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Karuvalam R.P.,Kannur University | Haridas K.R.,Kannur University | Shetty S.N.,Justice Ks Hegde Medical Academy
Journal of the Chilean Chemical Society | Year: 2012

A convenient method using TMSCl (20 mol%) and microwave-induced technique for the synthesis of various benzimidazole is described. This has reduced the reaction time drastically as well as improved the yield when compared to conventional heating. The synthesized compounds were evaluated for their in vitro antibacterial and antifungal activities against four strains each. Preliminary results indicated that, compounds 3e, 3f, 3g, 3k, 3m, 3n and 3o demonstrated very good antimicrobial activity, comparable to the first line standard drugs. The most effective compounds have exhibited activity at MIC of 6.25 μg/mL. © 2012 Sociedad Chilena de Química. Source


Karuvalam R.P.,Kannur University | Haridas K.R.,Kannur University | Nayak S.K.,Indian Institute of Science | Guru Row T.N.,Indian Institute of Science | And 3 more authors.
European Journal of Medicinal Chemistry | Year: 2012

A series of (2-aminothiazol-4-yl)methylester (5a-t) derivatives were synthesized in good yields and characterized by 1H NMR, 13C NMR, mass spectral and elemental analyses. The crystal structure of 5a was evidenced by X-ray diffraction study. The compounds were evaluated for their preliminary in vitro antibacterial, antifungal activity and were screened for antitubercular activity against Mycobacterium tuberculosis H37Rv strain. The synthesized compounds displayed interesting antimicrobial activity. © 2012 Elsevier Masson SAS. All rights reserved. Source


Karuvalam R.P.,Kannur University | Pakkath R.,Kannur University | Haridas K.R.,Kannur University | Rishikesan R.,and Research Center | Kumari N.S.,Justice Ks Hegde Medical Academy
Medicinal Chemistry Research | Year: 2013

In this article, we report herein the SAR studies of a series of (1H-indol-3-yl)alkyl-3-(1H-indol-3-yl)propanamide 10(a-j), 11(a-j). The synthesized compounds were evaluated for their preliminary in vitro antibacterial, antifungal activity and were screened for antitubercular activity against Mycobacterium tuberculosis H37Rv strain. The synthesized compounds displayed interesting antimicrobial activity. © 2013 Springer Science+Business Media New York. Source


Ranjith P.K.,Kannur University | Rajeesh P.,Kannur University | Haridas K.R.,Kannur University | Susanta N.K.,Indian Institute of Science | And 3 more authors.
Bioorganic and Medicinal Chemistry Letters | Year: 2013

In this Letter, we report the structure-activity relationship (SAR) studies on series of positional isomers of 5(6)-bromo-1-[(phenyl)sulfonyl]-2-[(4- nitrophenoxy)methyl]-1H-benzimidazoles derivatives 7(a-j) and 8(a-j) synthesized in good yields and characterized by 1H NMR, 13C NMR and mass spectral analyses. The crystal structure of 7a was evidenced by X-ray diffraction study. The newly synthesized compounds were evaluated for their in vitro antibacterial activity against Staphylococcus aureus, (Gram-positive), Escherichia coli and Klebsiella pneumoniae (Gram-negative), antifungal activity against Candida albicans, Aspergillus flavus and Rhizopus sp. and antitubercular activity against Mycobacterium tuberculosis H37Rv, Mycobacterium smegmatis, Mycobacterium fortuitum and MDR-TB strains. The synthesized compounds displayed interesting antimicrobial activity. The compounds 7b, 7e and 7h displayed significant activity against Mycobacterium tuberculosis H37Rv strain. © 2013 Elsevier Ltd. All rights reserved. Source


Paniraj A.S.,University of Mysore | Paniraj A.S.,Advinus Therapeutics Ltd | Rai K.M.L.,University of Mysore | Bhat P.V.,Advinus Therapeutics Ltd | And 4 more authors.
Der Pharma Chemica | Year: 2011

New 5-halo-4, 6-dimethoxy-2-(alkoxy or aryloxy) pyrimidines (4a-r) were prepared from 5-halo-4,6-dialkoxy,2-methylsulfonylpyrimidine. The structure of newly synthesized compounds was characterized by their spectral date. The newly synthesized compounds were evaluated for their anmicrobial and antifungal studies. Some of the compounds showed moderate to good activity. Source

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