Ulukent S.C.,Kanuni Sultan Suleyman Training and Research Hospital |
Sarici I.S.,Kanuni Sultan Suleyman Training and Research Hospital |
Ulutas K.T.,Kadirli State Hospital Osmaniye
International Journal of Clinical and Experimental Medicine | Year: 2016
Objective: To investigate leukocyte count, neutrophil percentage, Neutrophil-Lymphocyte Ratio (NLR), Platelet-Lymphocyte ratio (PLR), mean platelet volume (MPV), red cell distribution width (RDW), platelet distribution width (PDW) and CRP in the diagnosis of acute appendicitis (AA). Materials and methods: A retrospective case-controlled study was designed in two groups. Ninety-seven patients containing AA and 94 patients in control group. Leukocyte count, neutrophil percentage, NLR, PLR, MPV, RDW, PDW and CRP were compared in two groups. Results: The mean PLR values in AA and control were 166±97 and 107±28 respectively, and there was a significant difference in PLR values between the groups (P<0.0001). Best cutoff point for WBC count in the diagnosis of AA was 8650 106/μL, which had a sensitivity of 76% and a specificity of 94%. Best cutoff in diagnosis AA for NLR 3.15, which had a sensitivity of 77% and a specificity of 94%. Acute appendicitis group having low levels in MPV and RDW values but there were no significant differences in two groups. Leukocyte levels correlated with NLR, PLR and PDW. Conclusion: Neutrophil-Lymphocyte Ratio and leukocyte count seems to be a better inflammatory marker in AA. Higher PLR levels important parameter in diagnosis of AA. However, ROC analysis showed that MPV and RDW levels is not marker in terms of sensivity and specifity compared to other markers. © 2016, E-Century Publishing Corporation. All rights reserved.
Kala F.,Kadirli State Hospital |
Sarici I.S.,Kayseri Training and Research Hospital |
Ulutas K.T.,Kadirli State Hospital Osmaniye |
Sevim Y.,Kayseri Training and Research Hospital |
And 5 more authors.
International Journal of Clinical and Experimental Medicine | Year: 2015
Objective: Postoperative iPTH assay may predict significant hypocalcemia after thyroid surgery. The present study aimed to evaluate the ability of iPTH assay to monitor parathyroid function and to identify the risk of postoperative hypocalcemia in patients underwent thyroid surgery. Materials and methods: One hundred patients participated in the study (7 male and 93 female). Hypocalcemia was defined as a serum calcium concentration less than 8.0 mg/dL and symptoms of hypocalcemia. Concomitant serum calcium and iPTH levels were measured before operation and at 1st h for iPTH, 24th h for calcium after thyroidectomy. Results: Postoperative hypocalcemia was observed in 31 patients. The mean postoperative serum calcium concentration in normocalcemic patients was 8.8 ± 0.5 mg/dL, whereas it was 7.6 ± 0.3 mg/dL in hypocalcemic patients. The mean postoperative 1st hour iPTH of patients in the hypocalcemia group was 9.1 ± 4.9 pg/mL, whereas patients of the normocalcemia group had a mean postoperative iPTH of 35.8 ± 20.2 pg/mL. Conclusion: Postoperative 1st hour iPTH < 8 pg/mL with drop in iPTH level ≥ 81.5% together showed the highest diagnostic accuracy in predicting postoperative hypocalcemia. © 2015, E-Century Publishing Corporation. All rights reserved.
PubMed | Harran University, Mustafa Kemal University and Kadirli State Hospital Osmaniye
Type: Journal Article | Journal: International journal of clinical and experimental medicine | Year: 2014
Platelets have an important role in atherosclerosis and arterial thrombosis. Cardiovascular complication prevalence of type 2 diabetes mellitus (type 2 DM) may be associated with glycosylated hemoglobin (HbA1c) and mean platelet volume (MPV). The aim of the study was to investigate if platelets were activated in diabetes and its associated vascular complications by measuring the MPV in the diabetics compared to the non-diabetics, and to determine the correlation of MPV with fasting serum glucose (FSG), HbA1c and duration of diabetes in the diabetic patients, respectively.The study carried out in 65 patients with type 2 DM and 40 non-diabetic subjects. In addition to non-diabetic patients, all diabetic patients were divided into two groups according to their HbA1c levels: group A consisted of patients with HbA1c levels 7% and group B consisted of patients with HbA1c levels >7%.MPV was significantly higher in Group B as compared to both non-diabetics and Group A. MPV had a high positive correlation with HbA1c and FSG, as with diabetes duration. It is found that MPV was increased in type 2 DM.Our findings suggested an association between MPV and HbA1c. Therefore, MPV would be a beneficial prognostic marker of cardio-vascular complications in patients with type 2 DM.