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Kadirli, Turkey

Cavus G.,Aksaray State Hospital | Altas M.,Mustafa Kemal University | Aras M.,Mustafa Kemal University | Ozgur T.,Mustafa Kemal University | And 4 more authors.
European Review for Medical and Pharmacological Sciences | Year: 2014

OBJECTIVE: The development of secondary brain injury after trauma is known to involve in many cellular mediators. The aim of the study was to evaluate and compare the effects of the use of both methylprednisolone and montelukast on serum and tissue concentrations of NO, malondialdehyde (MDA) levels, superoxide dismutase (SOD) activity, and tissue glutathione peroxidase (GSH-Px) activity in rats with spinal cord injury (SCI). MATERIALS AND METHODS: SCI was induced in Wistar albino rats by dropping a 10 g rod from a 5.0 cm height at T9-10. The 28 rats were randomly divided into four equal groups: montelukast, methylprednisolone, non-treatment and sham groups. Rats were neurologically tested at 24 hours after trauma and spinal cord tissue levels of MDA, SOD, GSH-PX, CAT levels and blood CK, CK-BB, LDH levels were measured. In addition, histopathological changes were also examined. RESULTS: There was a significant improvement in Tarlov scores in methylprednisolone and montelukast administered group compared to the trauma group (p = 0.001).When compared to trauma group, methylprednisolone and montelukast groups had significant differences in MDA (p < 0.05), SOD (p < 0.001), CK-BB (p < 0.001) and LDH (p < 0.05) levels. Histopathologically, no significant changes were observed. CONCLUSIONS: The present study shows effects of montelukast with biochemical and histopathological parameters and compares its effects with those of methylprednisolone for the first time. Our research has shown that montelukast and methylprednisolone have a neuroprotective effect on spinal cord injury.

Oral Y.,Lutfi Kirdar Training and Research Hospital | Gunaydin N.,Kadirli State Hospital | Ozgur O.,Lutfi Kirdar Training and Research Hospital | Arsan A.K.,Lutfi Kirdar Training and Research Hospital | Oskan S.,Lutfi Kirdar Training and Research Hospital
Journal of Pediatric Ophthalmology and Strabismus | Year: 2012

Purpose: To compare the results of diff erent refractive error measurement devices including table-mounted and hand-held autorefractors and videoretinoscopy with cycloplegic retinoscopy (CR) in children to evaluate the usability and reliability of these devices in measuring refractive errors. Methods: Two hundred eyes of 100 children underwent autorefraction using table-mounted autorefractor with and without cycloplegia and videoretinoscopy after cycloplegia. All results were compared statistically. Results: The mean spheric values (SV) and spherical equivalent values (SEV) of the non-cycloplegic tablemounted autorefractor were found to be signifi cantly lower and those of the cycloplegic table-mounted autorefractor were found to be signifi cantly higher than CR results. There was no statistically signifi cant diff erence in terms of mean SV and SEV between the handheld autorefractor and CR. Although the mean SV using videoretinoscopy were 0.15 diopters lower than CR, this diff erence was not signifi cant. Comparing CR with the other refraction methods, all devices correlated with each other. Sensitivity in diagnosing myopia was low for all methods but sensitivity in diagnosing hyperopia and astigmatism was high for table-mounted and hand-held autorefractors. The other reliability parameters were found to be similar for all devices. Conclusions: Both videoretinoscopy and hand-held autorefractor can be used in both screening and examination for children as an alternative to CR and tablemounted autorefractor. © SLACK Incorporated.

