Kuchiiwa S.,Kagoshima University | Kuchiiwa T.,Kagoshima University | Kuchiiwa T.,Kagoshima Immaculate Heart University
Journal of Neuroscience Methods | Year: 2014

Background: Currently, behavioral research of aggressiveness is often conducted with intraspecific intermale aggression tests. Intraspecific aggression is not detectable in early stages of psychiatric disorders or in female animals, except during the nursing period. New method: We developed a semi-automated apparatus (ARM: Aggression Response Meter) for measurement of aggressive biting behavior (ABB) in mice. The apparatus is loaded with computer-controlled sticks that stimulate the mouse through touch, inducing irritation and anger. When the mouse bites the sticks in anger, a load sensor attached to the sticks detects ABB dynamically. Changes in ABB were assessed with isolation-reared/re-socialized mice using the ARM, and additional isolation-reared mice were tested using both the ARM and the resident-intruder test, and then buspirone, a serotonin 1A receptor agonist, was administered. Results: ABB significantly increased during isolation rearing, and then significantly decreased throughout the re-socialization period; both changes were time-dependent. The ARM also detected ABB of female mice after 3 weeks of isolation rearing. Buspirone significantly inhibited aggressive behavior in both tests in a similar manner. Comparison with existing method: The ARM detects aggressiveness in psychiatric disorders at an earlier stage and in both male and female mice. Conclusions: ABB toward inanimate objects is a reliable paradigm that makes it possible to detect aggressiveness in the early stage of psychiatric disorders. The ARM is useful for the quantification of aggressiveness using the same individual repeatedly, and for objective evaluation of the effects of drugs on aggressiveness. The ARM can be used with both male and female mice. © 2014 Elsevier B.V.


PubMed | Kagoshima University and Kagoshima Immaculate Heart University
Type: | Journal: Journal of neuroscience methods | Year: 2015

Most laboratory research on aggressive behavior has focused on intraspecific intermale aggression tests. The intraspecific confrontation is not available for the evaluation of female aggressiveness, since androgens are critical for maintenance of this behavior, whereas aggressive biting behavior toward inanimate objects (ABI) occurs in both males and females.We propose an experimental method for evaluating female aggressiveness. We improved the previously developed semi-automated apparatus (Aggression Response Meter, ARM) to apply it to measurement of female ABI, and measured changes of ABI in stressed mice and drug actions on ABI.ABI assessment was performed daily in sexually mature female mice using ARM. The intensity and number of ABI in one session did not significantly change during an estrous cycle, suggesting that ABI is not influenced by the dynamics of sex hormones. Additional female mice were socially isolated for 7 weeks and then re-socialized for 2 weeks, and ABI was monitored weekly. ABI significantly increased during the isolation period, and then significantly decreased during re-socialization; both were time-dependent. In prolonged-isolated aggressive mice, a serotonin 1A receptor agonist, buspirone, significantly decreased ABI.There are no experimental methods or apparatus available for evaluating female aggressiveness using one individual repeatedly. We could measure ABI semi-quantitatively using the ARM.ABI is a useful behavioral paradigm in the evaluation of aggressiveness in female mice, regardless of the estrous cycle, and can also be used for evaluating the actions of drugs on aggressiveness.


Kimura K.,Niigata University | Nakano K.,Niigata University | Ohashi S.,Niigata University | Takizawa K.,Niigata University | Nakano T.,Kagoshima Immaculate Heart University
Biosystems Engineering | Year: 2015

In Japan, fertilised chicken eggs are used to produce influenza vaccines; however, some eggs die and then contaminate the vaccine stock solution, which causes large economic losses and raises health concerns. Therefore, a non-destructive test that allows distinction of normal and unsuitable chicken eggs was developed, first using visible and near-infrared (VNIR) spectroscopy and subsequently a light-emitting diode (LED) light source. Eggs were sampled from an egg farm, and each of the eggs categorised as either normal or unsuitable using candling. Linear discriminant analysis was applied using wavelength absorbance data to distinguish between normal and unsuitable eggs. All of the optical absorbance values of the normal eggs were found to be higher than those of unsuitable eggs. To reduce the production cost, LED lights and photodiodes were used as the light source and light receptors, respectively. A discrimination rate of 92.9% was obtained when LED was used as the light source. © 2015 IAgrE.


