Kaduna State University is located Kaduna State Nigeria. It was established in 2004. It was established to provide an all-round university of the highest standard for the development of individuals and state. It is currently one of the fastest growing state owned institutions in Nigeria.Kaduna state university have a total number of 7 faculties with over 39 departments, the school library contains over 17,000 volumes of books. The school has a functioning e-library and is striving to become a center of academic excellence. Kaduna State University has a student size of about 6000 to 10000. It was ranked 5th best university by National Universities Commissions Wikipedia.
PubMed | Kaduna State University, Otto Von Guericke University of Magdeburg and Friedrich - Schiller University of Jena
Type: | Journal: Journal of ethnopharmacology | Year: 2016
Extracts of the stem bark of Ficus platyphylla (FP) have been used in traditional the Nigerian medicine to treat psychoses, depression, epilepsy, pain and inflammation. Previous studies have revealed the analgesic and anti-inflammatory effects of FP in different assays including acetic acid-induced writhing, formalin-induced nociception, and albumin-induced oedema.In this study, we assessed the effects of the standardised extract of FP on hot plate nociceptive threshold and vocalisation threshold in response to electrical stimulation of the tail root in order to confirm its acclaimed analgesic properties. We also investigated the molecular mechanisms underlying these effects, with the focus on opiate receptor binding and the key enzymes of eicosanoid biosynthesis, namely cyclooxygenase (COX) and 5-lipoxygenase (5-LO).FP (i) increased the hot plate nociceptive threshold and vocalisation threshold. The increase in hot plate nociceptive threshold was detectable over a period of 30min whereas the increase in vocalisation threshold persisted over a period of 90min. (ii) FP showed an affinity for opiate receptors but not for or opiate receptors, and (iii) FP inhibited the activities of COX-2 and 5-LO but not of COX-1.We provided evidence supporting the use of FP in Nigerian folk medicine for the treatment of different types of pain, and identified opioid and non-opioid targets. It is interesting to note that the dual inhibition of COX-2 and 5-LO appears favourable in terms of both efficacy and side effect profile.
Chindo B.A.,Kaduna State University |
Chindo B.A.,Nigerian National Institute for Pharmaceutical Research and Development |
Chindo B.A.,Otto Von Guericke University of Magdeburg |
Ya'U J.,Ahmadu Bello University |
And 4 more authors.
Journal of Ethnopharmacology | Year: 2014
Ethnopharmacological relevance Decoctions of Ficus platyphylla Del.-Holl (Family: Moraceae) are used in Nigeria's folk medicine for the management of epilepsy and their efficacies are widely acclaimed among the rural communities of northern Nigeria. The aim of the study is to examine the behavioral and anticonvulsant properties of the standardized methanol extract of Ficus platyphylla (FP) stem bark, in order to scientifically describe its potential values in the management of convulsive disorders. Materials and methods High performance liquid chromatography (HPLC) and preliminary phytochemical analysis of the methanol extract were utilized and the intraperitoneal median lethal dose (LD50) determined in mice. The effects of FP were investigated on some murine models of behavior and its anticonvulsant effects studied on pentylenetetrazole (PTZ)-, strychnine (STN)-, picrotoxin (PCT)-, isoniazid (INH)-, aminophylline (AMI)- and maximal electroshock (MES)-induced seizures in mice. Results The intraperitoneal oral LD50 of FP was estimated to be 5000 mg/kg. FP significantly reduced the locomotor activities including the total distance covered, speed, active time and rearing counts. It shortened the onset and prolonged the duration of diazepam-induced sleep, but had no effect on motor coordination on the rota-rod treadmill or beam-walking assay in mice at the doses tested. The extract protected the mice against PTZ- and STN-induced seizures and significantly delayed the latencies of myoclonic jerks and tonic seizures induced by all the standard convulsant agents (PTZ, PCT, INH, STN and AMI) used in this study, but failed to protect the mice against MES seizures at the doses tested. The HPLC fingerprint of the extract shows a spectrum profile characteristic of Ficus platyphylla, while the preliminary phytochemical screening revealed the presence of saponins, flavonoids and tannins. Conclusion Our study provides scientific evidence that FP may contain psychoactive principles with potential anticonvulsant properties, thus supporting further development of the psychoactive components of this plant as anticonvulsant agents. © 2014 Elsevier Ireland Ltd. All rights reserved.
PubMed | Kaduna State University and Vanderbilt University
Type: Journal Article | Journal: Expert review of hematology | Year: 2016
Sickle cell disease (SCD) is the most common inherited hemoglobinopathy in the world, with the majority of cases in sub-Saharan Africa. Concomitant nutritional deficiencies, infections or exposure to environmental toxins exacerbate chronic anemia in children with SCD. The resulting relative anemia is associated with increased risk of strokes, poor cognitive function and impaired growth. It may also attenuate optimal response to hydroxyurea therapy, the only effective and practical treatment option for SCD in sub-Saharan Africa. This review will focus on the epidemiology, clinical sequelae, and treatment of relative anemia in children with SCD living in low and middle-income countries in sub-Saharan Africa. Areas covered: The causes and treatment of relative anemia in children with SCD in sub-Saharan Africa. The MEDLINE database was searched using medical subject headings (MeSH) and keywords for articles regarding relative anemia in children with SCD in sub-Saharan Africa. Expert commentary: Anemia due to nutritional deficiencies and infectious diseases such as helminthiasis and malaria are prevalent in sub-Saharan Africa. Their co-existence in children with SCD increases morbidity and mortality. Therefore, preventing, diagnosing and treating the underlying cause of this relative anemia will improve SCD-related outcomes in children in sub-Saharan Africa.