Kokacya M.H.,Mustafa Kemal University | Copoglu U.S.,Mustafa Kemal University | Kivrak Y.,Kafkas University | Ari M.,Mustafa Kemal University | And 2 more authors.
Neuropsychiatric Disease and Treatment | Year: 2015

Objective: The relationship between platelet activation and psychiatric disorders has been shown in previous work. Mean platelet volume (MPV) is a measure of platelet size and a good indicator of platelet activity, which increases in cardiovascular diseases (CVDs). It is known that anxiety is a considerable factor in the etiology of mortality in CVDs. The aim of the present study was to investigate any probable difference in the MPV of patients with panic disorder (PD). Methods: Sixty-one drug-free patients, aged 18–65years and diagnosed with PD according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, were included in the study, along with 63 healthy age- and sex-matched volunteers. The body mass index (BMI) was calculated and MPV measured for each subject. Results: The MPV was found to be higher in the PD group compared to the control group (P=0.004). There were no significant differences between the two groups in terms of platelet count or BMI. Conclusion: Alterations in platelet activity may be a reflection of abnormal 5-hydroxytryptamine (5-HT) 1A receptor function in the central nervous system of subjects with a diagnosis of PD. These findings may elucidate the relationship between CVDs and PD. The findings of the present study suggest that MPV is increased in PD patients. © 2015 Kokacya et al.

Aras M.,Mustafa Kemal University | Altas M.,Mustafa Kemal University | Meydan S.,Bezmialem Foundation University | Nacar E.,Mustafa Kemal University | And 3 more authors.
International Journal of Neuroscience | Year: 2014

Aim: Interruption of blood flow may result in considerable tissue damage via ischemia/reperfusion (I/R) injury-induced oxidative stress in brain tissues. The aim of the present study was to investigate the effects of Ebselen treatment in short-term global brain I/R injury in rats. Material and Methods: The study was carried out on 27 Wistar-albino rats, divided into three groups including Sham group (n = 11), I/R group (n = 8) and I/R+Ebselen group (n = 8). Results: Malondialdehyde (MDA) levels were significantly increased in I/R group in comparison with the Sham group and I/R+Ebselen group (p < 0.001 and p < 0.01). Superoxide dismutase (SOD) activity was significantly lower in I/R group in comparison to both Sham (p < 0.001) and I/R+Ebselen (p < 0.01) groups. Similarly, SOD activity was decreased in I/R+Ebselen group when compared with Sham group (p < 0.001). Sham and I/R groups were similar in terms of nitric oxide (NO) levels. In contrast, the NO level was lower in I/R+Ebselen group when compared with Sham (p < 0.001) and I/R (p < 0.01) groups. There was no significant difference among the groups in terms of glutathione peroxidase and catalase activities. In histopathological examination, the brain tissues of rats that received Ebselen showed morphological improvement. Conclusion: Ebselen has neuron-protective effects due to its antioxidant properties as shown by the decrease in MDA overproduction, increase in SOD activity and the histological improvement after administration of Ebselen to I/R in brain tissue. © 2014 Informa Healthcare USA, Inc.

Cicek G.,Ankara Numune Education and Research Hospital | Acikgoz S.K.,Turkiye Yuksek Ihtisas Training and Research Hospital | Bozbay M.,Marmara University | Altay S.,Edirne State Hospital | And 3 more authors.
Angiology | Year: 2015

We assessed the effect of combination of neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) in predicting in-hospital and long-term mortality in patients (n = 2518) undergoing primary percutaneous coronary intervention (pPCI). Cutoff values for NLR and PLR were calculated with receiver-operating characteristic (ROC) curves. If both PLR and NLR were above the threshold, patients were classified as "high risk." If either PLR or NLR was above the threshold individually, patients were classified as "intermediate risk." High-risk (n = 693) and intermediate-risk (n = 545) groups had higher in-hospital and long-term mortality (7.2 4% vs 0.7%, P <.001; 14.1, 9.5% vs 4.5%, P <.001, respectively). Classifying patients into intermediate-risk group (hazards ratio [HR]: 1.492, 95% confidence interval [CI]: 1.022-2.178, P =.038) and high-risk group (HR: 1.845, 95% CI: 1.313-2.594, P <.001) was an independent predictor of in-hospital and long-term mortality. The combination of PLR and NLR can be useful for the prediction of in-hospital and long-term mortality in patients undergoing pPCI. © The Author(s) 2014.

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