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Kobayashi M.,Kagawarousai Hospital | Kishi M.,Kagawarousai Hospital | Taniguchi F.,Kagawarousai Hospital | Kuwata K.,Kagawarousai Hospital | And 6 more authors.
Japanese Journal of Cancer and Chemotherapy | Year: 2012

The patient was a 75-year-old woman with advanced esophageal cancer and lymph-node swelling in the mediastinum (cStage III). We administered preoperative chemotherapy (5-FU 500 mg/body X 10, CDDP 10 mg/body X 10). She received the two courses without showing any serious side effects. The primary tumor revealed remarkable improvement, but the rigidity of the esophagus wall and swelling of the lymph nodes were not resolved, and images showed that the patient exhibited a partial response to the treatment. Radical resection of the esophageal carcinoma was performed. Pathological examination of the resected specimens revealed no malignant cells in the esophagus, no metastasis of the lymph node, and the response evaluation was grade 3. The patient showed no recurrence 4 years and eleven months after the operation. In tonclusion, this rare case of esophageal carcinoma showed a pathologically complete response when treated with low-dose 5-FU/CDDP as neoadjuvant chemotherapy. Source

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