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Kaduna, Nigeria

Kaduna State University is located Kaduna State Nigeria. It was established in 2004. It was established to provide an all-round university of the highest standard for the development of individuals and state. It is currently one of the fastest growing state owned institutions in Nigeria.Kaduna state university have a total number of 7 faculties with over 39 departments, the school library contains over 17,000 volumes of books. The school has a functioning e-library and is striving to become a center of academic excellence. Kaduna State University has a student size of about 6000 to 10000. It was ranked 5th best university by National Universities Commissions Wikipedia.

Olugbenga A.M.,University of Uyo | Musa A.E.,Kaduna State University | Oluwatoyin A.H.,University of Ibadan
Asian Journal of Pharmaceutical and Clinical Research | Year: 2012

Due to problems associated with the use of synthetic drugs and lack of affordability, effort has been made to prepare useful drugs from medicinal plants which would have less significant side effects and can be easily affordable to the poor people. The use of medicinal plants in therapy is becoming significant in Africa with the publishing of African Pharmacopeia which regulates and set standard for the use of various medicinal plants in Africa. It is commonly used for alleviating disease conditions like insomnia, pain, depression and agitation. The plant was obtained from the forest and three parts namely the leaf, stem bark and root bark were grinded into powder. The powder was triturated with natural feed and cassava was added to make mixed feed cake. After conditioning two albino rats in the metabolic cage for eight weeks, they were fed with the prepared mixed feed cake. The urine obtained was used for heamolysis test. At both 26oC and 27oC room temperature, extraction of saponins from leaf, stem bark and root bark were done for a period of 20 hours and 33 minutes respectively in both water and methanol solvent and the duration of heamolysis on blood cells was obtained. The result of the research showed that shaking of the grinded samples of the leaf, stem bark and root bark produced lather (foam) that persisted for 40 minutes. The blood cells were also heamolysed leaving a clear solution on top and a dark-brownish cloudy suspension below. At both room temperature measurements, the heamolysis duration for methanol was shorter for methanol than water as solvent. More urine was obtained when the animals were fed with the plant extracts than when they consumed pure animal feed and the color of urine also changed from dark-yellow cloudy urine to reddish-brown cloudy urine. The rats eventually died after ingestion of mixed feed cake. Methanol was undoubtedly a better solvent for saponins. Though there are many biological activities of saponin which are of importance to man such as reduction of serum cholesterol, antiviral and anti-fungal activities and their effects on the uterus and vaginal infection, the use of saponin is limited due to its toxicity. The surface activity of saponin on erythrocyte and its tendency for accumulation have limited the use of saponin.

Ajibola A.,Kaduna State University
Malaysian Journal of Medical Sciences | Year: 2015

Honey is a sweet, flavourful liquid substance with several beneficial constituents. Extensive research has shown the therapeutic promise of the use of honey in enhancing health values and improving body systems. This manuscript documents the ancient medicinal uses of honey and provides evidence-based data demonstrating its benefits in animal models, patients, and healthy individuals. Several reports by various researchers are discussed regarding health indices and biomarkers used following apitherapy. These include physiological processes in virtually all animal and human organs. The responses of body systems after oral and systemic administration of honey are also mentioned. Honey is also evaluated for its wide acceptability as a complementary and alternative medicine for most ailments. All types of honey exhibit different biochemical activities and show greater variability in their potency as apitherapeutic agents than conventional medicines. The mechanisms of action conferring honey’s protective effects, as suggested by various authors, are documented. These entail synergistic interaction of the bioactive physical and chemical constituents of honey to produce the desired beneficial effects. The use of apitherapy in synergy with chemotherapy to manage microbial and cancer ailments is also helpful in reducing drug-induced cytotoxicity. The mechanistic insights into the overall protective, preventive, and therapeutic effects of honey portend the presence of a unique factor, a ‘synergistic multiple ingredients factor’, designated SMIF. © Penerbit Universiti Sains Malaysia, 2015.