PubMed | Kaduna State University, University Of Abuja and National Hospital
Type: Journal Article | Journal: African journal of paediatric surgery : AJPS | Year: 2017
Primary wound closure following laparotomy for peritonitis is generally believed to be associated with wound complications and long hospital stay. Open wound management has long been the most common practice after laparotomy for peritonitis. Primary closure (PC), however, has recently been advocated to reduce cost and morbidity. This study determined the incidence and severity of wound complications and their impact on hospital stay and overall outcome when PC of abdominal wounds is done following laparotomy for peritonitis.A prospective review of patients who had PC of abdominal wounds following laparotomy for peritonitis over a 6-year period.Fifty-six children were analysed (35 boys and 21 girls), aged 11 months to 13 years (median: 8 years). The indication for laparotomy was typhoid intestinal perforation 47 (83.9%), perforated appendicitis 4 (7.1%), complicated cholecystitis 3 (5.3%) and penetrating abdominal injury with bowel perforation and intestinal obstruction with bowel perforation, 1 (1.8%) each, respectively. Postoperatively, 34 patients had wound complications. Nine patients (16.1%) had superficial wound infection alone, 12 (21.4%) had superficial wound infection with partial wound dehiscence, 6 (10.7%) had deep wound infection, 7 (12.5%) had deep wound infection with complete wound dehiscence, whereas 22 (39.3%) had no wound complication. Overall, wound complications in 13 (23.2%) patients were considered to be severe, but none resulted in mortality. Hospital stay in patients who developed wound complications was 8-37 days (median: 25 days) and 6-22 days (median: 10 days) in patients who had no wound complications (P = 0.02).The rate of wound complications following PC of dirty abdominal wounds remain but PC is safe and gives good healing outcomes.
Aliyu A.B.,Ahmadu Bello University |
Ibrahim M.A.,Ahmadu Bello University |
Musa A.M.,Ahmadu Bello University |
Bulus T.,Kaduna State University |
Oyewale A.O.,Ahmadu Bello University
International Journal of Biological Chemistry | Year: 2011
Leaf extract and fractions of Vernonia blumeoides were evaluated for total phenolics content (Folin-Ciocalteu method), free radical scavenging activity (1, l-diphenyl-2-picrylhydrazyl radical assay), total antioxidant capacity (Phosphomolybdate assay) and ferric reducing power. The results of the phenolics content expressed in mg/100 g of Gallic Acid Equivalent (GAE) showed that the n-butanol fraction has significantly (p<0.05) higher phenolics content (410±0.8) than the chloroform fraction and ethanol extract. The radical scavenging activity of the extract and solvent fractions displayed strong concentration dependent activity. But it was also observed that the ethyl acetate fraction showed highest activity in all concentration tested ranging from 70.56 to 99.04%. However, the total antioxidant capacity (mg g -1 ascorbic acid) showed that n-butanol fraction has the highest capacity (60.0 mg g -1). The results also showed that the n-butanol extract has strongest reducing ability (2.105±0.109 nm) at higher concentration which is comparable to that of Gallic acid at all the concentrations tested. Phytochemical screening on the extracts revealed the presence of flavonoids, saponins and tannins. The results suggest that the plant especially the n-butanol and ethyl acetate fractions are very rich in antioxidant compounds worthy of further investigations. © 2011 Academic Journals Inc.
Oyefabi A.,Kaduna State University |
Yahuza B.,Ahmadu Bello University
Nigerian Journal of Clinical Practice | Year: 2016
Introduction: Patient relatives are a significant part of the health care team in any hospital setting. This study determines their knowledge, perceptions, and factors responsible for their exposure to health hazards at the Ahmadu Bello University Teaching Hospital (ABUTH), Zaria, Kaduna State. The outcome of this study is intended to help the hospital managers to have a reference to make plans for the patient relatives' welfare and also address the ethical issues regarding patients' relatives safety while in the hospital. Materials and Methods: This is a cross-sectional descriptive study involving 100 participants selected by systematic random sampling technique from the ten admission wards of the ABUTH. The data were analyzed using the Statistical Package for Social Sciences IBM 20 and STATA SE12. Results: The mean age of the respondents was 35 years. They were mainly Hausa (58%), female (79%), and Muslims (76%). About 21%, 25%, and 54% of the respondents have poor, fair, and good knowledge, respectively, with a mean knowledge score of 33.3% while 24% perceived that blood urine and feces from patient relatives are safe to handle. Sexual harassment (13.3%), abusive insults from health care workers, (13.3%) and aggression from other patients were reported. Being the sole caregiver, type of illness, handling of patients' blood and feces, and length of hospital stay were significantly associated with exposure to hospital hazards (P < 0.05, χ2 > 1, odds ratio >1). Conclusion: The participants' knowledge and perception of hospital hazard were poor. Abusive insults by health workers, sexual harassment, and indiscriminate handling of patients' specimen constitute major ethical challenges in this setting. The hospital management should have a guideline specifying the roles and responsibilities of patients and their relatives. There is a need for the health care workers' ethics education and safe accommodation for patient relatives. © 2016 Nigerian Journal of Clinical Practice.
