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Kagawa, Japan

Wang Y.,Ocean University of China | Wang J.,Ocean University of China | Yanagita R.C.,Kagawa UniversityKagawa | Liu C.,Ocean University of China | And 4 more authors.
Bioscience, Biotechnology and Biochemistry | Year: 2014

Two similarly sulfated triterpene saponins from Pearsonothuria graeffei were prepared to investigate the anti-obesity effects of echinoside A (EA) and holothurin A (HA). The in vitro inhibitory activities of EA and HA toward pancreatic lipase were investigated, and two in vivo studies were performed: (i) Male Wistar rats were orally administered the lipid emulsion with or without a saponin (HA or EA). The serum's total triglyceride concentration was measured at various times. (ii) C57BL/6 mice were assigned to four groups, high fat (HF), EA (0.03%), HA (0.04%), and orlistat (0.01%), and the weight of adipose tissue and level of fatty acids excreted in the feces were determined. Both EA and HA repressed the pancreatic lipase activity and increased fatty acid excretion in the feces. Treatment with EA and HA significantly decreased the adipose tissue accumulation in mice. EA and HA manifested different inhibitory activities in vitro, but each of them dramatically inhibited lipid absorption in vivo and showed strong anti-obesity activity. © 2014 Japan Society for Bioscience, Biotechnology, and Agrochemistry. Source

Kuboi T.,Shikoku Medical Center for Children and Adults | Okazaki K.,Shikoku Medical Center for Children and Adults | Kusaka T.,Kagawa UniversityKagawa | Shimada A.,Tokushima University
Pediatrics International | Year: 2015

Congenital dacryocystocele is a relatively rare type of nasolacrimal duct obstruction that may induce respiratory distress during the early neonatal period. We encountered a case of bilateral congenital dacryocystoceles with intranasal cysts in a premature infant delivered at 34 weeks of gestation. The patient developed symptoms of respiratory failure immediately after birth, but no ophthalmologic symptoms. Treatment with nasal continuous positive airway pressure via a nasal mask, instead of a nasal prong, effectively relieved the symptoms. Early diagnosis and appropriate treatment are critical for infants with nasal obstruction. © 2015 Japan Pediatric Society. Source

Fujiwara S.,Kagawa UniversityKagawa | Toyama Y.,Takamatsu Redcross HospitalKagawa | Miyashita T.,Kagawa UniversityKagawa | Osaki Y.,Osaka Medical Center and Research Institute for Maternal and Child Health | And 3 more authors.
Auris Nasus Larynx | Year: 2016

Objective The aim of the study is to evaluate the usefulness of multislice computed tomography (MSCT) using multiplanar reconstruction (MPR) in obtaining preoperative information on the ossicular lesions of middle ear diseases by comparing the ossicular findings of MPR images with the operative findings. Methods Sixty-two ears and 10 ears with preoperative middle ear diseases underwent 4- and 64-detector row CT of the temporal bone in Kagawa University Hospital, respectively. MPR images of three ossicles were created at the planes parallel to the long axis of ossicles. Results The findings of the three ossicles in MPR images were compatible with their operative findings in approximately 91% of 72 ears with various middle ear diseases. There was no significant difference in the coincidence rate of both findings between 4- and 64-detector row CT scanners. The ears with no soft tissue shadows around the ossicles had the coincidence rate of 96–100% in each ossicular part, whereas the coincidence rate was lower in the ears with soft tissue shadows around the ossicles. Conclusion MPR imagings of the ossicles provide accurate preoperative information on the ossicular lesions in middle ear diseases. The 4-detector CT is still a useful device for imaging of the ossicles. © 2015 Elsevier Ireland Ltd Source

Fujihara S.,Kagawa UniversityKagawa | Mori H.,Kagawa UniversityKagawa | Kobara H.,Kagawa UniversityKagawa | Nishiyama N.,Kagawa UniversityKagawa | And 6 more authors.
Oncology Letters | Year: 2015

Clinically available targeted agents to treat advanced renal cell carcinoma (RCC) include sunitinib, sorafenib and temsirolimus. Sorafenib and sunitinib have been associated with bleeding in selected trials, but clinical and endoscopic characteristics of gastrointestinal bleeding are not well described. Herein, we report four cases of advanced RCC in which endoscopic hemostasis effectively resolved high-grade, life-threatening gastrointestinal bleeding that occurred during targeted therapy. Although stomatitis and mucositis have occurred during targeted therapies, life-threatening gastrointestinal bleeding is less common. In these four patients, the origins of gastrointestinal bleeding were identified, and complete endoscopic hemostasis was achieved. Endoscopies revealed variable characteristics including angiodysplasia, multiple gastric ulcers and oozing bleeding of the normal mucosa. Although the most effective diagnostic and treatment strategies are disputed, endoscopic examinations are best performed before starting targeted therapies. Additionally, these patients should be monitored even for rare life-threatening events. © 2015, Spandidos Publications. All rights reserved. Source

Tanaka N.,Kagawa UniversityKagawa | Kinoshita H.,Kagawa UniversityKagawa | Takakura A.,Kagawa UniversityKagawa | Jamal M.,Kagawa UniversityKagawa | And 5 more authors.
Legal Medicine | Year: 2016

We investigated gunshot wounds in two autopsy cases using energy dispersive X-ray spectrometry (EDX). Lead and copper were detected in the entrance wound of one case and lead, antimony, and copper were detected in that of the other case. In the exit wounds of both cases, lead, antimony, and copper were below detection limits. These findings indicate that the detection of metallic elements, such as lead, antimony, and copper, which are found in bullets, may be useful for differentiating entrance from exit wounds using EDX. © 2016 Elsevier Ireland Ltd Source

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