Kimura K.,Niigata University | Nakano K.,Niigata University | Ohashi S.,Niigata University | Takizawa K.,Niigata University | Nakano T.,Kagoshima Immaculate Heart University
Conference Proceeding - 5th International Conference, TAE 2013: Trends in Agricultural Engineering 2013 | Year: 2013

In Japan, fertilized chicken eggs are used to produce influenza vaccines. However, some fertilized eggs do not develop after fertilization, develop late, or die during development. If these unsuitable eggs are overlooked and included with normal eggs in the vaccine production process, the manufacturer must dispose whole of the vaccine stock solution in a tank, which results in large economic losses and raises health concerns. Therefore, a nondestructive method that allows distinction of normal and unsuitable chicken eggs was developed, using visible and near-infrared (VNIR) spectroscopy and a light-emitting diode (LED) light source. Normal and unsuitable eggs were sampled from an egg farm, where an experienced farmer assessed the eggs by candling. Linear discriminant analysis was applied using wavelength absorbance data to distinguish between normal and unsuitable eggs, and all of the optical absorbance values of the normal eggs were found to be higher than those of unsuitable eggs. The rate of discrimination between the two types of eggs exceeded 95.8 % when LED board was used. To reduce the production cost, LED lights and photodiodes were used as the light source and light receptors, respectively. The discrimination rate when LED was used as the light source was lower than that when a halogen lamp was used, but was almost the same discrimination rate. LED should be used singly to prevent the adjacent LED light sources from affecting detection because the surrounding LED lights affected the photodiode, thereby reducing the discrimination rate. © 2013 Czech University of Life Sciences Prague.


We aimed to clarify the relationships of the different stages of behavior change in dietary habits followed by the mothers of school-age children with the actual breakfast intake of these children and the health-associated behavior of the family. We carried out a questionnaire-based survey of 1949 children at 18 elementary schools and of 881 families with children attending seven elementary schools in Kagoshima prefecture. We were supplied with information about children's breakfast intake and content on the day they took the survey and information about mothers' breakfast intake and the stage of behavior change in dietary habits to which they belonged, for which five stages were defined using the stage-of-change model. The collection rates were 83.3% and 83.1% among children and mothers respectively. Of the children, 83.1% ate breakfast every day, while 15.1% were not in the habit of having breakfast. Furthermore, 98.6% children had eaten breakfast on the day of the survey, but 15.1% had eaten only staple foods such as rice or bread; only 34.0% children combined staple foods, a main dish, and vegetables/fruits in their breakfast. Regarding dietary stage, 28.1% of the mothers belonged to the "maintenance" stage; 24.0%, the "action" stage; 6.9%, the "preparation" stage; 9.8%, the "contemplation" stage; and 5.7%, the "precontemplation" stage. Mothers belonging to the first two stages constituted the "action group," because they were already taking care of their dietary habits, and mothers belonging to the latter three stages constituted the "no-action group", because they were not taking care of their dietary habits. The mothers who could provide no answers to the question constituted the "no-answer group" (25.5%). A comparison of the three groups revealed that mothers belonging to the no-answer group had more children who went without breakfast than the action group (P = 0.000). The children of mothers belonging to the no-action group (P = 0.003) and the no-answer group (P = 0.036) were not in general eating vegetables/fruits in their breakfast, in contrast with the action group. Furthermore, in the case of families with mothers belonging to the no-action and no-answer groups, the families did not often talk about diet, and the incidence of smokers among the fathers was high. In this study, the breakfast habits of children and the health behavior of families differed by stage of dietary behavior change to which the mother belonged.


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PubMed | Kagoshima Immaculate Heart University
Type: Journal Article | Journal: [Nihon koshu eisei zasshi] Japanese journal of public health | Year: 2012

We aimed to clarify the relationships of the different stages of behavior change in dietary habits followed by the mothers of school-age children with the actual breakfast intake of these children and the health-associated behavior of the family.We carried out a questionnaire-based survey of 1949 children at 18 elementary schools and of 881 families with children attending seven elementary schools in Kagoshima prefecture. We were supplied with information about childrens breakfast intake and content on the day they took the survey and information about mothers breakfast intake and the stage of behavior change in dietary habits to which they belonged, for which five stages were defined using the stage-of-change model.The collection rates were 83.3% and 83.1% among children and mothers respectively. Of the children, 83.1% ate breakfast every day, while 15.1% were not in the habit of having breakfast. Furthermore, 98.6% children had eaten breakfast on the day of the survey, but 15.1% had eaten only staple foods such as rice or bread; only 34.0% children combined staple foods, a main dish, and vegetables/fruits in their breakfast. Regarding dietary stage, 28.1% of the mothers belonged to the maintenance stage; 24.0%, the action stage; 6.9%, the preparation stage; 9.8%, the contemplation stage; and 5.7%, the precontemplation stage. Mothers belonging to the first two stages constituted the action group, because they were already taking care of their dietary habits, and mothers belonging to the latter three stages constituted the no-action group, because they were not taking care of their dietary habits. The mothers who could provide no answers to the question constituted the no-answer group (25.5%). A comparison of the three groups revealed that mothers belonging to the no-answer group had more children who went without breakfast than the action group (P = 0.000). The children of mothers belonging to the no-action group (P = 0.003) and the no-answer group (P = 0.036) were not in general eating vegetables/fruits in their breakfast, in contrast with the action group. Furthermore, in the case of families with mothers belonging to the no-action and no-answer groups, the families did not often talk about diet, and the incidence of smokers among the fathers was high.In this study, the breakfast habits of children and the health behavior of families differed by stage of dietary behavior change to which the mother belonged.

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