PubMed | Kaduna State University, University Putra Malaysia and Zhengzhou University
Type: | Journal: Journal of ethnopharmacology | Year: 2016
Clausena excavata Burm.f. is used locally in folk medicine for the treatment of cancer in South East Asia.To determine the mechanism of action of pure clausenidin crystals in the induction of hepatocellular carcinoma (hepG2) cells apoptosis.Pure clausenidin was isolated from Clausena excavata Burm.f. and characterized using Clausenidin induced significant (p<0.05) and dose-dependent apoptosis of hepG2 cells. Cell cycle assay showed that clausenidin induced a G2/M phase arrest, caused mitochondrial membrane depolarization and significantly (p<0.05) increased expression of caspases 3 and 9, which suggest the involvement of the mitochondria in the apoptotic signals. In addition, clausenidin caused decreased expression of the anti-apoptotic protein, Bcl 2 and increased expression of the pro-apoptotic protein, Bax. This finding was confirmed by the downregulation of Bcl-2 gene and upregulation of the Bax gene in the treated hepG2 cells.Clausenidin extracted from Clausena excavata Burm.f. is an anti-hepG2 cell compound as shown by its ability to induce apoptosis through the mitochondrial pathway of apoptosis. Clausenidin can potentially be developed into an anticancer compound.
Ajibola A.,Kaduna State University
Malaysian Journal of Medical Sciences | Year: 2015
Honey is a sweet, flavourful liquid substance with several beneficial constituents. Extensive research has shown the therapeutic promise of the use of honey in enhancing health values and improving body systems. This manuscript documents the ancient medicinal uses of honey and provides evidence-based data demonstrating its benefits in animal models, patients, and healthy individuals. Several reports by various researchers are discussed regarding health indices and biomarkers used following apitherapy. These include physiological processes in virtually all animal and human organs. The responses of body systems after oral and systemic administration of honey are also mentioned. Honey is also evaluated for its wide acceptability as a complementary and alternative medicine for most ailments. All types of honey exhibit different biochemical activities and show greater variability in their potency as apitherapeutic agents than conventional medicines. The mechanisms of action conferring honey’s protective effects, as suggested by various authors, are documented. These entail synergistic interaction of the bioactive physical and chemical constituents of honey to produce the desired beneficial effects. The use of apitherapy in synergy with chemotherapy to manage microbial and cancer ailments is also helpful in reducing drug-induced cytotoxicity. The mechanistic insights into the overall protective, preventive, and therapeutic effects of honey portend the presence of a unique factor, a ‘synergistic multiple ingredients factor’, designated SMIF. © Penerbit Universiti Sains Malaysia, 2015.
Daniel Y.S.,Kaduna State University |
Daniel S.K.,Kaduna State University
Alexandria Engineering Journal | Year: 2015
This paper investigates the theoretical influence of buoyancy and thermal radiation on MHD flow over a stretching porous sheet. The model which constituted highly nonlinear governing equations is transformed using similarity solution and then solved using homotopy analysis method (HAM). The analysis is carried out up to the 5th order of approximation and the influences of different physical parameters such as Prandtl number, Grashof number, suction/injection parameter, thermal radiation parameter and heat generation/absorption coefficient and also Hartman number on dimensionless velocity, temperature and the rate of heat transfer are investigated and discussed quantitatively with the aid of graphs. Numerical results obtained are compared with the previous results published in the literature and are found to be in good agreement. It was found that when the buoyancy parameter and the fluid velocity increase, the thermal boundary layer decreases. In case of the thermal radiation, increasing the thermal radiation parameter produces significant increases in the thermal conditions of the fluid temperature which cause more fluid in the boundary layer due to buoyancy effect, causing the velocity in the fluid to increase. The hydrodynamic boundary layer and thermal boundary layer thickness increase as a result of increase in radiation. © 2015 Faculty of Engineering, Alexandria University. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license.
Jock J.,Kaduna State University
Proceedings - 2010 3rd IEEE International Conference on Computer Science and Information Technology, ICCSIT 2010 | Year: 2010
In this paper, we identify and analyze a set of characteristics that increasingly distinguish today's complex software systems from "traditional" ones. Several examples in different areas show that these characteristics are not limited to a few application domains but are widespread. Then, we discuss how these characteristics are likely to impact dramatically the very way software systems are modeled and engineered. In particular, we appear to be on the edge of a radical shift of paradigm, about to change our very attitudes in software systems modeling and engineering. © 2010 IEEE.