Chindo B.A.,Kaduna State University | Chindo B.A.,Otto Von Guericke University of Magdeburg | Chindo B.A.,Nigerian National Institute for Pharmaceutical Research and Development | Schroder H.,Otto Von Guericke University of Magdeburg | Becker A.,Otto Von Guericke University of Magdeburg
Phytomedicine | Year: 2015

Decoctions of Ficus plathyphylla are used in Nigeria's folk medicine to manage epilepsy for many years and their efficacies are widely acclaimed among the rural communities of Northern Nigeria. In this study, we examined the ameliorative effects of the standardized methanol extract of Ficus platyphylla (FP) stem bark on seizure severity, cognitive deficit and neuronal cell loss in pentylenetetrazole-kindled mice. The 35S-GTPγS, glutamate and γ-aminobutyric acid receptors binding properties of the extract were also evaluated. Male CD-1 mice were kindled with an initial subeffective dose of pentylenetetrazole (PTZ, 37.5 mg/kg, i.p.) for a total of 13 convulsant injections and the treatment groups concurrently received FP (100 and 200 mg/kg). Control animals received the same number of saline injections. Twenty-four h after kindling completion the animals' learning performance was tested in a two-way shuttle-box. The animals were challenged with another subeffective dose of PTZ (32.5 mg/kg, i.p.) on day 7 after kindling completion. Animals were sacrificed a day after the challenged experiment and the brains were processed for histological investigation. FP ameliorates seizure severity, cognitive deficits and neuronal cell loss in PTZ kindled mice. Components of the extract showed affinity for GABAergic and glutamatergic receptors. Glutamate release was diminished and the 35S-GTPγS binding assay revealed no intrinsic activity at glutamatergic receptors. Our results revealed that FP contains psychoactive secondary metabolites with anticonvulsant properties, thus supporting the isolation and development of the biologically active components of this medicinal plant as antiepileptic agents. © 2014 Elsevier GmbH. All rights reserved.

Shehu A.,Kaduna State University | Mohammed A.,Ahmadu Bello University | Magaji R.A.,Ahmadu Bello University | Muhammad M.S.,Gombe State University
Metabolic Brain Disease | Year: 2015

Research on the effects of Mobile phone radio frequency emissions on biological systems has been focused on noise and vibrations as auditory stressors. This study investigated the potential effects of exposure to mobile phone electromagnetic field radiation, ringtone and vibration on anxiety-like behaviour and oxidative stress biomarkers in albino wistar rats. Twenty five male wistar rats were randomly divided into five groups of 5 animals each: group I: exposed to mobile phone in switched off mode (control), group II: exposed to mobile phone in silent mode, group III: exposed to mobile phone in vibration mode, group IV: exposed to mobile phone in ringtone mode, group V: exposed to mobile phone in vibration and ringtone mode. The animals in group II to V were exposed to 10 min call (30 missed calls for 20 s each) per day for 4 weeks. Neurobehavioural studies for assessing anxiety were carried out 24 h after the last exposure and the animals were sacrificed. Brain samples were collected for biochemical evaluation immediately. Results obtained showed a significant decrease (P < 0.05) in open arm duration in all the experimental groups when compared to the control. A significant decrease (P < 0.05) was also observed in catalase activity in group IV and V when compared to the control. In conclusion, the results of the present study indicates that 4 weeks exposure to electromagnetic radiation, vibration, ringtone or both produced a significant effect on anxiety-like behavior and oxidative stress in young wistar rats. © 2015 Springer Science+Business Media New York

Egwaikhide P.A.,University of Benin | Bulus T.,Kaduna State University | Emua S.A.,Ambrose Alli University
Electronic Journal of Environmental, Agricultural and Food Chemistry | Year: 2010

In this study, the antimicrobial activities of the aqueous, hexane, methanol, chloroform, ethyl acetate extracts from the roots of Eucalyptus globulus, was carried out against ten (10) gram positive and four (4) gram negative pathogenic bacteria by agar well diffusion method. The methanol and ethyl acetate root extracts showed pronounced inhibition against all the bacteria used. Maximum zone of inhibition was exhibited by methanol extract with 23mm, 21mm, 22mm, 23mm, and 24mm zones of inhibition to the growth of C. pyogenes, B. stearothermophilus, S.epidemidis, K. pneumonia and B. cereus respectively. These values were comparatively higher than those of the standard drug, streptomycin. Phytochemical screening of all extracts revealed the presence of alkaloids and steroids in the active extracts. The results obtained suggest that E. globulus could be exploited in the management of various infectious diseases.

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