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Misgav, Israel

Juvenis Corporation | Date: 2013-12-16

Non-medicated skin care preparations, namely, creams, lotions, gels, facial toners, skin cleansers, facial scrubs, anti aging creams, skin and scalp conditioning lotions.

Juvenis Corporation | Date: 2013-12-08

Non-medicated skin care preparations, namely, creams, lotions, gels, skin cleansers, facial scrubs.

Ickowicz D.E.,Hebrew University of Jerusalem | Haim-Zada M.,Hebrew University of Jerusalem | Abbas R.,Juvenis Ltd | Touitou D.,Juvenis Ltd | And 7 more authors.
Polymers for Advanced Technologies | Year: 2014

Biodegrable polyesters derived from hydroxy acids have a broad clinical use. The aim of the study was to synthesize polymer compositions based on citric acid and castor oil for use as soft tissue augmentation. Two polymers were synthesized, a branched viscous polyester with a monomer ratio of 93.5:6.5 w/w and an apparent molecular weight of 11,000Da and a crosslinked semisolid polymer with a monomer ratio of 92.5:7.5 w/w. The branched polymer lost less than 10% of its weight during a 30-day degradation study. In vivo biocompatibility study in rats showed 20% formulation weight loss 9months post-subcutaneous administration. These results were in accordance with the in vitro hydrolytic degradation of the polymer. The in vivo study revealed good tolerability of the copolymer. © 2014 John Wiley & Sons, Ltd.

Ramot Y.,Hebrew University of Jerusalem | Touitou D.,Juvenis Ltd | Levin G.,Juvenis Ltd | Ickowicz D.E.,Hebrew University of Jerusalem | And 5 more authors.
Toxicologic Pathology | Year: 2015

Soft tissue filler products have become very popular in recent years, with ever-increasing medical and aesthetic indications. While generally considered safe, the number of reported complications with tissue fillers is growing. Nevertheless, there is no specific animal model that is considered as the gold standard for assessing safety or efficacy of tissue fillers, and there are very little data on interspecies differences in reaction to these products. Here, we report on interspecies differences in reaction to a subcutaneous injectable co-polyester, composed of castor oil and citric acid. Comparison of the histopathological local tissue changes following 1-month postimplantation, indicated that in rats the reaction consisted of cavities, surrounded by relatively thin fibrotic enveloping capsule. In contrast, an unexpected severe inflammatory granulomatous reaction was noticed in Sinclair minipigs. To our knowledge, this is the first report on significant interspecies differences in sensitivity to tissue fillers. It emphasizes the importance of using the appropriate animal model for performing preclinical biocompatibility assays for biodegradable polymers, tissue fillers, and implanted medical devices in general. It also makes the Sinclair minipig subject for scrutiny as an animal model in future biocompatibility studies. © 2014 by The Author(s).

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